Cancer - Advances...
Follow
Find
15.9K views | +11 today
 
Scooped by Graham Player Ph.D.
onto Cancer - Advances, Knowledge, Integrative & Holistic Treatments
Scoop.it!

Breast Cancer Metastasis Process Better Understood

Breast Cancer Metastasis Process Better Understood | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Working with mice, researchers report they have identified chemical signals that certain breast cancers use to recruit two types of normal cells needed for the cancers’ spread.
Graham Player Ph.D.'s insight:

Research has shown that breast cancer cells send out chemical signals to recruit other cells for the process of spreading the cancer.

The cancer cells, which differ from normal cells in their oxygenation, send out a chemical signal called hypoxia-inducible factor 1 (HIF-1), which they release to help them cope with low-oxygen conditions. The researchers also group found that HIF-1 induced adult stem cells called mesenchymal stem cells to release a signal to nearby breast cancer cells, which made them more likely to spread. Breast cancers need the support of several types of host cells in order to metastasize.

Gregg Semenza, a professor and director of the Vascular Biology Program in the Johns Hopkins University School of Medicine’s Institute for Cell Engineering, commented that the study adds to the evidence that an HIF-1 inhibitor drug could be an effective addition to chemotherapy regimens.

more...
No comment yet.

From around the web

Cancer - Advances, Knowledge, Integrative & Holistic Treatments
Your new post is loading...
Your new post is loading...
Scooped by Graham Player Ph.D.
Scoop.it!

Knowing Cancer Risk May Not Affect Screening Rates

Knowing Cancer Risk May Not Affect Screening Rates | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Telling people of their potential increased risk of colon cancer did not spur them to get the recommended screening.
Graham Player Ph.D.'s insight:

Personalized genetic information to guide medical decisions is increasingly becoming available. A study was done to determine if individualized genetic and environmental risk assessment (GERA) of colorectal cancer susceptibility improves adherence to screening tests in average-risk persons.

Researchers studied 783 people aged over 50 who were found to be at risk for colorectal cancer and who had not undertaken prior screening. All the participants were told of their apparent risk for the cancer.

Two-thirds of the people in the study received comprehensive advice about colon cancer screening, a session of genetic counseling and a blood test that could tell them whether they were at average or increased risk for colon cancer. The other third received only the advice about the advantages of screening.

Over the next 6-months those people who chose to have screening tests in each of the two groups was basically the same – 33.1% and 35.7% respectively. This study example shows that giving people knowledge of the availability of personalized risk assessment testing made no difference to their decision to undertake testing.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

The Truth About Cancer – Free Replay (Free Offer Ends Sunday evening Oct 26)

The Truth About Cancer – Free Replay (Free Offer Ends Sunday evening Oct 26) | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Find out how to prevent and treat cancer 100% naturally, watch the episodes for FREE today, Oct. 13th ~ 24th
Graham Player Ph.D.'s insight:

For anybody interested in understanding the natural therapeutic approaches to cancer that many people have found successful, here is a free offer to select and watch any of the eleven episodes of a recent Cancer Summit, as follows.

Watching this will give you an immediate jump-start on all the most up-to-date knowledge about what may be working for many people.

Episode 1:  Modern Medicine & The Cancer Pandemic
Episode 2:  Your First Line Of Defense
Episode 3:  Eliminate These “Dirty Dozen” To Prevent Cancer
Episode 4:  Your Secret Fountain of Youth
Episode 5:  Nature’s Pharmacy
Episode 6:  Clean Foods & The Cancer-Free Diet
Episode 7:  Diagnostic “Do’s & Don’ts” – Proven Treatment Protocols Part 1
Episode 8:  Proven Treatment Protocols Part 2
Episode 9:  Proven Treatment Protocols Part 3
Episode 10: Doctor’s Orders
Episode 11: How to Survive and Thrive

This is the replay link - http://www.thetruthaboutcancer.com/live/replay.php

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Has the Evolution of Cooking and the Foods We Eat Contributed to Increased Cancer Rates?

Has the Evolution of Cooking and the Foods We Eat Contributed to Increased Cancer Rates? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Michael Pollan is an author, activist, journalist and professor of journalism at the UC Berkeley Graduate School of Journalism. He mainly focuses on the industrial food chain with regards to his research. He emphasizes how cooking is one of the simplest and most important steps people can take to improve their family’s health, build communities, […]
Graham Player Ph.D.'s insight:

In this short video Michael Pollan gives an interesting perspective on the role of cooking – how it has changed and how we have become dependent on corporations to cook our food.

This may provide valuable insight into one important aspect of why cancer rates are rising in our society. We see study after study showing how pesticides, GMOs and a number of other things we choose to surround ourselves with on a daily basis are indeed harmful to human health.

Perhaps it is time for us to wake up and fully acknowledge the various contributing factors to the ill-health of our society. If we consider that 75% of the US health budget is spent on the treatment of lifestyle-related chronic diseases that have been associated with diet and nutrition, we may need to make better choices in our lives.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

How to Not Get Cancer - According to the Experts at WHO

How to Not Get Cancer - According to the Experts at WHO | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Cancer experts at the World Health Organisation (WHO) have published a 12-point code aimed at preventing cancer.
Graham Player Ph.D.'s insight:

Dr Joachim Schuez, who led the research, explained “these are all recommendations where you can change your behavior as an individual”.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Thomas Seyfried Ph.D. Questions the Origin of Cancer - Suggesting Conventional Therapies for Cancer Should be Directed Towards the Causes of Cancer

Thomas Seyfried Ph.D. Questions the Origin of Cancer - Suggesting Conventional Therapies for Cancer Should be Directed Towards the Causes of Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

If oncogenes are the drivers of this disease, why is it that when you take the nucleus from a tumor cell and put it into a normal cytoplasm, the nucleus is no longer capable of producing the disease?

