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Chemicals That Make Plants Defend Themselves Could Replace Pesticides - Elsevier (2015)

Chemical triggers that make plants defend themselves against insects could replace pesticides, causing less damage to the environment. New research... identifies five chemicals that trigger rice plants to fend off a common pest – the white-backed planthopper, Sogatella furcifera

 

Pesticides are used around the world to control insects that destroy crops... One of the problems with many pesticides is that they kill indiscriminately. For rice plants, this means pesticides kill the natural enemies of one of their biggest pests, the white-backed planthopper... This pest... causes the plants to wilt and can damage the grains. It also transmits a virus disease... which stunts the plants’ growth and stops them from “heading,” which is when pollination occurs.

 

Left untreated, many of the insects’ eggs would be eaten, but when pesticides are used these hatch, leading to even more insects on the plants. What’s more, in some areas as many as a third of the planthoppers are resistant to pesticides... “Therefore, developing safe and effective methods to control insect pests is highly desired”... 

 

Because of the problems of using pesticides, it’s vital to find new solutions to help protect rice plants from infestation. Plants have natural self-defense mechanisms that kick in when they are infested with pests like the planthopper. This defense mechanism can be switched on using chemicals that do not harm the environment and are not toxic to the insects or their natural enemies... 

 

Researchers... developed a new way of identifying these chemicals. Using a specially designed screening system, they determined to what extent different chemicals switched on the plants’ defense mechanism... The researchers used bioassays to show that these chemicals could trigger the plant defense mechanism and repel the white-backed planthopper. This suggests that these chemicals have the potential to be used in insect pest management... 

 

“This new approach to pest management could help protect the ecosystem while defending important crops against attack.”

The next step for the research will be to explore how effective the chemicals are at boosting the plants’ defenses and controlling planthoppers in the field.

 

https://www.elsevier.com/about/press-releases/research-and-journals/chemicals-that-make-plants-defend-themselves-could-replace-pesticides

 

Original article: http://dx.doi.org/10.1016/j.bmcl.2015.10.041

 


Via Alexander J. Stein
ComplexInsight's insight:

Its good to see more research in these areas - but it would be good if in parallel we looked at potential impact of activated and elevated triggers and response  in terms of ecosystems and human health.  Multi-systemic approaches are going to be increasingly needed, which is worrying given how limited funding in this area already is..

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A new threat to bees? Entomopathogenic nematodes used in biological pest control cause rapid mortality in Bombus terrestris - Dutka &al (2015) - PeerJ

A new threat to bees? Entomopathogenic nematodes used in biological pest control cause rapid mortality in Bombus terrestris - Dutka &al (2015) - PeerJ | Complex Insight  - Understanding our world | Scoop.it

There is currently a great deal of concern about population declines in pollinating insects. Many potential threats have been identified which may adversely affect the behaviour and health of both honey bees and bumble bees: these include pesticide exposure, and parasites and pathogens.

 

Whether biological pest control agents adversely affect bees has been much less well studied: it is generally assumed that biological agents are safer for wildlife than chemical pesticides. The aim of this study was to test whether... nematodes sold as biological pest control products could potentially have adverse effects on the bumble bee... One product was a broad spectrum pest control agent... the other product was specifically for weevil control...

 

Both nematode products caused ≥80% mortality within the 96 h test period when bees were exposed to soil containing... nematodes at the recommended field concentration... Of particular concern is the fact that nematodes from the broad spectrum product could proliferate in the carcasses of dead bees, and therefore potentially infect a whole bee colony or spread to the wider environment.

 

https://dx.doi.org/10.7717/peerj.1413

 


Via Alexander J. Stein
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Alexander J. Stein's curator insight, November 21, 2015 9:44 AM

Also see these two articles in The Times: 

 

Organic pesticide increases risk to bees, 20 November:  www.thetimes.co.uk/tto/science/article4618597.ece

 

Organic farms used pesticide lethal to bees, 17 June:  www.thetimes.co.uk/tto/environment/article4472324.ece

 

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Scope and Opportunities of Bioengineering and Biotechnology in Agriculture and Related Industries - APO (2015)

Scope and Opportunities of Bioengineering and Biotechnology in Agriculture and Related Industries - APO (2015) | Complex Insight  - Understanding our world | Scoop.it

p. 305-313: With Asia having some of the fastest-growing economies with over 60% of the world’s population, 34% of the world’s arable land, and 36% of the world’s water resources, the region’s need to overcome formidable challenges and improve its total agricultural production and agricultural productivity are urgent... 

