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Harmless Virus is Able to Kill Triple Negative Breast Cancer Cells

Harmless Virus is Able to Kill Triple Negative Breast Cancer Cells | Breast Cancer News | Scoop.it

"Scientists at the Penn State College of Medicine have discovered that a virus that is harmless to humans will kill triple-negative breast cancer cells and tumour cells in mice when applied to cancers.

Breast cancer is the leading cause of cancer death in women in the world, and triple-negative breast cancer is the hardest type of breast cancer to treat.

Some types of tumours contain protein receptors that are activated by one of three proteins – namely the human epidermal growth factor receptor 2 (HER2), the hormone oestrogen or the hormone progesterone.

Chemotherapies usually target one of these three receptors, but since triple-negative cancers do not express these genes, doctors have to treat them with a combination of therapies.

"Treatment of breast cancer remains difficult because there are multiple signalling pathways that promote tumour growth and develop resistance to treatment," said Craig Meyers, a professor of Microbiology and Immunology at Penn State.

"There is an urgent and ongoing need for the development of novel therapies which efficiently target triple-negative breast cancers."

Susan Zager's insight:

Even though this is an early study in mice, any study that helps triple negative breast cancer is worthy of attention. To see the study got to: https://www.landesbioscience.com/journals/cbt/article/29172/


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Get Involved | World Cancer Day

Get Involved | World Cancer Day | Breast Cancer News | Scoop.it
"World Cancer Day is a day to collectively raise our voices and push for greater awareness, actively implement what we know in the areas of prevention, early detection, treatment and care and to push governments [...]...
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Today id World Cancer Day. Here's information about getting involved.
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Drug Shortages Forcing Hard Decisions on Rationing Treatments

Drug Shortages Forcing Hard Decisions on Rationing Treatments | Breast Cancer News | Scoop.it
Such shortages are the new normal in American medicine. But the rationing that results has been largely hidden from patients and the public.
Susan Zager's insight:

Great Article by Sheri Fink referencing drug shortages including chemotherapy drugs. 

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Biden staff asks cancer researchers for quick 'moonshot' ideas

Biden staff asks cancer researchers for quick 'moonshot' ideas | Breast Cancer News | Scoop.it
The meeting shows he's aware that he's running out of time to make a big impact on cancer.
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Breast Cancer Patient Protesting Big Pharma’s ‘Death Sentence’ Arrested Outside TPP Talks

Breast Cancer Patient Protesting Big Pharma’s ‘Death Sentence’ Arrested Outside TPP Talks | Breast Cancer News | Scoop.it
Breast cancer patient Zahara Heckscher was arrested for going against the Trans-Pacific Partnership, a deal that would hurt many cancer patients.
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2015 San Antonio Breast Cancer Symposium #SABCS15

2015 San Antonio Breast Cancer Symposium #SABCS15 | Breast Cancer News | Scoop.it

"Coverage of the 2015 San Antonio Breast Cancer Symposium"

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Here's a great range of articles  and videos that summarize much of the latest news from the (San Antonio Breast Cancer Symposium) #SABCS15 all in one place.

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When Mother and Daughter Both Have Breast Cancer

When Mother and Daughter Both Have Breast Cancer | Breast Cancer News | Scoop.it
A Seattle mother and her daughter both have breast cancer. They support each other through arduous treatments and the pain of watching a loved one suffer.
Susan Zager's insight:

Great Article by Sumathi Reddy about Beth Caldwell and her mom Colleen ‘Susi’ Stevens  supporting each other while both are going through breast cancer treatment. I am so lucky that I am with Beth at the San Antonio Breast Cancer Symposium and I can't wait to blog more about this incredible experience.

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S.A. congressman investigating prescription costs

S.A. congressman investigating prescription costs | Breast Cancer News | Scoop.it

WASHINGTON — Citing Texans’ complaints of soaring prescription costs, U.S. Rep. Lloyd Doggett is leading an effort in Congress seeking causes and remedies. Doggett, D-Austin, has formed an entity called the Prescription Drug Pricing Task Force, and one of the initial efforts is pressuring the Obama administration to use its authority to stem an ongoing rise in the costs of pharmaceuticals. [...] Doggett and allies point to price boosts for many drugs, evidenced in a government study last week showing a 12.2 percent increase last year in prescription drug spending. Leigh Purvis, director of Health Services Research at AARP's Public Policy Institute, has been studying drug pricing since 2004. In a bipartisan investigation, the Senate Finance Committee released emails last week showing that executives of California-based Gilead Sciences were keenly aware of potential public outrage when they set the $84,000 cost for a 12-week treatment of Sovaldi, a potent new drug for hepatitis C. [...] the Senate’s bipartisan Special Committee on Aging is investigating the decision by Turing Pharmaceuticals, formed recently by hedge fund manager Martin Shkreli, to raise the price of the anti-infection drug Daraprim by 5,000 percent.."

