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Breast cancer: second opinions spare women pointless surgery

Breast cancer: second opinions spare women pointless surgery | Breast Cancer News | Scoop.it
Barbara Ellen: Patients with any serious ailment shouldn't worry that they'll cause offence...
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Latest News, Research,  Articles of Interest, and Blog Posts
Curated by Susan Zager
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Is ER the new HER2 (which used to be the new ER)? Drs Lisa Carey and Eric Winer elaborate

Is ER the new HER2 (which used to be the new ER)? Drs Lisa Carey and Eric Winer elaborate | Breast Cancer News | Scoop.it

The very first educational video our CME group produced — entitled “Hormonal Manipulation for the 1980s” — featured a homemade animation from the nascent University of Miami audiovisual department depicting the mechanism of action of tamoxifen complete with side-by-side Pac-Man-like images of the drug and an estrogen molecule scooting across the cell membrane and racing to the nucleus to bind with a reverse-Pac-Man-looking estrogen receptor.

Back then this biology was very cool, and although we welcomed aromatase inhibitors (AIs) and fulvestrant to clinical practice, for a long time thereafter it seemed like there wasn’t much progress beyond this primitive concept of the very first form of targeted treatment of cancer. Instead the new target on the block, HER2, was generating considerably more interest as dashing figures like Dr Dennis Slamon regaled us with impressive science and trial results to match.

It was only in 2011 that research on endocrine treatment began to awaken from its long slumber, when data from the Phase III BOLERO-2 study demonstrated an impressive progression-free survival (PFS) hazard rate (HR) of 0.36 with the addition of the mTOR inhibitor everolimus to exemestane in patients with ER-positive advanced disease. Unfortunately, the toxicity of this agent, particularly mucositis, somewhat dulled our collective enthusiasm.


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New Blood Test Can Reveal Breast Cancer Well Before Tumor Grows - CBS Local

New Blood Test Can Reveal Breast Cancer Well Before Tumor Grows - CBS Local | Breast Cancer News | Scoop.it
Scientists say they've developed a blood test for breast cancer that could predict a relapse of the disease months before tumors start forming again.
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Nanotechnology Now - Press Release: "Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs"

Nanotechnology Now - Press Release: "Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs" | Breast Cancer News | Scoop.it
Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs: Iranian researche... http://t.co/gacGZbYkv0 #nanotechnology
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Shanon Hausler's curator insight, September 1, 10:24 PM

This article talks about how scientists may have found a plant that can produce breast cancer drugs. Scientists have tested this drug on animal samples, and it has proven to be successful so far. If scientists further this experiment and come up with a drug that can help cure breast cancer, the world will obviously change drastically. Thousands of people die from breast cancer every year, and there is nothing that anyone can do about it, because as of now, there is not a cure. I think that scientists should further this experiment, as they probably already are, to see if this plant can actually do what this article says it can. 

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Black Women at Raised Risk of Carrying Breast Cancer Genes

Black Women at Raised Risk of Carrying Breast Cancer Genes | Breast Cancer News | Scoop.it
In study of those under 50 with invasive form of disease, 12 percent had BRCA1, BRCA2 mutations
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Demand the EPA Tell the Truth about Fracking and Drinking Water

Demand the EPA Tell the Truth about Fracking and Drinking Water | Breast Cancer News | Scoop.it

Dear Environmental Protection Agency (EPA), 

Breast Cancer Action is a national grassroots organization whose mission is to achieve health justice for all women at risk of and living with breast cancer. Our members below signed the following statement for the EPA's consideration before releasing the official version of the EPA's Assessment of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources:


Susan Zager's insight:

It only takes a moment to fill this out and tell the EPA to stop protecting the fracking industry and start protecting our public health. 

(Courtesy of Breast Cancer Action.) 
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Acupuncture best for hot flashes in breast cancer survivors, study finds

Acupuncture best for hot flashes in breast cancer survivors, study finds | Breast Cancer News | Scoop.it
(HealthDay News) —Needles beat pills for treating hot flashes in breast cancer survivors, according to a new trial that compared acupuncture, "sham" acupuncture, the medication gabapentin and a placebo pill.
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Doubt Is Raised Over Value of Surgery for Breast Lesion at Earliest Stage

Doubt Is Raised Over Value of Surgery for Breast Lesion at Earliest Stage | Breast Cancer News | Scoop.it
Almost all women given a diagnosis of ductal carcinoma in situ, considered a possible precursor to breast cancer, have a lumpectomy or mastectomy, but data show they may not benefit.
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Great insight by 

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Tell-tale biomarker detects early breast cancer

Tell-tale biomarker detects early breast cancer | Breast Cancer News | Scoop.it
Researchers have shown that magnetic resonance imaging (MRI) can detect the earliest signs of breast cancer recurrence and fast-growing tumors.
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Clinical Oncology News - Massimo Cristofanilli, MD: How I Manage My Luminal A and Luminal B Breast Cancers

Clinical Oncology News - Massimo Cristofanilli, MD: How I Manage My Luminal A and Luminal B Breast Cancers | Breast Cancer News | Scoop.it

"Women with relatively low-risk breast cancer have more options today than in the past decade, due in large part to novel genomic and genetic tests. These tests have demonstrated the ability to predict cancers that are more aggressive and more likely to recur. Although genetic tests for heritable mutations to genes including BRCA1 and 2 have become more commonplace, genomic tests for identifying which cancer-related genes are over- or underproduced are still relatively rare in clinical practice.

