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DNA Origami Nanobots vs. Cancer – It's about the Creativity of Bioengineering

DNA Origami Nanobots vs. Cancer – It's about the Creativity of Bioengineering | Creativity | Scoop.it

Shawn Douglas has big ideas to help fight cancer. His two roadblocks to a cure are that cancer drugs lack specificity and the cancer cells develop resistance to treatment over time. His radical solution in this Solve for X talk is to develop a new class of drugs from nanoscale devices. Inspiration comes in part from the way that penicillin fights infection. Penicillin can eat the harmful bacteria in an infection without doing harm to the host body.

 

Cancer cells, however, are close in makeup to the healthy cells that they have replaced and harder to individually target. Douglas uses animations and a gruesome graphic of a melanoma patient to explain how cancer cells can develop resistance to medicine and return stronger than original levels. To solve the specificity problem Douglas proposes a targeted delivery method that can differentiate between healthy cells and cancer cells. To solve the resistance problem he proposes combining different treatment methods to ensure all the different types of cancer cells are removed.

 

The solution to fit both sets of problems and constraints is nanoscale devices. In the lab Douglas and his team use a method codenamed DNA origami where hundreds of short DNA strands combine to create custom shapes with nanoscale precision. The devices act as a shell that delivers payload atoms to the exact cell that is targeted. Top and bottom halves are held together with strands and when signaled can open up like a clamshell, delivering the drug.

 

Extensive testing has been done in the lab to obtain a proof-of-concept level of confidence. Goals for the future include much more testing on live subjects, a method of mass production, finding new applications for nanobot delivery, and lots of new scientists. Douglas ends the talk discussing his BioMod student design competition and reminding us that bringing up the next generation of nanoscale device engineers is his most important project.

 

http://tinyurl.com/l4nel5w


Via Dr. Stefan Gruenwald
eva teruzzi's insight:

There's more than psychology in creativity!!!

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Creativity Lessons from Charles Dickens and Steve Jobs

Creativity Lessons from Charles Dickens and Steve Jobs | Creativity | Scoop.it
Creativity is the most essential skill for navigating an increasingly complex world — or so said 1,500 CEOs across 60 countries in a recent survey by IBM. And yet federally funded research an...
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Two seconds to capture attention: How to be great at email and social media marketing

Two seconds to capture attention: How to be great at email and social media marketing | Creativity | Scoop.it
email In a workshop at the semi-final and final of BusinessZone's small business competition The Pitch 2013, Tamsin Fox-Davies, small business marketing mentor at Constant Contact, explained how to develop an effective marketing strategy for (RT...
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DNA Origami Nanobots vs. Cancer – It's about the Creativity of Bioengineering

DNA Origami Nanobots vs. Cancer – It's about the Creativity of Bioengineering | Creativity | Scoop.it

Shawn Douglas has big ideas to help fight cancer. His two roadblocks to a cure are that cancer drugs lack specificity and the cancer cells develop resistance to treatment over time. His radical solution in this Solve for X talk is to develop a new class of drugs from nanoscale devices. Inspiration comes in part from the way that penicillin fights infection. Penicillin can eat the harmful bacteria in an infection without doing harm to the host body.

 

Cancer cells, however, are close in makeup to the healthy cells that they have replaced and harder to individually target. Douglas uses animations and a gruesome graphic of a melanoma patient to explain how cancer cells can develop resistance to medicine and return stronger than original levels. To solve the specificity problem Douglas proposes a targeted delivery method that can differentiate between healthy cells and cancer cells. To solve the resistance problem he proposes combining different treatment methods to ensure all the different types of cancer cells are removed.

 

The solution to fit both sets of problems and constraints is nanoscale devices. In the lab Douglas and his team use a method codenamed DNA origami where hundreds of short DNA strands combine to create custom shapes with nanoscale precision. The devices act as a shell that delivers payload atoms to the exact cell that is targeted. Top and bottom halves are held together with strands and when signaled can open up like a clamshell, delivering the drug.

 

Extensive testing has been done in the lab to obtain a proof-of-concept level of confidence. Goals for the future include much more testing on live subjects, a method of mass production, finding new applications for nanobot delivery, and lots of new scientists. Douglas ends the talk discussing his BioMod student design competition and reminding us that bringing up the next generation of nanoscale device engineers is his most important project.

 

http://tinyurl.com/l4nel5w


Via Dr. Stefan Gruenwald
eva teruzzi's insight:

There's more than psychology in creativity!!!

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Vitaminwater Marketing Campaign Goes Horribly Wrong - Huffington Post

Vitaminwater Marketing Campaign Goes Horribly Wrong - Huffington Post | Creativity | Scoop.it
CTV News
Vitaminwater Marketing Campaign Goes Horribly Wrong
Huffington Post
Coca-Cola apologized on Thursday for a marketing promotion for its Vitaminwater brand in Canada that went terribly wrong.
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The 5 Things Every (Great) Marketing Story Needs | Copyblogger

The 5 Things Every (Great) Marketing Story Needs | Copyblogger | Creativity | Scoop.it
Storytelling is a remarkably powerful marketing tool — but what goes into making a good one?
eva teruzzi's insight:

"The biggest mistake businesses make is thinking that their business is the hero of the story. This is prevalent among a lot of insecurity-based advertising (“buy our toothpaste or you’ll die friendless and alone”), but it makes for a selfish, easily ignored marketing message."

