This data emphasizes the importance of primary care in the management of respiratory disease. Primary care physicians are and will remain an important source of care for patients with COPD, and in many areas of the country, the only source of care for patients with COPD. —Neil Skolnik, MD
La medida se toma a la vista de que el número de casos de enfermedad neumocócica registrados en población adulta >60 años en la Comunidad de Madrid sigue siendo importante, lo que justifica esta intervención directa sobre un grupo de edad para maximizar el beneficio poblacional de la vacunación infantil con la vacuna conjugada, a través de un…
In the United States, we treat almost all infections for 10 days. Why? In France, most infections are treated for 8 days. In the U.K., most infections are treated for 5 days. In many other countries, infections are treated until symptomatic improvement occurs. Can everyone outside the United States be wrong? What is the evidence base for the various recommended durations?
BACKGROUND: COPD is a major cause of morbidity and mortality in the United States as well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of symptoms of cough, dyspnea, and sputum production) is a major contributor to worsening lung function, impairment in...
RESULTS A total of 656 patients were included during the beta-lactam strategy periods, 739 during the beta-lactam–macrolide strategy periods, and 888 during the fluoroquinolone strategy periods, with rates of adherence to the strategy of 93.0%, 88.0%, and 92.7%, respectively. The median age of the patients was 70 years. The crude 90-day mortality was 9.0% (59 patients), 11.1% (82 patients), and 8.8% (78 patients), respectively, during these strategy periods. In the intention-to-treat analysis, the risk of death was higher by 1.9 percentage points (90% confidence interval [CI], −0.6 to 4.4) with the beta-lactam–macrolide strategy than with the beta-lactam strategy and lower by 0.6 percentage points (90% CI, −2.8 to 1.9) with the fluoroquinolone strategy than with the beta-lactam strategy. These results indicated noninferiority of the beta-lactam strategy. The median length of hospital stay was 6 days for all strategies, and the median time to starting oral treatment was 3 days (interquartile range, 0 to 4) with the fluoroquinolone strategy and 4 days (interquartile range, 3 to 5) with the other strategies.
BERLIN, diciembre 10: Así lo decidió el Instituto Federal de Medicamentos y Productos Médicos (BfArM), luego de una larga investigación. En su mayoría son medicamentos producidos por laboratorios indios y españoles. Si bien no hay peligro potencial para la salud, se encontró que algunos estudios, como los electrocardiogramas, fueron manipulados.
The Food and Drug Administration has approved flibanserin as the first drug treatment for acquired, generalized hypoactive sexual desire disorder in premenopausal women. The drug – marketed as Addyi – is expected to be available by Oct. 17. Conditions of the drug’s third – and successful – bid for approval, however, include a risk evaluation and mitigation strategy (REMS), post-marketing research, and a boxed warning to highlight the risk of severe hypotension and syncope for some patients. Th
Background. Consensus on how best to express bronchodilator reversibility (BDR) is lacking. We tested different BDR criteria against the null hypotheses that BDR should show no sex or size bias. To determine the best criterion for defining BDR we hypothesized that clinically important BDR...
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