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The “War on Cancer” - Slogan or Solution?

The “War on Cancer” - Slogan or Solution? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
A Retro Report and a medical writer reflect on the grand hopes and stuttering progress of Richard Nixon’s “war on cancer.”
Graham Player Ph.D.'s insight:

This New York Times report looks at the “war on cancer” since its commencement in 1971, and after $100 million of spending by the U.S. government on research. It is clear that the war has not been won.

Drops in some cancer rates were mostly attributable not to cancer breakthroughs but to preventative strategies such as not smoking cigarettes; menopausal women not undertaking hormone therapy; and early detection testing.

Drugs are emerging that attack various mutated genes in cancer cells. However cancers almost inevitably grow resistant to a drug that attacks a crucial mutation. The new drugs are incredibly expensive, but rarely are cures.

Other drugs focused on immunotherapies, allowing the immune system to stop the cancer, are beginning to show promise and may have an advantage over drugs that attack mutated genes.

It is clear there is still a long way to go towards winning the “war on cancer”. One cannot help wonder why there isn’t much more funding to research things that have been shown anecdotally to cure cancer. Such research may not result in patentable medicines. However it is possible that it may result in an improved cure rate.

I have been researching cancer for the past twenty years, and now on a daily basis I am likely to see everything written about cancer. During that time there have been many people cured from cancer anecdotally without the use of patentable drugs or expensive invasive procedures. Typically when asked about these cases a standard response from medical professionals is that “there has been no research that supports the effectiveness of these apparent cures”. People reading that response will automatically assume that the research has been done. However in most cases there has been no research done at all. It does seem that research money is not available unless the outcome of the research includes something patentable and therefore profit-making.

Meanwhile from what I read there seems to be many people undergoing self-treatment, and practitioners throughout the world who are treating patients for cancer in all its stages and forms using various non-conventional methods, and who seem to have a higher cure rate than the conventional medical approach. I am no expert and do not say it is all valid and correct. But it perhaps needs more focus and research if the right group of people or organization can be found and funded to be sufficiently objective to do so without seeking a financial reward at the end of the rainbow. Maybe the first step is to define and agree what percentage of government funding towards the “war on cancer” should be allocated towards such research. The results after more than 40 years and $100 million would seem to indicate a need for this approach.

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Do Cancer Drug Prices Reflect the Value They Bring?

Do Cancer Drug Prices Reflect the Value They Bring? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Studies are showing that if cancer drug prices reflected their value to patients, they'd cost less.
Graham Player Ph.D.'s insight:

According to a study published in the JAMA Oncology many cancer drugs are overpriced and do not represent value.

This determination was based on generally suggested values by economists. Cancer drug prices are also not linked to the benefits they provide.

Necitumumab, is an experimental lung cancer drug made by Eli Lilly & Co. that isn't approved yet, and Eli Lilly has not set a price. Researchers found that adding the drug to chemotherapy extended life by 1.6 months, on average, for patients with a dire prognosis. What is the value of this drug to a patient, and will the price that is set reflect that value? Very difficult questions to answer.

Daniel Goldstein, an oncologist at the Winship Cancer Institute at Emory University who led the study, proposes that "drugs that provide a minimal benefit should have a low price, while drugs that provide a major benefit should have a high price. This method of value based pricing will financially incentivize researchers and industry to develop truly game-changing innovations."

"How they price the drug is they price it at whatever the market is wiling to bear," said Benjamn Djulbegovic, an oncologist at the University of South Florida.

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Link Between Inflammation and Colon Cancer

Link Between Inflammation and Colon Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
A new Arizona State University research study led by Biodesign Institute executive director Raymond DuBois, M.D., Ph.D., has identified for the first time the details of how inflammation triggers colon cancer cells to spread to other organs, or metastasize.
Graham Player Ph.D.'s insight:

A study led by Raymond DuBois, M.D., Ph.D., a leader in colorectal cancer research for more than two decades, has been exploring the risk factors between chronic inflammation and cancer, including colorectal cancer.

The research team was able to show how a colon cancer tumor could outwit its host, using an inflammatory mediator to expand its cancer stem cells in order to seek out other organs. They showed a direct link between the pro-inflammatory mediator prostaglandin E2 and increased colorectal cancer stem cells.

Prostaglandin E2 is the most abundant pro-inflammatory bioactive fat, or lipid, found in colon, lung, breast, head and neck cancers. When high levels of PGE2 are found in cancer, it often indicates a poor prognosis.