Susan Zager's insight:

Soaring costs of prescription medication is very alarming.

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These Cancer Drugs Cause The Worst ‘Chemobrain’

These Cancer Drugs Cause The Worst ‘Chemobrain’ | Breast Cancer News | Scoop.it
Study suggests patients may want to be wary of chemotherapy treatment that’s been found to cause more cognitive damage.
Susan Zager's insight:

To see the study in Jama Oncology go to: http://oncology.jamanetwork.com/article.aspx?articleid=2473507


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Hospitals Form Patient Advisory Councils to Learn How They Can Improve Care

Hospitals Form Patient Advisory Councils to Learn How They Can Improve Care | Breast Cancer News | Scoop.it
The panels work on projects and policies along with hospital staff—and may help hospitals score higher in measures of patient satisfaction.
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Parabens in Shampoo and Body Lotions Linked to Breast Cancer - EmaxHealth

Parabens in Shampoo and Body Lotions Linked to Breast Cancer - EmaxHealth | Breast Cancer News | Scoop.it
Parabens are commonly used in cosmetics and personal care items to protect again
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Why this Dana-Farber Cancer Institute oncologist says less is more for breast cancer treatment

Why this Dana-Farber Cancer Institute oncologist says less is more for breast cancer treatment | Breast Cancer News | Scoop.it
Dr. Craig Bunnell with Dana-Farber discusses where breast cancer treatments are headed, and the biggest obstacle to progress.
Susan Zager's insight:
Why this Dana-Farber Cancer Institute oncologist says less is more for breast cancer treatment

Chemotherapy and radiation may eventually be treatments of the past"(We’ve) discovered what it was that allows us to turn the immune system back on around those cancers. If I look to the future…it will be this targeted approach and the ability to help modify or improve our own immune systems to be able to fight the cancers in the future.

And in the future, I imagine chemo and radiation being treatments of the past. I won't say we … will look at them as ancient therapies…But I really do think this sort of Star Trek approach is not something that’s so far fetched. I think in my lifetime, for many cancers, chemo and radiation will be therapies of the past."

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Without prescription coverage, some cancer patients do without even low-cost drugs

"A University of Colorado Cancer Center study published in the journal Breast Cancer Research and Treatment shows that breast cancer patients whose health insurance plans included prescription drug benefits were 10 percent more likely to start important hormonal therapy than patients who did not have prescription drug coverage. Women with household income below $40,000 were less than half as likely as women with annual household income greater than $70,000 to continue hormonal therapy. Hormonal therapy for patients with estrogen- or progesterone-positive breast cancers can reduce the risk of cancer recurrence by as much as 50 percent."

Susan Zager's insight:

To see the original study go to: http://link.springer.com/article/10.1007%2Fs10549-015-3630-x


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Drugmakers explore response to pricing debate

Drugmakers explore response to pricing debate | Breast Cancer News | Scoop.it
Some pharma companies are taking steps to address concerns about the high prices of drugs at a time when Democratic lawmakers are urging price controls.
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Seattle woman who said she was cancer survivor never had it

Seattle woman who said she was cancer survivor never had it | Breast Cancer News | Scoop.it
A Seattle woman who said she survived breast cancer three times and helped raise over $400,000 for charity never had cancer.
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This is horrible.

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If You Really Want to Help Cancer Research, Don't Give Money to the NFL | Broadly

If You Really Want to Help Cancer Research, Don't Give Money to the NFL | Broadly | Breast Cancer News | Scoop.it
Despite the National Football League's contributions to the American Cancer Society through its official "Crucial Catch" campaign, data shows the league doesn't prioritize much besides its own corporate interests.
Susan Zager's insight:

Thank you Gayle for this important article.

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F.D.A. Regulator, Widowed by Cancer, Helps Speed Drug Approval

F.D.A. Regulator, Widowed by Cancer, Helps Speed Drug Approval | Breast Cancer News | Scoop.it
Dr. Richard Pazdur, the Food and Drug Administration’s oncology chief, says his wife’s ordeal was influential in a change that many had advocated but that critics say erodes safeguards.
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Hope in the Face of Death: Living With Metastatic Breast Cancer

Hope in the Face of Death: Living With Metastatic Breast Cancer | Breast Cancer News | Scoop.it

"In this issue of CURE magazine, we review the current approaches for the evaluation and treatment of metastatic breast cancer, and what the future holds. In some sense, the future is now, because much of what is going on in laboratories as part of research programs is being translated into clinical trials that are currently ongoing. The last decade has witnessed the introduction of next-generation gene sequencing and other technologies that have shown us that every cancer case is truly unique in the abnormalities that are carried in cancer cells, and that many of these alterations are “drivers” that make cancer grow and spread in an uncontrolled fashion. We have also learned that there are even differences between the cells within an individual tumor, leading to the emergence of resistance to drugs that may be initially effective."

