Althoug marine organisms produce an incredible array of bioactive natural products, only few of such secondary metabolites display anti-viral activity. The aim of this study was to evaluate antiviral activity against Herpes simplex virus type 1 (HSV-1) and Avian metapneumovirus (aMPV) of some marine natural products. HSV-1 cause herpes labials in humans and aMPV cause respiratory disease in avian, which accounts for considerable economic losses worldwide. Fourteen pure compounds isolated and identified were tested in non-toxic concentrations for virus-infected cells. Norbatzelladine L isolated from a marine sponge of the genus Monanchora displayed MNTC at 2,5µg/mL against HSV-1, with 97% of inhibition in the viral adsorption phase. Further studies are underway in order to establish the anti-viral mode-of-action of norbatzelladine L.
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