"The normal role of PGE2 is to come to the rescue when you do something like cut your finger," said DuBois. "It attracts the body's immune cells and stimulates pathways that heal the wound site. The level of PGE2 goes up and then goes down within a few days of healing the wound.

But in cancer, the cells keep making PGE2 chronically, so it's like this wounding process that never heals. In doing so, it generates these cancer stem cells that promote cancer progression and metastatic spread."

DuBois' research team proved that when PGE2 binds to its receptor on the surface of the cancer cell, PGE receptor 4, or EP4, it triggers a signaling cascade for cancer stem cells to renew, differentiate and eventually become resistant to chemotherapy.

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Employing Dogs To Sniff Out Cancer

Employing Dogs To Sniff Out Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
According to sensory scientists, the olfactory acuity of dogs enables them to detect odorant concentration levels at 1 to 2 parts per trillion, roughly 10,000 to 100,000 times that of a human.
Graham Player Ph.D.'s insight:

Researchers have established that dogs can recognize melanoma as well as bladder, lung, breast and ovarian cancers.

Dogs have been successfully trained to distinguish the breath samples of lung and breast cancer patients from those of healthy volunteers. Trainers are able to further develop dogs' abilities to identify the scent of cancer in samples of saliva, breath and urine.

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The U.S. Government’s Department of Health Finally Admits That Marijuana Kills Cancer

The U.S. Government’s Department of Health Finally Admits That Marijuana Kills Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
The U.S. Government’s Department of Health Finally Admits That Marijuana Kills Cancer
Graham Player Ph.D.'s insight:

The US federal government and NIH have quietly confirmed that cannabis (marijuana) is very effective at killing cancer cells without harming healthy cells like radiation and chemotherapy.

Several scientific studies over the past twenty years have produced empirical data proving the effectiveness of cannabinoids in killing cancer, and there are numerous people who have cured themselves of cancer using cannabis. Now the NIH website contains supporting information which you can see here - http://www.cancer.gov/about-cancer/treatment/cam/patient/cannabis-pdq/#link/_13

I have documented the effectiveness of cannabis for more than 2-years. You can read more here - http://www.scoop.it/t/cancer-advances-knowledge-integrative-holistic-treatments?q=cannabis

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Researchers Find New Breast Cancer Gene

Melbourne researchers have isolated a gene that plays a complex role in breast cancer.
Graham Player Ph.D.'s insight:

The PIPP gene ordinarily works to suppress tumors, but when breast cancer forms it causes the cancer to spread to the other parts of the body.

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Cancer survival rates three times higher with early diagnosis

Cancer survival rates three times higher with early diagnosis | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Data from Cancer Research UK suggests 80% of patients survive for at least 10 years after being diagnosed in early stages of eight of most common cancers
Graham Player Ph.D.'s insight:

The survival rate for people with eight of the most common cancers is more than three times higher when the disease is diagnosed early.

The cancers studied were bladder, bowel, breast, cervical, womb, malignant melanoma, ovarian and testicular cancers, which together account for more than four in 10 cancers. For the eight cancers, more than a quarter of cases are still diagnosed in the later stages, three and four.

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Immune discovery exposes cancer cells’ camouflage

Immune discovery exposes cancer cells’ camouflage | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

a common blood cancer thrives by concealing itself from the body’s immune system

Graham Player Ph.D.'s insight:

Chronic lymphocytic leukaemia (CLL) attacks the white blood B cells that usually produce antibodies to fight off infections.

Most CLL patients die of other diseases because their bodies can no longer protect them.

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Sugar Molecule Neu5Gc Links Red Meat Consumption and Elevated Cancer Risk

Sugar Molecule Neu5Gc Links Red Meat Consumption and Elevated Cancer Risk | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
While people who eat a lot of red meat are known to be at higher risk for certain cancers, other carnivores are not, prompting researchers at the University of California, San Diego School of Medicine to investigate the possible tumor-forming role of a sugar called Neu5Gc, which is naturally found in most mammals but not in humans.
Graham Player Ph.D.'s insight:

Red meats including beef, lamb and pork are rich in Neu5Gc (N-Glycolylneuraminic acid), which is a simple sugar molecule found in most mammals. It is not present in poultry, and there are only trace amounts in fish. It has been suggested that the human gene to encode for production of Neu5Gc was eliminated from the human race long ago in antiquity in response to prevailing disease. Therefore Neu5GC is only found in trace amounts in humans, as a result of consumption of animals in the human diet.