Graham Player Ph.D.'s insight:

According to Boston College professor of biology, and cancer research scientist, Thomas Seyfried Ph.D., the very origin of cancer is in dispute. He explains why it is not a genetic disease and says that we will not likely make any substantial progress until we recognize and direct our therapies toward the true causes of cancer.

The current view now is that cancer is mainly a genetic disease. The cancer field was built on this foundation, that genes are regulating the entire process. However it is known that there are carcinogens that do not damage nuclear DNA but do still cause cancer. This tends to contradict the gene theory somewhat.

There are other issues to do with lactic acid production, and how this has been seen to vary in cancer cells in-vitro when compared with in-vivo analysis.

If oncogenes are the drivers of cancer, why is it that when you take the nucleus from a tumor cell and put it into a normal cytoplasm, the nucleus is no longer capable of producing the disease?

And now within the last few years people have been able to transplant mitochondria. So if you transplant normal mitochondria into a tumor cell's cytoplasm, you suppress the tumor-genic phenotype. And if you transplant abnormal mitochondria into a normal cytoplasm, you can produce developmental abnormal cells or dead cells. This tends to indicate that mitochondria may be responsible for tumor development.

This is an interesting interview with Thomas Seyfried discussing the above issues as well as other analyses that question the origin and nature of cancer, and consequently the logical choice of therapy.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Green Tea Based Chemotherapy-Delivery-System Shown to Target and Kill Cancer Cells More Effectively

Green Tea Based Chemotherapy-Delivery-System Shown to Target and Kill Cancer Cells More Effectively | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. A group of researchers from the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR has taken the health benefits of green tea to the next level by using one of its ingredients to develop ...
Graham Player Ph.D.'s insight:

A key challenge in chemotherapy is ensuring that the drugs are delivered only to the tumor in order to avoid harming the surrounding healthy tissues and organs. To address this, researchers have focused their efforts on developing more effective drug carriers.

A major stumbling block in designing more effective carriers for drugs has been the drug-to-carrier ratio. Specifically, the capacity of a particular carrier limits the amount of drug that it can deliver.

A group of researchers from the Institute of Bioengineering and Nanotechnology (IBN) has designed a therapeutic nano-carrier for drug delivery using novel compounds derived from EGCG. Epigallocatechin gallate (EGCG), is an antioxidant and key ingredient in green tea which is known to have therapeutic applications in the treatment of many disorders including cancer.

Using EGCG, the IBN researchers have successfully engineered nano-carriers that can deliver drugs and kill cancer cells more efficiently. The study revealed that IBN's green tea nanocomplex loaded with Herceptin (a protein drug currently used to treat breast cancer) reduced tumor growth much more effectively when compared to administering Herceptin on its own. Using the new nano-carrier, twice as much drug accumulated in the cancer cells, indicating an improved tumor targeting ability. At the same time, the drug accumulation in the other organs was lowered substantially, by 70% in the liver and kidney, and by 40% in the lung.

The research is published at this link in the journal Nature Nanotechnology - http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2014.208.html

more...
Howard Fox's curator insight, October 14, 7:53 PM

Interesting article about the effectiveness of Green Tea

Scooped by Graham Player Ph.D.
Scoop.it!

The Cost of Cancer Drugs

The Cost of Cancer Drugs | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Lesley Stahl discovers the shock and anxiety of a cancer diagnosis can be followed by a second jolt: the astronomical price of cancer drugs.
Graham Player Ph.D.'s insight:

Perhaps we need to start treating the cost of cancer drugs almost as a financial toxicity side-effect of cancer. Watch this 60-Minutes broadcast to learn more. I have summarized below for those who prefer to read.

The investigator for this report was surprised to find:
- just how expensive cancer drugs were, and
- that many oncologists receive a commission when they prescribe cancer drugs

Most cancer drugs are targeted at extending life rather than curing cancer. That life extension likelihood is sometimes suggested as days rather than years. So for patients it may be difficult to decide whether life extension for an additional 42 days is worth the high cost of the drug – such as Zaltrap (for advanced colon cancer) discussed in the report.

The pharmaceutical companies do make a significant contribution to the treatment of cancer. They are entitled to make a profit which continues to fuel innovation. However the high cost of these drugs can result in bankruptcy of the patient’s family. A cancer diagnosis is one of the leading causes of personal bankruptcy today. It is not unusual for patients to take 2 or 3 different drugs for their cancer treatment, each costing $100,000. An entry-level cost of drug treatment probably is around $250,000 in costs.

We may be in a situation where people’s fear and anxiety is being taken advantage of by the cancer industry. Many oncologists believe the cost of the cancer drugs are too high. Drug companies assert that the cost of bringing a new drug to market is $1 billion. So prices reflect the cost of innovation.

Dr Leonard Saltz, Chief of Gasto-Intestinal Oncology at Memorial Sloan Kettering, compared the clinical trial costs of Zaltrap (mentioned above) approved in 2012 to those of another drug already on the market – Avastin. Both drugs target the same patient population, work essentially in the same way, and deliver the identical result of extending median survival by 1.4 months (42 days) when given as chemotherapy. The two drugs look to be the same. Although the Zaltrap study showed it to be a little more toxic than Avastin. So why does Zaltrap cost more than $11,000 per month which is more than twice the cost of Avastin at $5,000 per month?

