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Postdoctoral Research Fellow - Scientific American

Postdoctoral Research Fellow - Scientific American | Centro de Química da Madeira | Scoop.it
Scientific American
Postdoctoral Research Fellow
Scientific American
He developed peptide dendrimers as synthetic vaccines. His current research also includes herbalomics in traditional medicines to discover novel peptides as potential therapeutics.
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Researchers take cues from nature in designing a programmable nanomaterial ... - Nanowerk

Researchers take cues from nature in designing a programmable nanomaterial ... - Nanowerk | Centro de Química da Madeira | Scoop.it
Researchers take cues from nature in designing a programmable nanomaterial ...
Nanowerk
(Nanowerk News) Taking inspiration from the human immune system, researchers at the U.S.
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How to build a low-cost AFM nanoscope out of LEGO + Arduino board

How to build a low-cost AFM nanoscope out of LEGO + Arduino board | Centro de Química da Madeira | Scoop.it

The world’s first low-cost atomic force microscope (AFM) has been developed in Beijing by a group of PhD students from University College London (UCL), Tsinghua University, and Peking University — using LEGO.

 

LEGO2NANO brought together students, experienced makers and scientists to take on the challenge of building a cheap and effective AFM, a device able to probe objects only a nanometer in size — far smaller than anything an optical microscope can observe.

 

The design brief for the student teams: build a functional nanoscope, using only LEGO, Arduino microcontrollers, 3D-printed parts, and consumer electronics.

 

It took just five days for the student team to demonstrate the scanning functionality of their AFM, earning them the award for Best Technical Design.

 


Via Sepp Hasslberger
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Sepp Hasslberger's curator insight, September 20, 2013 5:26 AM

Doing more with less. 

"Research-grade AFMs typically cost $100,000 or more, and use custom hardware. The newly designed low-cost version could cost less than $500 to produce.

 

“Low-cost scientific instrumentation is can be a huge enabler for hospitals and clinics in developing countries too..."

 

Trimtab-in-Training 's curator insight, September 26, 2013 5:05 PM

NICE!!

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The Optical Society - Imaging Breast Cancer with Light

The Optical Society - Imaging Breast Cancer with Light | Centro de Química da Madeira | Scoop.it

"If effective, the new device, called a photoacoustic mammoscope, would represent an entirely new way of imaging the breast and detecting cancer. Instead of X-rays, which are used in traditional mammography, the photoacoustic breast mammoscope uses a combination of infrared light and ultrasound to create a 3-D map of the breast. The researchers describe their device in a paper published today in The Optical Society’s (OSA) open-access journal Biomedical Optics Express.
 
A 3-D Map of the Breast
 
In the new technique, infrared light is delivered in billionth-of-a-second pulses to tissue, where it is scattered and absorbed. The high absorption of blood increases the temperature of blood vessels slightly, and this causes them to undergo a slight but rapid expansion. While imperceptible to the patient, this expansion generates detectable ultrasound waves that are used to form a 3-D map of the breast vasculature. Since cancer tumors have more blood vessels than the surrounding tissue, they are distinguishable in this image.


Via Susan Zager
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As nanotechnology is being used to develop new drugs, FDA is working to ... - FDA.gov (blog)

As nanotechnology is being used to develop new drugs, FDA is working to ... - FDA.gov (blog) | Centro de Química da Madeira | Scoop.it
FDA.gov (blog)
As nanotechnology is being used to develop new drugs, FDA is working to ...
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Nanomateriais que decompõem a luz solar em cores separadas podem aumentar em até 50% de eficiência dos painéis solares

Nanomateriais que decompõem a luz solar em cores separadas podem aumentar em até 50% de eficiência dos painéis solares | Centro de Química da Madeira | Scoop.it
The processes to make these panels are still expensive, but with economies of scale, they should come down in price dramatically over time.

Via Antonio Bucci
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Antonio Bucci's curator insight, January 24, 2013 12:06 AM

A cada ano temos baterias muito melhorares, os LEDs se tornam mais brilhantes, CPUs se tornam mais rápidas, discos rígidos podem armazenar mais dados, etc E o bonito é que a maioria dessas melhorias geralmente acabam sendo mais baratas, ou pelo menos com preço semelhante , para as novas tecnologias que suplantam as anteriores em escala logarítimica.