Researchers have suggested that the consumption of the red meat can be very fatal for the immune system. The immune system of the human body is always in the continuous process of releasing antibodies that keeps the fight alive against Neu5Gc which is a foreign molecule. This can lead to inflammation, which if gets chronic can lead to tumor formation.

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DDT Linked to Fourfold Increase in Breast Cancer Risk

DDT Linked to Fourfold Increase in Breast Cancer Risk | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
it's possible that DDT could be responsible for raising the risk of breast cancer for a whole generation of women," says Shanna Swan, an environmental health scientist at Mount Sinai Hospital in New York.
Graham Player Ph.D.'s insight:

Studying what happens before birth may hold the key to understanding who gets breast cancer.

Environmental scientists have long suspected, based on lab studies, that prenatal exposure to DDT—which can mimic estrogen and might turn key genes on and off—could fundamentally alter the way a woman's breast tissue grows, making her more susceptible to breast cancer decades later.

Nearly everyone between the 1940s and early 1970s was exposed to DDT, which was widely sprayed on crops and vegetation to kill an array of insects. Women who were exposed to the pesticide during the 1950s and 1960s are just now reaching the age of heightened breast cancer risk.

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Early Cancer Detection Based on Discovery of New Glucose Pathway.

Early Cancer Detection Based on Discovery of New Glucose Pathway. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
The researchers suggest probing the new pathway through specific radioactive imaging probe along with positron-emission tomography (PET) that can enable early detection of these cancers cells.
Graham Player Ph.D.'s insight:

Cancer cells require large amounts of glucose to survive and grow. So far, passive glucose transporters — membrane proteins known as GLUTS — were known to be the primary method used by the body to deliver glucose to tumors. However, through an extensive three-year study, UCLA scientists have now identified a new pathway, which helps cancer cells to survive and grow.

"We have identified a new mechanism to import glucose into pancreatic and prostate cancer cells, namely active glucose transport mediated by sodium-dependent glucose tran8s8porters (SGLTs)," researchers said. The researchers suggest probing the new pathway through specific radioactive imaging probe along with positron-emission tomography (PET) that can enable early detection of these cancers cells.

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Cancer Experts Cast Doubt on Breast Cancer Screening Benefits.

Cancer Experts Cast Doubt on Breast Cancer Screening Benefits. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

Researchers study original Swedish trial data, which provided evidence for UK’s and other screening programmes, and claim benefits were vastly overestimated

Graham Player Ph.D.'s insight:

Leading cancer epidemiologists have gone back to the original trials carried out in Sweden in the 1960s and 1970s, which provided the evidence on which the UK and other screening programmes were based. Those trials found that screening could prevent 20-25% of breast cancer deaths.

In a paper in the Journal of the Royal Society of Medicine, the experts say the methodology of the study was wrong and that figure is far too high. They believe that any reduction of deaths is probably less than 10%.

“Contrary to expectations, numerous studies in North America, Europe and Australia have shown that the rates of advanced breast cancer have not declined in countries where most women regularly attend mammography screening,” said the lead author, Prof Philippe Autier.

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The UK ‘Medical System’ Denies a Potentially Life Saving Smear-Test to a 21 Year Old Mother with Cancer Symptoms, Because She is Under 25 Years of Age.

The UK ‘Medical System’ Denies a Potentially Life Saving Smear-Test to a 21 Year Old Mother with Cancer Symptoms, Because She is Under 25 Years of Age. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
aged 21, is now undergoing chemotherapy and radiotherapy which will leave her unable to have any more children.
Graham Player Ph.D.'s insight:

Here is a classic example of the medical system protecting its own system, no matter what the consequences for the patient may be. Obviously in this case protection of the system far outweighed the importance of protection of the patient’s life.

While it is commendable and necessary to have guidelines to protect from system abuse, it makes you wonder what role common sense plays in the practice of medical diagnosis today. Doctors are trained well to make diagnoses and understand presenting symptoms. Yet simply because of a patient’s age they are in this case not permitted to carry out the proper diagnoses they are trained to practice.

In the case reported here a young mother suffered in pain with cervical cancer for six months before she was diagnosed - because doctors said she was too young to have a smear test. Now aged 21 she is now undergoing chemotherapy and radiotherapy which will leave her unable to have any more children.

As a community we need to question whether this is the type of medical system we really want.