Sometimes called genomic, mole- cular, or gene-expression analysis, these tests are most useful in stratifying patients with breast cancer into disease subtypes. This is particularly useful in cases of hormone receptor (HR)-positive or luminal-type disease, which can be further stratified into the cancer subtypes luminal A and luminal B. These 2 subtypes frequently are grouped because the cancers often can be treated successfully for many years with hormone-blocking therapies. Luminal A cancers generally are characterized as those that express high levels of the estrogen receptor (ER) and the progesterone receptor (PR), as well as low levels of the human epidermal growth factor receptor 2 (HER2), which is involved in signaling cell proliferation (Figure). Luminal B cancers generally are more aggressive and more likely to recur than luminal A cancers. Luminal B cancers also are hormone-positive, but they are highly proliferative and may have high levels of HER2, making them candidates for trastuzumab (Herceptin, Genentech/Roche).

Is chemotherapy necessary for every patient?

Definitely not. Physicians are beginning to realize that some breast cancers have a very low likelihood of becoming life-threatening. Women today can make an educated decision about the right treatment course, considering how taxing chemotherapy can be and its short and long-term adverse events (AEs).

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Paradigm, TME Research Sign Deal to Build Breast Cancer Genomic Registry

Paradigm, TME Research Sign Deal to Build Breast Cancer Genomic Registry | Breast Cancer News | Scoop.it
Paradigm will use its next-generation sequencing-based test and other technologies to genomically characterize invasive breast cancer patients.
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Anyone Else Surprised by These Symptoms?

Anyone Else Surprised by These Symptoms? | Breast Cancer News | Scoop.it
Ok, I need your help. I've found that the most emotionally difficult time since my cancer diagnosis has been since my last day of treatment. There are all of these things that no one tells you about. For example, I'm thirsty ALL of the time - and I'm always freezing cold. But the most startling thing I've noticed is that I've lost that "outer coating" that allows me to deal with stressful situations. Does anyone else feel this way? Is it the chemo, or is it just age?
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Patient Support Not Just a Buzzword for New England Doc

Patient Support Not Just a Buzzword for New England Doc | Breast Cancer News | Scoop.it

"As medical director of radiation oncology at Lowell General Hospital in Massachusetts, Matthew Katz, MD, is well attuned to trends in breast cancer treatment.


He and his colleagues have adopted the practice of using shorter radiation courses—for example, treating lumpectomy patients when appropriate with a slightly higher dose for 3 to 4 weeks rather than a standard dose for 5 to 6 weeks. They have patients with left-sided breast cancers use deep inspiration breath hold to inflate the lungs, moving the heart momentarily to reduce its radiation exposure. And they’re interested in identifying older women who can avoid post surgical radiation that is unlikely to lengthen their lives.

But the area that most distinguishes Katz may be his interest in understanding the subtle nuances of doctor-patient communication that contribute to patients’ decision making and their experiences of treatment. That has led him to focus on supportive conversations in his practice and to venture into the wilderness of online social media to learn more about how patients view their treatment."

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OnPage.com HIPAA Compliant Messaging's curator insight, August 3, 3:33 PM

He and his colleagues have adopted the practice of using shorter radiation courses—for example, treating lumpectomy patients when appropriate with a slightly higher dose for 3 to 4 weeks rather than a standard dose for 5 to 6 weeks.


Scoop Via:  OnPage.com

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Darlene Gant remembered as a 'fighter'

Darlene Gant remembered as a 'fighter' | Breast Cancer News | Scoop.it
We have a sad update to a story we’ve been following for years. Darlene Gant, the breast cancer patient using an experimental drug to fight for life, has passed away.
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Male Breast Cancer Coalition steps up to aid Beachwood man's fight for treatment drug: Faces of the Suns

Male Breast Cancer Coalition steps up to aid Beachwood man's fight for treatment drug: Faces of the Suns | Breast Cancer News | Scoop.it
The Male Breast Cancer Coalition stepped in when Jerry Rubenstein of Beachwood learned that his insurance company would not cover a drug for his treatment.
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When Breast Cancer Strikes Without Symptoms | VICE | United States

