Differently Abled and Our Glorious Gadgets
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Differently Abled and Our Glorious Gadgets
Articles on the joys and challenges of being differently abled and the gadgets that help us be independent and productive.
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Braille smartphone to revolutionise life on the go for the blind - West

Braille smartphone to revolutionise life on the go for the blind - West | Differently Abled and Our Glorious Gadgets | Scoop.it

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The Souls of Black Autistic Folk, Part III: Difference and the Question of Visibility

The Souls of Black Autistic Folk, Part III: Difference and the Question of Visibility | Differently Abled and Our Glorious Gadgets | Scoop.it
One Negro speaks of rivers: change the term, but the color’s still the same – and I speak of computer hard drive brains, over-wired circuitry, and hearts that fracture at the slightest jolt. The so...
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10 Para-Athletes That Will Make You Redefine "Disabled"

10 Para-Athletes That Will Make You Redefine "Disabled" | Differently Abled and Our Glorious Gadgets | Scoop.it
Blistering track times. Unbeatable heats in the pool. Incredible power behind the oars. Meet some of the para-athletes setting (and breaking) records worldwide.
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T-Cell Therapy Eradicates an Aggressive Leukemia in Two Children

T-Cell Therapy Eradicates an Aggressive Leukemia in Two Children | Differently Abled and Our Glorious Gadgets | Scoop.it

Two children with an aggressive form of childhood leukemia had a complete remission of their disease—showing no evidence of cancer cells in their bodies—after treatment with a novel cell therapy that reprogrammed their immune cells to rapidly multiply and destroy leukemia cells. A research team from The Children’s Hospital of Philadelphia and the University of Pennsylvania published the case report of two pediatric patients Online First today in The New England Journal of Medicine. It will appear in the April 18 print issue.

 

The current study builds on Grupp’s ongoing collaboration with Penn Medicine scientists who originally developed the modified T cells as a treatment for B-cell leukemias. The Penn team reported on early successful results of a trial using this cell therapy in three adult chronic lymphocytic leukemia (CLL) patients in August of 2011. Two of those patients remain in remission more than 2½ years following their treatment, and as the Penn researchers reported in December 2012 at the annual meeting of the American Society of Hematology, seven out of ten adult patients treated at that point responded to the therapy. The team is led by the current study’s senior author, Carl H. June, M.D., the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine and the Perelman School of Medicine at the University of Pennsylvania and director of Translational Research in Penn’s Abramson Cancer Center.

 

“We’re hopeful that our efforts to treat patients with these personalized cellular therapies will reduce or even replace the need for bone marrow transplants, which carry a high mortality risk and require long hospitalizations,” June said. “In the long run, if the treatment is effective in these late-stage patients, we would like to explore using it up front, and perhaps arrive at a point where leukemia can be treated without chemotherapy.”

 

The research team colleagues adapted the original CLL treatment to combat another B-cell leukemia: ALL, which is the most common childhood cancer. After decades of research, oncologists can currently cure 85 percent of children with ALL. Both children in the current study had a high-risk type of ALL that stubbornly resists conventional treatments.

The new study used a relatively new approach in cancer treatment: immunotherapy, which manipulates the immune system to increase its cancer-fighting capabilities. Here the researchers engineered T cells to selectively kill another type of immune cell called B cells, which had become cancerous.

 

The researchers removed some of each patient’s own T cells and modified them in the laboratory to create a type of CAR (chimeric antigen receptor) cell called a CTL019 cell. These cells are designed to attack a protein called CD19 that occurs only on the surface of certain B cells.

 

By creating an antibody that recognizes CD19 and then connecting that antibody to T cells, the researchers created in CTL019 cells a sort of guided missile that locks in on and kills B cells, thereby attacking B-cell leukemia. After being returned to the patient’s body, the CTL019 cells multiply a thousand times over and circulate throughout the body. Importantly, they persist for months afterward, guarding against a recurrence of this specific type of leukemia.

 

While the CTL019 cells eliminate leukemia, they also can generate an overactive immune response, called a cytokine release syndrome, involving dangerously high fever, low blood pressure, and other side effects. This complication was especially severe in Emily, and her hospital team needed to provide her with treatments that rapidly relieved the treatment-related symptoms by blunting the immune overresponse, while still preserving the modified T cells’ anti-leukemia activity.

 

“The comprehensive testing plan that we have put in place to study patients’ blood and bone marrow while they’re undergoing this therapy is allowing us to be able to follow how the T cells are behaving in patients in real time, and guides us to be able to design more detailed and specific experiments to answer critical questions that come up from our studies,” Kalos said.