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P2P - The Person 2 Person Engagement Blog: Your Top 10 Most Engaging B2B Content Marketing Strategies for 2014 -Benchmarks, Budgets and Trends

P2P - The Person 2 Person Engagement Blog: Your Top 10 Most Engaging B2B Content Marketing Strategies for 2014 -Benchmarks, Budgets and Trends | Creativity | Scoop.it
Your Top 10 Most Engaging B2B Content Marketing Strategies for 2014 http://t.co/ay5EGx6YDg #Engagement #B2B #B2C #P2P
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Diffusion of Innovations in Service Organizations: Systematic Review and Recommendations

Take 2: Great talk last night on innovation from Ed Etchells. Referenced syst. review by @trishgreenhalgh: http://t.co/dN4AOmbMCF #CSIM2013
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for the health service business

 

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Seven Rules for Managing Creative-But-Difficult People - Tomas ...

Seven Rules for Managing Creative-But-Difficult People - Tomas ... | Creativity | Scoop.it
Business bloggers at Harvard Business Review discuss a variety of business topics including managing people, innovation, leadership, and more.
eva teruzzi's insight:

creative BUT.... Some are pathological bastards, some are not. AND, I'd say, many pathological bastards AND NOT creative at all! 

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The Top 7 Online Marketing Trends That Will Dominate 2014 - Forbes| #TheMarketingAutomationAlert

The Top 7 Online Marketing Trends That Will Dominate 2014 - Forbes| #TheMarketingAutomationAlert | Creativity | Scoop.it
The Internet has drastically altered the way in which information is shared, and has had a profound impact on marketing.

 

With these trends in mind, let’s discuss my predictions for the top online marketing trends of 2014.

 

1.      Content Marketing Will be Bigger Than Ever

One of the main ways that companies are establishing authority and gaining trust with consumers is by consistently creating valuable content through a variety of channels. This typically involves relevant industry information that provides insight or entertainment to an audience. Doing so allows a company to steadily build rapport with its demographic and develop a loyal following. According to the Content Marketing Institute, the top B2B content marketing strategies are social media, articles on a business’s website, eNewsletters, case studies, videos and articles on other websites.

 

2.      Social Media Marketing Will Require More Diversity

Consequently, it has become common for businesses to branch out and experiment with multiple networks with the aim of reaching the maximum amount of consumers. This diversification seems to prove fruitful for many companies because it often builds brand equity by making it easier for consumers to recognize a particular brand. For help figuring out which social media networks are right for your business, see my article “How to Determine Which Social Media Network Fits Your Business.”

 

3.      Image-Centric Content Will Rule

Successful blog posts that receive the most social shares also usually have a common characteristic: they pepper in some well-placed pictures to break content up and emphasize certain points. Another example is infographics, which combine images with a minimal amount of text to explain a topic and provide statistical information or data from research studies.

 

4.      Less Will be More

With many consumers feeling burned out by a constant barrage of information and advertisements that scream “look at me”, some of the most innovative marketers are going the opposite direction. The’re now making efforts to tone-down their campaign messages and not overwhelm consumers with hype.

 

5.      Mobile-Friendly Content Will Be Necessary

Due to the widespread (and quickly growing) use of smartphones and tablets, it’s necessary for companies to create content that’s accessible to mobile users. According to Forbes, “87% of connected devices sales by 2017 will be tablets and smartphones.”

 

6.      Ad Retargeting Will Grow in Effectiveness

This is a marketing strategy that has really caught on recently. In a nutshell, it works by utilizing browser cookies to track the websites that users visit. Once they leave a certain site, the products or services they viewed will be shown to them again in advertisements across different websites.

 

7.      SEO and Social Signals Will Become Even More Intertwined

Although social signals still don’t typically carry the same weight as traditional inbound links, it’s pretty undeniable that they play a role in organic search rankings these days. After all, they’re one of the three pillars of SEO. Since the goal of Google and other search engines is to provide users with the most relevant and highest quality content possible, it makes sense why they would factor in the number of social shares that a blog post, article or product page receives.

 

The more people that are sharing a piece of content, the higher quality it’s likely to be, and therefore its position should increase within the search engine results pages. It’s no coincidence that the top-ranking search results tends to have lots of social shares, while those ranked lower have fewer.


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marketingIO's curator insight, September 18, 2013 11:04 AM

There's far more than these 7 trends, but I can understand the article given the generalist publication. But within the confines of the aforementioned, let me add:

1) Smaller chunks of content...

2) ...delivered in animated fashion...

3) ...repeatable and shareable.


And don't forget retargeting: one of the great unused B2B marketing tactics out there today.


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Business and Marketing's curator insight, September 20, 2013 2:04 AM
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ItsMenaJo (GetGeekemarketing)'s curator insight, October 8, 2013 4:18 PM

Just thinking about content and images in particular... I think content will become more interactive. I'm seeing a couple of the top bloggers with embedded PDFs and quizzes on their websites. Really unique stuff that's totally engaging. Right now we need coders to create such content but I see this coming more into the mainstream, with providers making such functionality available and affordable to all.

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What Is Creativity? Cultural Icons on What Ideation Is and How It ...

What Is Creativity? Cultural Icons on What Ideation Is and How It ... | Creativity | Scoop.it
A library of cross-disciplinary interestingness and combinatorial creativity.
eva teruzzi's insight:

If creativity escapes a unique definition, let's go for quantity!

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