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Big Pharma, scoppia lo scandalo dei test nella DDR

Big Pharma, scoppia lo scandalo dei test nella DDR | Disease mongering | Scoop.it
Più di cinquanta grandi gruppi farmaceutici occidentali avrebbero effettuato sperimentazioni in Germania dell'Est, con l'avallo del ministero della Sanità, senza informare i pazienti.
Giuseppe Fattori's insight:

I test, complessivamente, sarebbero stati165, effettuati tra il 1983 ed il 1989. Ciascuna delle sperimentazioni sarebbe stata pagata dalle aziende - tra le quali Tagespiegel cita Bayer, Schering, Hoechst(acquisita da Sanofi), Boehringer Ingelheim e Gödecke (oggi Pfizer) - circa 860 mila marchi. 

Il giornale cita inoltre sette casi concreti di pazienti che affermano di non aver ricevuto alcuna informazione in merito. Anche la tv locale MDR si è interessata alla questione, raccontando la storia di Gerhard Lehrer, in terapia intensiva nel 1989 all’ospedale di Dresda in seguito ad un infarto. L’uomo assunse farmaci speciali, che all’epoca non si trovavano in commercio, prescritti da un medico della struttura. Il risultato fu un peggioramento delle sue condizioni di salute.

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Giuseppe Fattori's curator insight, December 30, 2012 2:37 PM

I test, complessivamente, sarebbero stati165, effettuati tra il 1983 ed il 1989. Ciascuna delle sperimentazioni sarebbe stata pagata dalle aziende - tra le quali Tagespiegel cita Bayer, Schering, Hoechst(acquisita da Sanofi), Boehringer Ingelheim e Gödecke (oggi Pfizer) - circa 860 mila marchi. 

Il giornale cita inoltre sette casi concreti di pazienti che affermano di non aver ricevuto alcuna informazione in merito. Anche la tv locale MDR si è interessata alla questione, raccontando la storia di Gerhard Lehrer, in terapia intensiva nel 1989 all’ospedale di Dresda in seguito ad un infarto. L’uomo assunse farmaci speciali, che all’epoca non si trovavano in commercio, prescritti da un medico della struttura. Il risultato fu un peggioramento delle sue condizioni di salute.

Disease mongering
Overdiagnosis of disease: a modern epidemic sickness.
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MSD minaccia azioni legali per far cessare le critiche ad un suo prodotto. Pillole.org

La MSD ha minacciato azioni legali contro l'epidemiologo clinico Alberto Donzelli, per indurlo a cessare di esprimere critiche nei confronti dell'uso di un prodotto dell'azienda. 

Assume connotati internazionali la controversia tra la Merck Sharp & Dohme e il Dottor Alberto Donzelli, responsabile appropriatezza clinica della ASL di Milano. Il BMJ ha pubblicato un articolo che riassume la vicenda.

La filiale italiana della compagnia farmaceutica Merck Sharp & Dohme (MSD) ha stoppato un medico di primo piano nella gestione della salute pubblica intimandogli di cessare di indirizzare ai Medici di Medicina Generale testi medici critici nei confronti dell'uso di uno dei farmaci della società. 

Nei testi, Alberto Donzelli, il capo della formazione, appropriatezza e medicina basata sulle evidenze presso l'azienda di sanità pubblica di Milano (ASL Milano), aveva analizzato le prove pubblicate sul farmaco ezetimibe scoraggiandone l'uso in aggiunta alle statine. 

Una lettera a "cessare e desistere" è stata inviata in febbraio dal direttore medico di MSD, Patrizia Nardini, ed è stata recapitata dal direttore degli affari legali della società. Hanno accusato Donzelli di colpa grave e di una violazione dell'etica medica e minacciato di far causa a lui e a Milano Sanità per una cifra di € 1,3 milioni (1 milione di sterline; $ 1.78m). La lettera era indirizzata a Donzelli, con copia inviata al direttore generale della ASL di Milano e al presidente dell'Ordine dei Medici di Milano Roberto Carlo Rossi.  aggiornamento, ricerca, supporto, promozione del ruolo dei medici.
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Is digital health neglecting The Big Preventable–medical errors?

Is digital health neglecting The Big Preventable–medical errors? | Disease mongering | Scoop.it

Preventable medical errors persist as the No. 3 killer in the US – third only to heart disease and cancer – claiming the lives of some 400,000 people each year.