 

Feeding and nourishing a larger, more urban, and increasingly affluent Asian population sustainably and equitably will be an unprecedented challenge in the coming years. It will require a more holistic approach to address agricultural production an

d productivity more effectively.

 

Increasing production of food, feed, and fiber through the use of modern biosciences and biotechnology is only one among many strategies needed to meet this challenge. Access to modern science and technology will need to be supported by more comprehensive policies on investment, regulations, and education. In addition, while rural areas currently hold most of the world’s poor and hungry, and will continue to do so for many years to come, the urban areas of Asia will require more attention and distinct focus from national governments... 

 

Increasing productivity is a development imperative, whether urban or rural, if more agricultural production is to be achieved with reduced arable land, labor, and water in Asia. And therein lies the huge potential for biotechnology as a “green” technology.

 

http://www.apo-tokyo.org/publications/wp-content/uploads/sites/5/Productivity-in-the-Asia-Pacific_Past-Present-and-Future-20151.pdf#page=320

 


Via Alexander J. Stein, ComplexInsight
ComplexInsight's insight:

Having grown up  in a northumberland mining village in the north east of England, surrounded by farming and small woodlands - agriculture is something i think of intimately interwound with industry and how we live. If you grew up in a city - it can seem distant, but its always fundamental. If you grew up around farms - you know they are places of high and low tech. Strains and breeds are early forms of bio-engineering, agricultural equipment gives access to pragmatic engineering principles early on. In the coming decades advanced in bioengineering and biotech will increasingly be larger components of modern agriculture in order to meet increasing population pressures and demands generated by increased urban living. This report clearly helps identify the opportunities and possibilities and policy requirements that exist. If you are tracking the technology aspects of modern agriculture or interested in how agriculture will ahve to change to address increasing social needs - this report is well worth reading.

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IndieBio Will Accelerate Synthetic Biology To Tech Startup Speed - Forbes

IndieBio Will Accelerate Synthetic Biology To Tech Startup Speed - Forbes | Complex Insight  - Understanding our world | Scoop.it
Can biology move at "internet speed"? Is there a Moore's Law for cells? What about the problems that cannot be solved by information technology alone? IndieBio is proposing to answer these questions and more.
ComplexInsight's insight:

IndieBio will likely be a bell weather  fro how life sciences are adapting to accelerated rates of innovation and discovery - as well as a center point for policy, public perception and discourse. Good article - worth reading for insight into life sciences and biotech incubation as of 2015.

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I Contain Multitudes | Quanta Magazine

I Contain Multitudes |  Quanta Magazine | Complex Insight  - Understanding our world | Scoop.it
Our bodies are a genetic patchwork, possessing variation from cell to cell. Is that a good thing?
ComplexInsight's insight:

With new methods of single cell DNA sequencing becoming available - biologists are beginning to look a the degrees of variations that exist across cells and the extent of cell to cell diversity and what this implies for biological adaptation.

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Laser spotlight reveals machine 'climbing' DNA

Laser spotlight reveals machine 'climbing' DNA | Complex Insight  - Understanding our world | Scoop.it

New imaging technology has revealed how the molecular machines that remodel genetic material inside cells 'grab onto' DNA like a rock climber looking for a handhold.

 

The experiments, reported in this week's Science, use laser light to generate very bright patches close to single cells. When coupled with fluorescent tags this 'spotlight' makes it possible to image the inner workings of cells fast enough to see how the molecular machines inside change size, shape, and composition in the presence of DNA.

 

The Oxford team built their own light microscopy technology for the study, which is a collaboration between the research groups of Mark Leake in Oxford University's Department of Physics and David Sherratt in Oxford University's Department of Biochemistry.

 

The molecular machines in question are called Structural Maintenance of Chromosome (SMC) complexes: they remodel the genetic material inside every living cell and work along similar principles to a large family of molecules that act as very small motors performing functions as diverse as trafficking vital material inside cells to allowing muscles to contract.