 

The CTL019 therapy eliminates all B cells that carry the CD19 cell receptor: healthy cells as well as those with leukemia. Patients can live without B cells, although they require regular replacement infusions of immunoglobulin, which can be given at home, to perform the immune function normally provided by B cells.

 

The research team continues to refine their approach using this new technology and explore reasons why some patients may not respond to the therapy or may experience a recurrence of their disease. Grupp said the appearance of the CD19-negative leukemia cells in the second child may have resulted from her prior treatments. Unlike Emily, the second patient had received an umbilical cord cell transplant from a matched donor, so her engineered T cells were derived from her donor (transplanted) cells, with no additional side effects. Oncologists had previously treated her with blinatumomab, a monoclonal antibody, in hopes of fighting the cancer. The prior treatments may have selectively favored a population of CD19-negative T cells.

 

“The emergence of tumor cells that no longer contain the target protein suggests that in particular patients with high-risk ALL, we may need to broaden the treatment to include additional T cells that may go after additional targets,” added Grupp. “However, the initial results with this immune-based approach are encouraging, and may later even be developed into treatments for other types of cancer.”


Via Dr. Stefan Gruenwald
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Soumya Rao's comment, May 1, 2013 10:17 AM
Wow... really amazing!!! Hope it transforms lives soon...
Nacho Vega's curator insight, May 1, 2013 6:58 PM

YES we CAN!!!

Nacho Vega's comment, May 1, 2013 7:02 PM
YES we CAN!
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Guest Post: Looking Ahead with Hope: Financial Planning for Your Child with Special Needs | Special & Determined | A Special Needs Mom Blog

Guest Post: Looking Ahead with Hope: Financial Planning for Your Child with Special Needs | Special & Determined | A Special Needs Mom Blog | Differently Abled and Our Glorious Gadgets | Scoop.it
For families raising a child with special needs, balancing the emotional and financial responsibilities can be challenging. Often your current situation is so all-encompassing that long-term planning is pushed aside.

Via Special & Determined | A Special Needs Mom Blog
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Parents must have their say in special-needs kids' education - Orlando Sentinel

Parents must have their say in special-needs kids' education - Orlando Sentinel | Differently Abled and Our Glorious Gadgets | Scoop.it
Parents must have their say in special-needs kids' education Orlando Sentinel Among the provisions in House Bill 465 and Senate Bill 1108, moms and dads would be involved in crucial decisions affecting their son or daughter with a disability,...
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Hoyer on Testimony on Disability Forum - Southern Maryland News Net

Hoyer on Testimony on Disability Forum
Southern Maryland News Net
House Democratic Whip Steny H. Hoyer (MD) submitted testimony to the National Council on Disability's policy forum on voting access for people with disabilities.
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2013 Abilities Expo Includes Wheelchair Dancing and Adaptive Sports

Abilities Expo 2013 will be held on May 3 to 5 at New Jersey Convention and Expo Center in Edison New Jersey

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Stoke Mandeville Hospital: recognition for the birthplace of the Paralympics

Stoke Mandeville Hospital: recognition for the birthplace of the Paralympics | Differently Abled and Our Glorious Gadgets | Scoop.it
Agitos






The Agitos logo is the Paralympic equivalent of the Olympic rings, and is made up of three ‘swooshes’ coloured red, blue and green.

Via Jane Young
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Disability Advocates Arrested Outside White House - Disability Scoop

Disability Advocates Arrested Outside White House - Disability Scoop | Differently Abled and Our Glorious Gadgets | Scoop.it
More than three-dozen disability rights activists were arrested while protesting near the White House gates Monday.
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The British Paraorchestra supporting Coldplay at the Paralympics Closing Ceremony 2012

The British Paraorchestra supporting Coldplay at the Paralympics closing Ceremony 2012. Founded by British conductor Charles Hazlewood, the British Paraorche...
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Scholar candidate moves past disability to find ways to excel

Scholar candidate moves past disability to find ways to excel | Differently Abled and Our Glorious Gadgets | Scoop.it
When Rebecca Combs, 17, sits down to take a test in her favorite class, Advanced Placement biology, she’s not just focusing on writing the correct answers.
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Vanderbilt also presents an exoskeleton

Vanderbilt also presents an exoskeleton | Differently Abled and Our Glorious Gadgets | Scoop.it
Advanced exoskeleton promises more independence for people with paraplegia. A team of Vanderbilt engineers has developed a powered exoskeleton that enables people with severe spinal cord injuries to stand, walk, sit and climb stairs.

 

These devices act like an external skeleton. They strap in tightly around the torso. Rigid supports are strapped to the legs and extend from the hip to the knee and from the knee to the foot. The hip and knee joints are driven by computer-controlled electric motors powered by advanced batteries. Patients use the powered apparatus with walkers or forearm crutches to maintain their balance.