Together with Dr. Saltz, Dr. Peter Bock, Sloan Kettering’s in-house expert on cancer drug prices, decided to reject Zaltrap based on its high price. This was reported in the New York Times. This raised the issue that the drug companies are permitted to charge whatever they want and there are no controls on this as part of the approval process. The pricing system for drugs is dictated by those who make the drugs. The prices seem to be decided on their own views only, and according to Dr. Brock are based on how brave they are and how little they want to end up being criticized in the New York Times or on 60-Minutes programs.

Media criticism does seem to work. Right after the New York Times article reporting on Zaltrap, the pharmaceutical manufacturer of Zaltrap, Sanofi, cut the price of their drug by half. This was irrefutable evidence that the original price had no basis, and was only profit oriented to meet the company’s financial greed. As a consequence all those arguments heard for decades from the pharmaceutical companies – we have to recoup our money, we are good for society, trust us to set the right price, etc – simply no longer had any credibility. Sanofi lowered the price of Zaltrap in a way that doctors could get the drug for less. But patients were still paying as if it was high priced. According to Dr. Bock, doctors were buying the drug for $11,000 and the company sent the doctors a cheque for $6,000. Then the doctor gets to bill the patient’s insurance company as if it costs $11,000. This made it extremely profitable for the doctors. Basically doctors could double their money if they used Zaltrap.

The commission based approach provides an incentive for the doctors to choose and recommend the most expensive drugs for patients. While this may be advantageous for the drug companies and doctors, it is a system that should be carefully considered in terms of its morality and fairness to patients.

All of this is currently accepted industry practice. John Castellani, President and CEO of the Pharmaceutical Research and Manufacturers of America (PhRMA) – the Trade and Drug Industry’s lobbying group in Washington - comments that the price of the drug needs to reflect the cost of development, and the value it can provide. When asked how it can be that a patient can be taking a drug that is no better than another drug on the market, yet costs twice as much, Castellani responded that “we don’t set the prices; what a patient pays is determined by the patient’s insurance company.”

Another drug example is Glevec, from Novartis, which treats a common blood cancer and requires patients to keep taking the drug indefinitely. This is the top-selling drug for Novartis, bringing in more than $4 billion per year in sales, and $35 billion since the drug came to market. There are several other similar drugs that compete with Glevec. Such competition would normally bring down the prices in a typical marketplace. But the price of Glevec has tripled from $28,000 per year in 2001 to $92,000 per year in 2012. So drug companies are also raising their prices on their older drugs, not just the new ones.

According to Hagop M. Kantarjian, Professor at Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, the drug companies are setting prices that are unreasonable, unsustainable and immoral. He believes that the law needs to change that currently prevents Medicare from negotiating for lower prices, which now results in American patients paying two to three times more for the same drug compared to the cost for the same drug in other countries.

To complete the picture, the single biggest source of income for private practice oncologists is the commission they make on prescribing cancer drugs. They buy the drugs wholesale from the pharmaceutical companies and sell them retail to their patients. This fuels the incentive for oncologists to use more expensive drugs for their own financial gain.

Dr. Saltz believes that the challenge is knowing where to draw the line between how long drugs may extend life and how much they cost. We as a society have been unwilling to discuss this topic, and as a result the only people that are setting the line are the people selling the drugs.

more...
Tambre Leighn's curator insight, October 6, 2:36 PM

More evidence of the far reaching impacts cancer diagnosis and treatment has on survivors, their families, and our economy. When we bankrupt people and add things like financial stress, job loss, navigating complex insurance environments, and more to an already heavy burden of life threatening and, often, chronic disease we are causing injury to our communities and our country.

 

Survivorship coaches know very well how many aspects of life survivors struggle with - career, intimacy, fertility, fears of recurrence, relationships, physical energy. We must begin to address the whole person and provide tools and resources for all of the major challenges - and addressing the sticker shock when it comes to the escalating cost of treatments is an essential area to focus on.

Scooped by Graham Player Ph.D.
Scoop.it!

Genetically Modified Rice Implicated in Higher Cancer Rates

Genetically Modified Rice Implicated in Higher Cancer Rates | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
These accusations are corroborated by a study conducted by Brazilian researchers, one which showed that Bt toxins found in GM rice are toxic to the blood of mice and cause red blood cells to rupture.
Graham Player Ph.D.'s insight:

It appears that an alleged illegal GM rice trial on University students in China has led to an incidence rate of acute leukemia of up to 3 times the normal rate in the country.

Normally, leukemia among young adults in China is about 2 to 3 cases per 100,000 people. In the case of the students claiming to be fed GMO rice at the University’s base, the rate is at least three times higher. Seven students are on record now as having developed the disease.

These accusations are corroborated by a study conducted by Brazilian researchers - http://www.gmoevidence.com/dr-mezzomo-bt-toxins-toxic-to-blood-of-mice/

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Low Dose Aspirin Reduces Cancer Risk

Low Dose Aspirin Reduces Cancer Risk | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
The researchers also found that by blocking platelet COX-1, aspirin inhibits the adherence of platelets to the cancer cells to prevent metastasis, suggesting that the two mechanisms described act in concert to reduce the risk for cancer mortality.
Graham Player Ph.D.'s insight:

Studies have shown that aspirin administration for five or more years reduces the incidence of all cancers by 38% by inhibiting the COX-1 pathway, according to Pierre Massion, MD, professor of medicine and cancer biology in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee.