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Chemicals in Common Use Found to Cause Cancer! 20% of Cancer Diagnoses Could be Due to Chemicals!

Chemicals in Common Use Found to Cause Cancer! 20% of Cancer Diagnoses Could be Due to Chemicals! | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Current research estimates that up to one in five cancer diagnoses could be caused by chemical exposures in the environment.
Graham Player Ph.D.'s insight:

Researchers have published their findings on the links between common chemicals and cancer risk. They studied 85 different chemicals that are not considered carcinogenic on their own. They found that, when combined, 50 of the chemicals supported key cancer-related mechanisms at exposure levels currently found in the environment.

Paola Marignani, a professor at Dalhousie University, participated in the research project. She said the chemicals of concern are commonly found in our environment, as well as in products we use on a daily basis. "(They include) some of the fuels, some of the plastics, and some of the cosmetics we use," and “They're in our food, our products, our preservatives, our pesticides."

Current research estimates that up to one in five cancer diagnoses could be caused by chemical exposures in the environment.

On the subject of chemicals, there are approximately 85,000 in current use and listed with the Environmental Protection Agency. A logical conclusion of most people is that they have of course been thoroughly tested and confirmed to be safe. That is definitely not the case, however surprising that may be to people. There is no law requiring industrial chemicals be tested for safety before being put on the market.

To make matters worse if you consult the National Toxicity Program (an agency whose mission is to evaluate agents of public health concern), which is part of the US Department of Health and Human Services they quite openly state “More than 80,000 chemicals are registered for use in the United States. Each year, an estimated 2,000 new ones are introduced for use in such everyday items as foods, personal care products, prescription drugs, household cleaners, and lawn care products. We do not know the effects of many of these chemicals on our health, yet we may be exposed to them while manufacturing, distributing, using, and disposing of them or when they become pollutants in our air, water, or soil.” See for yourself here - http://ntp.niehs.nih.gov/about/index.html

So it certainly seems that nobody has any responsibility to focus on the introduction of chemicals, and whether they present any health problems to the community. If you consider the fact that chemicals in combination is a completely different concern, it is virtually impossible to determine safety levels to any satisfactory degree.

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New Blood Test Can Very Accurately Predict Recurrence of Breast Cancer Many Months Before Any Visible Signs

New Blood Test Can Very Accurately Predict Recurrence of Breast Cancer Many Months Before Any Visible Signs | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
7.9 months before any visible signs
Graham Player Ph.D.'s insight:

A study, published in the journal Science Translational Medicine, shows that it is possible to discover small numbers of residual cancer cells that have resisted therapy by detecting cancer DNA in the bloodstream.

Researchers took tumor and blood samples from 55 breast cancer patients with early-stage disease who had received chemotherapy followed by surgery, and who had potentially been cured of their disease.

By monitoring patients with blood tests taken after surgery and then every six months in follow-up, the researchers were able to predict very accurately who would suffer a relapse.

Women who tested positive for circulating tumor DNA were at 12 times the risk of relapse of those who tested negative, and the return of their cancer was detected an average of 7.9 months before any visible signs emerged.

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Cancer Cells Can be Re-Programmed to Become Normal Cells

Cancer Cells Can be Re-Programmed to Become Normal Cells | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

A team of scientists from Mayo Clinic in Florida have managed to reverse the progress of cancer by “reprogramming” its cells preventing further tumor growth.

Graham Player Ph.D.'s insight:

The mechanism behind how cancer cells become malignant has been the focus of many biological studies. Recent research done at the Department of Cancer Biology at Mayo Clinic's Florida campus has revealed a major step forward in further understanding this mechanism.

The process by which normal cells undergo the transition to become tumorigenic has become much clearer. This discovery could change the way we think about cancer progression and open up other avenues of consideration, confirmation and study.

Cells bind together as a normal part of the process of maintaining biological health and the integrity of organs, tissues and structures. The binding together is facilitated by adhesion molecules which are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix. In effect they act like glue to help cells stick to each other and to their surroundings. However it has been known for many years that these adhesion molecules also play another important signaling role.

Both the shape and the physiology of cancer cells are irregular in comparison to normal health cells. In cancer cells the adhesion molecules no longer form particular structures that enable cells to connect, and they signal by turning on or off certain microRNA molecules. These microRNAs are a recently discovered class of non-coding RNAs that play key roles in the regulation of gene expression which can result in alteration of the program of cell growth.