 

From a rehabilitation perspective the Vanderbilt design also has two potential advantages, Hartigan pointed out:

 

    *  The amount of robotic assistance adjusts automatically for users who have some muscle control in their legs. This allows them to use their own muscles while walking. When a user is totally paralyzed, the device does all the work. The other designs provide all the power all of the time.
    *  It is the only wearable robot that incorporates a proven rehabilitation technology called functional electrical stimulation. FES applies small electrical pulses to paralyzed muscles, causing them to contract and relax. FES can improve strength in the legs of people with incomplete paraplegia. For complete paraplegics, FES can improve circulation, change bone density and reduce muscle atrophy.


Via Carlos Garcia Pando, Figen Ayhan
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Audioboo: Social Audio Sharing Site for Visually Impaired

Audioboo allows you to record and upload audio for friends, broadcast, customers, colleagues or the rest of the world to hear

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Do disabled students get enough support at university?

Do disabled students get enough support at university? | Differently Abled and Our Glorious Gadgets | Scoop.it
Applying to universities, sorting out student finance, finding accommodation, all while trying to get the grades, is a stressful process for any student before they set off for uni.
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Young People With Autism at Work in a Digital World | CPI

Young People With Autism at Work in a Digital World | CPI | Differently Abled and Our Glorious Gadgets | Scoop.it
Ever wonder about what resources are available to help young adults with autism to thrive in the workplace?

Via Becky B
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Samantha Ellis's curator insight, May 17, 2013 3:11 AM

This article does not surprise me one bit! My little brother is Autism finds that he will excel when working with anything that is Digital Technology. He seems to find this form of work very engaging and is happy to continue to sit and complete his work if it is on a computer or an IPad.  Other than that - he absolutely is against completing any assignments at all.  So it does not surprise me that people with Autism are working in the Digital World and thriving at it!

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How Assisted Technology Is Being Used In Speech Therapy for Children with Learning & Developmental Disabilities | Special & Determined | A Special Needs Mom Blog

How Assisted Technology Is Being Used In Speech Therapy for Children with Learning & Developmental Disabilities | Special & Determined | A Special Needs Mom Blog | Differently Abled and Our Glorious Gadgets | Scoop.it
What is Assistive Technology? The Wikipedia term states: Assistive Technology is an umbrella term that includes assistive, adaptive, and rehabilitative devices for people with disabilities and also includes the process used in selecting, locating,...

Via Special & Determined | A Special Needs Mom Blog
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Special Olympics spring games to be held in Owensboro Saturday - Courierpress/news/gleaner/

Special Olympics spring games to be held in Owensboro Saturday - Courierpress/news/gleaner/ | Differently Abled and Our Glorious Gadgets | Scoop.it
Special Olympics spring games to be held in Owensboro Saturday Courierpress/news/gleaner/ Participants in the Spring Games automatically qualify to compete in the Special Olympics Kentucky State Summer Games, which are held May 31-June 2 at Eastern...
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In a First, Judge Orders Legal Aid for Mentally Disabled Immigrants Facing ... - New York Times

In a First, Judge Orders Legal Aid for Mentally Disabled Immigrants Facing ... - New York Times | Differently Abled and Our Glorious Gadgets | Scoop.it
ThinkProgress
In a First, Judge Orders Legal Aid for Mentally Disabled Immigrants Facing ...
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Myths & Facts Behind The Campaign To Attack Disability Benefits

Myths & Facts Behind The Campaign To Attack Disability Benefits | Differently Abled and Our Glorious Gadgets | Scoop.it
RT @hannahgracegb: Everything the media isn't telling you about Social Security #disability benefits IN ONE AWESOME DOCUMENT http://t.co/q5pzLBWyCa
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2013 Abilities Expo Includes Wheelchair Dancing and Adaptive Sports

Abilities Expo 2013 will be held on May 3 to 5 at New Jersey Convention and Expo Center in Edison New Jersey

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Clinical Trial Could Pave Way For Autism Blood Test - Disability Scoop

Clinical Trial Could Pave Way For Autism Blood Test - Disability Scoop | Differently Abled and Our Glorious Gadgets | Scoop.it
In what's believed to be the largest such effort to date, a clinical trial expected to launch this week will examine the effectiveness of a possible blood test to detect autism.
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Call This Home (music video)

NEW music video from the rock band, Flame, made up of people who have disabilities. Visit Flame online - www.flametheband.com Download the album, "Outside Th...
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'Rapid strides': Limb advances offer hope for Boston amputees

'Rapid strides': Limb advances offer hope for Boston amputees | Differently Abled and Our Glorious Gadgets | Scoop.it
It will be weeks, at least, before Celeste Corcoran is anywhere near ready to think about artificial limbs.
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