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Unique clinicopathological features of metaplastic breast carcinoma compared with invasive ductal carcinoma and poor prognostic indicators

Unique clinicopathological features of metaplastic breast carcinoma compared with invasive ductal carcinoma and poor prognostic indicators | Breast Cancer News | Scoop.it

Abstract

Background

Metaplastic breast carcinoma is a rare aggressive malignant neoplasm. The purposes of this study are to review the pathologic features and clinical outcomes of metaplastic breast carcinoma compared to invasive ductal carcinoma and to evaluate the prognosis of metaplastic breast carcinoma.

Methods

The cases of 55 patients with metaplastic breast carcinomapresenting between 1991 and 2006 were analyzed and compared to the cases of 767 age-matched patients with invasive ductal carcinoma from the same time period.

Results

The group of patients with metaplastic breast carcinoma presented with a larger tumor size, lower lymph node involvement, higher percentage of triple-negative (estrogen receptor-, progesterone receptor- and human epidermal growth factor receptor-2-negative) cases, and Ki-67 over-expression compared with the group of patients with invasive ductal carcinoma and triple-negative invasive ductal carcinomas. Patients in the metaplastic breast carcinoma group tended to have more local (often chest wall) recurrences (P = 0.038) and distant (often lung) metastases (P = 0.001) than those in the invasive ductal carcinomas group. The prognosis of metaplastic breast carcinoma was poorer than that of invasive ductal carcinoma and triple-negative invasive ductal carcinomas; the 5-year overall survival rate was 54.5% in metaplastic breast carcinoma versus 85.1% in invasive ductal carcinoma, and 73.3% in triple-negative invasive ductal carcinomas (P <0.001). The 5-year disease-free survival rate was 45.5% in metaplastic breast carcinoma versus 71.2% in invasive ductal carcinoma, and 60.3% in triple-negative invasive ductal carcinomas (P <0.001). Multivariate analysis revealed tumor size larger than 5.0 cm, lymph node involvement and Ki-67≥14% were significantly related to 5-year overall survival (P = 0.010; P = 0.010; P = 0.035) and 5-year disease-free survival (P = 0.020; P = 0.018; P = 0.049).       

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Conclusions:

MBC had distinct clinicopathological features, which include a larger tumor size at presentation, higher Ki-67proliferation index, and a higher proportion of ER-negative and/or PR-negative tumors compared to IDC and TN-IDC. Our study demonstrated that MBC was an extremely aggressive disease and showed poorer prognosis compared with general IDC and TN-IDC. We found that better systemic treatment was required to prevent recurrence. Poor prognostic indicators for MBC include a tumor size larger than 5.0 cm, lymph node involvement and Ki-67 ≥14%.


For more information about Metaplastic Breast Cancer read the full abstract and go to: http://www.metaplasticbc.com/

      

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He lost his wife to metastatic breast cancer: Letters

He lost his wife to metastatic breast cancer: Letters | Breast Cancer News | Scoop.it

"Elevate attention to metastatic cancer On Jan. 29, a bill designating February as Metastatic Breast Cancer Awareness Month was signed into Florida law. To date, MBC had only one day obscurely embedded within October's "early stage" Breast Cancer awareness month.

More than 60 percent of Americans claim little or no knowledge about metastatic breast cancer. This is a brutal, insidious and lethal disease claiming more than 110 lives every day in this country. MBC patients, both women and men, and their loved ones are all too aware of metastatic cancer and its accompanying draconian medical treatments and grim prognoses.

My beautiful, vivacious and beloved wife, Diana, who served 30 years defending her country and was one of the first women on Navy ships in the 1970s, fought her MBC with that same courage, fortitude and faith. She lost her valiant battle. Cancer spread to her bones and vital organs, despite the myriad surgeries, radiation and chemotherapy treatments.

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This should be added to many more states.