In normal cells the adhesion molecules regulate microRNAs and signal to inhibit cell growth. In cancer cells the absence of the adhesion molecules results in lack of microRNA signaling to inhibit cell growth. This leads to uncontrolled growth of the cancer cells.

The Mayo Clinic study identified the two key components of the adhesion structures and the microRNAs. One drives tumor progression and growth, and the other is acting in opposition by inhibiting that process. In the majority of tumor samples they found that the inhibition component is missing, while the component that drives tumor progression and growth remains active and unopposed.

The study also found that by reintroducing the deregulated microRNAs that inhibit cell growth into cancer cells, it had the effect of reprogramming the cancer cells to become normal cells again. This is a critical turning point in understanding the biology of cancer and how it may be therapeutically addressed.

The challenge that remains is to find the delivery method of introducing the deregulated microRNAs into the cancer cells to regulate the expression of the genes that will reprogram cancer cells to normal cells.

Another benefit of this research is that it may lead to more definitive diagnostic conclusions from biopsies in terms of identifying the presence of cancer. If deregulation of the adhesion signaling is found to be present, then it may determine the presence of cancer.

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Chance Of Getting Cancer For Second Time Rising In The U.S.

Chance Of Getting Cancer For Second Time Rising In The U.S. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Second cancers are on the rise. Nearly 1 in 5 new cases in the U.S. now involves someone who has had the disease before.
Graham Player Ph.D.'s insight:

Second cancers can arise from the same risk factors that may have caused the first one. So it makes sense to explore the likely root-causes of any cancer. If the causes are not addressed it is logical to assume the disease is likely to recur. Yet exploration of the causes does not seem to be part of the present medical model. 

Other causes of a second cancer diagnosis can of course be the very treatments that help people survive their first cancer, such as radiation.

With 20% of cancer cases today being those who have had the disease before, compared to only 9% in the 1970s, it is rapidly becoming a critical issue to address.

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More Than 4-Years Increase In Survival For Women With Ovarian Cancer.

More Than 4-Years Increase In Survival For Women With Ovarian Cancer. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
A common heart drug called a beta blocker was associated with a striking increase in survival for women with ovarian cancer in a study that suggests a possible new strategy for treating a variety of tumors.
Graham Player Ph.D.'s insight:

A study of 1,425 women with ovarian cancer found those who had taken a certain type of beta blocker lived more than four years longer on average than those who hadn’t been prescribed the drug.

The median survival for women not taking a beta blocker during chemotherapy was 42 months. Whereas the median survival for women taking a nonselective (first generation) beta blocker during chemotherapy was 94.9 months, effectively more than doubling their survival time.

Taking a selective (second generation) beta blocker during chemotherapy, or taking just any beta blocker, a common heart drug, during chemotherapy did not show any benefit. So the only benefit came from taking a nonselective (first generation) beta blocker.

The study authors recommend that people do not rush out and take beta blockers until further research is done. Beta blockers can have quite dangerous side-effects. As beta blockers are predominately generic drugs without patents, it is unlikely that drug companies would be willing to sponsor any research in this area. The ‘for-profit’ medical system business model does not support research without the potential for profit. So the only way forward in cases like this is from grants.

While this is an important observation in the treatment of cancer, it is an important reminder that our medical science does not have all the answers. The body still holds many surprises that the Newtonian science model of cause and effect will perhaps never be able to answer.

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Tiny Sensor Can Wirelessly Track Tumors

Tiny Sensor Can Wirelessly Track Tumors | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Scientists at MIT’s Koch Institute for Integrative Cancer Research have developed a tiny sensor that can be implanted in cancerous tissue during a biopsy. The sensor then measures predetermined biomarkers and wirelessly sends data to an external device, allowing physicians to adjust and monitor therapies accordingly.
Graham Player Ph.D.'s insight:

The sensor is based off findings that showed that cancer tissue sometimes becomes more acidic when it is under assault from chemotherapy. The sensor subsequently reads pH levels.

The sensor also measures dissolved oxygen. Tumors thrive in low-oxygen conditions, and the lower the oxygen, the more radiation that is needed. The sensors could allow doctors to adjust radiation levels depending on the oxygen levels in the tumor.

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Versatile Vitality's curator insight, August 10, 1:41 AM

The sensor is based off findings that showed that cancer tissue sometimes becomes more acidic when it is under assault from chemotherapy. The sensor subsequently reads pH levels.

