Angiogenesis
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PLOS ONE: Cell Survival Signalling through PPARδ and Arachidonic Acid Metabolites in Neuroblastoma

PLOS ONE: Cell Survival Signalling through PPARδ and Arachidonic Acid Metabolites in Neuroblastoma | Angiogenesis | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Genetic ablation of the fatty acid binding protein FABP5 suppresses HER2-induced mammary tumorigenesis

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Rescooped by Samantha Lipsky from Stem Cells & Tissue Engineering
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3D patterning of blood vessels: Creating a fertile landscape for engineered tissues - Signals Blog

3D patterning of blood vessels: Creating a fertile landscape for engineered tissues - Signals Blog | Angiogenesis | Scoop.it

Via Jacob Blumenthal
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Jacob Blumenthal's curator insight, May 22, 2013 4:06 PM

This is a short overview of the two main strategies in blood vessels patterning: 1. generate the tissue and the vasculature system in-vitro, prior to implantation or 2. design implants that will attract blood vessels of the host into the implant.

A new study on the second approach:

"

Geometric control of vascular networks to enhance engineered tissue integration and function"

http://www.ncbi.nlm.nih.gov/pubmed/23610423

 

Rescooped by Samantha Lipsky from Science News
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Molecular Movies - A Portal to Cell & Molecular Animation

Molecular Movies - A Portal to Cell & Molecular Animation | Angiogenesis | Scoop.it

Adhesion / Extracellular Matrix - Angiogenesis / Metastasis - Apoptosis - Cell Division / Cell Cycle - Chemistry / Organic Synthesis - Cytoskeleton / Molecular Motors - Developmental Processes - Disease / Immune System - DNA / Chromatin - Drug / Mechanism of Action - Evolution / Origins of Life - Metabolic / Respiration - Neuronal Signaling - Prokaryotes - Protein Folding & Stability - Replication - RNA Stability & RNAi - RTKs & Signal Transduction - Stem Cells - Transcription - Translation - Viruses / Infectious Disease


Via dromius, Dr. Stefan Gruenwald, Sakis Koukouvis
Samantha Lipsky's insight:

Very cool visualizations.

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aamoros2's curator insight, June 24, 2014 12:36 PM

Películas de animación molecular de células.

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Angiogenesis: An Adaptive Dynamic Biological Patterning Problem

Angiogenesis: An Adaptive Dynamic Biological Patterning Problem | Angiogenesis | Scoop.it

Formation of functionally adequate vascular networks by angiogenesis presents a problem in biological patterning. Generated without predetermined spatial patterns, networks must develop hierarchical tree-like structures for efficient convective transport over large distances, combined with dense space-filling meshes for short diffusion distances to every point in the tissue. Moreover, networks must be capable of restructuring in response to changing functional demands without interruption of blood flow. Here, theoretical simulations based on experimental data are used to demonstrate that this patterning problem can be solved through over-abundant stochastic generation of vessels in response to a growth factor generated in hypoxic tissue regions, in parallel with refinement by structural adaptation and pruning. Essential biological mechanisms for generation of adequate and efficient vascular patterns are identified and impairments in vascular properties resulting from defects in these mechanisms are predicted. The results provide a framework for understanding vascular network formation in normal or pathological conditions and for predicting effects of therapies targeting angiogenesis.


Via Ashish Umre
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Introduction to Cancer Biology (Part 4): Angiogenesis

As the tumor grows, it eventually reaches a size where it requires additional vasculature in order to sustain continued growth. To achieve this, tumor cells ...
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Rescooped by Samantha Lipsky from Lung Cancer Research Digest
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Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

The molecular mechanisms that control the balance between antiangiogenic and proangiogenic factors and initiate the angiogenic switch in tumors remain poorly defined. By combining chemical genetics with multimodal imaging, we have identified an autocrine feed-forward loop in tumor cells in which tumor-derived VEGF stimulates VEGF production via VEGFR2-dependent activation of mTOR, substantially amplifying the initial proangiogenic signal.


Via Cancer Commons
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Cancer Commons's curator insight, March 7, 2013 6:28 PM

Chatterjee S, Heukamp LC ... Thomas RK, Ullrich RT. The Journal of Clinical Investigation. Mar 1, 2013