Complex Insight ...
Follow
Find
9.3K views | +0 today
Complex Insight  - Understanding our world
Latest news on complex systems in life sciences, engineering, education and government
Curated by ComplexInsight
Your new post is loading...
Your new post is loading...
Scooped by ComplexInsight
Scoop.it!

The Delhi Mumbai Industrial Corridor Development Corporation Ltd embarks on major 'smart cities' project

The Delhi Mumbai Industrial Corridor Development Corporation Ltd (DMICDC) is scouting for land to establish the proposed seven ‘smart cities’ alongside the 1,500-km industrial corridor planned across six states – Uttar Pradesh, Haryana, Rajasthan, Gujarat, Maharashtra and Madhya Pradesh. The seven smart cities, to be developed as world-class manufacturing hubs, are to have individual master plans. Each of these would require different sizes of land, for which DMICDC, a special purpose vehicle comprising government and private entities, is in talks with the state governments to acquire land in the six states

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

complexity invented in 1965, Turing and sampling ...

complexity invented in 1965, Turing and sampling ... | Complex Insight  - Understanding our world | Scoop.it
The ACM hosts forum in which lectures from its Turing Award winners are delivered, to the illustrious. See http://amturing.acm.org/lectures.cfm. In short, only in 1965 was the domain of “computational complexity” invented (by ...
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Writing graphics software gets easier and faster with new language

Writing graphics software gets easier and faster with new language | Complex Insight  - Understanding our world | Scoop.it


A new programming language for image-processing algorithms called Halide  yields code that’s  often much shorter and clearer — but also faster than traditional programming languages such as C++ Click on the image or title to learn more.

more...
No comment yet.
Rescooped by ComplexInsight from 4D Pipeline - trends & breaking news in Visualization, Mobile, 3D, AR, VR, and CAD.
Scoop.it!

How To Create A Minimum Viable Product

How To Create A Minimum Viable Product | Complex Insight  - Understanding our world | Scoop.it

Timely catch from jed Fisher since we are working on next gen of our products - this has a lot of really good informaiton if you are building webservices. If you are developing products - its a good overview of how web app development is changing and what to use for billing, scaling, HTML and javascript frameworks etc. Worth reading - to find out more click on the image or click on the title... 


Via Jed Fisher
more...
No comment yet.
Rescooped by ComplexInsight from Social Simulation
Scoop.it!

Urban world: Cities and the rise of the consuming class

Urban world: Cities and the rise of the consuming class | Complex Insight  - Understanding our world | Scoop.it

Cities have long been the world’s economic dynamos, but today the speed and scale of their expansion are unprecedented. Through a combination of consumption and investment in physical capital, growing cities could inject up to $30 trillion a year into the world economy by 2025. Understanding cities and their shifting demographics is critical to reaching urban consumers and to preparing for the challenges that will arise from increasing demand for natural resources (such as water and energy) and for capital to invest in new housing, office buildings, and port capacity.

 

Report|McKinsey Global Institute
Urban world: Cities and the rise of the consuming class
June 2012 | by Richard Dobbs, Jaana Remes, James Manyika, Charles Roxburgh, Sven Smit and Fabian Schaer


Via Complexity Digest, Frédéric Amblard
more...
No comment yet.
Rescooped by ComplexInsight from Papers
Scoop.it!

Digital Epidemiology

Digital Epidemiology | Complex Insight  - Understanding our world | Scoop.it

Mobile, social, real-time: the ongoing revolution in the way people communicate has given rise to a new kind of epidemiology. Digital data sources, when harnessed appropriately, can provide local and timely information about disease and health dynamics in populations around the world. The rapid, unprecedented increase in the availability of relevant data from various digital sources creates considerable technical and computational challenges.

 

Salathé M, Bengtsson L, Bodnar TJ, Brewer DD, Brownstein JS, et al. (2012) Digital Epidemiology. PLoS Comput Biol 8(7): e1002616. http://dx.doi.org/10.1371/journal.pcbi.1002616


Via Complexity Digest
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

PLoS Computational Biology: Which of Our Modeling Predictions Are Robust?

