Multiple sclerosis New Drugs Review
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Daclizumab (Biogen, Abbott) Review: Multiple sclerosis - Krishan Maggon

Daclizumab (Biogen, Abbott) Review: Multiple sclerosis - Krishan Maggon | Multiple sclerosis New Drugs Review | Scoop.it
Daclizumab is a humanized monoclonal antibody which targets the CD25 alpha subunit of the high affinity receptor and inhibits...
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Alterations of the human gut microbiome in multiple sclerosis

Alterations of the human gut microbiome in multiple sclerosis | Multiple sclerosis New Drugs Review | Scoop.it
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes.
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Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015. 
Alterations of the human gut microbiome in multiple sclerosis. 

Jangi S1, Gandhi R1, Cox LM1, Li N2, von Glehn F1, Yan R1, Patel B1, Mazzola MA1, Liu S1, Glanz BL1, Cook S1, Tankou S1, Stuart F1, Melo K1, Nejad P1, Smith K1, Topçuolu BD3, Holden J3, Kivisäkk P1, Chitnis T1, De Jager PL1, Quintana FJ1, Gerber GK2, Bry L2, Weiner HL1.

PMID: 27352007 PMCID: PMC4931233 DOI: 10.1038/ncomms12015
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Increased connectivity of hub networks and cognitive impairment in multiple sclerosis

Increased connectivity of hub networks and cognitive impairment in multiple sclerosis | Multiple sclerosis New Drugs Review | Scoop.it
Objective:
To investigate default-mode network (DMN) and frontoparietal network (FPN) dysfunction in cognitively impaired (CI) patients with multiple sclerosis (MS) because these networks strongly relate to cognition and contain most of the hubs of the brain.
Methods:
Resting-state fMRI and neuropsychological assessments were performed in 322 patients with MS and 96 healthy controls (HCs). Patients with MS were classified as CI (z score < –2.0 on at least 2 tests; n = 87), mildly cognitively impaired (z score < –1.5 on at least 2 tests and not CI; n = 65), and cognitively preserved (CP; n = 180). Within-network connectivity, connectivity with the rest of the brain, and between-network connectivity were calculated and compared between groups. Connectivity values were normalized for individual means and SDs.
Results:
Only in CI, both the DMN and FPN showed increased connectivity with the rest of the brain compared to HCs and CP, with no change in within- or between-network connectivity. Regionally, this increased connectivity was driven by the inferior parietal, posterior cingulate, and angular gyri. Increased connectivity with the rest of the brain correlated with worse cognitive performance, namely attention for the FPN as well as information processing speed and working memory for both networks.
Conclusions:
In CI patients with MS, the DMN and FPN showed increased connectivity with the rest of the brain, while normal within- and between-network connectivity levels were maintained. These findings indicate that cognitive impairment in MS features disturbed communication of hub-rich networks, but only with the more peripheral (i.e., nonhub) regions of the brain.
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Three-year clinical outcomes of relapsing multiple sclerosis patients treated with dimethyl fumarate in a United States community health center. - PubMed - NCBI

Three-year clinical outcomes of relapsing multiple sclerosis patients treated with dimethyl fumarate in a United States community health center. - PubMed - NCBI | Multiple sclerosis New Drugs Review | Scoop.it
Mult Scler. 2017 May 1:1352458517709956. doi: 10.1177/1352458517709956. [Epub ahead of print]
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What is multiple sclerosis and what are the causes of multiple sclerosis?

What is multiple sclerosis and what are the causes of multiple sclerosis? | Multiple sclerosis New Drugs Review | Scoop.it
MS is an autoimmune disease that affects the Central Nervous System (CNS). Read to know more. - What is multiple sclerosis and what are the causes of multiple sclerosis?
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Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis

Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis | Multiple sclerosis New Drugs Review | Scoop.it
Accumulating evidence supports a role for exosomes in immune regulation. In this study, we investigated the total circulating exosome transcriptome in relapsing–remitting multiple sclerosis (RRMS
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Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events. - PubMed - NCBI

Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events. - PubMed - NCBI | Multiple sclerosis New Drugs Review | Scoop.it
Acta Neurol Belg. 2017 May 20. doi: 10.1007/s13760-017-0794-7. [Epub ahead of print] Review
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Cost-Effectiveness of Peginterferon Beta-1a and Alemtuzumab in Relapsing-Remitting Multiple Sclerosis. - PubMed - NCBI

Cost-Effectiveness of Peginterferon Beta-1a and Alemtuzumab in Relapsing-Remitting Multiple Sclerosis. - PubMed - NCBI | Multiple sclerosis New Drugs Review | Scoop.it
J Manag Care Spec Pharm. 2017 Jun;23(6):666-676. doi: 10.18553/jmcp.2017.23.6.666.
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New biomarkers of multiple sclerosis pathogenesis

New biomarkers of multiple sclerosis pathogenesis | Multiple sclerosis New Drugs Review | Scoop.it
Multiple sclerosis (MS) is a chronic debilitating inflammatory disease targeting the brain. The pathogenesis of MS remains largely unknown, though brain tissue damage in MS is likely due to immune cells attacking myelin basi
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Serum neurofilament light: A biomarker of neuronal damage in multiple sclerosis. - PubMed - NCBI

Serum neurofilament light: A biomarker of neuronal damage in multiple sclerosis. - PubMed - NCBI | Multiple sclerosis New Drugs Review | Scoop.it
Ann Neurol. 2017 May 16. doi: 10.1002/ana.24954. [Epub ahead of print]
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Roche Seeks to Mend Damaged Nerves in Multiple Sclerosis Push

Roche Seeks to Mend Damaged Nerves in Multiple Sclerosis Push | Multiple sclerosis New Drugs Review | Scoop.it
Roche Holding AG is seeking a partner with experimental drugs that might help repair the damage caused to the nervous system by multiple sclerosis -- considered a key step in managing the debilitating disease.
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International consensus report on multiple sclerosis from the MS Brain Health initiative

International consensus report on multiple sclerosis from the MS Brain Health initiative | Multiple sclerosis New Drugs Review | Scoop.it
Consensus campaign to improve diagnosis and treatment of MS worldwide. Recommendations include swift action, regular MRI scans and shared decisions about drug treatment
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Oral and intravenous steroids for multiple sclerosis relapse: a systematic review and meta-analysis. - PubMed - NCBI

Oral and intravenous steroids for multiple sclerosis relapse: a systematic review and meta-analysis. - PubMed - NCBI | Multiple sclerosis New Drugs Review | Scoop.it
J Neurol. 2017 May 10. doi: 10.1007/s00415-017-8505-0. [Epub ahead of print] Review
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Lattanzi, S., Cagnetti, C., Danni, M. et al. J Neurol (2017). doi:10.1007/s00415-017-8505-0
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The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance? | Multiple sclerosis New Drugs Review | Scoop.it
Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous
system (CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections
promote MS remains unclear. However, there is increasing evidence that the CNS is
continuously surveyed by virus-specific T cells, which protect against reactivating
neurotropic viruses. Here, we discuss how viral infections could lead to the breakdown
of self-tolerance in genetically predisposed individuals, and how the reactivations
of viruses in the CNS could induce the recruitment of both autoaggressive and virus-specific
T cell subsets, causing relapses and progressive disability.
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Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis | Multiple sclerosis New Drugs Review | Scoop.it
Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate of disease progression and cognitive decline. The pathomechanisms initiating and driving gray matter dam
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MS isn't caused by antibodies to myelin

MS isn't caused by antibodies to myelin | Multiple sclerosis New Drugs Review | Scoop.it
A blog on multiple sclerosis research
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Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis | Brain | Oxford Academic

Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis | Brain | Oxford Academic | Multiple sclerosis New Drugs Review | Scoop.it
RT @Brain1878: Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis https://t.co/tOmOqT9oG3 https:…
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ECTRIMS 2018 - European Committee for Treatment and Research in Multiple Sclerosis Congress, Berlin, Germany | eMedEvents

ECTRIMS 2018 - European Committee for Treatment and Research in Multiple Sclerosis Congress, Berlin, Germany | eMedEvents | Multiple sclerosis New Drugs Review | Scoop.it
European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress is organized by European Committee For Treatment And Research in Multiple Sclerosis (ECTRIMS) and would be held during Oct 10 - 12, 2018 at Berlin, Germany.
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Celgene - $ 10 billion drop in market value, Crippled By Its Pipeline MS Drug Ozanimod ? 

