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Aspirin May Double Life Expectancy for Patients With Gastrointestinal Tract Cancers.

Aspirin May Double Life Expectancy for Patients With Gastrointestinal Tract Cancers. | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Aspirin 'may double life expectancy of cancer patients'
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A study of 14,000 cancer patients in the Netherlands found that regular users of aspirin were twice as likely to still be alive after a four-year period as those who did not take the cheap drug. The most common tumor sites for patients in the study were the colon, rectum and esophagus.

The study concludes that a daily dose of aspirin can double the life expectancy of patients with cancers affecting the gastrointestinal tract.

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How NSAIDs Initiate Suicide of Intestinal Cells That May Become Cancerous

How NSAIDs Initiate Suicide of Intestinal Cells That May Become Cancerous | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
team found that NSAIDs activate the "death receptor pathway." This means that the drugs initiate suicide in intestinal stem cells that have a mutation in the APC gene.

The APC mutation makes these genes dysfunctional. Cells affected by the mutation can potentially develop into precancerous polyps and tumors. Although cells that have a mutation in the APC gene are targeted by NSAIDs, healthy cells with the non-mutated gene are unaffected.
Graham Player Ph.D.'s insight:

It has been known for some time that nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, lower the risk of developing intestinal polyps, which can develop into cancer. However, it has not been understood how NSAIDs may reduce this cancer risk.

A study done by Lin Zhang, PhD, associate professor of the Department of Pharmacology and Chemical Biology at the Pitt School of Medicine and the University of Pittsburgh Cancer Institute has highlighted how the preventative effect from NSAIDs may happen.

The research team found that NSAIDs activate the "death receptor pathway." This means that the drugs initiate suicide in intestinal stem cells that have a mutation in the APC (adenomatous polyposis coli) gene. The APC mutation makes these genes dysfunctional, and cells affected by the mutation can potentially develop into precancerous polyps and tumors. Although cells that have a mutation in the APC gene are targeted by NSAIDs, healthy cells with the non-mutated gene are unaffected.

The research was published online in the Proceedings of the National Academy of Sciences - http://www.pnas.org/content/early/2014/10/29/1415178111.abstract

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Daily Aspirin May Reduce Risk of Cancer

Daily Aspirin May Reduce Risk of Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Daily pill for middle-aged could save 130,000 lives over 20 years in Britain alone, scientists suggest
Graham Player Ph.D.'s insight:

A research team led by Professor Jack Cuzick, head of the centre for cancer prevention at Queen Mary University of London, concluded that people between 50 and 65 should consider regularly taking daily aspirin to reduce cancer risk.

Cuzick said that taking aspirin "looks to be the most important thing we can do to reduce cancer after stopping smoking and reducing obesity, and will probably be much easier to implement". However, to obtain the newfound benefits of the drug, people would have to take aspirin for at least five years and probably ten, the review said.

Cuzick's team, writing in the cancer journal Annals of Oncology, said that by taking low-dose aspirin every day for ten years, bowel cancer cases could be cut by about 35% and deaths by 40%. Aspirin could reduce rates of oesophageal and stomach cancers by 30% and deaths from them by 35% to 50%.

Taking aspirin every day increases the risk of stomach bleeds. Aspirin is already given to some people to reduce their risk of heart attacks or ischemic stroke, caused by blood clots, which it does by thinning the blood. But it is likely to worsen a haemorrhagic stroke, caused by bleeding in the brain.

It is believed that aspirin may reduce the risk of cancer due to its ability to reduce inflammation, and by thinning the blood thereby making it more difficult for cancer cells to adhere to blood platelets.

You can also read more about aspirin in a recent Consumer Update published at the FDA’s own website – http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm390539.htm , where they state – “after carefully examining scientific data from major studies, FDA has concluded that the data do not support the use of aspirin as a preventive medication by people who have not had a heart attack, stroke or cardiovascular problems, a use that is called "primary prevention." In such people, the benefit has not been established but risks—such as dangerous bleeding into the brain or stomach—are still present.”

As with any medication it is important to do your own further investigation, consult with your chosen health professional, and bear in mind that adding any medication to an unhealthy lifestyle and diet still results in an unhealthy lifestyle and diet. Always make decisions only after you have become well-informed.

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Doctors Suggest An Aspirin Daily to Prevent Cancer

Doctors Suggest An Aspirin Daily to Prevent Cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
The new guidelines affect people aged 50-69 with elevated heart disease risk.
Graham Player Ph.D.'s insight:

An expert panel, United States Preventive Services Task Force, is recommending daily aspirin to prevent heart attacks, stroke, and colorectal cancer.

An independent group of physicians appointed by the Department of Health and Human Services suggested adults between 50-69 years old and at an elevated risk for heart disease take a low-dose aspirin daily.

The recommendation goes on to say that those in the next age bracket of 60-69 with a high risk for heart disease consider taking a lower dosage amount, as the risk of stomach and brain bleeding—common side effects of aspirin intake—increase with age.

There is no recommendation for aspirin intake listed for those under 50 or those above 70.

This is the first time a prominent American medical association has issued a recommendation to take aspirin to prevent cancer. It follows a growing body of research that shows that aspirin may be more powerful in the fight against cancer than originally thought.

 

Over the past 2-years I have written about a dozen articles on aspirin and cancer. So if you want to learn more about it see this link which will show you all those articles - http://www.scoop.it/t/cancer-advances-knowledge-integrative-holistic-treatments?q=ASPIRIN

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Low Dose Aspirin Reduces Cancer Risk

Low Dose Aspirin Reduces Cancer Risk | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
The researchers also found that by blocking platelet COX-1, aspirin inhibits the adherence of platelets to the cancer cells to prevent metastasis, suggesting that the two mechanisms described act in concert to reduce the risk for cancer mortality.
Graham Player Ph.D.'s insight:

Studies have shown that aspirin administration for five or more years reduces the incidence of all cancers by 38% by inhibiting the COX-1 pathway, according to Pierre Massion, MD, professor of medicine and cancer biology in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee.

 

In a new study, Massion and his colleagues found that the potency of low-dose aspirin in inhibiting COX-2 in the tumor cells is as great as or greater than its potency as an inhibitor of COX-1 in the platelet.

 

The researchers also found that by blocking platelet COX-1, aspirin inhibits the adherence of platelets to the cancer cells to prevent metastasis, suggesting that the two mechanisms described act in concert to reduce the risk for cancer mortality.

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Aspirin May Extend Lives and Prevent Metastasis of Colorectal Cancer Patients

Aspirin May Extend Lives and Prevent Metastasis of Colorectal Cancer Patients | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Researchers found that aspirin can improve outcomes in colon cancer patients.
Graham Player Ph.D.'s insight:

Patients with colon cancer could extend their lives by regularly using aspirin, according to a study of the tissue of 999 patients with colon cancer who had received surgery between 2002 and 2008.

Aspirin-associated survival was strongest in patients with HLA I antigen expression. Researchers are not sure about the molecular reasoning behind the improved survival rate, but it could have to do with aspirin's effect on "circulating tumor cells and their ability to develop into metastatic deposits," the news release reported. In contrast, in patients whose tumors had lost their HLA class I antigen expression, aspirin use did not change the outcome.

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