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What is flipped learning?


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What is flipped Learning?

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Deirdre Bonnycastle's curator insight, March 15, 11:48 AM

An infographic on flipped classroom

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Rescooped by Christian Yamashiba Kasongo from A Tale of Two Medicines
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Onion extracts may boost uptake of berry polyphenols.

Onion extracts may boost uptake of berry polyphenols. | Christian Yamashiba Kasongo's medical review | Scoop.it

Three glucuronidated conjugates of strawberry–cranberry phenolic compounds, p-hydroxybenzoic acid glucuronide, catechins glucuronide, and methyl catechins glucuronide were found in higher quantities when GlucoPhenol was ingested together with onion extract (+252%, +279%, and +118% respectively), suggesting a possible induction of glucuronidation processes by quercetin. This work allowed the characterization of actual phenolic metabolites generated in vivo following a phenolic intake, the analysis of their kinetics and suggested a possible synergistic activity of phenolic compounds for improving bioavailability.


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Onion extracts may boost uptake of berry polyphenols.

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Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation

Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation | Christian Yamashiba Kasongo's medical review | Scoop.it

In chronic kidney disease, vitamin K–dependent proteins, including the calcification inhibitor matrix Gla protein, are largely uncarboxylated indicating that functional vitamin K deficiency may contribute to uremic vascular calcification. Since the effects of uremia on the vitamin K cycle are unknown, we investigated the influence of uremia and vitamin K supplementation on the activity of the vitamin K cycle and extraosseous calcification. Uremia was induced in rats by an adenine-supplemented diet and vitamin K1 or K2 was administered over 4 and 7 weeks. After 4 weeks of adenine diet, the activity of the vitamin K cycle enzyme γ-carboxylase but not the activities of DT-diaphorase or vitamin K epoxide reductase were reduced. Serum levels of undercarboxylated matrix Gla protein increased, indicating functional vitamin K deficiency. There was no light microscopy–detectable calcification at this stage but chemically determined aortic and renal calcium content was increased. Vitamin K treatment reduced aortic and renal calcium content after 4 weeks. Seven weeks of uremia induced overt calcification in the aorta, heart, and kidneys; however, addition of vitamin K restored intrarenal γ-carboxylase activity and overstimulated it in the liver along with reducing heart and kidney calcification. Thus, uremic vitamin K deficiency may partially result from a reduction of the γ-carboxylase activity which possibly contributes to calcification. Pharmacological vitamin K supplementation restored the vitamin K cycle and slowed development of soft tissue calcification in experimental uremia.


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Vitamine K avec facultés affaiblies recyclage dans l'urémie est sauvé par vitamine K le point AJOUTER de Votre de vue ...

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elearn Magazine: Helping Dyslexic Medical Students Pass Their OSCE Exams

elearn Magazine: Helping Dyslexic Medical Students Pass Their OSCE Exams | Christian Yamashiba Kasongo's medical review | Scoop.it
En Septembre 2008, deux étudiants ayant des troubles d'apprentissage ont été admis à l'Université de Doctorat d'Ottawa programme de médecine en. Parce que les deux sont dyslexiques, des aménagements spéciaux ont dû être faits ....

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Investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms

Diseases caused by infectious and inflammatory microorganisms are among the most common and most severe nosocomial diseases worldwide. Therefore, developing effective agents for treating these illnesses is critical. In this study, essential oils from two tea tree species, kanuka (Kunzea ericoides) and manuka (Leptospermum scoparium), were evaluated for use in treating diseases and inflammation caused by microorganism infection.

 

Isolates of clinically common bacteria and fungi were obtained from American Type Culture Collection and from Kaohsiung Veterans General Hospital. Minimum inhibitory concentrations for Trichosporon mucoides, Malassezia furfur, Candida albicans, and Candida tropicalis were determined by the broth microdilution method with Sabouraud dextrose broth. The antibacterial susceptibility of Staphylococcus aureus, Streptococcus sobrinus, Streptococcus mutans, and Escherichia coli were determined by the broth microdilution method. A human acute monocytic leukemia cell line (THP-1) was cultured to test the effects of the essential oils on the release of the two inflammatory cytokines, tumor necrosis factor-α and interleukin-4.

