Research paper by Biliouris K, Babson D, Schmidt-Dannert C, Kaznessis Y.
The field of synthetic biology has greatly evolved and numerous functions can now be implemented by articially engineered cells carrying the appropriate genetic information. However, in order for the cells to robustly perform complex or multiple tasks, co-operation between them may be necessary. In this paper, the team model a synthetic ecosystem comprising of bacteria and yeast that communicate with and benefit from each other using small diffusible molecules using stochastic modeling. The stochastic model captures the relevant intra-cellular and inter-cellular interactions taking place in and between the eukaryotic and prokaryotic cells. Integration of well-characterized molecular regulatory elements into these two microbes allows for communication through quorum sensing. The way that the model is built allows for studying the dynamics of any system consisting of two species communicating with one another via chemical signals and therefore is of interest to a wide domain and may potentially drive the experimental design of various synthetic heterogeneous ecosystems.". A provisional full version of the paper is available at: http://www.biomedcentral.com/content/pdf/1752-0509-6-58.pdf
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