Defeat MSA: JGF Foundation for Multiple System Atrophy
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$5 million for neurodegenerative disease research - Londoner

$5 million for neurodegenerative disease research - Londoner | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Londoner $5 million for neurodegenerative disease research Londoner A recent $5 million donation to Western University will help researchers studying neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
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Weston family gives $50-million boost to 'high-risk, high-reward' brain research - The Globe and Mail

Weston family gives $50-million boost to 'high-risk, high-reward' brain research - The Globe and Mail | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
RT @milankarol: Take #ALS #MND #Alzheimers #neuroscience #neurodegeneration and add #CANADA and you get AWESOME http://t.co/kAcyNBW5vz
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Gene variant that makes brains resilient against Alzheimer's discovered - Zee News

Gene variant that makes brains resilient against Alzheimer's discovered - Zee News | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Nature World News Gene variant that makes brains resilient against Alzheimer's discovered Zee News But those with a genetic predisposition toward no inflammatory response, or a reduced one, are able to endure the pathology without marked...
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Novel Magnesium Compound Reverses Neurodegeneration - Life Extension

Novel Magnesium Compound Reverses Neurodegeneration - Life Extension | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Alzheimer’s disease is the sixth leading cause of death among aging individuals in the United States. A team of MIT researchers has identified a form of magnesium that targets correctable factors involved in Alzheimer’s onset.
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New Parkinson's Disease Chemical Messenger Discovered

New Parkinson's Disease Chemical Messenger Discovered | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Researchers identify a new chemical messenger that is critical for protecting the brain against PD.
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Protein Protects Aging Brain - Scientist (blog)

Protein Protects Aging Brain - Scientist (blog) | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
NPR Protein Protects Aging Brain Scientist (blog) “This work establishes REST as a regulator protein we have to pay a lot of attention to in the context of neurodegeneration,” said Susan Lindquist, a molecular biologist at the MIT Whitehead...
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Blocking Destruction of Defective Proteins Unexpectedly Delays Neurodegeneration in Mice

Blocking Destruction of Defective Proteins Unexpectedly Delays Neurodegeneration in Mice | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
alzheimer's, dementia, caregiving (Blocking Destruction of Defective Proteins Unexpectedly Delays Neurodegeneration in Mice http://t.co/YePXjxJcCk #dementia, #alz)...
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Brain May Flush out Toxins During Sleep; Sleep Clears Brain of Molecules Associated With Neurodegeneration

Brain May Flush out Toxins During Sleep; Sleep Clears Brain of Molecules Associated With Neurodegeneration | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
alzheimer's, dementia, caregiving (RT @DementiaToday: Brain May Flush out Toxins During Sleep; Sleep Clears Brain of Molecules Associated With...
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The Multiple System Atrophy Coalition, Other MSA Groups, Rock Stars, and Celebrity Chefs Rally in Support as CHEF SIMON SAYS FIGHT MSA!

The Multiple System Atrophy Coalition, Other MSA Groups, Rock Stars, and Celebrity Chefs Rally in Support as CHEF SIMON SAYS FIGHT MSA! | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Las Vegas, NV (PRWEB) February 18, 2014 -- Rock stars, celebrity chefs, and rare disease advocates band together to FIGHT MSA, a rare and fatal neurodegenerative disorder.

Via MSA Coalition
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Pathways to neurodegeneration: mechani... [Am J Neurodegener Dis. 2013] - PubMed - NCBI

Pathways to neurodegeneration: mechani... [Am J Neurodegener Dis. 2013] - PubMed - NCBI | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
DefeatMSA: JGF Foundation's insight:
BIOMARKERS !
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Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and... http://t.co/exiWwikMYq #Bonn #publications
DefeatMSA: JGF Foundation's insight:

Possible Neuroprotection For PD !

 

"We propose that targeting strategies enhancing nucleotide synthesis pathways may reverse mitochondrial dysfunction and rescue neurodegeneration in PD and, potentially, other diseases linked to mitochondrial impairment."

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Viruses and neurodegeneration

Viruses and neurodegeneration | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Neurodegenerative diseases (NDs) are chronic degenerative diseases of the central nervous system (CNS), which affect 37 million people worldwide.

