Researchers assessed the impact of whole grains on the risk of type 2 diabetes, obesity and body weight measures, and cardiovascular disease in human studies as the basis for establishing an American Society for Nutrition (ASN) position
Rabinovitz et al evaluated the effect of breakfast size on diabetic control. The study included overweight and obese patients, non-insulin dependent adults with type 2 diabetes. Patients were randomized to receive either a large breakfast consisting of a higher percentage of protein and fat or a smaller breakfast. Greater HbA1c and systolic blood pressure reductions were observed with the patients consuming the larger breakfasts. Satiety was maintained longer in those consuming a larger breakfast as well. Diabetic medications were also reduced in the bigger breakfast group.
Findings from a longitudinal nutrition study led by Dr. Guillaume Ruel showed that a diet consisting of more fruits, vegetables, and whole grains (excluding rice and wheat) was associated with a lower risk of developing a multimorbidity (two or more diseases in one person).
This study systemically reviewed randomized controlled trials and observational studies to evaluate whether actual exposure of metformin can be associated with cancer and cancer mortality in type 2 diabetes patients
The study suggests that glucose fluctuation in blood can be a risk predictor for occurrence and progression of cardiovascular disease in T2DM patients. This can be a beneficial tool in clinical treatment for T2DM patients.
A research team from the University of Montreal revealed the mechanism of how metformin slows aging and cancer progression. In a study, they found that metformin reduces the production of inflammatory cytokines. These inflammatory cytokines are key players activating the immune system in tissue damage during aging and tumor growth in cancer development.
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