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Latest news on complex systems in life sciences, engineering, education and government
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Big Data Myths…BUSTED. | Innovation

Big Data Myths…BUSTED. | Innovation | Complex Insight  - Understanding our world | Scoop.it

 I like articles that let the air out of hype balloons. A surprisingly balanced one from SAP blogs  on many of the assumptions, misunderstandings, and confusion surrounding the concept of BigData.

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Open Data for Development Camp 2012 | *iHub_

Open Data for Development Camp 2012 | *iHub_ | Complex Insight  - Understanding our world | Scoop.it

The Open Data for Development Camp is part of The Kenya Open Data Pre-Incubator Program. This is a six-month experiment to help accelerate the ability for the public to make sense of data and to galvanize engagement around critical public issues. This event will take place from Wednesday, June 27, 2012 at 10:00 AM - Thursday, June 28, 2012 at 6:00 PM at Strathmore University. It promises a combination of Keynote Speakers, Workshops, Best Practices, Speed Geeking, Hack Space, Networking, Exchange of knowledge and needs, Sharing Data Sets, Co-Creation, Open Data Visualizations, and Inspiration.

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Video: Synthetic Biologist Karmella Haynes | The Synthetic Bestiary – Synthetic Biology, Genetic Engineering, and The Future

Video: Synthetic Biologist Karmella Haynes | The Synthetic Bestiary – Synthetic Biology, Genetic Engineering, and The Future | Complex Insight  - Understanding our world | Scoop.it

 Good introduction to synthetic biology from practioner Karmella Haynes, a post doc researcher at Harvard. 


Via Gerd Moe-Behrens
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The Sustainable City: Opening New Doors For Collaboration and Corporate Social Innovation!

...business can't build smart cities on its own. As identified at a recent Hitachi stakeholder dialogue on smart cities in Brussels, collaboration can add further value. Through liaising with representatives of government, academia, civil society and business, enterprises are able to dedicate their business efforts towards creating shared value and and ensuring a concentrated effort is developed towards confronting global challenges and transforming them into opportunities.. from The Sustainable City: Opening New Doors For Collaboration and Corporate Social Innovation!' blog post by Hans Daems, Hitachi

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SMU biochemist creates dynamic model of human P-glycoprotein

SMU biologists Pia Vogel and John Wise are using the computational power of SMU's high-performance supercomputer to screen millions of drug compounds. A key aspect of their approach is to animate the protien structure to give a dynamic moving model of the protien which aids in understanding. Interestingly SMU's approach is using highend computer visualization also echoed in the approach of the open source bioBlend project that combines the open source Blender and Python libs for parsing protein database info. Click image for more on SMU project and see bioblender.eu for more on BioBlender.

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Why health IT systems integrate poorly today, and what future EHRs can do about it - O'Reilly Radar

Why health IT systems integrate poorly today, and what future EHRs can do about it - O'Reilly Radar | Complex Insight  - Understanding our world | Scoop.it

New Internet-centric approaches to health IT systems are needed, and the government should be mandating a more modern open style of data exchange that breaks through monolithic systems. Worth reading - the challenge of proprietary vendors versus open systems is going to be a central theme in healthcare, smart cities, and internet of things. This article explains the healthcare IT situation in the US. Worth reading...

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Engineering mosquitos to reject malaria | Ars Technica

Engineering mosquitos to reject malaria | Ars Technica | Complex Insight  - Understanding our world | Scoop.it
via RKelwick

 

by
John Timmer
"Pests that carry a human antibody make poor hosts for parasites.
One of the easiest and often most effective means of controlling the spread of malaria is to control the mosquitos that carry it to humans. Unfortunately, that has proven to be just as much of an evolutionary arms race as targeting malaria itself; mosquitos evolve resistance to pesticides almost as quickly as malaria has evolved resistance to drugs.

Recent efforts have focused on forms of control that don't impose a huge fitness burden on the mosquito population. This general approach has been tested in the wild on the mosquitos that carry Dengue fever, which scientists infected with bacteria that block the spread of the virus. Now, researchers are reporting that they've developed genetically modified mosquitos that turn mosquitos into a dead-end for the malarial parasite. Their method: have the mosquitos express antibodies against the parasite whenever it feeds on blood.