 

In a new study, Massion and his colleagues found that the potency of low-dose aspirin in inhibiting COX-2 in the tumor cells is as great as or greater than its potency as an inhibitor of COX-1 in the platelet.

 

The researchers also found that by blocking platelet COX-1, aspirin inhibits the adherence of platelets to the cancer cells to prevent metastasis, suggesting that the two mechanisms described act in concert to reduce the risk for cancer mortality.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Child's Cancer Cured with Cannabis Oil

Child's Cancer Cured with Cannabis Oil | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Medical marijuana is gaining acceptance, but could it even help kids? Dr. William Courtney has seen it happen, and on Friday, told HuffPost Live host Alyona Minkovski about it. Saying he was "quite a skeptic 5 or 6 years ago", Dr. Courtney ...
Graham Player Ph.D.'s insight:

There is increasing awareness in the community that medical cannabis has proven to be a beneficial therapy for cancer. There is also considerable scientific research worldwide that supports the effectiveness of medical cannabis.

An 8-month old infant with a centrally located brain tumor was cured by using only cannabis oil, completely without any side effects.

I have posted many articles here on my magazine over the past year on the subject of cannabis oil – you can access them at this link http://www.scoop.it/t/cancer-advances-knowledge-integrative-holistic-treatments?q=cannabis .

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

When Thousands of People Use non-Conventional Methods to Cure Their Own Cancer, Should we Simply Discard Those Methods as Unscientific and Useless?

When Thousands of People Use non-Conventional Methods to Cure Their Own Cancer, Should we Simply Discard Those Methods as Unscientific and Useless? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

significant lifestyle changes, such as radically altering the diet, using herbs and supplements, and embracing social support.

Graham Player Ph.D.'s insight:

This article brings to light the fact that people have been able to cure their own cancer using natural and unproven remedies focused primarily on significant lifestyle changes, such as radically altering the diet, using herbs and supplements, and embracing social support. It points out that these approaches have no scientific basis and can give false hope.

As people become more informed and interested in natural approaches to helping to overcome cancer, there is bound to be considerable debate, disagreement and doubt over what works and what doesn’t work. On the one hand the conventional scientific approach will predictably support chemotherapy, radiation and surgery as the only viable standard of care. This is not an unreasonable view based on the past 50 years of scientific research, investment and focus of the medical system and pharmaceutical companies.

However on the other hand many people believe that the proclaimed ‘War on Cancer’ by President Nixon in the early 1970s has very little likelihood of success. Amidst the best of what science, medicine, research and money has been able to offer over more than 40 years of focus, cancer prevalence has now increased to affect 1 in 2 males and 1 in 3 females. So it is not an unreasonable view that science does not yet have the answers.

Lately there have been popular and best-selling books written that have analyzed what cancer survivors have done who have had apparent spontaneous remission of their cancer without any use of the conventional science-based standard of care.

It is quite predictable that advocates and supporters of the conventional science-based standard of care speak out against these books and natural methods saying the approaches have not been scientifically proven, and offer false hope. In terms of false hope we also need to look at the conventional model and realize that after 40+ years of dedicated and focused research there is not only no cure, but the cancer incidence has increased significantly. So I suggest it is up to the individual patient to determine for themselves which approach has what degree of false hope.

It is very easy and convenient to relegate natural approaches to treatment into the “not been scientifically proven” basket, and to regard them as ‘anecdotal’ only. However if thousands of people are overcoming cancer by using non-conventional methods (as seems to be the case), then maybe we should be asking ourselves at what stage does ‘anecdotal’ evidence (i.e. unproven scientifically but proven in terms of evidence of outcome) begin to have some relevance? Surely there is a point at which it is normal and logical for that evidence to be relevant and significant. We may begin to wonder about the objectives - are we protecting science or are we protecting people.

Following cancer on a daily basis I get to see both sides of the argument. I report mostly on what is being discovered and researched in the conventional scientific world, simply because that is what is mostly reported in scientific journals and the media. However it certainly does seem to me that evidenced-based natural therapies surely warrant serious consideration, if only based on the fact that there seem to be thousands of cases of people overcoming their own cancer using various ‘non-proven’ methods. In addition there are hundreds of natural holistic practitioners and clinics worldwide helping cancer patients. Another consideration is that when ordinary people do things that seem to be able to achieve what previously was considered not possible (according to the conventional view) then those things may quickly become the normal approach for everybody. The fact that science cannot explain it, has very little relevance.

Science will always have its important role and relevance in society. But we certainly know that science’s focus on cancer for 40+ years does not have all the answers. Perhaps part of the problem is the desire to hang on to and understand everything from only the perspective of Newtonian science rather than embrace quantum science, and to step outside the box with a willingness to objectively consider the holistic principles, what nature has always been able to provide, what cultures have successfully done for thousands of years, and what today people are doing to help cure themselves of cancer. While it may not lead to the development of any patented medicines, may reduce the profits of some of the present drug therapies, and may turn out to be inconvenient in upsetting the status quo, it is something that needs to be done based on the growing evidence in front of us all.

Long ago in 1847 Dr. Ignaz Semmelweis had anecdotal evidence that doctors carried germs on their hands that infected patients, and therefore they should wash their hands before treating patients. However his anecdotal observations conflicted with the established scientific and medical opinions of the time and as a result, his ideas were rejected by the medical community and he was forced to leave his career. Let’s hope that same rigid unbending thinking and dogma does not still prevail in the contemporary medical system.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Exercise Found to Increase Tumor Fighting Effect of Chemotherapy

Exercise Found to Increase Tumor Fighting Effect of Chemotherapy | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
believes it could be in part because exercise increases blood flow to the tumor, bringing with it more of the drug in the bloodstream.
Graham Player Ph.D.'s insight:

A study by University of Pennsylvania scientists found that combining exercise with chemotherapy shrunk tumors more than chemotherapy alone. Exercise has long been recommended to cancer patients for its physical and psychological benefits.