 

The researchers studied a particular SMC, MukBEF (which is made from several different protein molecules), inside the bacterium E.coli. David Sheratt and his team found a way to fuse 'fluorescent proteins' directly to the DNA coding for MukBEF, effectively creating a single dye tag for each component of these machines.

 

Up until now conventional techniques of biological physics or biochemistry have not been sufficiently fast or precise to monitor such tiny machines inside living cells at the level of single molecules.

 

'Each machine functions in much the same way as rock-climber clinging to a cliff face,' says Mark Leake of Oxford University’s Department of Physics, 'it has one end anchored to a portion of cellular DNA while the other end opens and closes randomly by using chemical energy stored in a ubiquitous bio-molecule called adenosine triphosphate, or 'ATP': the universal molecular fuel for all living cells.

 

'This opening and closing action of the machine is essentially a process of mechanical 'grabbing', in which it attempts to seize more free DNA, like the rock-climber searching for a new handhold.'

 

It is hoped that pioneering biophysics experiments such as this will give fresh insights into the complex processes which are vital to life, and pave the way for a whole new approach to biomedical research at the very tiny length scale for understanding the causes of many diseases in humans, and how to devise new strategies to combat them. 


Via Dr. Stefan Gruenwald
ComplexInsight's insight:

its turtles all the way down... as we obtain more and more data and insight into cellular molecular mechanisms  their organisation, interactions, spatial and temporal dynamics become increasingly mechanistic with multiscale emergent propertiesarising from local interactions. This pioneering biophysics approach will likely generate a lot more insights into molecular mechanisms as it gets increasingly adopted for other experiments.

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Interview with Brian Mathews, Group CTO @ Autodesk

Great insight into types of developments being done at Autodesk as Robert Scoble interviews Brian Mathews, group CTO at Autodesk. Conversation covers 3D printing, cloud computing, nano technology, biomimetics, applied genetic algorithms to design etc. Great interview Click image or title to learn more..

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Reviewing the anti-cancer efficacy of curcumin « Integrative Biology Blog

Reviewing the anti-cancer efficacy of curcumin « Integrative Biology Blog | Complex Insight  - Understanding our world | Scoop.it

Tumeric is long held in to have healing effects in ayurvedic medicine. Curcumin, a bioactive ingredient in the fragrant orange spice tumeric, is thought to be effective in suppressing tumor growth and promoting chemoprevention of certain cancers.

In this review article Bassel El-Rayes et al. summarise the recent studies which describe preventive and therapeutic effects of curcumin and its analogues. In particular they concentrate on the breast cancer model, as curcumin has shown responses in reversing the human breast cancer cell resistance against paclitaxel and may be responsible for the lower incidence of breast cancer in Asian countries. Click on image or title to learn more.

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Scientists reveal mechanism for cellular remodeling

Knowing precisely how a cell is built will enable scientists to reconfigure and repurpose them for various biomedical applications,” says Bruce Goode, professor of biology whose lab studies the cytoskeleton. Until recently, scientists believed that there were different nucleators, or cell- igniters, responsible for making different types of actin structures or networks. But over the last few years, genetic research has suggested that nucleators might actually collaborate more often than they act alone. Click on title to learn more...

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Scientists discover cell surface 'docking stations' play important function in membrane protein trafficking

Scientists discover cell surface 'docking stations' play important function in membrane protein trafficking | Complex Insight  - Understanding our world | Scoop.it

(Phys.org) -- Ion channel proteins – teeny batteries in cells that are the basis for all thought and muscle contraction, among other things – also serve as important docking stations for other proteins that need help figuring out where to go according to groundbreaking new research by a team of Colorado State University scientists. The research by Diego Krapf, an assistant professor in the Department of Electrical and Computer Engineering, Mike Tamkun, a professor in the Department of Biomedical Sciences and Emily Deutsch  appears this month in the peer-reviewed journal, Molecular Biology of the Cell.  Click image or title to learn more.

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Whole Cell Biosensors in the Era of Synthetic Biology - July 3 London

Whole Cell Biosensors in the Era of Synthetic Biology - July 3 London | Complex Insight  - Understanding our world | Scoop.it

If you can make it the Whole Cell Biosensors in the Era of Synthetic Biology on July 3rd in London (at the BIS conference Centre) looks very worth attending. The purpose of this meeting is to facilitate knowledge exchange between the two closely related disciplines of Whole Cell Biosensors and Synthetic Biology and stimulate further ideas for successful future developments. Learn more...