Antibodies have a relatively poor history when it comes to targeting malaria in humans. Vaccines against the parasite tend to be ineffective, because Plasmodium falciparum has evolved ways of evading an immune response, often completely changing the proteins that coat its surface in order to keep antibodies from recognizing it. But these changes are only triggered once the parasite is already inside the human body...."
http://bit.ly/LkMXEm


Via Gerd Moe-Behrens
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Biomolecular computing systems: principles, progress and potential

Published in Nature by Yaakov Benenson

"The task of information processing, or computation, can be performed by natural and man-made 'devices'. Man-made computers are made from silicon chips, whereas natural 'computers', such as the brain, use cells and molecules. Computation also occurs on a much smaller scale in regulatory and signalling pathways in individual cells and even within single biomolecules. Indeed, much of what we recognize as life results from the remarkable capacity of biological building blocks to compute in highly sophisticated ways. Rational design and engineering of biological computing systems can greatly enhance our ability to study and to control biological systems. Potential applications include tissue engineering and regeneration and medical treatments. This Review introduces key concepts and discusses recent progress that has been made in biomolecular computing." Learn more at: http://bit.ly/Ll8Lg2 ;

(Note you will need a Nature login or need to purchase the paper)


Via Gerd Moe-Behrens
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Data Science Summit Videos | Greenplum

Data Science Summit Videos | Greenplum | Complex Insight  - Understanding our world | Scoop.it

A number of videos from the 2012 Data Science Summit via Greenplum that are worth watching. (useful selection from 2011 as well). The Data Science Summit brings together thought leaders from academia, the social enterprise, start-ups, and the public sector to help attendees explore and define their path forward in  our emergeing big data-driven world. Through data mining, statistics, advanced analytics and innovative visualizations, data scientists are drawing insights from the abundance of structured and unstructured data. Learn more.

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Debating a Proposed Moratorium On Synthetic Biology Research | Ali | Intersect: The Stanford Journal of Science, Technology and Society

by Sanna J. Ali : "This essay explores the ethical issues surrounding the public policy debate of imposing a moratorium on synthetic biology research. In particular, this article explores the risks of synthetic biology research, including those of safety, intellectual property rights, and a shift in the global economy, while assessing whether these risks are dangerous enough to call for a moratorium." http://bit.ly/LhPZcH


Via Gerd Moe-Behrens
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ACM A.M. Turing Centenary Celebration

ACM A.M. Turing Centenary Celebration | Complex Insight  - Understanding our world | Scoop.it

Thanks to Franz Dill (Eponymous Pickle blog) for this link. On Friday, June 15 and Saturday, June 16, more than 30 Turing Award recipients will gather to commemorate the 100th anniversary of Alan Turing's birth with personal remembrances, talks, and panel discussions. The ACM is webcasting the entire event live (and a stream will be available after the event).  This is a great way to get an insisight into computing's past and future, from the unique perspectives of its pioneers and leading contemporary thinkers. Please note that all times listed are Pacific Daylight Time (PDT). Worth Watching.

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Economics and Morality: Paul Krugman’s Framing.

Economics and Morality: Paul Krugman’s Framing. | Complex Insight  - Understanding our world | Scoop.it

Markets are not provided by nature. They are constructed — by laws, rules, and institutions. All of these have moral bases of one sort or another. Hence, all markets are moral, according to someone’s sense of morality. The only question is, Whose morality? In contemporary America, it is conservative versus progressive morality that governs forms of economic policy. The systems of morality behind economic policies need to be discussed. Learn more...

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Big ethics for big data - O'Reilly Radar

Big ethics for big data - O'Reilly Radar | Complex Insight  - Understanding our world | Scoop.it

Good discussion on the ethics of applying BigData techniques by Howard Wen at O`Reilly Radar. Big data itself, like all technology, is ethically neutral. The use of big data, however, is not. While the ethics involved are abstract concepts, they can have very real-world implications. The goal is to develop better ways and means to engage in intentional ethical inquiry to inform and align our actions with our values. Learn more...

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24 Million Industrial Wireless Sensing Points in 2016, Says ON World - Virtual-Strategy Magazine

24 Million Industrial Wireless Sensing Points in 2016, Says ON World - Virtual-Strategy Magazine | Complex Insight  - Understanding our world | Scoop.it
24 Million Industrial Wireless Sensing Points in 2016, Says ON WorldVirtual-Strategy MagazineON World's recently completed research study finds that the industrial Wireless Sensor Network (WSN) market has doubled over the past two years.
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Scientists Tie DNA Repair to Key Cell Signaling Network - Bioscience Technology

Scientists Tie DNA Repair to Key Cell Signaling Network - Bioscience Technology | Complex Insight  - Understanding our world | Scoop.it

University of Texas Medical Branch at Galveston researchers have found a surprising connection between a key DNA-repair process and a cellular signaling network linked to aging, heart disease, cancer and other chronic conditions. The discovery promises to open up an important new area of research — one that could ultimately yield novel treatments for a wide variety of diseases. Learn more...