The sensor also measures dissolved oxygen. Tumors thrive in low-oxygen conditions, and the lower the oxygen, the more radiation that is needed. The sensors could allow doctors to adjust radiation levels depending on the oxygen levels in the tumor.

SocialHx's curator insight, August 10, 9:58 AM

The sensor is based off findings that showed that cancer tissue sometimes becomes more acidic when it is under assault from chemotherapy. The sensor subsequently reads pH levels.

The sensor also measures dissolved oxygen. Tumors thrive in low-oxygen conditions, and the lower the oxygen, the more radiation that is needed. The sensors could allow doctors to adjust radiation levels depending on the oxygen levels in the tumor.

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How do medical dogs smell cancer?

How do medical dogs smell cancer? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Dogs that can sniff cancer have been approved for use in a trial by the NHS.
Graham Player Ph.D.'s insight:

A study showed specially trained dogs can detect prostate cancer in urine in 93% of cases.

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The Lifetime Accumulation Of the Mix Of Everyday Chemicals We Are Exposed To Contributes To Cancer.

Analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies.

Graham Player Ph.D.'s insight:

The World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) suggest that cancers due to toxic environmental exposures are between 7% and 19%. Scientists from within the chemical industry suggest the numbers are less at 5% or 10%.

The typical research done on the likelihood of chemicals to cause cancer, and the basis of these estimates, is focused on a single chemical. This is in keeping with today’s pharmaceutical and medical reductionist model where the emphasis is to find the one thing that works or the one thing that may cause disease. There is a body of literature that suggests this approach is flawed, yet it continues to be the standard.

For example, a chemical that disrupts DNA repair capacity might prove to be non-carcinogenic at any level of exposure (when tested on its own), but that very same chemical may have the potential to be an important contributor to carcinogenesis (e.g. in the presence of mutagens that cause DNA damage). Similarly, a chemical that has immuno-suppressive qualities may not be carcinogenic on its own, but if it acts to suppress the immune response, it may contribute to carcinogenesis (by dismantling an important layer of defense) in the presence of other disruptive chemicals.

Considering the multistep nature of cancer and it is clear how a series of complementary exposures to a mix of chemicals acting together might prove to be far more carcinogenic than predictions related to any single exposure might suggest.

A new report written by a team of international scientists from 28 countries reveals that low doses of chemicals considered safe on their own might cause cancer when mixed together. William Goodson III, MD, lead author of the report has suggested that we are swimming in a chemical soup and don’t know what it is doing to us.

Of the 80,000+ chemicals in use throughout the world the majority have not been tested for their effects on our health. Whether or not lifetime exposures to mixtures of non-carcinogenic chemicals in the environment (at low-dose levels) have carcinogenic potential, we don’t know. Many chemicals are known to accumulate in bodily tissues over time, but little is known about their combined effects and their impact on cancer-related mechanisms and carcinogenesis.

This latest report reviewed 85 examples of environmental chemicals and 59% of them were found to exert unanticipated low-dose effects. Clearly there is an issue here with the lifetime cumulative effects of a mix of chemicals that together influence genetic instability, chronic inflammation, and changes in cell-signaling, which all contribute to the growth of cancer. This could be the single most contributing factor to the high levels of cancer that we see today.

Here is the complete report from the study for anybody interested - http://m.carcin.oxfordjournals.org/content/36/Suppl_1/S254.full

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GcMaf as a Possible Cancer Therapy.

GcMaf has been shown to activate and restore the integrity of the macrophage immune cells which attack and destroy cancer cells.

Graham Player Ph.D.'s insight:

First some terminology – cytokines, lymphokines, macrophage activating factor (MAF), the GC protein, and nagalase.

Cytokines are a category of small proteins produced and released by a broad range of cells to signal and affect the behavior of other cells. They are important in response to cancer.

Lymphokines (a sub group of cytokines) are produced by the lymphocyte immune cells to direct the immune response.

Macrophage activating factor (MAFs) are lymphokines that control the expression of antigens on the surface of macrophages (white blood cells that destroy cancer cells), and one of their functions is to make macrophages become cytotoxic to tumors.

The GC protein is used by macrophages. The combination of the GC protein and Vitamin D in the body produces GcMaf (GC protein-derived macrophage activating factor). GcMaf has been shown to activate and restore the integrity of the macrophage immune cells which attack and destroy cancer cells.

