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3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org

3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org | Complex Insight  - Understanding our world | Scoop.it

Using NMR spectroscopy, the team mapped the arrangement of atoms in a protein called CXCR1, which detects the inflammatory signal interleukin 8 and, through a G protein located inside the cell, triggers a cascade of events that can mobilize immune cells, for example. Because G protein-coupled receptors are critical for many cellular responses to external signals, they have been a major target for drugs. More precise knowledge of the shapes of these receptors will allow drugmakers to tailor small molecules to better fit specific targets, avoiding collateral hits that can cause detrimental side effects. "This finding will have a major impact on structure-based drug development since for the first time the principal class of drug receptors can be studied in their biologically active forms where they interact with other proteins and potential drugs," said Stanley Opella, professor of chemistry and biochemistry at the University of California, San Diego who led the work, which Nature published online October 21st in advance of the print edition. Read more at: http://phys.org/news/2012-10-3d-unmodified-protein-coupled-receptor-natural.html#jCp or click on the image or title for more info.

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Interview with Brian Mathews, Group CTO @ Autodesk

Great insight into types of developments being done at Autodesk as Robert Scoble interviews Brian Mathews, group CTO at Autodesk. Conversation covers 3D printing, cloud computing, nano technology, biomimetics, applied genetic algorithms to design etc. Great interview Click image or title to learn more..

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3Gear Systems Blog

3Gear Systems Blog | Complex Insight  - Understanding our world | Scoop.it

New vision control api from 3GearSystems turns two Microsoft Kinnect devices into finger precise visual control system. Interesting approach and results look impressive. SDK is now in public beta - will be a charge for commercial use for companies with 100K+ turnover.

Their demo video is well worth watching. Click on the image or title for more info.

 

 

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Travel Through 2,000 Years of Paris' History With Interactive 3D Model

Travel Through 2,000 Years of Paris' History With Interactive 3D Model | Complex Insight  - Understanding our world | Scoop.it

Dassault has created Paris 3d, an interactive model that transports any Internet user through two millennia of the city's history. The 3D visualization application enables viewers to see the French capital developed since its Roman conquest in 52 BC until the present day. Witness the construction of the Bastille and Notre Dame, navigate through winding stone streets in the middle ages and visit the 1889 World’s Fair to see the revelation of the Eiffel Tower. Click on the image or the title to learn more.

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Spar Point Group - Head in the Point clouds - Esri just got a whole lot more 3D

Spar Point Group - Head in the Point clouds - Esri just got a whole lot more 3D | Complex Insight  - Understanding our world | Scoop.it

Esri announced this week the availability of CityEngine Web Viewer in ArcGIS Online this week, allowing anyone with a WebGL-enabled browser to navigate and explore uploaded 3D cities and environments created in CityEngine 2012.


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John Carmack is making a virtual reality headset, $500 kits available soon, video interview inside | PC Gamer

John Carmack is making a virtual reality headset, $500 kits available soon, video interview inside  | PC Gamer | Complex Insight  - Understanding our world | Scoop.it

John Carmack is one of the best graphics programmers in the game industry. His research and development work has tended to pioneer a number of new techniques that later become mainstream. It was with interest to learn that he is currently re-examining virtual reality head mounted displays.  The videos explain where he is at and what the state of development is. If you are interested in display technology and remember the original promise of headsets for certain applications this is well worth watching. Learn more...

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GTC 2012 Keynote (Part 1): Introduction video and welcome with NVIDIA CEO Jen-Hsun Huang

Watch the rest of the GTC 2012 Keynote here: http://bit.ly/gtc2012keynote GTC 2012 Keynote (Part 1) - Introduction video and welcome with NVIDIA CEO Jen-Hsun...
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GraphicSpeak » New Modo Power SubD-Nurbs reverses the CAD pipeline

GraphicSpeak » New Modo Power SubD-Nurbs reverses the CAD pipeline | Complex Insight  - Understanding our world | Scoop.it

Modo is a leading 3D modeling and rendering tool got a new market this week. A new Plug-in allows designers to start in Modo and pass a model to 3D CAD enabling Modo to migrate upstream as a concept design tool. Learn more...

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Sketchup leaves Google, moves to Trimble

Sketchup leaves Google, moves to Trimble | Complex Insight  - Understanding our world | Scoop.it

Sketchup - the 3D modeling application - a favourite of architects  and builders for quick 3D sketches- finds a new home.  Originally acquired by Google to help add 3D content to Google Earth,  the software is moving to Trimble where it will become part of Trimble's Office-to-Field Platform. The acquisition is part of Trimble's continuing expansion into the building and spatial information solutions market spanning design and planning offices to onsite construction and development measurement.