Celgene - $ 10 billion drop in market value, Crippled By Its Pipeline MS Drug Ozanimod ?  | Multiple sclerosis New Drugs Review | Scoop.it
CELG has lost close to $10 B in market cap from its recent high. This may be due in large part to news relating to its MS and colitis drug ozanimod. Some timely
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A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is The... - PubMed - NCBI

A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is The... - PubMed - NCBI | Multiple sclerosis New Drugs Review | Scoop.it
Mol Neurobiol. 2017 May 17. doi: 10.1007/s12035-017-0598-z. [Epub ahead of print] Review
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Chronic comorbidity in multiple sclerosis is associated with lower incomes and dissolved intimate relationships

Chronic comorbidity in multiple sclerosis is associated with lower incomes and dissolved intimate relationships | Multiple sclerosis New Drugs Review | Scoop.it
The social and economic consequences of comorbidity in multiple sclerosis (MS) are largely unexplored. Differences were investigated in income and in the rate of broken relationships between cases o
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NEDA 3 in multiple sclerosis preserves from retinal axonal loss by Marco Pisa

NEDA 3 in multiple sclerosis preserves from retinal axonal loss by Marco Pisa | Multiple sclerosis New Drugs Review | Scoop.it
Instantly find & access educational materials and complete eLearning activities at your leisure. Native iPad/iPhone/Android Apps are available for the convenience of on-the-go users.
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A blood test for multiple sclerosis? Expect one in late May

A blood test for multiple sclerosis? Expect one in late May | Multiple sclerosis New Drugs Review | Scoop.it
“To our knowledge, we’re going to be the first blood-based RNA test for multiple sclerosis and definitely among the first – if not the first – in the field of autoimmune diseases,” IQuity CEO Chase Spurlock stated.
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Genentech's Ocrevus heralds new chapter in MS treatment

Genentech's Ocrevus heralds new chapter in MS treatment | Multiple sclerosis New Drugs Review | Scoop.it
The widely anticipated FDA approval of Genentech's CD20-targeting antibody Ocrevus (ocrelizumab) for treating both relapsing and primary progressive forms of multiple sclerosis (MS), on March 28, marks the beginning of a new era in MS therapy.
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Genentech's Ocrevus heralds new chapter in MS treatment Cormac Sheridan 
Nature Biotechnology 35, 393–394 (2017) doi:10.1038/nbt0517-393 Published online 09 May 2017
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The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis

The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis | Multiple sclerosis New Drugs Review | Scoop.it
Background Moderate correlation exists between the imaging quantification of brain white matter lesions and cognitive performance in people with multiple sclerosis (MS). This may reflect the greater importance of other features, including subvisible pathology, or methodological limitations of the primary literature. Objectives To summarise the cognitive clinico-radiological paradox and explore the potential methodological factors that could influence the assessment of this relationship. Methods Systematic review and meta-analysis of primary research relating cognitive function to white matter lesion burden. Results Fifty papers met eligibility criteria for review, and meta-analysis of overall results was possible in thirty-two (2050 participants). Aggregate correlation between cognition and T2 lesion burden was r = -0.30 (95% confidence interval: -0.34, -0.26). Wide methodological variability was seen, particularly related to key factors in the cognitive data capture and image analysis techniques. Conclusions Resolving the persistent clinico-radiological paradox will likely require simultaneous evaluation of multiple components of the complex pathology using optimum measurement techniques for both cognitive and MRI feature quantification. We recommend a consensus initiative to support common standards for image analysis in MS, enabling benchmarking while also supporting ongoing innovation.
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AAN 2017 : Patrick Vermersch Talks About B-Cell Activity & T-Cell Activity in Multiple Sclerosis

AAN 2017 : Patrick Vermersch Talks About B-Cell Activity & T-Cell Activity in Multiple Sclerosis | Multiple sclerosis New Drugs Review | Scoop.it
https://youtu.be/f4tPvmsCovM
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