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Nanotechnology and the Treatment of HIV Infection

Nanotechnology and the Treatment of HIV Infection | Centro de Química da Madeira | Scoop.it

Suboptimal adherence, toxicity, drug resistance and viral reservoirs make the lifelong treatment of HIV infection challenging. The emerging field of nanotechnology may play an important role in addressing these challenges by creating drugs that possess pharmacological advantages arising out of unique phenomena that occur at the “nano” scale. At these dimensions, particles have physicochemical properties that are distinct from those of bulk materials or single molecules or atoms. In this review, basic concepts and terms in nanotechnology are defined, and examples are provided of how nanopharmaceuticals such as nanocrystals, nanocapsules, nanoparticles, solid lipid nanoparticles, nanocarriers, micelles, liposomes and dendrimers have been investigated as potential anti-HIV therapies. Such drugs may, for example, be used to optimize the pharmacological characteristics of known antiretrovirals, deliver anti-HIV nucleic acids into infected cells or achieve targeted delivery of antivirals to the immune system, brain or latent reservoirs. Also, nanopharmaceuticals themselves may possess anti-HIV activity. However several hurdles remain, including toxicity, unwanted biological interactions and the difficulty and cost of large-scale synthesis of nanopharmaceuticals.


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Nanomaterials: The Science of the Small: Stefan Bon at TEDxWarwick 2013

Stefan Bon is an associate professor in Chemistry at Warwick, famously making the headlines in 2012 for halving the fat content of chocolate by replacing it ...
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USP, Unesp e Unicamp colocam produção científica na internet

USP, Unesp e Unicamp colocam produção científica na internet | Centro de Química da Madeira | Scoop.it

"Criado por iniciativa e com apoio da FAPESP, alguns dos objetivos do portal são reunir, preservar e proporcionar acesso aberto, público e integrado à produção científica dos pesquisadores das três universidades estaduais paulistas, que são as que mais publicam artigos científicos no país, de acordo com a última edição do SIR World Report, divulgada em julho pela Scimago Lab."


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scimago's curator insight, October 11, 2013 4:18 PM

EXAME (Brazil) - 10 OCT 2013

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Mutations linked to breast cancer treatment resistance

Mutations linked to breast cancer treatment resistance | Centro de Química da Madeira | Scoop.it

"Researchers at the University of Michigan Comprehensive Cancer Center have identified a type of mutation that develops after breast cancer patients take anti-estrogen therapies. The mutations explain one reason why patients often become resistant to this therapy.

The discovery stems from a program at the U-M Comprehensive Cancer Center called Mi-ONCOSEQ in which patients with advanced cancer have their DNA and RNA sequenced to identify all types of genetic mutations that could play a role in the cancer. Researchers use the findings to help direct therapies they think will work best. But they also use the data to find new genetic links. The detailed analysis means that researchers can identify anomalies among a small number of patients.

In this case, they looked at 11 patients with metastatic breast cancer that was classified as estrogen receptor positive, meaning the cancer is influenced by the hormone estrogen. This is the most common type of breast cancer.

The analysis found that six patients had mutations in the estrogen receptor. All of them had been treated with an aromatase inhibitor, a type of drug that blocks estrogen production"


Via Susan Zager
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Chemotherapy-Related Hospitalizations Common in Palliative Care

Chemotherapy-Related Hospitalizations Common in Palliative Care | Centro de Química da Madeira | Scoop.it

"Patients receiving chemotherapy solely for palliative intent have a high risk of chemotherapy-related hospitalization, defeating the goal of the care and increasing health care costs. A study presented by Ankit J. Kansagra, MD, found several independent predictors of such hospitalization, including Eastern Cooperative Oncology Group (ECOG) performance status score, cancer site, and other factors. 

“There is an increasing use of palliative chemotherapy,” said Dr. Kansagra, a hematology/oncology fellow at Tufts University School of Medicine. “If risks of toxicity of that chemotherapy are underappreciated or misunderstood, the goals of palliative care are undermined.”

Kansagra and colleagues conducted a nested case-control study of adult patients with cancer who received chemotherapy between January 2003 and December 2011. Of the 6,850 patients at Northshore Medical Center who received chemotherapy, 2,559 (37.3%) underwent the therapy with palliative intent. Of that cohort, 230 patients (9%) needed a chemotherapy-related hospitalization; 199 of those cases were included in the analysis. The study also included two matched controls for each case, yielding 398 patients in the control group who underwent the same lines of chemotherapy treatment but did not require hospitalization; three cases and 27 patients in the control group were excluded from the analysis due to insufficient data." 


Via Susan Zager
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Susan Zager's curator insight, November 1, 2013 4:02 PM

To see the abstract study referenced in this article go to: http://meetinglibrary.asco.org/content/120052-140


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The Crystal Cell - turning coherent quantum fluctuations into electric energy

The Crystal Cell - turning coherent quantum fluctuations into electric energy | Centro de Química da Madeira | Scoop.it

The Crystal Cell is a capacitor like device that generates a steady electric current.

 

Concerning its basic construction, the Crystal Cell is similar to an electrolytic capacitor which contains a solid polycrystalline silicate instead of an electrolyte.