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Through love, even in death, Louisville woman defeated breast cancer

Through love, even in death, Louisville woman defeated breast cancer | Breast Cancer News | Scoop.it
Family and friends say goodbye to a cancer warrior who never let the disease define her.
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Sad to know she is gone. While there's lots of battle language it appears this was her family expressing their loving thoughts.
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Seattle woman who said she was cancer survivor never had it

Seattle woman who said she was cancer survivor never had it | Breast Cancer News | Scoop.it
A Seattle woman who said she survived breast cancer three times and helped raise over $400,000 for charity never had cancer.
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This is horrible.

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If You Really Want to Help Cancer Research, Don't Give Money to the NFL | Broadly

If You Really Want to Help Cancer Research, Don't Give Money to the NFL | Broadly | Breast Cancer News | Scoop.it
Despite the National Football League's contributions to the American Cancer Society through its official "Crucial Catch" campaign, data shows the league doesn't prioritize much besides its own corporate interests.
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Thank you Gayle for this important article.

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F.D.A. Regulator, Widowed by Cancer, Helps Speed Drug Approval

F.D.A. Regulator, Widowed by Cancer, Helps Speed Drug Approval | Breast Cancer News | Scoop.it
Dr. Richard Pazdur, the Food and Drug Administration’s oncology chief, says his wife’s ordeal was influential in a change that many had advocated but that critics say erodes safeguards.
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Hope in the Face of Death: Living With Metastatic Breast Cancer

Hope in the Face of Death: Living With Metastatic Breast Cancer | Breast Cancer News | Scoop.it

"In this issue of CURE magazine, we review the current approaches for the evaluation and treatment of metastatic breast cancer, and what the future holds. In some sense, the future is now, because much of what is going on in laboratories as part of research programs is being translated into clinical trials that are currently ongoing. The last decade has witnessed the introduction of next-generation gene sequencing and other technologies that have shown us that every cancer case is truly unique in the abnormalities that are carried in cancer cells, and that many of these alterations are “drivers” that make cancer grow and spread in an uncontrolled fashion. We have also learned that there are even differences between the cells within an individual tumor, leading to the emergence of resistance to drugs that may be initially effective."

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What's your cancer color?

What's your cancer color? | Breast Cancer News | Scoop.it
Nearly 30 cancer types have inspired a growing collage of hues and patterns. Many people wear their shade proudly to represent their own disease or back a loved one. Others fear the river of colors represents unneeded divisions.
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Article by By Bill Briggs discussing awareness of cancer colors including the overwhelming pink ribbon. Included in the article are insights by Beth Caldwell and the Breast Cancer Consortium.
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SABCS15: 'Weeding the garden' with radiation while continuing breast cancer therapy

SABCS15: 'Weeding the garden' with radiation while continuing breast cancer therapy | Breast Cancer News | Scoop.it
An ongoing phase IIR/III clinical trial presented at the 2015 San Antonio Breast Cancer Symposium seeks to answer an important question in the treatment of early metastatic breast cancer: Should surgery or stereotactic body radiation be used to 'weed the garden' of a few sites of metastasis while continuing treatment that may still be controlling the initial tumor?
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To see the study go to: http://www.abstracts2view.com/sabcs15/view.php?nu=SABCS15L_1306


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What's Cool at the San Antonio Breast Cancer Symposium

What's Cool at the San Antonio Breast Cancer Symposium | Breast Cancer News | Scoop.it

"There is "no real blockbuster study" at next week's San Antonio Breast Cancer Symposium (SABCS), but there are a multitude of presentations that will potentially expand clinical understanding and improve care, said C. Kent Osborne, MD, director of the Dan L. Duncan Comprehensive Cancer Center at the Baylor College of Medicine in Houston.

He would know. Dr Osborne, who is a long-time breast cancer specialist, has been involved with the meeting since 1978 and, as he has been since 1992, is a director of the gathering again this year.

This year's meeting will feature notable studies on chemotherapy combinations for HER2-positive disease, targeted therapy for metastatic disease with a specific mutation, long-term outcomes of different surgeries for early-stage cancers, and the first-ever trial of a RANKL inhibitor as an adjuvant treatment for breast cancer in postmenopausal women."

