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Dengue and other Quasispecies-Like viruses
Dengue and quasispecies-like viral research with some vector thrown in for spice
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Scooped by Mel Melendrez-Vallard
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Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial : The Lancet

Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial. By - Maria Rosario Capeding MD, Pro...
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Structure of Acidic pH Dengue Virus Showing the Fusogenic Glycoprotein Trimers - Journal of Virology

Structure of Acidic pH Dengue Virus Showing the Fusogenic Glycoprotein Trimers Journal of Virology Here we have used Fab fragments of the neutralizing antibody DV2-E104 to stop the conformational change of dengue virus at an intermediate stage of...
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Integral Molecular IDs human antibodies that fight Chikungunya virus

TweetIntegral Molecular may have found a way for the body to fight the mosquito-borne Chikungunya virus (CHIKV).
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Positive selection and evolution of dengue type-3 virus in the Indian subcontinent (PDF)

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Virology Journal | Full text | Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-termin...

Approximately 100 million confirmed infections and 20,000 deaths are caused by Dengue virus (DENV) outbreaks annually. Global warming and rapid dispersal have resulted in DENV epidemics in formally non-endemic regions. Currently no consistently effective preventive measures for DENV exist, prompting development of transgenic and paratransgenic vector control approaches. Production of transgenic mosquitoes refractory for virus infection and/or transmission is contingent upon defining antiviral genes that have low probability for allowing escape mutations, and are equally effective against multiple serotypes. Previously we demonstrated the effectiveness of an anti-viral group I intron targeting U143 of the DENV genome in mediating trans-splicing and expression of a marker gene with the capsid coding domain. In this report we examine the effectiveness of coupling expression of ΔN Bax to trans-splicing U143 intron activity as a means of suppressing DENV infection of mosquito cells.
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Coexistence of Hepatitis B Virus Quasispecies Enhances Viral Replication and ... - Journal of Virology

Coexistence of Hepatitis B Virus Quasispecies Enhances Viral Replication and ...
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France reports 11 cases of chikungunya local transmission - Outbreak News Today

France reports 11 cases of chikungunya local transmission
Outbreak News Today
The 11 indigenous cases of chikungunya have been identified in one area of Montpellier (Hérault) and are a focus of transmission.
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Subgenotypes and Mutations in the S and Polymerase Genes of Hepatitis B Virus Carriers in the West Bank, Palestine

by Zakeih Abdelnabi, Niveen Saleh, Sabri Baraghithi, Dieter Glebe, Maysa Azzeh
The mutation rate and genetic variability of hepatitis B virus (HBV) are crucial factors for efficient treatment and successful vaccination against HBV.
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HIV-1 Diversity, Transmission Dynamics and Primary Drug Resistance in Angola

HIV-1 Diversity, Transmission Dynamics and Primary Drug Resistance in Angola | Dengue and other Quasispecies-Like viruses | Scoop.it
by Inês Bártolo, Suzana Zakovic, Francisco Martin, Claudia Palladino, Patrícia Carvalho, Ricardo Camacho, Sven Thamm, Sofia Clemente, Nuno Taveira Objectives To assess HIV-1 diversity, transmission dynamics and prevalence of transmitted drug...
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Dengue Roundup

Dengue Roundup, by Oxitec Ltd: A roundup of tweets and news relating to Dengue fever
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Rescooped by Mel Melendrez-Vallard from Virology and Bioinformatics from Virology.ca
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Virology Journal | Abstract | pH-Dependent entry of chikungunya virus fusion into mosquito cells

Millions of human infections caused by arthropod-borne pathogens are initiated by the feeding of an infected mosquito on a vertebrate.

Via Ken Yaw Agyeman-Badu
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Notes from the Field: Transmission of Chikungunya Virus in the Continental United States — Florida, 2014

RT @LJBeil: Locally acquired cases of chikungunya now up to 11 people, all in Florida. http://t.co/5gJwej1M7o
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Weird Weather: The global spread of Dengue fever

Warmer weather also pleases the mosquitos that spread Dengue fever, a sometimes fatal disease that has recoded a 30x increase in cases in 50 years. Up to 500m people…
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A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus : Nature Immunology : Nature Publishing Group

Dengue virus is an important emerging pathogen, but so far there is no vaccine effective for all serotypes. Screaton and colleagues identify a class of broadly reactive human antibodies focused on an epitope that bridges two virion subunits.
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New Dengue-Detecting Antibodies | The Scientist Magazine®

Researchers uncover a class of antibodies that may confer immunity to different serotypes of the dengue virus.
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Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity

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Analysis of the Evolution and Structure of a Complex Intrahost Viral Population in Chronic Hepatitis C Virus Mapped by Ultradeep Pyrosequencing

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Innate Immunity to Dengue Virus Infection and Subversion of Antiviral Responses

... manipulate cellular antiviral responses.Here, we discuss the host innate immune response to DENV and the mechanisms of immune evasion that DENV has developed to manipulate cellular antiviral responses.

Via Gilbert Faure au nom de l'ASSIM
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Ahead of Print -Autochthonous Dengue Fever, Tokyo, Japan, 2014 - Volume 21, Number 3—March 2015 - Emerging Infectious Disease journal - CDC

Ahead of Print -Autochthonous Dengue Fever, Tokyo, Japan, 2014 - Volume 21, Number 3—March 2015 - Emerging Infectious Disease journal - CDC | Dengue and other Quasispecies-Like viruses | Scoop.it
After 70 years with no confirmed autochthonous cases of dengue fever in Japan, 19 cases were reported during August–September 2014. Dengue virus serotype 1 was detected in 18 patients.
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HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya

Background:
The ever-expanding rollout of antiretroviral therapy in poor resource settings without routine virological monitoring has been accompanied with development of drug resistance that has resulted in limited treatment success.
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Venezuela, Colombia lead countries with increases of chikungunya - Outbreak News Today

Venezuela, Colombia lead countries with increases of chikungunya Outbreak News Today According to newly published chikungunya data from the Pan American Health Organization (PAHO) Friday, Venezuela and Colombia accounted for more than 36,000 of the...
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Chikungunya cases in Mexico climb to 74 - Outbreak News Today

Chikungunya cases in Mexico climb to 74 - Outbreak News Today | Dengue and other Quasispecies-Like viruses | Scoop.it
Chikungunya cases in Mexico climb to 74
Outbreak News Today
The number of locally acquired chikungunya cases in Mexico have climbed to 74 in epidemiological week 49 ending Dec 5.
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Rescooped by Mel Melendrez-Vallard from Biodefense News
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Puerto Rico chikungunya case count tops 20,000 | Outbreak News Today

The number of suspected and confirmed locally acquired chikungunya cases have topped the 20,000 mark of the epidemiological week 45(EW-45) ending Nov.

Via Biodefense News
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TWiV 314: Einstein goes viral

Virologists at Albert Einstein discuss ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and entry of togaviruses and flaviviruses into cells.
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International Dispersal of Dengue through Air Travel: Importation Risk for Europe

by Jan C. Semenza, Bertrand Sudre, Jennifer Miniota, Massimiliano Rossi, Wei Hu, David Kossowsky, Jonathan E. Suk, Wim Van Bortel, Kamran Khan
Background The worldwide distribution of dengue is expanding, in part due to globalized traffic and trade.
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