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What's your cancer color?

What's your cancer color? | Breast Cancer News | Scoop.it
Nearly 30 cancer types have inspired a growing collage of hues and patterns. Many people wear their shade proudly to represent their own disease or back a loved one. Others fear the river of colors represents unneeded divisions.
Susan Zager's insight:
Article by By Bill Briggs discussing awareness of cancer colors including the overwhelming pink ribbon. Included in the article are insights by Beth Caldwell and the Breast Cancer Consortium.
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SABCS15: 'Weeding the garden' with radiation while continuing breast cancer therapy

SABCS15: 'Weeding the garden' with radiation while continuing breast cancer therapy | Breast Cancer News | Scoop.it
An ongoing phase IIR/III clinical trial presented at the 2015 San Antonio Breast Cancer Symposium seeks to answer an important question in the treatment of early metastatic breast cancer: Should surgery or stereotactic body radiation be used to 'weed the garden' of a few sites of metastasis while continuing treatment that may still be controlling the initial tumor?
Susan Zager's insight:

To see the study go to: http://www.abstracts2view.com/sabcs15/view.php?nu=SABCS15L_1306


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What's Cool at the San Antonio Breast Cancer Symposium

What's Cool at the San Antonio Breast Cancer Symposium | Breast Cancer News | Scoop.it

"There is "no real blockbuster study" at next week's San Antonio Breast Cancer Symposium (SABCS), but there are a multitude of presentations that will potentially expand clinical understanding and improve care, said C. Kent Osborne, MD, director of the Dan L. Duncan Comprehensive Cancer Center at the Baylor College of Medicine in Houston.

He would know. Dr Osborne, who is a long-time breast cancer specialist, has been involved with the meeting since 1978 and, as he has been since 1992, is a director of the gathering again this year.

This year's meeting will feature notable studies on chemotherapy combinations for HER2-positive disease, targeted therapy for metastatic disease with a specific mutation, long-term outcomes of different surgeries for early-stage cancers, and the first-ever trial of a RANKL inhibitor as an adjuvant treatment for breast cancer in postmenopausal women."

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Increased Cancer Risk Seen After False-Positive Mammograms

Increased Cancer Risk Seen After False-Positive Mammograms | Breast Cancer News | Scoop.it

"Women with positive mammography screens ultimately judged to be false were still at significantly increased likelihood for developing invasive breast cancer within the next 10 years, a study involving 1.3 million women showed.

The 10-year breast cancer risk was higher by 39% in women who had false-positive mammograms and additional breast imaging as compared with women who had true-negative mammograms, Louise M. Henderson, PhD, of the University of North Carolina Lineberger Comprehensive Cancer Center in Chapel Hill, and co-authors reported in the December issue of Cancer Epidemiology, Biomarkers & Prevention."

Susan Zager's insight:

After the new guidelines from the ACS in reference to mammograms comes this study about false-positives indicating odds of developing invasive breast cancer. To see the study go to: http://cebp.aacrjournals.org/content/early/2015/11/09/1055-9965.EPI-15-0623.abstract

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Desiree Walker: Embracing Advocacy on my Breast Cancer Journey

Desiree Walker:  Embracing Advocacy on my Breast Cancer Journey | Breast Cancer News | Scoop.it
I am alive today because of a research grant funded by the Department of Defense Breast Cancer Research Program (DoD BCRP) to Dr. Dennis Slamon. That groundbreaking research led to the development of my personal miracle drug: Herceptin.
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Patients With Advanced Breast Cancer Address an International Conference About Misleading DiseaseSpecific Messages

Patients With Advanced Breast Cancer Address an International Conference About Misleading DiseaseSpecific Messages | Breast Cancer News | Scoop.it
Patients with advanced breast cancer spoke out about the damaging messages some organizations issue about advanced breast cancer. They need to be identified and educated to change the way they talk about the disease.
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What's New in Research for ER+ Metastatic Breast Cancer

Nikhil Wagle, MD, discusses new research and how it is leading the way toward improved treatments for ER+ metastatic breast cancer."

Susan Zager's insight:

For more information go to: www. MBCProject.org

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Cells Have A Death Clock, And It Can Predict Cancer

Cells Have A Death Clock, And It Can Predict Cancer | Breast Cancer News | Scoop.it

"Scientists discover ticking clock in cells that count down to cancer, and how quickly humans age.

Inside each of us is a clock that counts down to how fast we'll age and whether or not any genetic mutations will develop into cancer someday. Researchers from the Wellcome Trust Sanger Institute in Cambridge, UK, have discovered two different mutations that accumulate at a constant rate, similar to a ticking clock. The study, published in the journal Nature Genetics, is the first to identify these "death clocks" in nearly every cell in the human body.


Susan Zager's insight:

To see the study go to: http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3441.html

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