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Human Microbiome Project DACC - HMPDACC Data Browser

Human Microbiome Project DACC - HMPDACC Data Browser | Complex Insight  - Understanding our world | Scoop.it
via +Humberto González-Díaz

*NIH Human Microbiome Project*

Data Portal
http://bit.ly/LhsWi2


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Informatics, Biology Team Demonstrates Role of Foreign DNA Strands in Life-Supporting Bacteria

From - Lab Manager Magazine® : An Indiana University team of researchers has conducted the most in-depth and diverse genetic analysis of the defense systems that trillions of micro-organisms in the human body use to fend off viruses. Led by IU Bloomington assistant professor of informatics and computing Yuzhen Ye, the team of bioinformaticists and biologists reconstructed arrays of clusters of regularly interspaced short palindromic repeats -- CRISPRs -- which function as immune systems to the bacteria that play a vital role in human health. Between genomic repeats, CRISPR locations carry short strands of foreign DNA called spacers, which provide a history of past exposures to outside invaders like plasmids and bacteriophages (viruses that infect bacteria), and allow the bacteria to fight off viruses they have already encountered. This is an incredibly interesting piece of research and demonstrates the applications of CRISPRs to tracing the virus exposure of individuals  and it indicates the importance of effective identification and characterization of CRISPR loci to the study of the dynamic ecology of microbiomes and human health.  Learn more...

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Can CRISPR Avoid the Monsanto Problem?

Can CRISPR Avoid the Monsanto Problem? | Complex Insight  - Understanding our world | Scoop.it

It is distressing, but a fact, that the more rapidly any technology is adopted by scientists the more likely it is to leave people confused, anxious, and suspicious. This week, I wrote an article for the magazine about just such a revolutionary technique, called CRISPR, that permits scientists to edit the DNA of plants and animals with an ease and a precision that even a decade ago seemed inconceivable.

CRISPR research has already begun to transform molecular biology. There have been bold new claims about its promise and powers nearly every day. Yet, for the past fifty years, at least since Watson and Crick demonstrated that DNA contained the blueprints required to build everything alive, modern science has been caught in a hype trap. After all, if we possess such exquisitely detailed instructions, shouldn’t they be able to help us fix the broken genes that cause so many of our diseases?

The assumption has long been that the answer is yes. And for decades, we have been told (by the medical establishment, by pharmaceutical companies, and, sadly, by the press) that our knowledge of genetics will soon help us solve nearly every malady, whether it affects humans, other animals, or plants.

It turns out, however, that genetics and magic are two different things. Deciphering the blueprints in the three billion pairs of chemical letters which make up the human genome has been even more complex than anyone had imagined. And even though the advances have been real, and often dramatic, it doesn’t always seem that way. This has led many people to discount, and even fear, our most promising technologies. Somehow, we take lessons more readily from movies like “Jurassic Park” and “Gattaca” than from the very real, though largely incremental, advances in medical treatments.

This dangerous disconnect between scientific possibility and tangible results has already caused great harm: a scientifically unjustified fear of G.M.O.s, for example, has prevented many potentially life-enhancing crops from even being tested, let alone planted widely. The death of one patient, in 1999, halted all human-gene-therapy experiments in the United States for several years. We should, of course, be exceedingly cautious with such research, but if the U.S. is going to stop studies that could potentially help millions of people there are costs to that, too. (It’s worth remembering that there are real risks to everything we do: aspirin kills hundreds of Americans every year, and in the first half of 2015 nearly twenty thousand people have died in car accidents.)

Because it makes manipulating genes so much easier, CRISPR offers researchers the ability to rapidly accelerate studies of many types of illness, including cancers, autism, and AIDS. It will also make it possible to alter the genes of plants so that they can resist various diseases (without introducing the DNA of a foreign organism, which is how G.M.O.s are made). With CRISPR, almost anything could become possible: You want a unicorn? Just tweak the horse genome. How about a truly blue rose? The gene for the blue pigment does not exist naturally in roses. With CRISPR, it should be a trivial matter simply to edit that gene in.