Previous studies had shown that an exercise regime prior to receiving chemotherapy could protect heart cells from the toxic effects of chemotherapy. But few had looked to see whether an exercise regimen during chemotherapy could also be beneficial. The researchers believe that the benefit could be in part because exercise increases blood flow to the tumor, bringing with it more of the chemotherapy drug in the bloodstream. If this is the case then a smaller dose of chemotherapy may be able to be used together with exercise, and reduce side-effects of the chemotherapy.

more...
Tambre Leighn's curator insight, September 20, 11:34 AM

Great information that, once again, exercise makes a difference...but what resources and support are being put into place to support behavior change during a time of high stress for most? Information doesn't always = action.

 

Coaching helps patients create strategies, set goals, have accountability, and work through any blocks by aligning choices with values and priorities. For a white paper on coaching as the missing piece in survivorship, email tleighn@iPECcoaching.com

Tambre Leighn's curator insight, September 20, 11:35 AM

Great information that, once again, exercise makes a difference...but what resources and support are being put into place to support behavior change during a time of high stress for most? Information doesn't always = action.

 

Coaching helps patients create strategies, set goals, have accountability, and work through any blocks by aligning choices with values and priorities. For a white paper on coaching as the missing piece in survivorship, email tleighn@iPECcoaching.com

Beth A. Williams's curator insight, September 21, 12:54 PM

We've been told about the benefits of exercise for many years, and this research adds another benefit -- reducing tumors faster during chemotherapy treatments, which may also lead to using lower doses of the drugs and lowering related side effects. So we can get on with our lives with less rebuilding perhaps?

Scooped by Graham Player Ph.D.
Scoop.it!

High-Intensity Ultrasound Can Eliminate Cancerous Tumors

High-Intensity Ultrasound Can Eliminate Cancerous Tumors | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

The ultrasound also offers many advantages over conventional surgery. According to doctors, there is very little blood loss, surgery is shorter, only four small incisions for the ultrasound probe are needed and patients can go home hours after the procedure.

Graham Player Ph.D.'s insight:

Focused ultrasound procedures are already being used in Europe to treat prostate cancer. Doctors at the University of Southern California are using high-intensity focused ultrasound energy to destroy a tumor in a patient’s kidney.

more...
Beth A. Williams's curator insight, September 21, 1:00 PM

Another advancement toward less invasive, successful treatments of cancer! One of the big issues I've had with cancer treatments has been how toxic they are, affecting healthy cells as well as cancerous ones. This approach could be game changing.

Scooped by Graham Player Ph.D.
Scoop.it!

PSA Prostate-Cancer Screening Does More Harm Than Good, Task Force Says

PSA Prostate-Cancer Screening Does More Harm Than Good, Task Force Says | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
The guidelines are already being questioned by groups such as Prostate Cancer Canada and the Canadian Urological Association, both of which favour the PSA test so long as it is used judiciously. They say it is especially useful for men of African descent and men with a family history of prostate cancer, both of whom have a higher likelihood of developing the disease.
Graham Player Ph.D.'s insight:

Authorities are recommending that the PSA prostate cancer screening test be abandoned.

The Canadian Task Force on Preventive Health Care concluded that the harms of over-treatment outweigh the benefits of early detection.

The guidelines are already being questioned by groups such as Prostate Cancer Canada and the Canadian Urological Association, both of which favor the PSA test so long as it is used judiciously. They say it is especially useful for men of African descent and men with a family history of prostate cancer, both of whom have a higher likelihood of developing the disease.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Cancer May be Able to be Prevented and Cured Through Diet

Cancer May be Able to be Prevented and Cured Through Diet | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

T. Colin Campbell, the professor emeritus in nutritional biochemistry at Cornell University said research has proven that consumption of animal products, including meat, fish and dairy, triggers chronic diseases and impaired health and poses a greater risk than heredity or environment.

Graham Player Ph.D.'s insight:

T. Colin Campbell is a nutritional biochemist who specializes in the effect of nutrition on long-term health. He is Professor Emeritus of Nutritional Biochemistry at Cornell University, and well-known for his two books, Whole (2013), and The China Study (2005), which became one of America's best-selling books about nutrition.

His research shows that consumption of animal products, including meat, fish and dairy, triggers chronic diseases and impaired health and poses a greater risk than heredity or environment. He has linked casein, a protein in milk, with breast cancer. His lifelong professional focus has been cancer and nutrition, and Campbell says that our national and global fight with cancer has targeted the wrong enemy.

He believes physicians are not reliable sources of nutritional advice for their patients, as most physicians received minimal to no nutritional education in medical school and have not generally conducted investigative laboratory research themselves. “Diet can be used to prevent and reverse cancer just like it prevents and reverses heart disease,” he said. “A diet high in animal protein increases the amount of carcinogens going to the cells. It increases the enzyme MFO (mixed function oxidase) that causes increased carcinogenic activity.” In the lab, Campbell has shown that increasing consumption of animal protein alters MFO and activates cancer while decreasing consumption detoxifies cancer. A high protein diet derived from animal products increases cell replication and increases oxygen free radicals associated with cancer and aging.