 

Multiple analyses of microorganism growth confirmed that both essential oils significantly inhibited four fungi and the four bacteria. The potent fungicidal properties of the oils were confirmed by minimum inhibitory concentrations ranging from 0.78% to 3.13%. The oils also showed excellent bactericidal qualities with 100% inhibition of the examined bacteria. In THP-1 cells, both oils lowered tumor necrosis factor-α released after lipopolysaccharide stimulation. Finally, the antimicrobial and anti-inflammatory effects of the oils were obtained without adversely affecting the immune system.


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Une des Huiles Essentielles Pour Le Traitement in vitro de la maladie et de l'inflammation cellulaire Causee par des micro-organismes de la jouter Votre Point de Vue de ... Enquêtes de Kanuka et des huiles essentielles de manuka pour le traitement in vitro de la maladie et de l'inflammation cellulaire causée par des microorganismes infectieux

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What is flipped learning?


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What is flipped Learning?

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Deirdre Bonnycastle's curator insight, March 15, 11:48 AM

An infographic on flipped classroom

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Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte...

Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte... | Christian Yamashiba Kasongo's medical review | Scoop.it
Bilberry (Vaccinium myrtillus L.) has been known to play a protective role in human health due to its high anthocyanin content. This study investigated the anti-inflammatory effects of bilberry extract (BE, containing 42.04% anthocyanin) on Propionibacterium acnes (P. acnes) plus lipopolysaccharide (LPS) induced liver injury and croton oil-induced ear edema in mice. Results showed that BE could effectively inhibit croton oil-induced ear edema and liver inflammation provoked by P. acnes plus LPS, as reflected by the reduced plasma alanine aminotransferase and aspartate aminotransferase activities. These findings were confirmed by hepatic pathological examination. Moreover, BE administration markedly suppressed the increase of liver mRNA levels of iNOS, TNF-α, IL-1β and IL-6, and the protein levels of iNOS, TNF-α and NF-κB. In addition, liver malondialdehyde and NO contents were significantly reduced by BE treatment. These results indicated that BE has potent protective effects on acute and immunological inflammation, which might contribute to the study of the anti-inflammatory effects of natural products and healthy food.


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Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte...         

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Christian Yamashiba Kasongo's curator insight, March 11, 1:20 PM

Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte...ajouter votre point de vue ...

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Every 8 Minutes a Child goes to an Emergency Room for Medicine Poisoning -- WASHINGTON, March 13, 2014 /PRNewswire-USNewswire/ --

Every 8 Minutes a Child goes to an Emergency Room for Medicine Poisoning -- WASHINGTON, March 13, 2014 /PRNewswire-USNewswire/ -- | Christian Yamashiba Kasongo's medical review | Scoop.it
WASHINGTON, March 13, 2014 /PRNewswire-USNewswire/ -- Every 8 Minutes a Child goes to an Emergency Room for Medicine Poisoning. Safe Kids Worldwide Issues Alert: 3 out of 4 ER Visits for Medicine Poisoning are due to Kids Getting into Parents' or Grandparents' Medicine.

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Every 8 Minutes a Child goes to an Emergency Room for Medicine Poisoning -- WASHINGTON, March 13, 2014 /PRNewswire-USNewswire/ -- ajouter votre point de vue ...

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MyHealthShare's curator insight, March 13, 4:27 AM

Every 8 Minutes a Child goes to an Emergency Room for Medicine Poisoning http://myhealthshare.org http://sco.lt/...@myhealthshare

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Determining Resident Clinical Performance: Getting Beyond th... : Anesthesiology

Determining Resident Clinical Performance: Getting Beyond th... : Anesthesiology | Christian Yamashiba Kasongo's medical review | Scoop.it
Background: Valid and reliable (dependable) assessment of resident clinical skills is essential for learning, promotion, and remediation. Competency is defined as what a physician can do, whereas performance is what a physician does in everyday practice. There is an ongoing need for valid and rel...

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Détermination de la clinique performances résident: aller au-Delà e ...: Anesthésiologie AJOUTER point de vue de Votre ...

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Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte...

Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte... | Christian Yamashiba Kasongo's medical review | Scoop.it
Bilberry (Vaccinium myrtillus L.) has been known to play a protective role in human health due to its high anthocyanin content. This study investigated the anti-inflammatory effects of bilberry extract (BE, containing 42.04% anthocyanin) on Propionibacterium acnes (P. acnes) plus lipopolysaccharide (LPS) induced liver injury and croton oil-induced ear edema in mice. Results showed that BE could effectively inhibit croton oil-induced ear edema and liver inflammation provoked by P. acnes plus LPS, as reflected by the reduced plasma alanine aminotransferase and aspartate aminotransferase activities. These findings were confirmed by hepatic pathological examination. Moreover, BE administration markedly suppressed the increase of liver mRNA levels of iNOS, TNF-α, IL-1β and IL-6, and the protein levels of iNOS, TNF-α and NF-κB. In addition, liver malondialdehyde and NO contents were significantly reduced by BE treatment. These results indicated that BE has potent protective effects on acute and immunological inflammation, which might contribute to the study of the anti-inflammatory effects of natural products and healthy food.


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Christian Yamashiba Kasongo's insight:

Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte...ajouter votre point de vue ...

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Christian Yamashiba Kasongo's curator insight, March 13, 1:33 PM

Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice, Inte...         

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Claim that raw milk reduces lactose intolerance doesn't pass smell test, study finds - Office of Communications & Public Affairs - Stanford University School of Medicine

Claim that raw milk reduces lactose intolerance doesn't pass smell test, study finds - Office of Communications & Public Affairs - Stanford University School of Medicine | Christian Yamashiba Kasongo's medical review | Scoop.it

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Revendication que le lait cru réduit l'intolérance au lactose ne passe pas le test de l'odorat, selon une étude - Bureau des communications et affaires publiques - École de médecine de l'Université de Stanford

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MyHealthShare's curator insight, March 11, 5:01 AM

Claim that raw milk reduces lactose intolerance doesn't pass smell test, study finds http://myhealthshare.org http://sco.lt/...

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Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.

Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.


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Effet de pousses de brocoli sur la résistance à l'insuline de type 2 chez les patients diabétiques: un double aveugle essai clinique randomisé points AJOUTER de Votre de vue ...

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Human Fetus PowerPoint Template - Human fetus PowerPoint background - Medical PPT Templates

Human Fetus PowerPoint Template - Human fetus PowerPoint background - Medical PPT Templates | Christian Yamashiba Kasongo's medical review | Scoop.it

Découvrez Professionnellement Human Design Foetus Modèle PowerPoint, les diapositives PowerPoint, Modèles PowerPoint. Téléchargez votre PPT médicale Modèles connexes. et faire de votre conception PPT profession.


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Human Fetus PowerPoint Template - Human fetus PowerPoint background - Medical PPT Templatesajouter votre point de vue ...

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A blood test to predict imminent death? Would you want to take it?

A blood test to predict imminent death? Would you want to take it? | Christian Yamashiba Kasongo's medical review | Scoop.it
Here are some findings that could scare you to death: In a study published this week, Finnish and Estonian researchers report that they have identified specific levels of four chemicals circulating in the blood that offer a reliable signal that death is near. The four harbingers of death can be readily detected in a blood sample, and are even predictive when seen in apparently healthy people, their new study shows.

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Ultra-faible émission de photons comme un non-invasive d'évaluation de la santé: Un examen systématique de points AJOUTER Votre de vue ...

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Spanish Biologist Explains How Cannabinoids Kill Cancer Cells

Spanish Biologist Explains How Cannabinoids Kill Cancer Cells | Christian Yamashiba Kasongo's medical review | Scoop.it

Dr. Christina Sanchez -- a molecular biologist at Compultense University in Madrid, Spain -- explains how THC kills cancer cells.

 

"I cannot understand why in the States Cannabis is under schedule one. Because it is pretty obvious not only from our work but from the work of other researchers, that the plant has a very wide therapeutic potential..."


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Spanish Biologist Explains How Cannabinoids Kill Cancer Cellsajouter votre point de vue ...

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Sepp Hasslberger's curator insight, March 25, 12:42 PM

It is time to 'liberate' cannabis. Prohibition was a serious mis-step.

Arun Shrivastava's curator insight, March 26, 12:18 AM

It is not only in the USA but here in India as well. In the Himalayan region where high quality cannabis grows in the wild, the police can't do much but what they do frequently is destroy the plants [slash and burn] near human habitations and often conduct raids on villages. It is simply criminal.

