We cannot see it, taste it, or smell it. Nevertheless, carbon monoxide is a deadly poison; it is a frequent cause of poisoning all over the world. This gaseous product of incomplete combustion displaces the oxygen molecules carried by hemoglobin throughout the body, thereby starving tissues of oxygen and causing death. Now, Azarov et al. have reengineered neuroglobin, a hemoglobin-like protein from the brain, so that it binds carbon monoxide more quickly and tightly than does hemoglobin. When CO-poisoned mice are infused with the artificial neuroglobin, it scavenges the CO, freeing hemoglobin to perform its oxygen delivery duty. The engineered neuroglobin ensures the survival of CO-poisoned mice. The half-life of CO in human red blood cells treated with neuroglobin is only 25 s, compared with a published half-life of 20 min with hyberbaric oxygen, the best treatment currently available. Engineered globins show encouraging promise as antidotes for this lethal gas.
Ludovic M.'s insight:
Un vrai article scientifique un peu ardu mais qui explique qu'on vient de découvrir un nouveau procédé, sous forme d'antidote, pour les empoissonnements au monoxyde de carbone.
Source: A Necessary Retelling of the Smallpox Vaccine Story A curious confluence of events unfolded Tuesday night. Just hours before President Obama uttered the powerful “science and reason matter” in his farewell address, Robert F. Kennedy Jr. announced that the incoming president had tapped him to head a committee on vaccine safety. RFK Jr. is not a pediatric immunologist nor an epidemiologist, but a vocal “vaccine skeptic.” Although the PEOTUS dialed back on the purported appointment shortly after social media erupted, a tweet from March 28, 2014 makes his analysis of the history and science of vaccines clear: Healthy young child goes to doctor, gets pumped with massive shot of many vaccines, doesnt feel good and changes – AUTISM. Many such cases! As a child I devoured books on the history of medicine. One of my favorite stories was how Edward Jenner developed the first vaccine, testing an approach that had been used for centuries. Knowing his story made me understand why my little
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