PLoS Computational Biology: Which of Our Modeling Predictions Are Robust? | Complex Insight  - Understanding our world | Scoop.it

An interesting paper from Rob. j. De Boer on modelling predictions. If you are involved in predictive analytics or systems modeling and simulation - this is worth taking the time to read.  In theoretical ecology it is well known that the steady state expressions of the variables in a food chain crucially depend on the parity of the length of the chain. This poses a major problem for modeling real food webs because it is difficult to establish their true number of trophic levels, with sometimes rare predators and often rampant pathogens. Similar problems arise in the modeling of chronic viral infections. This Perspective aims to open the discussion on this problem..  Click on the title to learn more...

more...
No comment yet.
Rescooped by ComplexInsight from SynBioFromLeukipposInstitute
Scoop.it!

Hierarchical Modeling for Synthetic Biology

WE are huge fans of TinkerCell - its a great application, awesome open source framework and very useful too. This article scooped by the SynBio cool folks at the Leukippo Institute on TinkerCell by Deepak Chandran and Herbert M Sauro caught our eye.

 

"One of the characteristics of Synthetic Biology is that it often combines mathematical modeling with experimental work. The link between modeling and experiments is carried out by human researchers who have a conceptual understanding of the underlying biological system. At present, there is no method for representing a conceptual description that can be used to connect mathematical models and experimental data, especially sequence annotations, pertaining to the same underlying biological system. One reason for this limitation is that there can exist different mathematical models of the same biological system. In such cases, the same annotation in a DNA sequence would map differently to different models of the same system. In order to enable software support for synthetic biology, a software framework is needed such that it is able to capture a conceptual description of a biological system, including quantitative values, without confining itself to one mathematical model. The novel use of hierarchical modeling inside TinkerCell (www.tinkercell.com) provides one potential software solution for representing a "conceptual diagram" of a biological system. The conceptual diagram does not assume any underlying model. Rather, the diagram is mapped automatically to one of several models. The diagram can then contain information relevant for both modeling and experimental work. Computer-aided design (CAD) can be very useful to synthetic biology. CAD allows engineers to spend more effort at the design stage and less at the construction stage by automatically performing many tasks that are currently performed by human researchers. The ability to automatically link models and experimental results will be one step in the development of a practical CAD systems for synthetic biology."

http://bit.ly/SSDHaX


Via Socrates Logos
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

HIV antiretroviral resistance

The emergence and spread of high levels of HIV-1 drug resistance in resource-limited settings where combination antiretroviral treatment has been scaled up could compromise the effectiveness of national HIV treatment programmes. A study reported in the Lancet reports findings from systematic study of 26102 patients from sub-Saharan Africa, Asia and Latin America. The report findings suggest a significant increase in prevalence of drug resistance over time since antiretroviral rollout in regions of sub-Saharan Africa; this rise is driven by NNRTI resistance in studies from east and southern Africa. The findings are of concern and draw attention to the need for enhanced surveillance and drug-resistance prevention efforts by national HIV treatment programmes. Nevertheless, estimated levels, although increasing, are not unexpected in view of the large expansion of antiretroviral treatment coverage seen in low-income and middle-income countries—no changes in antiretroviral treatment guidelines are warranted at the moment.

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Cell - A Whole-Cell Computational Model Predicts Phenotype from Genotype

Cell - A Whole-Cell Computational Model Predicts Phenotype from Genotype | Complex Insight  - Understanding our world | Scoop.it

More on the Stanford teams success on creating a whole cell computational model predicting phenotype from genotype. Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. The Stanford team's publication describes a cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes all of its molecular components and their interactions.  Using an integrative approach to modeling that combines diverse mathematics enabled the simultaneous inclusion of fundamentally different cellular processes and experimental measurements.  The whole-cell model accounts for all annotated gene functions and was validated against a broad range of data. The model provides insights into many previously unobserved cellular behaviors, including in vivo rates of protein-DNA association and an inverse relationship between the durations of DNA replication initiation and replication. In addition, experimental analysis directed by model predictions identified previously undetected kinetic parameters and biological functions. The team conclude that comprehensive whole-cell models can be used to facilitate biological discovery.

more...
No comment yet.
Rescooped by ComplexInsight from SynBioFromLeukipposInstitute
Scoop.it!

Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering

by

Levin M, Stevenson CG.