Nutrition seems to be a forgotten science. Unfortunately there have been no large-scale clinical trials with humans to test the efficacy of the whole-food, plant-based diet for prevention and treatment of cancer. Edward Giovannucci, professor of nutrition and epidemiology at Harvard School of Public Health, believes diet is the leading cause of poor health in the US and worldwide. His own research findings are compatible with Campbell’s work.

However while public policy continues to be driven by commercial interests we will likely see no major changes in thinking, emphasis or policy regarding the impact of changed nutritional habits on improving health.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

HPV Infection and Oral Cancer

HPV Infection and Oral Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
However, not everyone infected with HPV will develop cancer.
Graham Player Ph.D.'s insight:

Increasing numbers of Danish men are being diagnosed with HPV-caused oral cancer.

The Danish Cancer Society (Kræftens Bekæmpelse) warns that oral sex increases the risk of HPV (human papilloma virus) infection, and suggest HPV can also be transmitted through mouth-to-mouth contact. However, not everyone infected with HPV will develop cancer.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Some Key Facts About Your Immune System and Cancer

Many people ask me about the immune system. So here are a few key facts for your information.

Graham Player Ph.D.'s insight:

Your Immune System


Your first line of defense against pathogens.

Your own inner personal ‘military-force’ to deal with unwanted invaders.

Its objective is always to fight, fix, repair, promote detoxification, and maintain your health

Inflammation is one of the instruments used by the immune system to regulate health, usually in acute situations. However chronic and uncontrolled inflammation can have devastating effects on the immune system and your health. Contributors to chronic inflammation include chemicals, pollutants, heavy metals, emotional state, depression, stress levels, certain foods, pathogens, improper lifestyle, inadequate nutrition, etc.

The immune system is a learning system and able to recognize previous infections and eradicate them in the future.

People who have never been ill throughout life with the typical infections we all get from childhood onwards and other disease states, will have a less prepared and ready immune system to fight off future disease.

Many doctors may worry more about the people who have never been sick, due to their potentially less developed immune systems.

We are designed to fight infection, to stay healthy into old age, and to keep brain function into old age. If we treat our body correctly our immune system will work well to ensure we function well as designed.

We need to put the right fuel in our bodies so that our immune system can function optimally. The body and its immune system needs the right nutrients, vitamins and minerals, proper hydration, sleep, exercise, and attention to healthy emotional state, social interaction and lowered stress levels.

We need to remove the stressors that impede our immune system from working optimally.

When the immune system becomes disrupted that’s when bad things can begin to happen that compromise our health, including cancer.


Immune System and Cancer:

We all produce cancer cells everyday as part of our normal metabolism. Our healthy immune system identifies and removes these cancer cells quite adequately.

You cannot have cancer if you have an in-tact optimally functioning and healthy immune system.

If you have cancer then by definition your immune system has been compromised, and your immune system has missed dealing with the cancer.Many people see cancer as a disease of the immune system. A weakened immune system allows cancer cells to grow better. A consequence of chemotherapy and radiation is a weakened immune system.

Conventional cancer treatments, chemotherapy and radiation, compromise the immune system.

Conventional cancer treatment is focused on killing cancer cells, and not addressing the cause of cancer.

Cancer is an ‘obligate glucose metabolizer’, meaning it thrives on sugar (carbohydrate, glucose). Sugar compromises the immune system. A recent study showed that within 15-minutes of eating a predominantly carbohydrate meal (pizza, pasta, etc) the leukocyte index (the number of pathogens a white blood cell can destroy in 1-hour) fell from the normal 16 to 1.9, and maintained that lower level for many hours afterwards. That means a reduction to 10% of normal immune capacity for several hours.

A century ago sugar was a delicacy, and the average person consumed 5 pounds of sugar per year. Today in the US people consume an average of 150 pounds of sugar per person per year.

Cancer cells have certain characteristics – they only survive on sugar (glucose); they are anaerobic (do not need or thrive in an oxygenated environment); and they thrive in an acidic environment (as opposed to an alkaline environment).

Sugar contributes to free radical damage, damage to the mitochondria, and weakens our body’s innate immune system resulting in an environment where cancer cells can continue to grow and strengthen without being checked.

Normal cells go through a process called ‘oxidative phosphorylation’ which means they use oxygen and sugar and make 32 molecules of ATP (our body’s energy-currency). If cells use anaerobic metabolism (don’t utilize oxygen – i.e. cancer cells) they cannot produce 32 molecules of ATP, and perhaps produce only 2. That is the reason cancer cells with their altered metabolism need more sugar – so they can continue to produce some ATP for their own survival.

The anaerobic metabolism of cancer cells produces a lot of waste products, particularly lactic acid.

Reduce the intake of sugar (carbohydrate, glucose) and you will reduce the food supply of cancer cells, and reduce compromising your own immune system.

42%-46% of cancer patients die of cachexia (malnutrition). Conventional therapies for cancer don’t address this adequately.

Excessive sugar intake has been linked to increased risks of obesity, inflammation and chronic diseases. Chronic inflammation is one of the main contributing factors to many of the chronic diseases in our society today. It also is one of the causes of metastases of cancer that spreads throughout the body to form tumors.


Cells of the Immune System

The largest number of immune system cells in the body are neutrophils, representing from 50%-70% of your body’s army of immune cells. Neutrophils cannot detect cancer. Natural killer cells are constantly surveying all the cells in the body for intruders and other problem abnormal cells, and destroying them.