Eventually, CRISPR should also permit technicians to edit embryos, which, at least in theory, could change the genetic lineage of mankind. The prospect is at least as frightening as it is exciting, and we need to start talking about that now. In the press, at least, that conversation—about perhaps the most exciting advance in the history of molecular biology—seems to have started. Two of the researchers I focussed on in my piece for The New Yorker have also been featured in other publications in the past two weeks: the Times has a profile of Jennifer Doudna, the Berkeley biochemist who helped figure out how to program CRISPR molecules to edit DNA, and STAT, a new online health and science publication launched by the Boston Globe’s owner, has one about Feng Zhang, a pioneering biologist at the Broad Institute of Harvard and M.I.T., who first made the technology work in mammals. The subject will soon get even more attention. Early next month, the National Academy of Sciences will convene an international conference devoted to the ethical use of this powerful new tool.


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Artificial vanillin receptor modulates transcription - PLOS Synthetic Biology Community

Artificial vanillin receptor modulates transcription - PLOS Synthetic Biology Community | Complex Insight  - Understanding our world | Scoop.it
Bacteria adjust to different environmental conditions mainly by modulating transcription. Internal and external stimuli affect regulatory elements, all of which formulate the complex transcriptional profile of an organism at any given moment. In synthetic biology, the use of synthetic genetic circuits and metabolic pathways, which are often unresponsive to the aforementioned native regulation, is a common procedure. Such behavior can be advantageous, as it allows the organism to remain unaffected by unpredictable perturbations. In many cases, however, the lack of interaction with the internal control leads to undesired effects: metabolic intermediate accumulation, reduced fitness, and decreased product yields. This sets the framework of a recent research paper from the groups of Stephen Mayo and Richard Murray, where they describe a de novo transcription factor that is regulated by vanillin.

Vanillin is a byproduct of lignin degradation and an important substrate for the flavor industry. It is a phenolic compound with cytotoxic effects. In this article, the researchers modified qacR, a tetR-family repressor to bind vanillin, which binds to DNA via a helix-turn-helix domain. In the absence of the effector molecule, qacR physically inhibits RNA polymerase from transcribing the region downstream the binding site (see figure). The inducer causes conformational changes that prevent this binding, thus activating the gene. The procedure for qacR engineering consists of three steps:

(i) computational protein design. The researchers superimposed vanillin with the qacR crystal structure, enabling them to identify the potential binding conformations and the crucial aminoacids. They subsequently came up with a number of protein mutants that could form the correct interactions with vanillin and did not have steric clashes.

(ii) cell-free initial screening. The proteins resulting from the previous step were tested in an in vitro transcription/translation system. This methodology let the authors of the paper validate the repression qacR imposes on a reporter gene (GFP), while screening the functionality of the engineered proteins. Since all of the initial modified proteins failed to be activated by vanillin, the researchers went back to step (i) and designed more modifications. This time, two mutants showed the desired phenotype.

(iii) in vivo validation. As a last step, the two proteins from step (ii) were tested in E.coli. Both were able to suppress GFP expression in the lack of activator. One of them responded positively to increasing concentrations of vanillin, resulting in increased fluorescence.

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Scope and Opportunities of Bioengineering and Biotechnology in Agriculture and Related Industries - APO (2015)

Scope and Opportunities of Bioengineering and Biotechnology in Agriculture and Related Industries - APO (2015) | Complex Insight  - Understanding our world | Scoop.it

p. 305-313: With Asia having some of the fastest-growing economies with over 60% of the world’s population, 34% of the world’s arable land, and 36% of the world’s water resources, the region’s need to overcome formidable challenges and improve its total agricultural production and agricultural productivity are urgent... 

 

Feeding and nourishing a larger, more urban, and increasingly affluent Asian population sustainably and equitably will be an unprecedented challenge in the coming years. It will require a more holistic approach to address agricultural production an

d productivity more effectively.

 

Increasing production of food, feed, and fiber through the use of modern biosciences and biotechnology is only one among many strategies needed to meet this challenge. Access to modern science and technology will need to be supported by more comprehensive policies on investment, regulations, and education. In addition, while rural areas currently hold most of the world’s poor and hungry, and will continue to do so for many years to come, the urban areas of Asia will require more attention and distinct focus from national governments... 

