Clinical Proteomics
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Clinical Proteomics
Clinical Proteomics
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Lille 1 University M2 Specialities - Laboratoire PRISM

Lille 1 University M2 Specialities - Laboratoire PRISM | Clinical Proteomics | Scoop.it
M2 Proteomics Speciality M2 Proteomics Spectiality of the Master of Genomics and Proteomics is a professionalized course aimed to train (...) ...
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Pursuing type 1 diabetes mellitus and related complications through urinary proteomics

Translational Research, Volume null, Issue null, Pages null, null, Authors:Armando Caseiro; António Barros; Rita Ferreira; Ana Padrão; Miguel Aroso; Cláudio Quintaneiro; Amélia Pereira; Rosário Marinheiro; Rui Vitorino; Francisco Amado...
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The impact of biosampling procedures on molecular data interpretation

The impact of biosampling procedures on molecular data interpretation | Clinical Proteomics | Scoop.it

The separation between biological and technical variation without extensive use of technical replicates is often challenging, particularly in the context of different forms of protein and peptide modifications. Biosampling procedures in the research laboratory are easier to conduct within a shorter time frame and under controlled conditions as compared to clinical sampling with the later often having issues of reproducibility. But is the research laboratory biosampling really less variable? Biosampling introduces within minutes rapid tissue specific changes in the cellular microenvironment; inducing a range of different pathways associated with cell survival. Biosampling involves hypoxia and hypothermia which are circumstances for which there are evolutionary conserved defense strategies in range of species and also are relevant for a range of biomedical conditions. It remains unclear to what extent such adaptive processes are reflected in different biosampling procedures or how important they are for the definition of sample quality. Lately, an increasing number of comparative studies on different biosampling approaches, post-mortem effects and pre-sampling biological state have investigated such immediate early biosampling effects. Commonalities between biosampling effects and a range of ischemia/reperfusion and hypometabolism/anoxia associated biological phenomena indicate that even small variations in post-sampling time intervals are likely to introduce a set of non-random and tissue specific effects of experimental importance (both in vivo and in vitro). This review integrates the information provided by these comparative studies and discusses how an adaptive biological perspective in biosampling procedures may be relevant for sample quality issues.


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ScienceDirect.com - Clinical Biochemistry - Protease profiling of different biofluids in type 1 diabetes mellitus

ScienceDirect.com - Clinical Biochemistry - Protease profiling of different biofluids in type 1 diabetes mellitus | Clinical Proteomics | Scoop.it
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European Consortium Launches Effort to Develop 'Actively ...

European Consortium Launches Effort to Develop 'Actively ... | Clinical Proteomics | Scoop.it
A European-led consortium of researchers and biotech firms are working together to develop and manufacture individualized vaccines based on the genomic, proteomic, and peptidomic characteristics of a particular glioblastoma patient's tumor and...
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Current Status and Advances in Quantitative Proteomic Mass ...

Current Status and Advances in Quantitative Proteomic Mass ... | Clinical Proteomics | Scoop.it
Quantitative Proteomics in Biomarker Discovery. The ultimate aim of biomarker discovery is to develop a simple differential test to be used as a clinical evaluation tool. This requires a lengthy and difficult process which involves candidate ...
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Proteome Science | Full text | MS/MS library facilitated MRM ...

Our overall goal was to develop a workflow leading from standardized preparation of serum samples, through data management facilitating the design of MRM quantification, to the validation in a clinically applicable assay.
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Salivary peptidome in type 1 diabetes mell... [Biomed Chromatogr. 2012] - PubMed - NCBI

PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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