Olley Edwards is a British campaigner for Autistic girls and women. She’s a published author, public speaker and a Film director. Her latest Autism documentary is in the Cannes short film corner this month.
The literary great Marcel Proust wore ear-stoppers because he was unable to filter out irrelevant noise—and lined his bedroom with cork to attenuate sound.
Now new Northwestern University research suggests why the inability to shut out competing sensory information while focusing on the creative project at hand might have been so acute for geniuses such as Proust, Franz Kafka, Charles Darwin, Anton Chekhov and many others. The Northwestern research provides the first physiological evidence that real-world creativity may be associated with a reduced ability to filter "irrelevant" sensory information. The research suggests that some people are more affected by the daily bombardment of sensory information—or have "leakier" sensory filters. "Leaky" sensory gating, the propensity to filter out "irrelevant" sensory information, happens early, and involuntarily, in brain processing and may help people integrate ideas that are outside of the focus of attention, leading to creativity in the real world, said Darya Zabelina, lead author of the study, calling the finding "impressive." The researchers investigated specific neural markers of a very early form of attention, namely sensory gating, indexed by P50 ERP, the neurophysiological response that occurs 50 ms (milliseconds) after stimulus onset, and how it relates to two measures of creativity: divergent thinking and real-world creative achievement. In the study, approximately 100 participants reported their achievements in creative domains via Creative Achievement Questionnaire, as well as performed a test of divergent thinking, generally considered to be a laboratory test of creative cognition. On this test participants were asked to provide as many answers as they could to several unlikely scenarios, within a limited amount of time. The number and the novelty of participants' responses comprised the divergent thinking score. As a result, the researchers had two different measures of creativity: a number of peoples' real-world creative achievements and a laboratory measure of divergent thinking. Divergent thinking tests are timed laboratory measures of creative cognition, in which participants produce numerous responses within a limited time. In the study, divergent thinking correlated with academic test scores and selective sensory gating—an increased ability to filter compared to lower divergent thinkers. In direct contrast, real-world creative achievement was associated with leaky sensory processing—or a reduced ability to screen or inhibit stimuli from conscious awareness. This shows that these creativity measures are sensitive to different forms of sensory gating. Divergent thinking does contribute to creativity, but appears to be separate from the process of creative thinking that is associated with the leaky sensory filter. The study suggests that creative people with "leaky" sensory gating may have a propensity to deploy attention over a wider focus or a larger range of stimuli. "If funneled in the right direction, these sensitivities can make life more rich and meaningful, giving experiences more subtlety," said Zabelina, a Ph.D. candidate in psychology at Northwestern. But the downsides to such sensory distraction have been well noted by some of the world's most creative thinkers. One of the most influential novelists of the 20th century, Kafka once said, "I need solitude for my writing; not 'like a hermit'—that wouldn't be enough—but like a dead man." Darwin, Chekhov and Johan Goethe also strongly lamented the distracting nature of noise. The study cannot yet determine whether reduced sensory gating is a stable trait, or if creative achievers can modulate their sensory processing depending on task demands.
Thousands of tiny ones and zeros pierce the aluminium skin of Denton Corker Marshall's new engineering faculty for the University of Technology in Sydney, spelling out the name of the building in binary code (+ slideshow).
Composite protein and antibody engineering technologies combine the best attributes of deimmunisation and humanization techniques to minimise the immunogenic potential of biopharmaceutical product candidates before they enter clinical development. An immune response can lead to the development of anti-drug antibodies (ADAs) which can reduce efficacy, through the rapid clearance or neutralization of the protein or antibody, and potentially cause toxicity by cross-reacting with other proteins in the body.
Humanized antibodies and deimmunised proteins are designed to be devoid of the T cell epitopes that lead to an adverse immune response while minimising the loss of antibody affinity or protein activity that can occur with standard protein engineering techniques.
Composite Human Antibodies™ Antibody humanization technology is used to generate humanized and fully functional antibodies devoid of T cell epitopes in the variable region sequences to reduce immunogenicity in patients. Composite Proteins™ Protein deimmunisation technology is used to generate therapeutic proteins devoid of human T cell epitopes to minimise potential immunogenicity in patients without compromising protein activity Once a lead humanized antibody or deimmunised protein candidate has been identified, EpiScreen™ immunogenicity assessment technology is used to confirm T cell epitopes have been removed. We can provide small quantities of antibody or protein for research purposes using either transient expression systems or through generating research-grade stable cell lines. For larger quantities for development a stable high-expressing manufacturing cell line can be established using ourcell line development service and then transferred to a cGMP compliant manufacturer.
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