 

The function of the Crystal Cell is related to a solar cell. Instead of sun light coherent quantum fluctuations are used to create a charge separation.

 

The emission free Crystal Cell can generate a direct electric current over an unknown period of time (since 1999).

 

Within the Crystal Cell processes play a role, which are similar to a hydropower plant. Just like a hydropower plant draws its energy from the flow of water the Crystal Cell draws its energy from an external source of energy.

 

Our hypothesis is, that the Crystal Cell extracts energy from the quantum vacuum. The power output is today at (10mW/kg/25°C).

 

 
 



Via Sepp Hasslberger
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Sepp Hasslberger's curator insight, October 1, 2013 10:28 AM

For those who think free energy is impossible, this is a tangible proof-of-principle that shows that electrical energy can indeed be extracted from an as-yet unacknowledged source...

SungKyun Chung's comment, October 31, 2013 6:41 PM
good
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New Method for Diagnosing Breast Cancer

New Method for Diagnosing Breast Cancer | Centro de Química da Madeira | Scoop.it

"According to a new study, a novel mammography procedure developed at the Paul Scherrer Institute (PSI), in cooperation with the Certified Breast Centre of the Kantonsspital Baden and the industrial partner Philips, could generate substantial added-value for the diagnosis of breast cancer in medical practice. The innovative mammography procedure draws on the fact that as X-rays pass through tissue, they are not only absorbed but also refracted. This additional refraction information contributes to a clearer, more detailed image of the breast and renders even the tiniest tissue changes visible. For this study, international breast experts compared standard mammograms of recently resected breast tissue to images produced using the new method, and the results were very positive. According to the authors of the study, the new image quality not only leads to a more accurate diagnosis of breast cancer, but it could also improve early detection."


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Researchers Aim to Mass-Produce Graphene Nanopetals for Battery Applications - Daily Fusion

Researchers Aim to Mass-Produce Graphene Nanopetals for Battery Applications - Daily Fusion | Centro de Química da Madeira | Scoop.it
Researchers Aim to Mass-Produce Graphene Nanopetals for Battery Applications Daily Fusion Researchers at Purdue University are developing a method to mass-produce a new type of nanomaterial for advanced sensors and batteries, with an eye toward...
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Development of a Natural Products Database from the Biodiversity of Brazil

Development of a Natural Products Database from the Biodiversity of Brazil | Centro de Química da Madeira | Scoop.it

We describe herein the design and development of an innovative tool called the NuBBE database (NuBBEDB), a new Web-based database, which incorporates several classes of secondary metabolites and derivatives from the biodiversity of Brazil. This natural product database incorporates botanical, chemical, pharmacological, and toxicological compound information. The NuBBEDB provides specialized information to the worldwide scientific community and can serve as a useful tool for studies on the multidisciplinary interfaces related to chemistry and biology, including virtual screening, dereplication, metabolomics, and medicinal chemistry. The NuBBEDB site is at http://nubbe.iq.unesp.br/nubbeDB.html.

 

Marilia Valli†, Ricardo N. dos Santos‡, Leandro D. Figueira†, Cíntia H. Nakajima†, Ian Castro-Gamboa†, Adriano D. Andricopulo‡, and Vanderlan S. Bolzani*††

Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, Instituto de Química, UNESP - Univ. Estadual Paulista, 14801-970, Araraquara-SP, Brazil‡ Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos, Universidade de São Paulo (USP), 13560-970, São Carlos-SP, Brazil

J. Nat. Prod., Article ASAP

DOI: 10.1021/np3006875Publication Date (Web): January 18, 2013


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Natural Skin Care by Mad Hippie | Advanced Anti-Aging Facial Products | All Natural Facial Care Formulated to Reduce Wrinkles & Skin Discoloration. Our Natural Skin Care Products Combine the Best o...

All Natural Facial Care Formulated to Reduce Wrinkles & Skin Discoloration. Our Natural Skin Care Products Combine the Best of Mother Nature & Modern Science.

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Nanomaterials Key to Developing Stronger Artificial Hearts

Nanomaterials Key to Developing Stronger Artificial Hearts | Centro de Química da Madeira | Scoop.it

Creation of these ultra-thin cardiac patches put medicine a step closer to durable, high-functioning artificial tissues that could be used to repair damaged hearts and other organs.

 

The cardiac tissue patches utilize a hydrogel scaffolding reinforced by nanomaterials called carbon nanotubes. To create the patches, the researchers seeded neonatal rat heart muscle tissue onto carbon nanotube-infused hydrogels. These novel patches showed excellent mechanical integrity and advanced electrophysiological functions. Moreover, they demonstrated a protective effect against chemicals toxic to heart tissue.


Via Dr. Stefan Gruenwald
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