The very first educational video our CME group produced — entitled “Hormonal Manipulation for the 1980s” — featured a homemade animation from the nascent University of Miami audiovisual department depicting the mechanism of action of tamoxifen complete with side-by-side Pac-Man-like images of the drug and an estrogen molecule scooting across the cell membrane and racing to the nucleus to bind with a reverse-Pac-Man-looking estrogen receptor.
Back then this biology was very cool, and although we welcomed aromatase inhibitors (AIs) and fulvestrant to clinical practice, for a long time thereafter it seemed like there wasn’t much progress beyond this primitive concept of the very first form of targeted treatment of cancer. Instead the new target on the block, HER2, was generating considerably more interest as dashing figures like Dr Dennis Slamon regaled us with impressive science and trial results to match.
It was only in 2011 that research on endocrine treatment began to awaken from its long slumber, when data from the Phase III BOLERO-2 study demonstrated an impressive progression-free survival (PFS) hazard rate (HR) of 0.36 with the addition of the mTOR inhibitor everolimus to exemestane in patients with ER-positive advanced disease. Unfortunately, the toxicity of this agent, particularly mucositis, somewhat dulled our collective enthusiasm.
Breast Cancer Action is a national grassroots organization whose mission is to achieve health justice for all women at risk of and living with breast cancer. Our members below signed the following statement for the EPA's consideration before releasing the official version of the EPA's Assessment of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources:
Susan Zager's insight:
It only takes a moment to fill this out and tell the EPA to stop protecting the fracking industry and start protecting our public health.
(HealthDay News) —Needles beat pills for treating hot flashes in breast cancer survivors, according to a new trial that compared acupuncture, "sham" acupuncture, the medication gabapentin and a placebo pill.
"Women with relatively low-risk breast cancer have more options today than in the past decade, due in large part to novel genomic and genetic tests. These tests have demonstrated the ability to predict cancers that are more aggressive and more likely to recur. Although genetic tests for heritable mutations to genes including BRCA1 and 2 have become more commonplace, genomic tests for identifying which cancer-related genes are over- or underproduced are still relatively rare in clinical practice.
Sometimes called genomic, mole- cular, or gene-expression analysis, these tests are most useful in stratifying patients with breast cancer into disease subtypes. This is particularly useful in cases of hormone receptor (HR)-positive or luminal-type disease, which can be further stratified into the cancer subtypes luminal A and luminal B. These 2 subtypes frequently are grouped because the cancers often can be treated successfully for many years with hormone-blocking therapies. Luminal A cancers generally are characterized as those that express high levels of the estrogen receptor (ER) and the progesterone receptor (PR), as well as low levels of the human epidermal growth factor receptor 2 (HER2), which is involved in signaling cell proliferation (Figure). Luminal B cancers generally are more aggressive and more likely to recur than luminal A cancers. Luminal B cancers also are hormone-positive, but they are highly proliferative and may have high levels of HER2, making them candidates for trastuzumab (Herceptin, Genentech/Roche).
Is chemotherapy necessary for every patient?
Definitely not. Physicians are beginning to realize that some breast cancers have a very low likelihood of becoming life-threatening. Women today can make an educated decision about the right treatment course, considering how taxing chemotherapy can be and its short and long-term adverse events (AEs).
Ok, I need your help. I've found that the most emotionally difficult time since my cancer diagnosis has been since my last day of treatment. There are all of these things that no one tells you about. For example, I'm thirsty ALL of the time - and I'm always freezing cold. But the most startling thing I've noticed is that I've lost that "outer coating" that allows me to deal with stressful situations. Does anyone else feel this way? Is it the chemo, or is it just age?
"As medical director of radiation oncology at Lowell General Hospital in Massachusetts, Matthew Katz, MD, is well attuned to trends in breast cancer treatment.
He and his colleagues have adopted the practice of using shorter radiation courses—for example, treating lumpectomy patients when appropriate with a slightly higher dose for 3 to 4 weeks rather than a standard dose for 5 to 6 weeks. They have patients with left-sided breast cancers use deep inspiration breath hold to inflate the lungs, moving the heart momentarily to reduce its radiation exposure. And they’re interested in identifying older women who can avoid post surgical radiation that is unlikely to lengthen their lives.
But the area that most distinguishes Katz may be his interest in understanding the subtle nuances of doctor-patient communication that contribute to patients’ decision making and their experiences of treatment. That has led him to focus on supportive conversations in his practice and to venture into the wilderness of online social media to learn more about how patients view their treatment."
Share In a nutshell The authors aimed to determine whether psychological therapy could relieve patients with fatigue (extreme tiredness) who are undergoing breast cancer radiation (uses high energy radiation to kill cancer cells by damaging their...
UC Davis researchers are harnessing the power of dogs’ innate sense of smell to detect cancer, especially at early stages of the disease. The team are training two puppies, each about 4 months old —Alfie, a Labradoodle and Charlie, a German Shepherd — who are undergoing a rigorous 12-month training program to develop their abilities to detect the scent of cancer in samples of saliva, breath and urine.
From stem cells to 3D-printed nipples, breast reconstruction is a highly technical and constantly evolving field.
In 1882 an American surgeon named William Steward Halsted popularized what’s now called the radical mastectomy. He didn’t think of the idea—one of the first written proposals for a mastectomy was published by a German surgeon in 1719. But it was Halsted who made invasive removal of breast tissue a mainstream part of cancer treatment, and his version of the surgery involved removing the entire breast, along with the nearby lymph nodes and both pectoral muscles. Removing that much tissue at that period of time, before many of the surgical techniques doctors are now familiar with were developed, often left women severely disfigured.
And with the removal of breasts, or pieces of them, came the demand for cosmetic replacements. In 1874 the U.S. Patent Office issued its first patent for a breast prosthetic, to a man named Frederick Cox. The prosthetic was made up of a cotton casing filled with an inflatable breast pad."
In the following years, women would come to dominate the world of breast replacement patents. In 1904, a woman named Laura Wolfe filed a patent for an “artificial breast pad.” Her version was solid, rather than inflatable, and in her patent she described the three things a woman wanted out of a replacement breast: comfort, appearance, and product quality."
Sharing your scoops to your social media accounts is a must to distribute your curated content. Not only will it drive traffic and leads through your content, but it will help show your expertise with your followers.
How to integrate my topics' content to my website?
Integrating your curated content to your website or blog will allow you to increase your website visitors’ engagement, boost SEO and acquire new visitors. By redirecting your social media traffic to your website, Scoop.it will also help you generate more qualified traffic and leads from your curation work.
Distributing your curated content through a newsletter is a great way to nurture and engage your email subscribers will developing your traffic and visibility.
Creating engaging newsletters with your curated content is really easy.