(US Senate hearing, cited in HealthcareITNews 18 July 2014)

At the end of last month, this Editor questioned the efficacy of our current state of ‘consumer engagement’ in Patients should be less engaged, not more. The ‘less engaged’ was a call for simplification: regimens and devices which were easier to use, less complicated and far easier to fit in everyday life. (Aesthetics helps too.) Back in 2013, HeartSister/Ethical Nag (and Canadian) Carolyn Thomas called for health app (and by inference consumer engagement) designers to ‘skate to where the puck is going’–as in “For Pete’s sake, go find some Real Live Patients to talk (and listen) to first before you decide where you’re going!” Often it seems like these apps and platforms are designed in a vacuum of the entrepreneur’s making. The proof is the low uptake (Pew, Parks, IMS) and the apps’/programs’ lack of stickiness after all this time (Kvedar 8 Sep blog post).

- See more at: http://telecareaware.com/is-digital-health-neglecting-the-big-preventable-medical-errors/#sthash.6A75LT9J.dpuf

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A new, evidence-based estimate of patient harms associated with hospital care.

Using a weighted average of the 4 studies, a lower limit of 210,000 deaths per year was associated with preventable harm in hospitals. Given limitations in the search capability of the Global Trigger Tool and the incompleteness of medical records on which the Tool depends, the true number of premature deaths associated with preventable harm to patients was estimated at more than 400,000 per year. Serious harm seems to be 10- to 20-fold more common than lethal harm.
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Peer Reviewed: A Systematic Review of Food Deserts, 1966-2007

We conducted a systematic review of primary, quantitative, observational studies, published in English or French, that used geographic or market-basket approaches in high-income countries. The literature search included electronic and hand searches and peer-reviewed and grey literature from 1966 through 2007. We also contacted key researchers to identify other studies. We analyzed the findings and quality of the studies qualitatively.

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Research Reveals How Sugar CAUSES Cancer

Research Reveals How Sugar CAUSES Cancer | Disease mongering | Scoop.it

Hospitals feed cancer patients sugar and high carbohydrate diets for a reason: they are abysmally ignorant of the role of nutrition in health and disease — hence their burgeoning growth and packed rooms.

Even though the science itself shows – at least since the mid-’20s with Otto Warburg’s cancer hypothesis – that tumors prefer to utilize sugar fermentation to produce energy rather than the much more efficient oxygen-based phosphorylation* – hospitals have actually invited corporations like McDonald’s to move into their facilities to ‘enhance’ their patient’s gustatory experience, presumably to provide comfort and take the edge off of the painful surgery, radiation and chemo treatments erroneously proffered to them as the only reasonable ‘standard of care.’


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Research Reveals How Sugar CAUSES Cancer

Research Reveals How Sugar CAUSES Cancer | Disease mongering | Scoop.it
A groundbreaking new study, uncovered by one of our volunteer researchers at Greenmedinfo – Jonathan Middleton – is the first of its kind to identify sugar, not only as fuel source for an already ...
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Vraies arrestations pour faux médicaments en Europe

Vraies arrestations pour faux médicaments en Europe | Disease mongering | Scoop.it

Quelque 12 personnes ont été arrêtées lors d'une opération européenne lundi, au cours de laquelle plusieurs millions de fausses pilules contre les troubles érectiles, plusieurs véhicules et beaucoup d'argent ont été saisis.


Via Giovanna Marsico
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Energy drinks cause heart problems

Energy drinks cause heart problems | Disease mongering | Scoop.it

Professor Drici said: “So-called ‘energy drinks’ are popular in dance clubs and during physical exercise, with people sometimes consuming a number of drinks one after the other. This situation can lead to a number of adverse conditions including angina, cardiac arrhythmia (irregular heartbeat) and even sudden death.”

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Pfizer agrees to pay $35 million for improper marketing of Rapamune

Pfizer agrees to pay $35 million for improper marketing of Rapamune | Disease mongering | Scoop.it
US pharma giant Pfizer has reached a $35 million settlement with 41 states in the USA and the District of Columbia for improper marketing and promotion of the i
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Dabigatran: how the drug company withheld important analyses

Dabigatran: how the drug company withheld important analyses | Disease mongering | Scoop.it

In an investigation by The BMJ Deborah Cohen finds that recommendations for use of new generation oral anticoagulants may be flawed because regulators did not see evidence showing that monitoring drug plasma levels could improve safety

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Plus du quart des césariennes pourraient être évitées

Plus du quart des césariennes pourraient être évitées | Disease mongering | Scoop.it

D'après cinq chercheurs, dont deux de l'Institut national de la santé et de la recherche médicale, 28 % d'entre elles en France auraient pu être évitées.


