Cancer - Advances, Knowledge, Integrative & Holistic Treatments
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Cancer - Advances, Knowledge, Integrative & Holistic Treatments
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Diet Contributes to 20% to 42% of All Human Cancers and 50% to 90% of Colon Cancer

Diet Contributes to 20% to 42% of All Human Cancers and 50% to 90% of Colon Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
A hidden lesson here may be that instead of waiting until after one is diagnosed with a serious health condition such as colon cancer it would make sense to incorporate smaller, culinary doses of these beneficial compounds on a daily basis as a food-as-preventive-medicine approach
Graham Player Ph.D.'s insight:

It would behoove medical professionals and their patients to take seriously this preliminary research by using non-toxic dietary modifications and/or therapeutic concentrations of these bio-active food ingredients early on as a preventive medicine strategy.

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Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma

Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die. Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.

Graham Player Ph.D.'s insight:

The culprit in sparking many cancers, particularly mesothelioma, is the intracellular protein and transcription factor STAT3 (signal transducer and activator of transcription 3). A signal transducer and activator is a pathway for instructing the growth and survival of cells, and a transcription factor is a protein that controls genetic information directing cells how to perform. STAT3 is notorious for sending signals to trigger the onset of human cancers and to fuel their continued growth.

The great neutralizer of STAT3 is PIAS3 (protein inhibitor of activated STAT3). PIAS3 possesses the strength to inhibit and block STAT3's ability to cause cancer. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrated that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die.

Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.

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Curcumin and Cancer Cells - A Preventative and Treatment.

Curcumin and Cancer Cells - A Preventative and Treatment. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
more than 40 biomolecules that are involved in cell death induced by curcumin
Graham Player Ph.D.'s insight:

I choose to report this more as a reminder than a new discovery. All too often traditional approaches that seem to work in combatting disease get passed over in favor of the profitable patented man-made drugs. But in this case we should not let that happen, and should continue to be mindful of this amazing natural compound.

Cancer is usually treated by chemotherapeutic agents that are toxic not only to tumor cells but also to normal cells. These chemotherapeutic agents typically produce major side effects, are very expensive, and are not considered candidates for cancer prevention.

On the other hand traditional medicines are generally free of the deleterious side effects, are usually inexpensive, and are often used in many cultures to promote health and prevent all types of disease including cancer.

Curcumin, a component of turmeric, is one of the traditional foods that has been consumed for thousands of years across Asia, and is regarded by many of the traditional cultures as an important medicine in maintaining health. Curcumin has been shown to inhibit the proliferation and survival of almost all types of tumor cells. Many studies indicate the selective role of curcumin towards cancer cells than normal cells.

It has a diverse range of molecular targets, supporting the concept that it acts upon numerous biochemical and molecular cascades. Curcumin physically binds to as many as 33 different proteins, including thioredoxin reductase, cyclooxygenase-2, (COX2), protein kinase C, 5-lipoxygenase (5-LOX), and tubulin. Various molecular targets modulated by this agent include transcription factors, growth factors and their receptors, cytokines, enzymes, and genes regulating cell proliferation, and apoptosis. There are more than 40 biomolecules that are involved in cell death induced by curcumin.

Curcumin seems to be universally useful for almost every type of cancer, and has the ability to modulate genetic activity and expression—both by destroying cancer cells and promoting healthy cell function.

If you wish to learn more about this please look at the research article I have shown here (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758121/), as well as the considerable information freely available by searching the subject.

I have also written about curcumin before here - http://www.scoop.it/t/cancer-advances-knowledge-integrative-holistic-treatments?q=curcumin

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Troy Sing's comment, June 16, 2015 1:08 AM
Tumeric is such a great herb !
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Curcumin Stops Spread of Prostate Cancer

Curcumin Stops Spread of Prostate Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Graham Player Ph.D.'s insight:

A research team led by PD Dr. Beatrice Bachmeier at Ludwig Maximilians University in Munich found that curcumin, an ingredient of the Indian spice Turmeric, stops the formation of metastases in prostate cancer patients - http://www.en.uni-muenchen.de/news/newsarchiv/2012/bachmeier.html

Dr. Robert Wascher, MD, a surgical oncologist from California, suggests that consuming turmeric may be enough to prevent and cure pancreatic cancer - http://www.naturalnews.com/033992_turmeric_pancreatic_cancer.html#ixzz2Q2ZaZWwV.

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