Via Dr Richard Badge
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Visualization of NYC Pizza Delivery Routes on PBS’s America Revealed

Visualization of NYC Pizza Delivery Routes on PBS’s America Revealed | Complex Insight  - Understanding our world | Scoop.it

http://youtu.be/OlIelAWikWQ New York City pizza delivery routes were tracked with GPS in this visualization from the "Food Machine" episode of the PBS series America Revealed.

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Emergence of drug resistance to ARVs has potential to 'curb, and even reverse' gains against HIV

"In sub-Saharan Africa, the region with the highest HIV/AIDS burden, high-level political commitment and substantial international funding have led to an unparalleled scale-up of access to treatment over the past eight years," they write, adding, "However, little attention has been paid to the potential emergence and spread of drug-resistant HIV and its public health implications." Learn more..

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Big Data, 30,000 Scientists and a Startup : Elliott's Thoughts

Big Data, 30,000 Scientists and a Startup : Elliott's Thoughts | Complex Insight  - Understanding our world | Scoop.it

Kaggle is coming close to reaching it’s first birthday and with their innovative approach for statistical/analytical crowdsourcing. With over 30,000 data scientists in their community companies from all over the globe can take their big data problems to Kaggle and receive some interesting results.

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NASA's Pleiades Supercomputer Gets A Little More Oomph - MarketWatch (press release)

NASA's Pleiades Supercomputer Gets A Little More Oomph - MarketWatch (press release) | Complex Insight  - Understanding our world | Scoop.it
NASA's Pleiades Supercomputer Gets A Little More OomphMarketWatch (press release)Pleiades is critical for the modeling, simulation and analysis of a diverse set of agency projects in aeronautics research, Earth and space sciences and the ...and more »...
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Human Microbiome Project DACC - HMPDACC Data Browser

Human Microbiome Project DACC - HMPDACC Data Browser | Complex Insight  - Understanding our world | Scoop.it
via +Humberto González-Díaz

*NIH Human Microbiome Project*

Data Portal
http://bit.ly/LhsWi2


Via Gerd Moe-Behrens
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Biologists grow human-eye precursor from stem cells

Biologists grow human-eye precursor from stem cells | Complex Insight  - Understanding our world | Scoop.it

A stem-cell biologist has had an eye-opening success in his latest effort to mimic mammalian organ development in vitro. Yoshiki Sasai of the RIKEN Center for Developmental Biology (CBD) in Kobe, Japan, has grown the precursor of a human eye in the lab. Learn more...

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Temporal percolation of the susceptible network in an epidemic spreading

L. D. Valdez, P. A. Macri, L. A. Braunstein
(Submitted on 13 Jun 2012)
In this work, we study the evolution of the susceptible individuals during the spread of an epidemic modeled by the susceptible-infected-recovered (SIR) process spreading on top of complex networks. Using a edge-based compartmental approach and percolation tools, we find that the network composed by susceptible individuals undergoes a dynamic node percolation transition with a time dependent control parameter. We show that there exists a critical time $t_c$ above which the giant susceptible cluster is destroyed. As a consequence, in order to protect a large fraction of the susceptible individuals, any mitigation strategy should be implemented before this critical time $t_c$. Our theoretical results are confirmed by extensive simulations of the SIR process.


Via Frédéric Amblard
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Informatics, Biology Team Demonstrates Role of Foreign DNA Strands in Life-Supporting Bacteria

From - Lab Manager Magazine® : An Indiana University team of researchers has conducted the most in-depth and diverse genetic analysis of the defense systems that trillions of micro-organisms in the human body use to fend off viruses. Led by IU Bloomington assistant professor of informatics and computing Yuzhen Ye, the team of bioinformaticists and biologists reconstructed arrays of clusters of regularly interspaced short palindromic repeats -- CRISPRs -- which function as immune systems to the bacteria that play a vital role in human health. Between genomic repeats, CRISPR locations carry short strands of foreign DNA called spacers, which provide a history of past exposures to outside invaders like plasmids and bacteriophages (viruses that infect bacteria), and allow the bacteria to fight off viruses they have already encountered. This is an incredibly interesting piece of research and demonstrates the applications of CRISPRs to tracing the virus exposure of individuals  and it indicates the importance of effective identification and characterization of CRISPR loci to the study of the dynamic ecology of microbiomes and human health.  Learn more...

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About PAXsims

About PAXsims | Complex Insight  - Understanding our world | Scoop.it

The PaxSims blog is devoted to the development and effective use of simulation-based learning concerning issues of conflict, peacebuilding, and development in fragile and conflict-affected states, as well as to the policy of application of gaming and simulation techniques. If you are using agent based models or complex systems related simulations for policy modelling or development then the PAXsims blog should be on your essential reading list. Learn more...

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