"Achieving control over cell behavior and pattern formation requires molecular-level understanding of regulatory mechanisms. Alongside transcriptional networks and biochemical gradients, there functions an important system of cellular communication and control: transmembrane voltage gradients (V(mem)). Bioelectrical signals encoded in spatiotemporal changes of V(mem) control cell proliferation, migration, and differentiation. Moreover, endogenous bioelectrical gradients serve as instructive cues mediating anatomical polarity and other organ-level aspects of morphogenesis. In the past decade, significant advances in molecular physiology have enabled the development of new genetic and biophysical tools for the investigation and functional manipulation of bioelectric cues. Recent data implicate V(mem) as a crucial epigenetic regulator of patterning events in embryogenesis, regeneration, and cancer. We review new conceptual and methodological developments in this fascinating field. Bioelectricity offers a novel way of quantitatively understanding regulation of growth and form in vivo, and it reveals tractable, powerful control points that will enable truly transformative applications in bioengineering, regenerative medicine, and synthetic biology."
http://1.usa.gov/MPjIVB


Via Socrates Logos
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

What Can Systems Theory of Networks Offer to Biology?

What Can Systems Theory of Networks Offer to Biology? | Complex Insight  - Understanding our world | Scoop.it

Cells are  naturally receptive to external influence, and this gives an opportunity  to manipulate a cell to achieve a desired function or outcome. To do this a deeper understanding of when and where to apply external influences is required. The application of network controllability theory may be the key to systematic reasoning about which nodes to target to achieve global impact toward a desired outcome, and when to target them in a perturbed system, such as cancer. Interesting paper discussing possibilies of applying systems theory of networks to biology. Worth a read. Click on image or title to learn more.

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

First Ever Complete Computer Model of a Cell Produced

First Ever Complete Computer Model of a Cell Produced | Complex Insight  - Understanding our world | Scoop.it

It might shock you to hear that nobody has ever developed a complete computational model of a living cell. That's because, despite their diminutive size, their internal processes are extremely complex—but now a team of Stanford engineers has succeeded where others have failed.ombining data from over 900 scientific papers, a team led by Professor Markus Covert was able to account for every single molecular interaction which takes place in the world's smallest free-living bacterium, Mycoplasma genitalium. Once they had that understanding, they were able write code describing those interactions, combining them into a piece of software which computationally replicates exactly how the cell behaves. The results are published in Cell. Click on image or title to learn more...

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

New Data Visualization Tool Helps Find the “Unknown Unknowns”

A research team at the Georgia Tech Research Institute (GTRI) has developed a software tool that enables users to perform in-depth analysis of modeling and simulation data, then visualize the results on screen. The new data analysis and visualization tool offers improved ease of use compared to similar tools, the researchers say, and could be readily adapted for use with existing data sets in a variety of disciplines to help identify hidden relationships and unknowns within the simulation.  The data analysis and visualization tool is a subset of the Test Matrix Tool (TMT). The new visualization capability offers a graphical user interface that provides both on-screen data-manipulation features like filters and the ability to see query results in the form of graphical images almost instantly. Click on the title to learn more.

more...
No comment yet.
Rescooped by ComplexInsight from Information, Complexity, Computation
Scoop.it!

A Computable Universe: Understanding and Exploring Nature as Computation

A Computable Universe: Understanding and Exploring Nature as Computation | Complex Insight  - Understanding our world | Scoop.it

A Computable Universe
Understanding and Exploring Nature as Computation
Edited by: Hector Zenil


This volume, with a foreword by Sir Roger Penrose, discusses the foundations of computation in relation to nature.

It focuses on two main questions:

What is computation?
How does nature compute?
The contributors are world-renowned experts who have helped shape a cutting-edge computational understanding of the universe. They discuss computation in the world from a variety of perspectives, ranging from foundational concepts to pragmatic models to ontological conceptions and philosophical implications.

The volume provides a state-of-the-art collection of technical papers and non-technical essays, representing a field that assumes information and computation to be key in understanding and explaining the basic structure underpinning physical reality. It also includes a new edition of Konrad Zuse's “Calculating Space” (the MIT translation), and a panel discussion transcription on the topic, featuring worldwide experts in quantum mechanics, physics, cognition, computation and algorithmic complexity.

The volume is dedicated to the memory of Alan M Turing — the inventor of universal computation, on the 100th anniversary of his birth, and is part of the Turing Centenary celebrations.