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3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org

3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org | Complex Insight  - Understanding our world | Scoop.it

Using NMR spectroscopy, the team mapped the arrangement of atoms in a protein called CXCR1, which detects the inflammatory signal interleukin 8 and, through a G protein located inside the cell, triggers a cascade of events that can mobilize immune cells, for example. Because G protein-coupled receptors are critical for many cellular responses to external signals, they have been a major target for drugs. More precise knowledge of the shapes of these receptors will allow drugmakers to tailor small molecules to better fit specific targets, avoiding collateral hits that can cause detrimental side effects. "This finding will have a major impact on structure-based drug development since for the first time the principal class of drug receptors can be studied in their biologically active forms where they interact with other proteins and potential drugs," said Stanley Opella, professor of chemistry and biochemistry at the University of California, San Diego who led the work, which Nature published online October 21st in advance of the print edition. Read more at: http://phys.org/news/2012-10-3d-unmodified-protein-coupled-receptor-natural.html#jCp or click on the image or title for more info.

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COMSOL 4.3a Release Highlights

COMSOL 4.3a Release Highlights | Complex Insight  - Understanding our world | Scoop.it

COMSOL announced Version 4.3a of COMSOL Multiphysics, its flagship software for modeling and simulating physics-based systems. With version 4.3a and in response to user requests, COMSOL introduces LiveLink for Excel to connect multiphysics results with spreadsheets. Version 4.3a also further extends the ability of engineers, scientists, and researchers to leverage multiphysics to design and optimize breakthrough products and technologies anywhere from the desktop to the cloud with new support for cluster computing on the Amazon Elastic Compute Cloud (Amazon EC2). New modules for analyzing fatigue and for importing ECAD files make their debut in Version 4.3a as does the new LiveLink for Solid Edge, a CAD software from Siemens PLM Software. Additionally, every one of the more than 30 application-specific COMSOL add-on modules for mechanical, electrical, fluid, and chemical modeling and simulation sees major new upgrades. Available from 8 October for download. Click on image or title to learn more.

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Interactive Physical Simulation

Interactive Physical Simulation | Complex Insight  - Understanding our world | Scoop.it

If interactive physics or comptuer graphics is your thing then you need to read tje collected Research from Computer Graphics Group at University of Copenhagen. A wonderful resource on graphics and simulation of itnerest to anyone doing visual simulaiton or mechanical simulation. click on the image or title to learn more.

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Gamasutra - Features - How Do You Put the Sim in SimCity?

Gamasutra - Features - How Do You Put the Sim in SimCity? | Complex Insight  - Understanding our world | Scoop.it

Games and games technology often inspire and sometimes lead the simulation industry. Over the years Sim City has been instrumental in many people learning about simulations, urban planning and land use in and outside of a class room. The next generation of Sim City is likely to do that and set expectations on what City Simulations should look like. :-) Great article at Gamasutra on the design and aesthetic of the new version and how it relates to the underpinning simulation. Learn more...

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Leap 3D Offers Amazing Gesture-Based Control of Your Computer for Just $70 | Singularity Hub

Leap 3D Offers Amazing Gesture-Based Control of Your Computer for Just $70 | Singularity Hub | Complex Insight  - Understanding our world | Scoop.it

It is going to be interesting finding out how much of this is hype and how much of this is reality.  Initial videos are intriguing. A startup called Leap Motion has announced the development of the Leap 3D motion control device that is sensitive down to 1/100 of a millimeter – that’s 200 times better than other sensors (i.e: Kinect). At this resolution, the Leap software is able to resolve the motion of individual fingers, allowing for intuitive gesture controls like pinch-to-zoom, highly accurate virtual drawing, and manipulation of 3D models. Learn more.

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GraphicSpeak » Nvidia launches the Kepler era of virtual GPU computing and accessible HPC

GraphicSpeak » Nvidia launches the Kepler era of virtual GPU computing and accessible HPC | Complex Insight  - Understanding our world | Scoop.it
Previously unobtainable performance opens the door to a variety of possibilities including streaming games like movies or doing sophisticated simulations from the cloud. Power efficiency gains are as important as the graphics gains.
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How Pixar almost deleted Toy Story 2

How Pixar almost deleted Toy Story 2 | Complex Insight  - Understanding our world | Scoop.it

Ever accidently deleted something - and didnt mean to... Yup you are not alone.. Taken from the Studio Stories series included on the Blu-ray versions of Toy Story 1 & 2, here's a short story about how they accidently deleted and recovered Toy Story 2. Worth watching..

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Valve: How I Got Here, What It’s Like, and What I’m Doing | Valve

Valve is one of the best and most innovative 3D companies on the planet. Michael Abrash is one of the best developers on the planet (if you are old enough to remember quake and know who John Carmack is - you will know why. If not - use google and be awed). The Valve blog is massively worth reading.... (as is Neil Stephenson's Snow Crash which is mentioned in the post- still prescient and massively entertaining nearly 20 years later).

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