 

Increasing productivity is a development imperative, whether urban or rural, if more agricultural production is to be achieved with reduced arable land, labor, and water in Asia. And therein lies the huge potential for biotechnology as a “green” technology.

 

http://www.apo-tokyo.org/publications/wp-content/uploads/sites/5/Productivity-in-the-Asia-Pacific_Past-Present-and-Future-20151.pdf#page=320

 


Via Alexander J. Stein
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ComplexInsight's curator insight, October 26, 2015 4:03 PM

Having grown up  in a northumberland mining village in the north east of England, surrounded by farming and small woodlands - agriculture is something i think of intimately interwound with industry and how we live. If you grew up in a city - it can seem distant, but its always fundamental. If you grew up around farms - you know they are places of high and low tech. Strains and breeds are early forms of bio-engineering, agricultural equipment gives access to pragmatic engineering principles early on. In the coming decades advanced in bioengineering and biotech will increasingly be larger components of modern agriculture in order to meet increasing population pressures and demands generated by increased urban living. This report clearly helps identify the opportunities and possibilities and policy requirements that exist. If you are tracking the technology aspects of modern agriculture or interested in how agriculture will ahve to change to address increasing social needs - this report is well worth reading.

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The man who grew eyes

The man who grew eyes | Complex Insight  - Understanding our world | Scoop.it
Growing nerve tissue and organs is a sci-fi dream. Moheb Costandi met the pioneering researcher who grew eyes and brain cells.
ComplexInsight's insight:

Interesting article on the work of Yoshiki Sasai  a Japanese biologist and Director of the Laboratory for Organogenesis and Neurogenesis at the research institute RIKEN in Kobe, Japan. Sasai was best known for developing new methods to grow stem cells into organ-like structures

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First ever biological amplifier created by Imperial scientists

First ever biological amplifier created by Imperial scientists | Complex Insight  - Understanding our world | Scoop.it

cientists have made an amplifier to boost biological signals, using DNA and harmless E. coli bacteria.

 Conventional amplifiers, such as those that are combined with loudspeakers to boost the volume of electric guitars and other instruments, are used to increase the amplitude of electrical signals. Now scientists from Imperial College London have used the same engineering principles to create a biological amplifier, by re-coding the DNA in the harmless gut bacteria Escherichia coli bacteria (E. coli). 
Via Gerd Moe-Behrens
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Gerd Moe-Behrens's curator insight, August 14, 2014 6:08 PM

by Gail Wilson

"Scientists have made an amplifier to boost biological signals, using DNA and harmless E. coli bacteria.

Conventional amplifiers, such as those that are combined with loudspeakers to boost the volume of electric guitars and other instruments, are used to increase the amplitude of electrical signals.
Now scientists from Imperial College London have used the same engineering principles to create a biological amplifier, by re-coding the DNA in the harmless gut bacteria Escherichia coli bacteria (E. coli). 

The team say this ‘bio-amplifier’ might be used in microscopic cellular sensors , which scientists have already developed, that could detect minute traces of chemicals and toxins, to make them more sensitive. Ultimately, this could lead to new types of sensors to detect harmful toxins or diseases in our bodies and in the environment before they do any damage.
In laboratory tests, the team’s bio-amplifier was able to significantly boost the detection limit and sensitivity of a sensor designed to detect the toxin arsenic. The device is also modular, which means that the devices can be easily introduced in different genetic networks, and can potentially be used to increase the sensitivity and accuracy of a broad range of other genetic sensors to detect pathogens and toxins.
The results of the study are published in the journal Nucleic Acids Research. 
Dr Baojun Wang, who is now based at the University of Edinburgh, but carried out the study while in the Division of Cell and Molecular Biology at Imperial, said: “One potential use of this technology would be to deploy microscopic sensors equipped with our bio-amplifier component into a water network. Swarms of the sensors could then detect harmful or dangerous toxins that might be hazardous to our health. The bio-amplifiers in the sensors enable us to detect even minute amounts of dangerous toxins, which would be of huge benefit to water quality controllers.”
Scientists have previously known that cells have their own inbuilt amplifiers to first detect and then boost biological signals, which are crucial for survival and reproduction. They have been attempting to understand how they work in more detail so as to remodel them for other applications. However the challenge for scientists has been engineering a device that can predictably amplify signals without distortion or feedback.
In the study, scientists first re-engineered genes involved in a special cell network called hrp (hypersensitive response and pathogenicity), which have naturally occurring amplifying proteins that function just like an electronic amplifier. They then cloned these amplifying components and inserted them into the harmless gut bacteria E. coli, fitting it with a synthetic arsenic input sensor and a fluorescent green protein gene as the output.  ..."


