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Cell Stem Cell - Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells

Cell Stem Cell - Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells | cancer | Scoop.it

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Via Jacob Blumenthal
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Jacob Blumenthal's curator insight, August 8, 2013 2:06 PM

Researchers from the Max-Planck institute and Carnegie Institution of Washington found that induced inactivation of Pax7 in Pax7-expressing cells of adult mice leads to loss of muscle stem cells and reduced heterochromatin condensation in rare surviving satellite cells. Inactivation of Pax7 in Myf5-expressing cells revealed that the majority of adult muscle stem cells originate from myogenic lineages, which express the myogenic regulators Myf5 or MyoD. Likewise, the majority of muscle stem cells are replenished from Myf5-expressing myogenic cells during adult life, and inactivation of Pax7 in Myf5-expressing cells after muscle damage leads to a complete arrest of muscle regeneration. The authors also  demonstrate that a relatively small number of muscle stem cells are sufficient for efficient repair of skeletal muscles. They conclude that Pax7 acts at different levels in a nonhierarchical regulatory network controlling muscle-satellite-cell-mediated muscle regeneration.

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To learn about skeletal muscle embryonic development :

http://discovery.lifemapsc.com/in-vivo-development/skeletal-muscle


For skeletal muscle-related, stem cells differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols


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Stem cell mutations in breast cancer may confer metastatic risk - Ob.Gyn. News Digital Network

Stem cell mutations in breast cancer may confer metastatic risk
Ob.Gyn.
  
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Tumor microenvironment allows cancer cells to hide from the immune system - Science Codex

Tumor microenvironment allows cancer cells to hide from the immune system - Science Codex | cancer | Scoop.it
Tumor microenvironment allows cancer cells to hide from the immune system
Science Codex
Cancer progression is aided by the ability of tumors to evade recognition by the immune system.
  
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Brain tumor cells in arrested development contribute to cell variety that ... - News-Medical.net

Brain tumor cells in arrested development contribute to cell variety that ...
  
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Stem Cell Research & Therapy | Abstract | Generation and ...

Stem Cell Research & Therapy | Abstract | Generation and ... | cancer | Scoop.it
The reprogramming of a patient's somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially oncogenic transgenic ...
  
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Channel Blockers for Blood Pressure Linked to Breast Cancer Risk ...

Channel Blockers for Blood Pressure Linked to Breast Cancer Risk ... | cancer | Scoop.it
Association, not cause and effect, noted with long-term use by older women.
  
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Understanding the movement of neurons sheds light on how cancer cells invade ... - News-Medical.net

Understanding the movement of neurons sheds light on how cancer cells invade ... - News-Medical.net | cancer | Scoop.it
Understanding the movement of neurons sheds light on how cancer cells invade ...
  
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