Cells are naturally receptive to external influence, and this gives an opportunity to manipulate a cell to achieve a desired function or outcome. To do this a deeper understanding of when and where to apply external influences is required. The application of network controllability theory may be the key to systematic reasoning about which nodes to target to achieve global impact toward a desired outcome, and when to target them in a perturbed system, such as cancer. Interesting paper discussing possibilies of applying systems theory of networks to biology. Worth a read. Click on image or title to learn more.