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Differences in Antibody Responses of Individuals with Natural Infection and Those Vaccinated against Pandemic H1N1 2009 Influenza

Differences in Antibody Responses of Individuals with Natural Infection and Those Vaccinated against Pandemic H1N1 2009 Influenza | Christian Yamashiba Kasongo's medical review | Scoop.it

The differential antibody response measured by the commonly used hemagglutination inhibition (HI) and microneutralization (MN) assays in patients with natural infection and vaccination has not been fully assessed. HI and conventional MN (CMN) assays were performed on sera from 651 patients with natural infection by pandemic H1N1 2009 influenza virus and on sera from 567 recipients of the corresponding vaccine. Surprisingly, the overall seroprotection rates determined by CMN and HI assays in vaccine recipients were only 44.8 and 35.1%, respectively. Antibody titers measured by the CMN assay was significantly higher than that obtained by HI assay in vaccine recipients aged ≥50 years, but these titers were not significantly different among younger vaccine recipients. In contrast, the HI titer was greater than the CMN titer for the age group from 16 to 29 years but was not significantly different in other age groups for natural infection. Lower antibody levels were found in both naturally infected patients and immunized recipients in the older than in the younger age groups, but naturally infected patients exhibited higher HI and CMN titers than did the corresponding vaccine recipients. In addition, we developed a rapid fluorescent focus microneutralization (FFMN) assay to test sera from naturally infected patients. The FFMN assay has a better correlation with CMN than with HI (ρ = 0.810 versus 0.684), which is expected of neutralizing antibody mainly targeted toward the inhibition of viral entry into cells. The higher antibody level elicited by natural infection than by vaccination may be related to differences between antigen presentation by the intramuscular route of vaccination and mucosal viral replication in mucosal cells of the respiratory tract.


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Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria.

Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria. | Christian Yamashiba Kasongo's medical review | Scoop.it

The main objective of this study was to evaluate the capacity of wild mushroom extracts to potentiate the action of standard antibiotics, through synergisms that allow a decrease in their therapeutic doses and ultimately contribute to the reduction of resistances.

 

Wild mushroom extracts were applied to different multiresistant micro-organisms (Escherichia coli, extended-spectrum beta-lactamase-producing (ESBL) E. coli and methicillin-resistant Staphylococcus aureus (MRSA), combined with commercial antibiotics (penicillin, ampicillin, amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, cotrimoxazol, levofloxacin). Microdilution method was used to determine minimum inhibitory concentrations (MICs). The results obtained showed higher synergistic effects against MRSA than against E. coli. Mycena rosea and Fistulina hepatica were the best extracts for synergistic effects against MRSA. The efficiency of Russula delica extract against E. coli 1 (resistant to ampicillin, ciprofloxacin and trimethoprim/sulfasoxazole) and E. coli 2 (resistant to amoxicillin/clavulanic acid and ampicillin) was higher than that of Leucopaxillus giganteus extract; nevertheless, the latter extract exhibited better synergistic effects against ESBL E. coli.

 

This study shows that, similarly to plants, some mushroom extracts can potentiate the action of antibiotics extensively used in clinical practice for Gram-positive or Gram-negative bacteria, with positive action even against multiresistant bacteria.


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ajo extraits de champignons sauvages potentialisent l'action des antibiotiques standards contre les bactéries multirésistantes. uter Votre Point de Vue ...

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Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth

Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization.

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Le lait n'est pas seulement la nourriture mais plus probablement un système de transfection génétique activation mTORC1 de signalisation pour la croissance postnatale points AJOUTER de Votre de vue ...

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The Saturated Fat, Cholesterol, and Statin Controversy A Commentary

The Saturated Fat, Cholesterol, and Statin Controversy A Commentary | Christian Yamashiba Kasongo's medical review | Scoop.it

 