The immune system can be regarded as having two arms – specific and non-specific. In the non-specific arm there are neutrophils, macrophages, and eosinophils which are basically front-line defenders whose purpose is to identify all cells as belonging to self (i.e. friendlies). In the specific arm there are B-cells and T-cells. B-cells borne from the bone marrow, make antibodies against antigens, develop into memory B cells after activation by antigen interaction, and release cytokines (proteins), which are used for signaling immune regulatory functions. T-cells mature mainly in the thymus (some in the tonsils), and play a central role in cell-mediated immunity. There are several subsets of T-cells, each with a distinct function – including helper, cytotoxic, memory, regulatory (suppressor), and natural killer T-cells.

80% of your immune system is in the mucosal lining of our intestinal tract. If you don’t have a healthy intestinal tract and are feeding your body a lot of the wrong things it will compromise your immune system. If we add excessive burdens to our immune system it prevents it from doing its important function of protecting us.

In 1 cubic-centimeter of tumor there is approximately 1 billion cancer cells. 65% of those cells are usually dormant (in the resting phase of the cell cycle), and 35% are active (in the synthesis phase of the cell cycle).

99% of all cancer cells are non-cancer-stem-cells. Meaning about 1% of cancer cells are cancer-stem-cells. Cancer-stem-cells survive in the blood stream, are immortal, and not usually affected by chemotherapy and radiation. Non-cancerous stem cells cannot metastasize. Only cancer-stem-cells can metastasize. The immune system cannot recognize cancer-stem-cells because they have a protein on their cell surface that shields them from the immune system.

There is a small list of substances that have been shown scientifically to attack cancer-stem-cells. These include metformin and ellagic acid (found in berries and green tea extract).
more...
Tambre Leighn's curator insight, October 17, 11:34 AM

Interested in prevention? Consider starting with your immune system as a first line of defense.

Scooped by Graham Player Ph.D.
Scoop.it!

Cancer As A Metabolic Disease

Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.

Graham Player Ph.D.'s insight:

For researchers and those interested in what goes on at the cellular level in cancer cells this is an interesting and useful reference paper.

The path from normal cell physiology to malignant behavior, where all major cancer hallmarks are expressed is quite complex. Respiratory insufficiency together with lactate production are some of the key features of tumor cell energy metabolism. A deficiency in some aspect of respiration can account for excessive lactic acid production which is typical in tumor cells.

One theory is that mitochondrial respiratory dysfunction is the origin of cancer. Tumor cells can have abnormalities in both the content and composition of their mitochondria. When viewed as a mitochondrial metabolic disease cancer progression is more in line with the evolutionary theory of Lamarck than with the theory of Darwin. According to Lamarck’s theory, it is the environment that produces changes in biological structures. Lamarck’s ideas could also accommodate a dominant role for epigenetics and horizontal gene transfer as factors that could facilitate tumor progression.

Many cancers are infected with human cytomegalovirus, which acts as an oncomodulator of tumor progression. Products of the virus can damage mitochondria in the infected tumor cells, thus contributing to a further dependence on glucose and glutamine for energy metabolism.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Is Cancer Growth Nocturnal?

Is Cancer Growth Nocturnal? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Scientists hope that their findings provide evidence that administering certain treatments in time with the body's day-night cycle could boost their efficiency.
Graham Player Ph.D.'s insight:

This study reveals there may be an advantage in considering the time of day when administering certain cancer treatments.

Professor Yosef Yarden of the Weizmann Institute of Science, one of the study's researchers, points out that "cancer treatments are often administered in the daytime, just when the patient's body is suppressing the spread of the cancer on its own."

You can read the full report published in the journal Nature Communications here - http://www.nature.com/ncomms/2014/141003/ncomms6073/full/ncomms6073.html

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Cancer Rates Double in Argentina’s GMO Crop Areas

Cancer Rates Double in Argentina’s GMO Crop Areas | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

A report by the Ministry of Health in Cordoba, Argentina reveals that deaths from cancerous tumours are double the national average in areas where genetically engineered crops are grown and agro-chemicals are used.

Graham Player Ph.D.'s insight:

Introduction of GMO crops in Argentina has resulted in a doubling of the cancer rates. The Ministry of Health of Córdoba released a comprehensive report on cancer in the province. It documented five years of information and, among other parameters, geographically determined the cases. The peculiarity which caused a major alarm is that the highest rate of deaths occurs in the "pampa gringa" area, where most transgenic and agrochemicals are used, and where the death rate is double the national average.

Damian Verzeñassi a doctor and professor of social and environmental health at the, Faculty of Medical Sciences in Rosario says; "The study of Córdoba matches the surveys we conducted in eighteen industrial agriculture areas. Cancer has skyrocketed in the last fifteen years."

He is scathing about the failure of government and industry to take preventative action. "They keep demanding studies on something that is already proven and do not take urgent measures to protect the population. There is ample evidence that the agricultural model has health consequences, we are talking about a production model that is a huge public health problem."

The only real long term solution is to change the GMO driven, intensive, industrial agricultural system that Argentina and other countries have become wedded to and to put in place a genuinely sustainable, agro-ecological alternative.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Study Finds That Common Fragrance Ingredient Can Cause Cancer

Study Finds That Common Fragrance Ingredient Can Cause Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Last month (July 28) a committee convened by the National Academy of Sciences confirmed a federal interagency group’s conclusion that styrene, a chemical building block used to produce a wide variety of everyday products, can cause cancer.
Graham Player Ph.D.'s insight:

The fragrance ingredient styrene has been classed as a compound that is “reasonably anticipated to be a human carcinogen” according to compelling evidence found by a committee convened by the National Academy of Sciences to do a study. The committee reported that some studies would support a strong argument for listing styrene as a known human carcinogen.