When Breast Cancer Strikes Without Symptoms | VICE | United States | Breast Cancer News | Scoop.it
When my childhood best friend was diagnosed with late-stage breast cancer, she was 26 years old, beautiful, and athletic—and there was no tell-tale "lump."
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For Survivors of Cancer, Finding Love Involves an Extra Hurdle | Cure Magazine

For Survivors of Cancer, Finding Love Involves an Extra Hurdle | Cure Magazine | Breast Cancer News | Scoop.it
For survivors of cancer, finding love involves discussing the disease and the changes it has brought.
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For Survivors of Cancer Finding Love Involves an Extra Hurdle.?
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U.S. scientists successfully turn human cancer cells back to normal in process that could 'switch off' disease

U.S. scientists successfully turn human cancer cells back to normal in process that could 'switch off' disease | Breast Cancer News | Scoop.it
For the first time, aggressive breast, lung and bladder cancer cells have been turned back into harmless benign cells
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To See the study go to: http://www.nature.com/ncb/journal/vaop/ncurrent/full/ncb3227.html


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Fatigue as a result of radiation; can psychological therapy help? - Medivizor

Fatigue as a result of radiation; can psychological therapy help? - Medivizor | Breast Cancer News | Scoop.it
Share In a nutshell The authors aimed to determine whether psychological therapy could relieve patients with fatigue (extreme tiredness) who are undergoing breast cancer radiation (uses high energy radiation to kill cancer cells by damaging their...
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Cancer-Detecting Dogs Sniff Out Samples

Cancer-Detecting Dogs Sniff Out Samples | Breast Cancer News | Scoop.it
UC Davis researchers are harnessing the power of dogs’ innate sense of smell to detect cancer, especially at early stages of the disease. The team are training two puppies, each about 4 months old —Alfie, a Labradoodle and Charlie, a German Shepherd — who are undergoing a rigorous 12-month training program to develop their abilities to detect the scent of cancer in samples of saliva, breath and urine.
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Breast cancer vaccine is 'huge discovery' that brings hope to thousands of women

Breast cancer vaccine is 'huge discovery' that brings hope to thousands of women | Breast Cancer News | Scoop.it
A breast cancer vaccine could be on the way to tackle a form of the illness that does not respond to common treatments
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Genetic Testing for Breast Cancer Risk

Genetic Testing for Breast Cancer Risk | Breast Cancer News | Scoop.it
Genetic testing for breast cancer risk including BRCA1 and 2 as well as less common mutations such as PTEN, TP53, CHEK2 and ATM.
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NCCN Breast Cancer Guidelines Acknowledge MammaPrint’s Ability to Predict Prognosis | Agendia

NCCN Breast Cancer Guidelines Acknowledge MammaPrint’s Ability to Predict Prognosis | Agendia | Breast Cancer News | Scoop.it
Respected Panel Cites RASTER, the Only Published Prospective Outcome Data of Its Kind, Which Demonstrates MammaPrint’s Ability to Identify Those Patients Who
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Study: Higher breast cancer risk for working women in certain occupations

Study: Higher breast cancer risk for working women in certain occupations | Breast Cancer News | Scoop.it
More than 20 occupations are associated with a significantly increased risk of breast cancer for working women, according to a report from t…
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To see the full report go to: http://www.breastcancerfund.org/assets/pdfs/publications/working-women-and-breast-cancer.pdf


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Blood test can predict your breast cancer risk 'years into the future'

Blood test can predict your breast cancer risk 'years into the future' | Breast Cancer News | Scoop.it
Scientists hailed the ‘truly amazing’ technique as better than a mammogram. They hope it will lead to earlier treatment of a disease which kills more than 11,000 women a year in the UK.
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Rebuilding the Breast

Rebuilding the Breast | Breast Cancer News | Scoop.it

From stem cells to 3D-printed nipples, breast reconstruction is a highly technical and constantly evolving field.

In 1882 an American surgeon named William Steward Halsted popularized what’s now called the radical mastectomy. He didn’t think of the idea—one of the first written proposals for a mastectomy was published by a German surgeon in 1719. But it was Halsted who made invasive removal of breast tissue a mainstream part of cancer treatment, and his version of the surgery involved removing the entire breast, along with the nearby lymph nodes and both pectoral muscles. Removing that much tissue at that period of time, before many of the surgical techniques doctors are now familiar with were developed, often left women severely disfigured.

And with the removal of breasts, or pieces of them, came the demand for cosmetic replacements. In 1874 the U.S. Patent Office issued its first patent for a breast prosthetic, to a man named Frederick Cox. The prosthetic was made up of a cotton casing filled with an inflatable breast pad."

In the following years, women would come to dominate the world of breast replacement patents. In 1904, a woman named Laura Wolfe filed a patent for an “artificial breast pad.” Her version was solid, rather than inflatable, and in her patent she described the three things a woman wanted out of a replacement breast: comfort, appearance, and product quality."


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