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Researchers evaluated 652 patients who underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP) at a single facility between March 2003 and December 2009. Follow-up was performed for a mean of 2.88 years after surgery. The cohort included 170 patients who had preoperative type 2 diabetes mellitus (T2DM).
Across all participants, the mean maximum excess weight loss (EWL) was 77.1%, with two-thirds of participants regaining an average of 19.1% of maximum EWL during follow-up. Most patients with T2DM (82.7%) were in remission upon completion of follow-up, with 5.8% of those with diabetes experiencing recurrence after remission. Recurrence was significantly associated with insulin use (75% compared with 18%) and longer T2DM duration (12.3 years vs. 6 years) compared with those who did not experience recurrence. Investigators said neither the maximum EWL nor the amount of weight regained were significantly different between recurrent and nonrecurrent patients.