Dans les années 1930, il y avait des publicités gérées dans JAMA avec des témoignages de médecins disent que fumer des cigarettes n'a pas nui à vos poumons. Il a fallu de nombreuses années d'augmentation de l'incidence du cancer du poumon à convaincre les gens que ce n'était pas un énoncé vrai. La situation actuelle de cholestérol sérique et la maladie coronarienne est très similaire dans son concept, mais cette fois les médecins sont largement convaincus que l'ancien provoque ce dernier, en dépit d'un manque flagrant de preuves scientifiques. Il n'y a pas eu des études qui prouvent le taux de cholestérol alimentaires causent directement l'athérosclérose. Il existe de nombreuses études de corrélation qui peuvent suggérer une association, mais aucun qui montrent cause et l'effet. En fait, si soigneusement analysé, il ya d'autres études qui réfutent la «cause et effet« l'hypothèse que même venu près de le prouver. Un locataire de base de la biostatistique et de la recherche épidémiologique est que vous ne pourrez jamais prouver une hypothèse - vous ne pouvez manquer de le réfuter. Conception expérimentale a trois composantes essentielles: 1) Estimation de l'erreur, 2) de contrôle d'erreur et 3) l'interprétation des résultats [1]. Les études de corrélation indiquent un lien possible entre deux facteurs, à savoir le taux de cholestérol et les maladies cardiovasculaires, mais ils ne prouvent pas la cause et l'effet. Les corrélations sont souvent observés dans les études épidémiologiques, mais des études soigneusement conçues avec un contrôle suffisant de facteurs de confusion et d'éviter d'autres biais potentiel doit être réalisée afin de démontrer la cause et l'effet. Dans ces cas, de petites différences dans la conception de l'étude peuvent provoquer des résultats différents. La plupart des études sur des modèles animaux ne sont pas un bon modèle pour comparer les mêmes systèmes que chez l'homme. Ils peuvent donner des conseils, mais ils ont finalement besoin d'être testé chez l'homme. Bon nombre des premières études ont été utilisés lapins alimentant un régime riche en cholestérol. Lapins dans la nature ne mangent jamais de cholestérol car ils sont herbivores et plantes ne font pas de cholestérol appréciable, de sorte que les animaux ne mangent pas normalement cholestérol dans leur alimentation. En outre, le cholestérol consommé par les animaux d'essai contenait cholestérol "nue", chimiquement préparée et ajoutée à l'alimentation, de sorte que tout à fait probable a été oxydé par le temps, les animaux ont mangé. Le taux de cholestérol dans l'alimentation humaine est une composante d'un tissu de la nourriture et souvent lié à un acide gras et à l'abri de l'oxydation. modèles de rongeurs ne sont pas un bon modèle pour l'homme, car la plupart d'entre eux ont HDL élevé et très peu de LDL par rapport à l'homme qui ont plus de HDL LDL dans le sang. Donc, l'alimentation des lapins un régime riche en cholestérol et en les rendant athrogenic ne prouve pas la causalité.  

 


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Antioxidant, Anti-inflammatory and Antinociceptive Properties of Black Pepper Essential Oil (Piper nigrum Linn)

Antioxidant, Anti-inflammatory and Antinociceptive Properties of Black Pepper Essential Oil (Piper nigrum Linn) | Christian Yamashiba Kasongo's medical review | Scoop.it

This study is aimed to investigate the chemical composition of essential oil isolated from fruits of Piper nigrum L. (black pepper) by GC-MS and to study its pharmacological properties. The main constituents identified were caryophyllene (23.98 %) and limonene (14.36 %). Black pepper oil scavenged superoxide, DPPH, hydroxyl radicals and inhibited tissue lipid peroxidation in vitro. Intraperitoneal administration of essential oil was found to inhibit PMA induced super oxide radicals elicited by macrophages. Oral administration of black pepper oil for one month, significantly increased superoxide dismutase, glutathione and glutathione reductase enzyme levels in blood of mice and glutathione-S-transferase, glutathione peroxidase, catalase, superoxide dismutase and glutathione enzymes in liver. Black pepper oil significantly reduced acute inflammation induced by carrageenan and dextran and formalin induced chronic models of inflammation. It also exhibited antinociceptive property in acetic acid induced writhing test. These studies reveal that black pepper essential oil possesses antioxidant, anti-inflammatory and antinociceptive property.


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Patients who question their doctors are changing the face of medicine – and physicians are embracing the shift

Patients who question their doctors are changing the face of medicine – and physicians are embracing the shift | Christian Yamashiba Kasongo's medical review | Scoop.it
Dr. James Aw: Last week I was in California for the Future of Genomic Medicine conference, and I heard a presentation by 'the patient of the future.'

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Détermination de la clinique performances résident: aller au-Delà e ...: Anesthésiologie AJOUTER point de vue de Votre ...

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Effects of coenzyme Q10 supplementation on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy.