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Vaincre le conflit d’intérêts médical, par Irène Frachon et Pierre Le Coz

Vaincre le conflit d’intérêts médical, par Irène Frachon et Pierre Le Coz | Disease mongering | Scoop.it
Après le scandale du Mediator et le décès de Jacques Servier, une page se tourne dans le combat pour la transparence, mais il reste encore beaucoup à faire

Via Renaloo, EVELYNE PIERRON
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Renaloo's curator insight, August 6, 3:59 AM

Le décret d’application de la loi Bertrand traduisant la nécessité de rendre les liens transparents, en référence au Physician Sunshine Act adopté aux Etats-Unis en 2010, qui, comme son nom l’indique [sunshine signifie « éclat du soleil »], oblige à mettre au jour les liens d’intérêt des médecins américains. Le décret français reste cependant loin des ambitions initiales : seule une transparence limitée entre médecins et laboratoires pharmaceutiques à la déclaration chiffrée de quelques « plateaux repas » et autres cadeaux dits « sans contrepartie » a été imposée, laissant dans l’ombre les montants de contrats juteux liant l’industrie pharmaceutique à des médecins-relais qui assurent la promotion de ses nouveaux produits.

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Online Medical Advice Can Be a Prescription for Fear

Online Medical Advice Can Be a Prescription for Fear | Disease mongering | Scoop.it
Despite the Mayo Clinic site’s credibility, symptom addicts still use WebMD.
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Social Media Fever Slow to Spread Among Doctors

Social Media Fever Slow to Spread Among Doctors | Disease mongering | Scoop.it

Don’t expect the doctor to diagnose you via social media anytime soon. A June 2014 study by MedData Group found that 44% of US physicians still weren’t using social media sites for professional purposes.

Among doctors who were social networking as part of their job, profession-related sites were the platforms of choice. Around one-third of respondents used LinkedIn, and 29% were active on online physician communities, compared with just 3% who used online patient portals. Social sites that tend to be popular among the general public also saw low usage.

Avoiding social media wasn’t due to a lack of knowledge, with less than one-quarter of doctors saying they didn’t use such platforms because they weren’t familiar with them. Instead, patient privacy and a lack of time were the leading reasons US physicians said they stayed away from using social networks for professional purposes.

Q1 2014 polling by Digital Insights Group found that the general consensus among physicians was that social just wasn’t an important resource when it came to doing their jobs. Just 14% of US primary care physicians said that social networks were a somewhat or very important clinical resource, compared with 30% who said they weren’t important at all.

When doctors do turn to digital resources to make decisions, they’re most likely using search engines, according to April 2014 research also conducted by MedData Group. Among US physicians surveyed, a whopping 78% said search engines were the online resource they used in the medical decision-making process. Meanwhile, just 5% cited social media.

- See more at: http://www.emarketer.com/Article/Social-Media-Fever-Slow-Spread-Among-Doctors/1011013/1#sthash.FSdtHT1h.dpuf



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Google, Apple et Amazon : la médecine comme eldorado - Revue médicale suisse

Fascinante manière qu’a Google d’avancer ses pions dans tous les domaines qui importent aux humains. L’entreprise aime les «coups de pied à la lune» : les projets qui cherchent à résoudre des «problèmes graves» avec des méthodes radicalement nouvelles. Et des problèmes graves, s’il y a bien un endroit où il s’en trouve, c’est en médecine. Google y progresse donc, l’esprit conquérant. Il y avait eu le projet Calico, dévoilé l’année dernière, dont le but est de lutter contre le vieillissement et même de «tuer la mort» (problème grave et difficile, c’est vrai). 
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The cost of satisfaction: a national study of patient satisfaction, health care utilization, expenditures, and mortality.

