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Rescooped by Deniz Agirbas from Natural Cancer Options
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The New Approach to Fighting Cancer: Vinegar by Darren Clair, M.D. - Cancer - InsidersHealth.com

The New Approach to Fighting Cancer: Vinegar by Darren Clair, M.D. - Cancer - InsidersHealth.com | cancer | Scoop.it

What if you could detect one of the leading causes of death in women, simply by using a cooking ingredient?What if you could detect one of the leading causes of death in women, simply by using a cooking ingredient? That's exactly what nurses and doctors are doing in developing countries where cervical cancer is prevalent and pap smear tests are too costly and time consuming. Using regular household vinegar, health experts are able to detect any precancerous bumps or warts and treat them before they become malignant ...


Via InsidersHealth
Deniz Agirbas's insight:

If this is true and is proven to be so then it could save billions of peoples lives. If the cancer is detected earlier, the patient will be treated when their cancer is at it's earlier stages and thus hopefully survive. In addition millions of money will be saved! 

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Rescooped by Deniz Agirbas from Breast Cancer News
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New finding points to potential options for attacking stem cells in triple-negative breast cancer | Science Codex

New finding points to potential options for attacking stem cells in triple-negative breast cancer | Science Codex | cancer | Scoop.it

"ANN ARBOR, Mich. — New research from the University of Michigan Comprehensive Cancer Center and Georgia Regents University finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells. This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease.

The researchers identified a protein, SOCS3, that is highly expressed in normal cells but undetectable in triple-negative breast cancer. They showed that this protein is degraded in cancers, blocking the cellular off-switch of a feedback loop involving the inflammatory protein interleukin 6, IL6. When the switch does not get turned off, it enables cancer stem cells to grow.

"We have known for a long time known that there are important links between inflammation and cancer, including similar pathways that regulate normal and cancer stem cells," says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer Center.

"This work helps explain why these pathways shut off in normal tissues after injury but remain active in cancers, resulting in an increase in cancer stem cells. Furthermore, they suggest that blocking these inflammatory loops may be a means of targeting cancer stem cells, improving patient outcome," he says."


Via Susan Zager
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Susan Zager's curator insight, February 17, 2014 4:31 PM

Although this study is not yet in clinical trials, according to the article, the research team previously showed that" IL6 can stimulate breast cancer stem cells in HER2-positive breast cancers and they are designing a clinical trial which uses an IL6 blocker. The new research suggests that adding bortezomib to the IL6 inhibitor may be a way to target stem cells in triple-negative breast cancer." 

The study was published in Oncogene at : http://www.nature.com/onc/journal/v32/n5/full/onc201285a.html




Maria Fowler's curator insight, February 20, 2014 9:23 PM

A study with promise. Let's hope that targeting inflammatory pathways is effective in more studies and trials. Being able to treat TNBC with drugs that already exist would be amazing.