We discuss the problems of modeling, control, and decision support in complex dynamic systems from a general system theoretic point of view. The main characteristics of complex systems and of system approach to complex system study are considered. We provide an overview and analysis of known existing paradigms and methods of mathematical modeling and simulation of complex systems, which support the processes of control and decision making. Then we continue with the general dynamic modeling and simulation technique for complex hierarchical systems functioning in control loop. Architectural and structural models of computer information system intended for simulation and decision support in complex systems are presented.