Styrene is commonly used as a fragrance to enhance the scent of many cosmetic and household products. Federal labeling law means that ingredients added to products to provide a pleasant scent, or to mask a bad one, need only be listed under the generic term “fragrance.” So users of products will not know if those products contain styrene.

Besides cologne and other personal care products, fragrances are also used to scent household care products such as dish and laundry detergent. Other sources of environmental exposures include food (from migration of styrene from polymer packaging materials), cigarette smoke, vehicle exhaust, and other forms of combustion and incineration of styrene polymers.

Over half the styrene that is produced in the United States is used for the manufacture of polystyrene, which is a component of such products as plastic packaging, building and refrigeration-equipment insulation, and disposable plates and cups. In the general population, the average daily exposure to styrene in air is estimated to be 18 to 54 µg/person/day and the average daily exposure to styrene in food is estimated to be 0.2 to 1.2 µg/person/day.

The only way to steer clear of styrene in personal care products is to avoid using any that say they contain “fragrance” but don’t list the perfume’s individual components.

For more information you can read the full report on styrene by the National Toxicology Program at this link - http://www.nap.edu/catalog.php?record_id=18725

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Skirt Size Increase Linked to Breast Cancer Risk

Skirt Size Increase Linked to Breast Cancer Risk | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Women who go up a skirt size every decade between their 20s and their 60s may be at increased risk of postmenopausal breast cancer, a new...
Graham Player Ph.D.'s insight:

Many studies have looked at the impact of a woman’s weight on breast cancer risk. However a study published in the journal BMJ Open looked at the risk that gradual changes in weight have on breast cancer risk. To do that the study gathered data from 92,834 postmenopausal women. The indicator used to determine weight increase was the progressive increase in their skirt size over the years from when they were in their twenties. Skirt size increase may be a good guide of the increase in abdominal fat.

What they found was that an increase of one size every 10 years led to a 33% rise in the risk of postmenopausal breast cancer, while an increase of two sizes per decade let to a 77% rise in risk.

The published study full results can be accessed here - http://bmjopen.bmj.com/content/4/9/e005400.full.pdf+html?sid=041103ce-656f-47ba-8c89-0efac85846eb  

more...
Tambre Leighn's curator insight, September 29, 3:14 PM

How might your skirt be a metric for your risk for post-menopausal breast cancer? Find out - and then make a commitment to living a life of wellbeing and prevention. While not everything is preventable, why not do everything you can to impact your health and longevity.

Rescooped by Graham Player Ph.D. from Breast Cancer News
Scoop.it!

Most Breast Cancer Patients Do Not Have Reconstruction Surgery

Most Breast Cancer Patients Do Not Have Reconstruction Surgery | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Most Breast Cancer Patients Forgo Reconstruction Surgery

Via Susan Zager
Graham Player Ph.D.'s insight:

In the USA only 30% to 40% of women who have a mastectomy undergo breast reconstruction surgery.

A study, published in JAMA Surgery, found that 58.4% of 485 patients surveyed decided not to undergo breast reconstruction surgery, citing such reasons as
- not wanting to have additional surgery (48.5%),
- it wasn’t important (33.8%),
- fear of implants (36.3%), and
- a concern about possible complications (33.6%).

more...
Susan Zager's curator insight, September 23, 12:41 PM

To see the study go to: http://archsurg.jamanetwork.com/article.aspx?articleid=1893807


Natalie Palmer's curator insight, September 24, 5:38 AM

To see the study published in JAMA go to: http://archsurg.jamanetwork.com/article.aspx?articleid=1893807

Tambre Leighn's curator insight, September 27, 2:07 PM

Choice - being at choice, feeling like you have a choice, being supported in your choices - for a survivor to feel empowered, choice is a big part of it. Healthcare professionals, personal caregivers, family, friends, loved ones, and the media must reserve judgment. There is no right or wrong when it comes to what a patient decides.

Scooped by Graham Player Ph.D.
Scoop.it!

Rate and Risk of Mesothelioma Increases Over Many Years After Initial Exposure to Asbestos

Rate and Risk of Mesothelioma Increases Over Many Years After Initial Exposure to Asbestos | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Mesothelioma risk endures over long-term
Graham Player Ph.D.'s insight:

Pleural and peritoneal mesothelioma are cancers that develop on the lining of the lungs and are almost always caused by asbestos exposure.

The Curtin University and UWA School of Public Health in Australia investigated 22,048 people exposed to asbestos across the globe. They found the rate and risk of pleural mesothelioma increased until 45 years after the first exposure. After 45 years the risk rate then appeared to slow down. However, the rate of peritoneal mesothelioma over 10-50 years continued to increase.

more...
No comment yet.
Scooped by Graham Player Ph.D.
Scoop.it!

Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma

Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die. Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.

Graham Player Ph.D.'s insight:

The culprit in sparking many cancers, particularly mesothelioma, is the intracellular protein and transcription factor STAT3 (signal transducer and activator of transcription 3). A signal transducer and activator is a pathway for instructing the growth and survival of cells, and a transcription factor is a protein that controls genetic information directing cells how to perform. STAT3 is notorious for sending signals to trigger the onset of human cancers and to fuel their continued growth.

The great neutralizer of STAT3 is PIAS3 (protein inhibitor of activated STAT3). PIAS3 possesses the strength to inhibit and block STAT3's ability to cause cancer. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrated that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die.

Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.

more...
No comment yet.