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Increased Cancer Risk Seen After False-Positive Mammograms

Increased Cancer Risk Seen After False-Positive Mammograms | Breast Cancer News | Scoop.it

"Women with positive mammography screens ultimately judged to be false were still at significantly increased likelihood for developing invasive breast cancer within the next 10 years, a study involving 1.3 million women showed.

The 10-year breast cancer risk was higher by 39% in women who had false-positive mammograms and additional breast imaging as compared with women who had true-negative mammograms, Louise M. Henderson, PhD, of the University of North Carolina Lineberger Comprehensive Cancer Center in Chapel Hill, and co-authors reported in the December issue of Cancer Epidemiology, Biomarkers & Prevention."

Susan Zager's insight:

After the new guidelines from the ACS in reference to mammograms comes this study about false-positives indicating odds of developing invasive breast cancer. To see the study go to: http://cebp.aacrjournals.org/content/early/2015/11/09/1055-9965.EPI-15-0623.abstract

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Desiree Walker: Embracing Advocacy on my Breast Cancer Journey

Desiree Walker:  Embracing Advocacy on my Breast Cancer Journey | Breast Cancer News | Scoop.it
I am alive today because of a research grant funded by the Department of Defense Breast Cancer Research Program (DoD BCRP) to Dr. Dennis Slamon. That groundbreaking research led to the development of my personal miracle drug: Herceptin.
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Patients With Advanced Breast Cancer Address an International Conference About Misleading DiseaseSpecific Messages

Patients With Advanced Breast Cancer Address an International Conference About Misleading DiseaseSpecific Messages | Breast Cancer News | Scoop.it
Patients with advanced breast cancer spoke out about the damaging messages some organizations issue about advanced breast cancer. They need to be identified and educated to change the way they talk about the disease.
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What's New in Research for ER+ Metastatic Breast Cancer

Nikhil Wagle, MD, discusses new research and how it is leading the way toward improved treatments for ER+ metastatic breast cancer."

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For more information go to: www. MBCProject.org

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Breast Cancer Survivors Find the Michelangelo of Nipple Tattoos | VICE | United States

Breast Cancer Survivors Find the Michelangelo of Nipple Tattoos | VICE | United States | Breast Cancer News | Scoop.it
For all of medicine’s advances, the best option for areola reconstruction after surgery is tattooing. And in the field of cosmetic tattooing, Vinnie Myers’s trompe-l’oeil “areola portraits,” as he calls them, are widely regarded as the best that money can buy.
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Get Involved | World Cancer Day

Get Involved | World Cancer Day | Breast Cancer News | Scoop.it
"World Cancer Day is a day to collectively raise our voices and push for greater awareness, actively implement what we know in the areas of prevention, early detection, treatment and care and to push governments [...]...
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Today id World Cancer Day. Here's information about getting involved.
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Drug Shortages Forcing Hard Decisions on Rationing Treatments

Drug Shortages Forcing Hard Decisions on Rationing Treatments | Breast Cancer News | Scoop.it
Such shortages are the new normal in American medicine. But the rationing that results has been largely hidden from patients and the public.
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Great Article by Sheri Fink referencing drug shortages including chemotherapy drugs. 

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Biden staff asks cancer researchers for quick 'moonshot' ideas

Biden staff asks cancer researchers for quick 'moonshot' ideas | Breast Cancer News | Scoop.it
The meeting shows he's aware that he's running out of time to make a big impact on cancer.
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Breast Cancer Patient Protesting Big Pharma’s ‘Death Sentence’ Arrested Outside TPP Talks

Breast Cancer Patient Protesting Big Pharma’s ‘Death Sentence’ Arrested Outside TPP Talks | Breast Cancer News | Scoop.it
Breast cancer patient Zahara Heckscher was arrested for going against the Trans-Pacific Partnership, a deal that would hurt many cancer patients.
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2015 San Antonio Breast Cancer Symposium #SABCS15

2015 San Antonio Breast Cancer Symposium #SABCS15 | Breast Cancer News | Scoop.it

"Coverage of the 2015 San Antonio Breast Cancer Symposium"

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Here's a great range of articles  and videos that summarize much of the latest news from the (San Antonio Breast Cancer Symposium) #SABCS15 all in one place.