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Will 'big data' prevent disease?

Will 'big data' prevent disease? | Complex Insight  - Understanding our world | Scoop.it
How the blistering pace of technological change could have a profound impact on healthcare.
ComplexInsight's insight:

Good article from the BBC Future health series. Video is worth watching if you want an insight into how new technologies will impact healthcare.

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Cancers Genomes and their Implications for Curing Cancer (by Bert Vogelstein, JHU)

The full lecture title is "Cancers - Their Genomes, Microenvironments, and Susceptibility to Bacteria-based Therapies" by Bert Vogelstein. The Johns Hopkins Center for Biotechnology Education and the Department of Biology in the Krieger School of Arts and Sciences hosted the American Society for Microbiology's Conference for Undergraduate Educators (ASMCUE) on the Homewood campus. Bert Vogelstein gave the closing plenary lecture, "Cancers - Their Genomes, Microenvironments, and Susceptibility to Bacteria-based Therapies". He teaches at John Hopkins University.

ASMCUE, now in its 18th year, is a professional development conference for approximately 300 educators. Each year, its steering committee organizes a program that offers access to premier scientists in diverse specialties and to educators leading biology education reform efforts. For more information on the conference, go to http://www.asmcue.org/page02d.shtml


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Computer Simulation Cracks Chicken-Egg Puzzle : Discovery News

Computer Simulation Cracks Chicken-Egg Puzzle : Discovery News | Complex Insight  - Understanding our world | Scoop.it

New computer technology cracks the age-old riddle, demonstrating how a protein kickstarts eggshell formation. Researchers at the Universities of Sheffield and Warwick, in northern and central England, demonstrate how vocledidin-17 (OC-17), plays a part in eggshell formation. In a computer simulation, the OC-17 protein acted as a catalyst to kickstart the formation of crystals that make up an eggshell by clamping itself on to calcium carbonate particles. In otherwords the chicken came first. Click on image or title to learn more...

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Researchers closer to understanding how proteins regulate immune system

Researchers closer to understanding how proteins regulate immune system | Complex Insight  - Understanding our world | Scoop.it

Researchers have revealed how white blood cells move to infection or inflammation in the body; findings which could help lead to developing drug therapies for immune system disorders. Click on the image or title to learn more.

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Flu immunity is affected by how many viruses actually cause the infection

Flu immunity is affected by how many viruses actually cause the infection | Complex Insight  - Understanding our world | Scoop.it

Both the number of viruses in initial flu infection, and the virus type, affects the patient's outcome. Mice infected by high concentrations developed immunity, and generated immune cells in the lungs to fight other strains. Mice that were infected with a relatively low concentration of the virus developed weaker immunity against the strain that infected them, did not build up this crucial population of immune cells in the lungs, and showed only delayed immunity toward other flu strains. This discovery could pave the way for new prophylactic strategies to fight flu infections and provides a novel basis for vaccine design. Learn more by clicking on the image or headline.

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Scientists Tie DNA Repair to Key Cell Signaling Network - Bioscience Technology

Scientists Tie DNA Repair to Key Cell Signaling Network - Bioscience Technology | Complex Insight  - Understanding our world | Scoop.it

University of Texas Medical Branch at Galveston researchers have found a surprising connection between a key DNA-repair process and a cellular signaling network linked to aging, heart disease, cancer and other chronic conditions. The discovery promises to open up an important new area of research — one that could ultimately yield novel treatments for a wide variety of diseases. Learn more...


Via Dr Richard Badge
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Biologists grow human-eye precursor from stem cells

Biologists grow human-eye precursor from stem cells | Complex Insight  - Understanding our world | Scoop.it

A stem-cell biologist has had an eye-opening success in his latest effort to mimic mammalian organ development in vitro. Yoshiki Sasai of the RIKEN Center for Developmental Biology (CBD) in Kobe, Japan, has grown the precursor of a human eye in the lab. Learn more...

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