In a nationally representative sample, higher patient satisfaction was associated with less emergency department use but with greater inpatient use, higher overall health care and prescription drug expenditures, and increased mortality.
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Amazon's author and reader betrayal- Battle with Hachette is a war for the future of reading and writing

Amazon's author and reader betrayal- Battle with Hachette is a war for the future of reading and writing | Disease mongering | Scoop.it
Battle with Hachette is a war for the future of reading and writing.
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Focus turns to expensive 'orphan drugs'

Focus turns to expensive 'orphan drugs' | Disease mongering | Scoop.it
Subsidies encouraged Big Pharma to develop medication for very rare conditions. But there's a catch.
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Doctor Skeptic: Calcium for healthy bones?

Doctor Skeptic: Calcium for healthy bones? | Disease mongering | Scoop.it
It’s one thing when my patients tell me that they are eating extra calcium to help their fractures heal or prevent new ones, but when my colleagues are advising them the same thing, its time to correct the bias. Taking calcium and/or vitamin D to heal fractures and prevent new fractures is another case of something that sounds good and is easy to believe, but doesn’t work as advertised.


Sounds like a no-brainer, right? After all, bones are made of calcium. Unfortunately, the usual combination of medical hubris, conclusion jumping, a desire to help, and some unintended consequences have turned this simple idea into a bad one. I am reminded of the quote from H.L. Mencken “For every complex problem, there is an answer that is clear, simple and wrong”
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Who Has The Most Tobacco Debt?

Who Has The Most Tobacco Debt? | Disease mongering | Scoop.it
After bruising legal fight, tobacco companies agreed in 1998 to compensate 46 states, the District of Columbia and five U.S. territories for the costs of smoking. Wall Street helped them turn those annual payments into instant cash, but some took high-risk deals that promised to repay billions in the future. This map shows where your state stands.
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One Drug. Two Prices. A Reporter Struggles to Find Out the Cost of His Son’s Prescription

One Drug. Two Prices. A Reporter Struggles to Find Out the Cost of His Son’s Prescription | Disease mongering | Scoop.it
$15 or $30? Health reporter Charles Ornstein is charged two different prices for the same drug. Which one is right? His effort to find out illustrates consumer frustrations with the health care system.
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Sugar: A Love/Hate Relationship. Why We Can't Ever Give Up The Sweet Stuff

Sugar: A Love/Hate Relationship. Why We Can't Ever Give Up The Sweet Stuff | Disease mongering | Scoop.it
The growing list of evils in almost any product is hard to keep track of. First it was fat. Then it was carbs, trans-fat. Then high fructose corn syrup. Salt: It’s bad!
Now it’s sugar.
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Higher glucose levels associated with lower memory and reduced hippocampal microstructure

Higher glucose levels associated with lower memory and reduced hippocampal microstructure | Disease mongering | Scoop.it

Editors' Note: Grabenhenrich and Roll critique the methodology and design in the study by Kerti et al. on the association between glucose metabolism and memory performance. The authors conduct additional statistical analysis to support their results. Neurology's sometime neuromythologist and historian, William Landau, cites quotations from Parkinson's historical monograph to comment on the article by Bohnen et al. on gait speed in Parkinson disease. The authors respond.—Chafic Karam, MD, and Robert C. Griggs, MD

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Routine prostate cancer screening 'reduces deaths but leads to overdiagnosis'

Routine prostate cancer screening 'reduces deaths but leads to overdiagnosis' | Disease mongering | Scoop.it
Long-term results of a major European study reveal that prostate cancer screening reduces deaths by more than 20%, but researchers say it is still too soon for routine screening.
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Self service, quando il consumatore finisce per lavorare - Nuove abitudini - Società - Lifestyle

Self service, quando il consumatore finisce per lavorare - Nuove abitudini - Società - Lifestyle | Disease mongering | Scoop.it
Addio al vecchio capitalismo, adesso c'è il 'prosumerismo', termina che accorpa produttori di lavoro e consumatori in un identico sfruttamento. A teorizzarlo è il sociologo dell'Università del Maryland George Ritzer, che sull'argomento ha tenuto una relazione al Futura Festival di Civitanova Marche (Macerata)
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New York’s Ban on Big Sodas Is Rejected by Final Court - NYT - #diseasemongering

New York’s Ban on Big Sodas Is Rejected by Final Court - NYT - #diseasemongering | Disease mongering | Scoop.it
The State Court of Appeals declined to reinstate New York City’s limits on sales of jumbo sugary drinks, exhausting the city’s legal options.
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