Effects of coenzyme Q10 supplementation on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy. | Christian Yamashiba Kasongo's medical review | Scoop.it

Dans cet essai clinique, nous avons démontré que la coenzyme Q10 à la dose de 300 mg / j pendant 12 semaines augmente les activités des enzymes antioxydantes (SOD, CAT et GPx) et diminue l'inflammation chez les patients atteints de coronaropathie au cours du traitement de statines. Tiano et al. Q10 administré coenzyme (300 mg / j) pour les patients atteints de cardiopathie ischémique pendant 1 mois, et ils ont constaté que l'activité extracellulaire de la superoxyde dismutase de ces patients et vasodilatation endothélium-dépendante ont été améliorées après la supplémentation. Enzymes anti-oxydantes telles que la SOD, CAT, la GPx et constituent la première ligne de défense contre les espèces réactives de l'oxygène, et une diminution de leurs activités contribuent à l'élévation du stress oxydatif chez les patients CAD. Nos résultats précédents ont montré que la coenzyme Q10 à la dose de 150 mg / j augmentation de l'activité de la SOD de 22,2% et de CAT de 4,5%, mais n'a eu aucun effet sur celle de la GPx. Dans la présente étude, la coenzyme Q10 à 300 mg / j augmente l'activité de la SOD de 48,5%, CAT de 9,1%, et la GPx de 4,3%, et les activités des enzymes antioxydantes ont tous été positivement corrélé avec le niveau de coenzyme Q10 après 12 semaines de supplémentation. Il semble que la dose de 300 mg de coenzyme Q10 a une meilleure antioxydante de 150 mg / j.

 

Les deux groupes de patients atteints de coronaropathie statines traités dans cette étude avaient un niveau de coenzyme Q10 faible au départ, et le niveau de coenzyme Q10 a été significativement augmenté d'environ 5 fois après 4 semaines de supplémentation en coenzyme Q10 (données non présentées, le niveau médian de la coenzyme Q10 était 0,4 à 2,0 pmol / L), qui ajuste rapidement leur niveau de coenzyme Q10 bas à des valeurs normales (0,5 à 1,7 pmol / L). En outre, la coenzyme Q10 a un effet synergique avec la vitamine E. Dans cette étude, nous avons observé que le taux de vitamine E est significativement plus élevée dans le groupe Q10-300 et était en corrélation positive avec le niveau de coenzyme Q10, après 12 semaines de supplémentation. La coenzyme Q10 protège non seulement la vitamine E contre l'oxydation conduit superoxyde, mais aussi régénère la vitamine E pendant les processus antioxydantes


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Insulin-related hypoglycemia, errors related to emergencies, hospitalizations

Elderly patients with diabetes treated with insulin were more likely than younger patients to visit the emergency department (ED) and be hospitalized for insulin-related hypoglycemia (low blood...

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Researchers track polio-like illness in kids - Office of Communications & Public Affairs - Stanford University School of Medicine

Researchers track polio-like illness in kids - Office of Communications & Public Affairs - Stanford University School of Medicine | Christian Yamashiba Kasongo's medical review | Scoop.it

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Researchers track polio-like illness in kids http://myhealthshare.org http://sco.lt/...@endpolionow @myhealthshare

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Interactive Ear tool showing how the ear works

Interactive Ear tool showing how the ear works | Christian Yamashiba Kasongo's medical review | Scoop.it
Use our Interactive Ear tool for a fun & visual Guide to Hearing. Enjoy amazing visuals of the journey of sound through each area of the ear.

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Will you check this scoop? Thank you so much. http://sco.lt/5okJ17 It's for my research project.
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New cross-kingdom communication mechanism found in gut bacteria

New cross-kingdom communication mechanism found in gut bacteria | Christian Yamashiba Kasongo's medical review | Scoop.it

 

Researchers from the Institute of Food Research and the University of East Anglia have discovered how the beneficial bacteria in our guts communicate with our own cells. Here, Dr Regis Stentz of the GHFS programme talks about uncovering a novel signalling mechanism from commensal bacteria with potential to influence host epithelial cells and how this signal is protected from degradation in the gut.

 

 

Over the past few decades, it became clear to gut physiologists and microbiologists that the establishment of complex symbiotic relationships between the gut microbiome and the host intestinal cells is essential for health. It is known that commensal bacteria from the gut use diffusible small molecules such as hormones and nutrients to interact at a distance with the host. In this article, we describe a new crosstalk mechanism involving an enzyme packaged into outer membrane vesicles (OMVs) produced by the prevalent symbiotic gut bacterium, Bacteroides thetaiotaomicron.

 

First of all, our study has identified and characterised for the first time a homolog of a eukaryotic inositolphosphate signaling phosphatase, MINPP, in major species of human gut bacterial genomes. This is novel, as bacteria have not previously been thought to use the inositol phosphate signaling cascade

 


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