 

http://www.worldscientific.com/worldscibooks/10.1142/8306

 


Via Complexity Digest, Eugene Ch'ng
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

eltcriticalmoments: The Johari Window as micro-simulation generator.

eltcriticalmoments: The Johari Window as micro-simulation generator. | Complex Insight  - Understanding our world | Scoop.it

The Johari Window has been around for a while (b. 1955) and although it sounds eastern and mystical it gets the name from its co-inventors Joe and Harry. Originally, Joseph Luft and Harrington V. Ingham developed the idea to help people improve self-awareness and personal development, and also mutual understanding between individuals within a group. The Johari-like grid  sets out situations where interlocutors may or may not know each other, and may or may not be expecting the event.  The Johari window provides a quick way of buiding soft skills simulations to teach people how to extend knowledge of one situation to address related but unknown situations. Worth a read.

more...
No comment yet.
Rescooped by ComplexInsight from SynBioFromLeukipposInstitute
Scoop.it!

Dawn of Virtual Cell Biology

You Tube Video

"A journal club and author interview about the recent paper "A Whole-Cell Computational Model Predicts Phenotype from Genotype", Karr et al., 2012. Stephen Larson presents a 45 minute overview of the paper and authors Jonathan Karr and Jayodita Sanghvi answer questions and clarify the paper. Organized by the members of OpenWorm.org"

The slide presentation is here:

https://docs.google.com/presentation/d/1UJl1XMeWkgI-qjtj6AkjsoUCpRQMoNWOEDShBLgmM54/edit

The comment stream here:

https://plus.google.com/u/0/117948341754627144949/posts

http://bit.ly/MpWUx8


Via Socrates Logos
more...
No comment yet.
Rescooped by ComplexInsight from Social Simulation
Scoop.it!

Activity driven modeling of time varying networks : Scientific Reports : Nature Publishing Group

Activity driven modeling of time varying networks : Scientific Reports : Nature Publishing Group | Complex Insight  - Understanding our world | Scoop.it

Network modeling plays a critical role in identifying statistical regularities and structural principles common to many systems. The large majority of recent modeling approaches are connectivity driven. The structural patterns of the network are at the basis of the mechanisms ruling the network formation. Connectivity driven models necessarily provide a time-aggregated representation that may fail to describe the instantaneous and fluctuating dynamics of many networks. We address this challenge by defining the activity potential, a time invariant function characterizing the agents' interactions and constructing an activity driven model capable of encoding the instantaneous time description of the network dynamics. The model provides an explanation of structural features such as the presence of hubs, which simply originate from the heterogeneous activity of agents. Within this framework, highly dynamical networks can be described analytically, allowing a quantitative discussion of the biases induced by the time-aggregated representations in the analysis of dynamical processes.


Via Frédéric Amblard
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Amazon.com: Signals and Boundaries: Building Blocks for Complex Adaptive Systems (9780262017831): John H. Holland: Books

Signals and Boundaries: Building Blocks for Complex Adaptive Systems

~ John H. Holland (author) More about this product
List Price: $40.00
Price: $33.30
You Save: $6.70 (17%)

Thanks to AntonJ and CXBooks for the heads up on this.

 

For me few books, papers and ideas I have ever read have been as  long term rewarding as those from John H. Holland. It could be simply that i fell for the ideas underpinning genetic algorithms(GA) when a young student, or that he generously took time to explain some finer points on applying GAs to certain classes of problems to me over the phone when I phoned his office for a copy of a paper when a young researcher. More than likely however it is the fact that that Holland and his cohorts have invented a big chunk of computer science tools and frameworks for thinking about complex systems. Either way a John Holland book is something I look forward to. His new one - Signals and Boundaries is now available.

 

In Signals and Boundaries, Holland argues that understanding the origin of the intricate signal/border hierarchies of complex adaptive systems (cas) such as ecosystems, governments, biological cells, and markets is the key to answering such questions. He develops an overarching framework for comparing and steering cas through the mechanisms that generate their signal/boundary hierarchies. Holland lays out a path for developing the framework that emphasizes agents, niches, theory, and mathematical models. He discusses, among other topics, theory construction; signal-processing agents; networks as representations of signal/boundary interaction; adaptation; recombination and reproduction; the use of tagged urn models (adapted from elementary probability theory) to represent boundary hierarchies; finitely generated systems as a way to tie the models examined into a single framework; the framework itself, illustrated by a simple finitely generated version of the development of a multi-celled organism; and Markov processes. Totally worth reading, chewing on and thinking about for a long time. Click on image or title to learn more.

more...
No comment yet.
Rescooped by ComplexInsight from SynBioFromLeukipposInstitute
Scoop.it!