Nagalase is an enzyme/protein produced by cancer cells and viruses, and its presence blocks the GC protein from attaching itself to vitamin D, and therefore inhibits the production of GcMaf which in turn weakens the immune response.

It is certainly feasible that nagalase testing and GcMaf therapy may have the potential to lead to the control and reduction of cancer. So is there any serious research taking place? The answer is yes it has been researched for the past 20+ years, particularly in Japan where it is used effectively today as a treatment protocol. The main person behind the research has been Dr. Nobuto Yamamoto from Japan. He spent a quarter of a century examining in minute detail the basic molecular biology and immunology supporting his discoveries.

Comments I have read about Dr. Yamamoto’s research are primarily focused on pointing out the flaws of his trials. Yet I don’t see anybody taking on the task of doing better trials. Instead the emphasis seems to be to shelve the entire concept.

Spending on cancer drugs is estimated to have reached $100 billion per year. That is certainly a major industry. The obvious risk that would put an end to that spending and to that industrial complex is if a cure for cancer was found. So it begs the question whether the cancer industrial complex is focused on finding a cure, or maintaining the status quo of manufacturing and selling drugs to extend life a few years. It would be nice to see some serious independent clinical trials taking place with GcMaf, rather than simply having people point out the faults in what has been done already by someone without the massive funding available to them.

All of this came to my attention as a result of the recent mysterious death of Dr. James Jeffrey Bradstreet in the USA. After some research I noticed that he was working with GcMaf and was raided by the FDA one week before he was mysteriously shot dead. I am not making any accusations, simply connecting some dots and following the money trail.

If you would like to know more about GcMaf there is a lot of information available. You may want to refer to the Saisei Mirai Clincs in Japan (http://www.saisei-mirai.or.jp/gan/macrophage_eng.html ) and this informative GcMaf book (http://gcmaf.timsmithmd.com/book/book/4/ )

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Cancer Patient Given 18 Months To Live. He Cured Himself of Cancer.

Cancer Patient Given 18 Months To Live. He Cured Himself of Cancer. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
At the age of 32, David Hibbitt of Staffordshire, UK, was diagnosed with cancer.
Graham Player Ph.D.'s insight:

This is another example of someone who decided to use cannabis oil  to cure himself of cancer, rather than depend on chemotherapy.

While the medical industry continues to say there is "no good evidence " or clinical trials that indicate cannabis oil cures cancer, many people continue to use it and to cure themselves.

If continued denials regarding cannabis oil from the orthodox medical industry persist, and yet patients continue to cure themselves, it will become a negative for the medical industry. Most patients would rather choose to do what is working, rather than what conveniently supports the medical industry and their processes.

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Patient with Rare Cancer for Which There is No Standard Treatment Available, Denied Insurance Coverage Due to Treatment Being Non-Standard. What a Strange World We Have Created!

Patient with Rare Cancer for Which There is No Standard Treatment Available, Denied Insurance Coverage Due to Treatment Being Non-Standard. What a Strange World We Have Created! | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

alveolar soft part sarcoma

Graham Player Ph.D.'s insight:

A patient with a rare cancer, alveolar soft part sarcoma, has been denied coverage by his insurer Blue Cross for the cost of chemotherapy drugs.

The denial is due to the fact that there is no standard of care for this particular cancer. Doctors have found an “off-label” solution, meaning that they are using a drug approved for another condition to treat the cancer. Yet Blue Cross will not pay for that “off-label” solution.

Most people would consider that their health insurance covers these life threatening situations. But evidently this is not the case.

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What Do We Do When Antibiotics Don’t Work Any More? Many Cancer Patients Would Likely Suffer the Consequences of Untreatable Infections!

What Do We Do When Antibiotics Don’t Work Any More?  Many Cancer Patients Would Likely Suffer the Consequences of Untreatable Infections! | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
What do we do when antibiotics don’t work any more
Graham Player Ph.D.'s insight:

Today we stand on the threshold of the post-antibiotic era. Our antibiotics have provided benefit to many in combatting bacterial infection, and provide critical support to contemporary life. But each time we develop an antibiotic, the bacteria simply develop resistance and we need another more powerful antibiotic to combat that resistance. The cycle has continued like this for the past 70 years.
- Penicillin arrived in 1945. Widespread resistance to penicillin was present by 1945.
- Vancomycin arrived in 1972. Widespread resistance to vancomycin arrived in 1988.
- Imepenim arrived in 1985. Widespread resistance to imepenin arrived in 1998.
- Daptomycin arrived in 2003. Widespread resistance to daptomycin arrived in 2004.