Viruses induce alterations and degenerations of neurons both directly and indirectly. Their ability to attack the host immune system, regions of nervous tissue implies that they can interfere with the same pathways involved in classical NDs in humans. Supporting this, many similarities between classical NDs and virus-mediated neurodegeneration (non-classical) have been shown at the anatomic, sub-cellular, genomic and proteomic levels suggesting that viruses can explain neurodegenerative disorders mechanistically. The main objective of this review is to provide readers a detailed snapshot of similarities viral and non-viral neurodegenerative diseases share, so that mechanistic pathways of neurodegeneration in human NDs can be clearly understood. Viruses can guide us to unveil these pathways in human NDs. This will further stimulate the birth of new concepts in the biological research, which is needed for gaining deeper insights into the treatment of human NDs and delineate mechanisms underlying neurodegeneration.

 


Via Ed Rybicki
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Ed Rybicki's curator insight, June 25, 2013 5:49 AM

Timely and interesting review.

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PERKing Up Protein Synthesis May Prevent Neurodegeneration ...

11 Oct 2013. In neurodegenerative diseases, misfolded proteins of various types accumulate in cells, evoking a compensatory stress response that squelches protein synthesis. Unfortunately, this attempt at damage control also compromises ...
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Common links between neurodegenerative diseases identified

Common links between neurodegenerative diseases identified | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
The pattern of brain alterations may be similar in several different neurodegenerative diseases, which opens the door to alternative therapeutic strategies to tackle these diseases, experts say.
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Retinal measurements associated with Parkinson's disease duration - News-Medical.net

Retinal measurements associated with Parkinson's disease duration - News-Medical.net | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Retinal measurements associated with Parkinson's disease duration News-Medical.net “This could be attributable to primary neurodegeneration of the retinal ganglion cells and their axons in [PD] patients or to retrograde trans-synaptic degeneration...
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Metals on our Mind - Scientist (blog)

Metals on our Mind - Scientist (blog) | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Scientist (blog) Metals on our Mind Scientist (blog) When and how biometals become dysregulated in neurodegenerative disease is now an area of intense study.
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JNI | Abstract | Deoxyglucose prevents neurodegeneration in culture by eliminating microglia

2-Deoxy-d-glucose is an inhibitor of glycolysis, which is protective in animal models of brain pathology, but the mechanisms of this protection are unclear.
DefeatMSA: JGF Foundation's insight:
Preventing Neurodegeneration!!
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Unravelling nerve-cell death in ataixa-telangiectasia - HealthCanal.com

Unravelling nerve-cell death in ataixa-telangiectasia - HealthCanal.com | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Unravelling nerve-cell death in ataixa-telangiectasia HealthCanal.com ... after binding to a protein known as A-T mutated (ATM).
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People's Pharmacy: Aluminum is toxic to brain cells - Online Athens

Aluminum is toxic to brain cells -------An aluminum researcher recently published a review titled “Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration”...
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t.co / Twitter

t.co / Twitter | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
RT @SleepResearch_: Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? http://t.co/…
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Scientists Stop Brain Cells from Dying in Mice: Potential Alzheimer's Treatment Breakthrough

Scientists Stop Brain Cells from Dying in Mice: Potential Alzheimer's Treatment Breakthrough | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
Response Prevents Neurodegeneration and clinical disease in Prion-infected Mice...
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How Neurogenic Orthostatic Hypotension Affects Patients and Caregivers

Stuart Isaacson, M.D. discusses the affects of neurogenic orthostatic hypotension (neurogenic OH or nOH) on patients and caregivers. Patients with Parkinson'...

Via MSA Coalition
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MSA Coalition's curator insight, February 13, 2014 11:36 AM

80% of multiple system atrophy patients are affected by neurogenic orthostatic hypotension

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Connecting Viruses to Neurodegeneration

Single Amino Acid Repeats Connect Viruses to #Neurodegeneration. http://t.co/ntyNSbVSk5 #neurologicaldisorders
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Brain Pacemaker Shows Promise in Fighting Alzheimer’s

Brain Pacemaker Shows Promise in Fighting Alzheimer’s | Defeat MSA: JGF Foundation for Multiple System Atrophy | Scoop.it
alzheimersdisease,alzheimers-disease,alzheimer's disease, lewy body dementia, vascular dementia, alzheimer's research, alzheimer's caregiving, Alzheimer's, dementia, early onset, early-onset, early stage, early-stage, brain disease, alzheimer's...
DefeatMSA: JGF Foundation's insight:

My Dream: Brain Pacemaker for MSA!

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