Cold Sore Remedies
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Cold Sore Buster: Overnight Cold Sore Remedies

Cold Sore Buster: Overnight Cold Sore Remedies | Cold Sore Remedies | Scoop.it
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The author found a few effective cold sore remedies that can work overnight. If you want quick relief, find out more from this post.

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NOR-Batzelladine L from the sponge Monanchora sp. displays antiviral acyivity against Herpes Simplex virus type 1

NOR-Batzelladine L from the sponge Monanchora sp. displays antiviral acyivity against Herpes Simplex virus type 1 | Cold Sore Remedies | Scoop.it

Althoug marine organisms produce an incredible array of bioactive natural products, only few of such secondary metabolites display anti-viral activity. The aim of this study was to evaluate antiviral activity against Herpes simplex virus type 1 (HSV-1) and Avian metapneumovirus (aMPV) of some marine natural products. HSV-1 cause herpes labials in humans and aMPV cause respiratory disease in avian, which accounts for considerable economic losses worldwide. Fourteen pure compounds isolated and identified were tested in non-toxic concentrations for virus-infected cells. Norbatzelladine L isolated from a marine sponge of the genus Monanchora displayed MNTC at 2,5µg/mL against HSV-1, with 97% of inhibition in the viral adsorption phase. Further studies are underway in order to establish the anti-viral mode-of-action of norbatzelladine L.


Via NatProdChem, Jian Guo
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Norbatzelladine L, a marine organism, was discovered to inhibit the HSV1 adsorption phase.

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PLOS Pathogens: A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication

PLOS Pathogens: A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication | Cold Sore Remedies | Scoop.it
From molecules to physiology (Med23/IFN-lambda pathway of innate immunity shown to play a significant role in HSV-1 infection http://t.co/oBp3LIpGtP)...

Via Gilbert C FAURE
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Scientists found Med23 could stop HSV1 replication.

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Société Francaise d'Immunologie's comment, July 30, 2014 10:34 AM
The Mediator complex links the cellular transcription machinery (RNA polymerase II) to specific transcription factors, and the identification of many Mediator subunits as HFs in other viral siRNA depletion screens highlights its significant role in viral genome transcription