Today bacteria are able develop resistance to antibiotics so fast that pharmaceutical companies have concluded that development of antibiotics is not in their best interests. In the year 2000 an infection was found (KPC) in a single case in a North Carolina hospital that was resistant to all but two drugs. Today that same infection has been spread across the USA and is now in present all states except for only three.

In 2008 Swedish doctors diagnosed an Indian man with an infection that was resistant to all but one drug. The gene (known as NDM) that creates that resistance has now spread amongst the population to China, Africa, Asia, Europe, Canada and the US.

Such resistance is an inevitable biological process. Particularly when you consider that bacteria produce a new generation every 20 minutes, compared to 10 years for a pharmaceutical company to derive a new drug. Evolution always wins.

In the USA and Europe 50,000 people die each year of infections that no drugs can help. Worldwide that figure is 700,000, according to the conclusion of an investigative project organized by the British government (The Review of Antimicrobial Resistance). The review predicts that if we cannot bring this under control, then by 2050 the worldwide toll will be 10 million deaths per year.

If antibiotics are no longer available or effective there would likely be immediate catastrophic results at least for the following people:
- Those with weakened immune system function
- Cancer Patients
- AIDS patients
- Transplant recipients
- Pre-mature babies
- Those receiving surgical implants or replacement joints etc

A recent estimate concluded that without antibiotics, perhaps one out of every six patients with bacterial infections may die. Today many surgical operations are preceded by prophylactic doses of antibiotics. Without that protection, the risk of surgery would increase considerably, and surgery may no longer be an option in many situations.

We arrived at this point by our abuse and overuse of antibiotics. Penicillin was at first sold over the counter until the 1950s, and many antibiotics throughout the developing world are today available this way. In the USA it has been estimated that 50% of antibiotics given in hospitals are unnecessary, and that 45% of antibiotic prescriptions written in doctors’ clinics are for conditions that antibiotics cannot help.

Across the world most animals bred for their meat receive antibiotics every day of their lives. In the USA 80% of antibiotics sold every year are for farm animals, not humans. This contributes to the creation of resistant bacteria that move off the farm and into our society. Aquaculture and fruit growing relies on antibiotics against disease too.

This dire situation was predicted by Sir Alexander Fleming, the man who invented penicillin. Yet his prediction was ignored in the interests of ‘progress’. Every time we use an antibiotic we give the bacteria billions of chances to crack the code against the defenses we have constructed.

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Doctors Fail to Listen to Pleas of Teenage Girl Convinced She Had Cancer. She Subsequently Dies of Cancer.

Doctors Fail to Listen to Pleas of Teenage Girl Convinced She Had Cancer. She Subsequently Dies of Cancer. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Bronte Doyne’s death from cancer after she was told to stop googling her symptoms raises questions about the doctor-patient relationship
Graham Player Ph.D.'s insight:

It is disheartening to learn that there are doctors who do not listen to their patients. Many doctors cling to the doctor-patient power relationship and choose to be aloof and evasive in communications with their patients.

Here is an example of such a relationship that turned out to be a contributing factor to the death of a young teenage girl, Bronte Doyne. Bronte begged doctors to listen to her as she was convinced she had liver cancer, based on her own online research. In her case she died 16 months after being told she would survive.

Another worrying aspect of the medical system is that there is very little accountability on the part of the doctors. In contrast if a garage mechanic did not fix a customer’s car there is indeed obvious accountability. However sometimes patients may even lose their life as a result of lack of care and attention from a doctor and there is no accountability. Doctors are well protected by the system that they are part of.

Medical information today is freely and quickly available online to anybody who wishes to look for it. Yes there are always questionable sources and incomplete details, but there are also very highly regarded organizations with well researched a complete information available online. So the knowledge is there for anybody. While doctors may not like their patients to have access to information and knowledge, it is a fact of contemporary society. Therefore doctors must learn how to work with informed patients in today’s society.

One obvious conclusion is that we can all now possess the information and knowledge. But perhaps the doctor’s real differentiator is the interpretation of that knowledge in the context of the patient and their symptoms. Health services typically support greater patient involvement as critical to making healthcare sustainable, with greater self-management of long-term conditions and improved understanding of prevention and risk.

However it would seem that some doctors may not have thought through the most effective way for them to deal with informed patients.

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