A team of bioengineers at Brigham and Women's Hospital (BWH), led by Dr. Ali Khademhosseini and Dr. Nasim Annabi of the Biomedical Engineering Division, have developed a protein-based, elastic gel that mimics the properties of skin and blood vessels when exposed to light and could therefore be used to heal wounds.
Alessandro Dentoni's insight:
The new material, known as a photocrosslinkable elastin-like polypeptide-based (ELP) hydrogel, offers several astounding benefits......
Traumatic bone injuries are often so severe that the body can’t effectively repair the damage on its own. To aid the recovery, clinicians inject patients with proteins called growth factors. The treatment is costly, requiring large amounts of growth factors. The growth factors also disperse, creating unwanted bone formation. A new developing technology could provide more efficient delivery of the bone regenerating growth factors.
Alessandro Dentoni's insight:
The research team developed a method of fabricating pure heparin microparticles from a modified heparin methacrylamide species that can be thermally cross-linked to growth factors. The technology avoids the bulky materials currently used to deliver growth factors.
Plant-protein based nano-fiber scaffolds for Wound Healing
This technology facilitates creation of three-dimensional tissue scaffolds (TTS) that can either be seeded with specific cells with the intent to form a particular target tissue (for instance liver tissue, lung tissue or nerve tissue), or can be implanted without cell seeding into a target tissue: for instance, connective tissue defects that need to be filled (e.g. in lung diseases leading to the formation of large connective tissue defects,) or in other uses, where augmentation of target tissues are desired.
Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.
Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management suggest that it can. It turns out that the structure of some woods at the microscopic level is very close to that of natural bone; both have unique biomechanical properties such as high strength and lightness
The NovoGen MMX Bioprinter™ is a novel hardware and software platform at the forefront of bioprinting research and development. The NovoGen MMX™ was developed to meet challenges in biological research.
The novel collagen fiber scaffold made in this way appears to be useful not only as a ''scaffold'' for tissue regeneration of wounds and surgical incisions but also as a so-called ''cell capsule'' to carry cells to a location.
Researchers at Harvard’s Brigham and Women’s Hospital engineered a new material that looks highly promising for use in accelerating wound healing, building replacement tissues, and growing new blood vessels..
Osteo Science News Bioingegneri della Rice University hanno sviluppato un idrogel che si trasforma istantaneamente in sito da liquido a semisolido Il gel promuove la formazione di osso e altri tessuti del corpo partendo proprio dalle cellule del paziente L idrogel creato nel laboratorio della Rice University liquido a temperatura ambiente ma quando iniettato su paziente con metodica mini invasiva reagisce alla temperatura corporea e diventa semisolido stabilizzandosi nel difetto osseo Lo studio realizzato alla Rice descrive lo sviluppo di un idrogel termogelificante a scoffold di cellule stam
A team of experts in mechanics, materials science, and tissue engineering at Harvard has created an extremely stretchy and tough gel that may suggest a new method for replacing damaged cartilage in human joints.
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