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When Mother and Daughter Both Have Breast Cancer

When Mother and Daughter Both Have Breast Cancer | Breast Cancer News | Scoop.it
A Seattle mother and her daughter both have breast cancer. They support each other through arduous treatments and the pain of watching a loved one suffer.
Susan Zager's insight:

Great Article by Sumathi Reddy about Beth Caldwell and her mom Colleen ‘Susi’ Stevens  supporting each other while both are going through breast cancer treatment. I am so lucky that I am with Beth at the San Antonio Breast Cancer Symposium and I can't wait to blog more about this incredible experience.

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S.A. congressman investigating prescription costs

S.A. congressman investigating prescription costs | Breast Cancer News | Scoop.it

WASHINGTON — Citing Texans’ complaints of soaring prescription costs, U.S. Rep. Lloyd Doggett is leading an effort in Congress seeking causes and remedies. Doggett, D-Austin, has formed an entity called the Prescription Drug Pricing Task Force, and one of the initial efforts is pressuring the Obama administration to use its authority to stem an ongoing rise in the costs of pharmaceuticals. [...] Doggett and allies point to price boosts for many drugs, evidenced in a government study last week showing a 12.2 percent increase last year in prescription drug spending. Leigh Purvis, director of Health Services Research at AARP's Public Policy Institute, has been studying drug pricing since 2004. In a bipartisan investigation, the Senate Finance Committee released emails last week showing that executives of California-based Gilead Sciences were keenly aware of potential public outrage when they set the $84,000 cost for a 12-week treatment of Sovaldi, a potent new drug for hepatitis C. [...] the Senate’s bipartisan Special Committee on Aging is investigating the decision by Turing Pharmaceuticals, formed recently by hedge fund manager Martin Shkreli, to raise the price of the anti-infection drug Daraprim by 5,000 percent.."

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Soaring costs of prescription medication is very alarming.

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These Cancer Drugs Cause The Worst ‘Chemobrain’

These Cancer Drugs Cause The Worst ‘Chemobrain’ | Breast Cancer News | Scoop.it
Study suggests patients may want to be wary of chemotherapy treatment that’s been found to cause more cognitive damage.
Susan Zager's insight:

To see the study in Jama Oncology go to: http://oncology.jamanetwork.com/article.aspx?articleid=2473507


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Hospitals Form Patient Advisory Councils to Learn How They Can Improve Care

Hospitals Form Patient Advisory Councils to Learn How They Can Improve Care | Breast Cancer News | Scoop.it
The panels work on projects and policies along with hospital staff—and may help hospitals score higher in measures of patient satisfaction.
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Parabens in Shampoo and Body Lotions Linked to Breast Cancer - EmaxHealth

Parabens in Shampoo and Body Lotions Linked to Breast Cancer - EmaxHealth | Breast Cancer News | Scoop.it
Parabens are commonly used in cosmetics and personal care items to protect again
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Why this Dana-Farber Cancer Institute oncologist says less is more for breast cancer treatment

Why this Dana-Farber Cancer Institute oncologist says less is more for breast cancer treatment | Breast Cancer News | Scoop.it
Dr. Craig Bunnell with Dana-Farber discusses where breast cancer treatments are headed, and the biggest obstacle to progress.
Susan Zager's insight:
Why this Dana-Farber Cancer Institute oncologist says less is more for breast cancer treatment

Chemotherapy and radiation may eventually be treatments of the past"(We’ve) discovered what it was that allows us to turn the immune system back on around those cancers. If I look to the future…it will be this targeted approach and the ability to help modify or improve our own immune systems to be able to fight the cancers in the future.

And in the future, I imagine chemo and radiation being treatments of the past. I won't say we … will look at them as ancient therapies…But I really do think this sort of Star Trek approach is not something that’s so far fetched. I think in my lifetime, for many cancers, chemo and radiation will be therapies of the past."

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