One Million Genomic Datasets | The Scientist

One Million Genomic Datasets | The Scientist | Complex Insight  - Understanding our world | Scoop.it

Publicly accessible databases now store nearly 1 million gene-expression datasets, giving researchers a robust resource for discovery.


Via Socrates Logos
more...
No comment yet.
Rescooped by ComplexInsight from SynBioFromLeukipposInstitute
Scoop.it!

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity | Complex Insight  - Understanding our world | Scoop.it

Paper by Miller M, Hafner M, Sontag E, Davidsohn N, Subramanian S, Purnick PE, Lauffenburger D, Weiss R.

"Synthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we present the design, system integration, and analysis of several large scale synthetic gene circuits for artificial tissue homeostasis. Diabetes therapy represents a possible application for engineered homeostasis, where genetically programmed stem cells maintain a steady population of β-cells despite continuous turnover. We develop a new iterative process that incorporates modular design principles with hierarchical performance optimization targeted for environments with uncertainty and incomplete information. We employ theoretical analysis and computational simulations of multicellular reaction/diffusion models to design and understand system behavior, and find that certain features often associated with robustness (e.g., multicellular synchronization and noise attenuation) are actually detrimental for tissue homeostasis. We overcome these problems by engineering a new class of genetic modules for 'synthetic cellular heterogeniety' that function to generate beneficial population diversity..." More at: http://bit.ly/P3S8nP


Via Socrates Logos
more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Your Laptop Can Now Analyze Big Data - Technology Review

Your Laptop Can Now Analyze Big Data - Technology Review | Complex Insight  - Understanding our world | Scoop.it

New software makes it possible to do in minutes on a small computer what used to be done by large clusters of computers by using hardisks rather than in memory stores. Carlos Guestrin a computer scientist at Carnegie Mellon's Select Lab who led developmet of GraphChi with student Aapo Kyrola, says  "a Mac Mini running GraphChi can analyze Twitter's social graph from 2010—which contains 40 million users and 1.2 billion connections—in 59 minutes. The previous published result on this problem took 400 minutes using a cluster of about 1,000 computers".  Developments such as GraphChi wil enable researcher in computational biology could do large-scale computations on their PC; a developer working on a data-center algorithm can test it on their laptop before pushing it to the cloud. Tools like GraphChi will let many companies and startups solve all their graph-computing needs on a single machine. It's cost effective, and it drives innovation, too. Learn more about GraphChi here: http://graphlab.org/graphchi/ or click on the image or title to read the orginal Technology Review article.

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Artificial jellyfish built from rat cells

Artificial jellyfish built from rat cells | Complex Insight  - Understanding our world | Scoop.it

From article in Nature.com. Bioengineers have made an artificial jellyfish using silicone and muscle cells from a rat’s heart. The synthetic creature, dubbed a medusoid, looks like a flower with eight petals. When placed in an electric field, it pulses and swims exactly like its living counterpart. Learn more..

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Eric Berlow: How complexity leads to simplicity

Eric Berlow: How complexity leads to simplicity | Complex Insight  - Understanding our world | Scoop.it

Reducing complexity: Looking at the “big picture” – the macro or system view – makes it easier to deal with the small problems – to micro manage. Micro managing without, first, establishing the inter-connections and potential impact adds additional complexity. Ecologist Eric Berlow's 3 minute talk at Ted Oxford on how to get to insight from complexity. Very Worth watching. Click on the image or title to learn more.

more...
No comment yet.
Scooped by ComplexInsight
Scoop.it!

Are Smarter Cities the Key to Social Mobility? | Sustainable Cities Collective

Are Smarter Cities the Key to Social Mobility? | Sustainable Cities Collective | Complex Insight  - Understanding our world | Scoop.it

Chris Cooper was recently appointed as IBM UK’s Architect for Smarter Cities. For many years Chris has helped IBM’s customers and partners in the transport industry build smarter systems with positive social and environmental impact. Rick Robinson posts his interview wiht Chris where they discuss Smarter Cities and Social mobility. Worth a read. Click on the image or the headline to learn more...

more...
No comment yet.