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Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases : Nature Structural & Molecular Biology : Nature Publishing Group

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases : Nature Structural & Molecular Biology : Nature Publishing Group | Complex Insight  - Understanding our world | Scoop.it
ADP-ribosylation is an important post-translational protein modification, yet enzymes capable of removing the protein-proximal ADP-ribose were unknown.
ComplexInsight's insight:

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology from the University of Zurich have identified enzymes that can regulate the activity of medically important proteins. Their discovery enables these proteins to be manipulated very selectively, opening up new treatment methods for inflammations and cancer. The work was published online on March 10, 2013 in Nature Structural & Molecular Biology. A related article was also published online at the same time in the same journal. For a healthy organism, it is crucial for proteins to be active or inactive at the right time. The corresponding regulation is often based on a chemical modification of the protein structure: Enzymes attach small molecules to particular sites on a protein or remove them, thereby activating or deactivating the protein. Identification of the enzymes and related mechanisms opens up the possiblity for new related treatments in related processes. Click on the iage or title to learn more.

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Plastic Logic, Queen's University and Intel demo a type of tablet display - that behaves a lot like flexible paper.

Plastic Logic, Queen's University and Intel demo a type of tablet display - that behaves a lot like flexible paper. | Complex Insight  - Understanding our world | Scoop.it
website description goes here
ComplexInsight's insight:

Big fan of the potential of Plastic Logic's display technology. While I am not sure of the use cases in the video - though fun to see - i am certain that  flexible displays like this will be a key innovation for future human computer interaction. Fun stuff.

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Amazon.com: Natural Language Generation in Artificial Intelligence and Computational Linguistics (The Springer International Series in Engineering and Computer Science) (9780792390985): Cecile L. P...

Adding this one to the future reading list. After experimenting with NLP in Python in recent weeks to improve possibility space search interfaces the cutting endge of natural language generation is of interest.  This looks like it is worth reading: Amazon.com: Natural Language Generation in Artificial Intelligence and Computational Linguistics (The Springer International Series in Engineering and Computer Science) (9780792390985): Cecile L. Paris, William R.

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3Gear Systems Blog

3Gear Systems Blog | Complex Insight  - Understanding our world | Scoop.it

New vision control api from 3GearSystems turns two Microsoft Kinnect devices into finger precise visual control system. Interesting approach and results look impressive. SDK is now in public beta - will be a charge for commercial use for companies with 100K+ turnover.

Their demo video is well worth watching. Click on the image or title for more info.

 

 

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