Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly
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Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly
Covering topics and controversies in Cognitive Neuroscience and Brain Imaging
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Rescooped by Donald J Bolger from Neuroscience_topics
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Brain mapping reveals neurological basis of decision-making in rats

Brain mapping reveals neurological basis of decision-making in rats | Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly | Scoop.it

Scientists at UC San Francisco have discovered how memory recall is linked to decision-making in rats, showing that measurable activity in one part of the brain occurs when rats in a maze are playing out memories that help them decide which way to turn. The more they play out these memories, the more likely they are to find their way correctly to the end of the maze. (...) - by UCSF, ScienceBlog


Via Julien Hering, PhD
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Rescooped by Donald J Bolger from Neuroscience and Psychology
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Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity

Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity | Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly | Scoop.it

Highlights

Slow-wave sleep induces long-term potentiation of evoked responses In vitro, stimulation mimicking SWS replicated these results Potentiation of responses was postsynaptic, Ca2+, AMPA, and NMDA dependent The mechanism of potentiation was compatible with the classical LTP mechanism

Summary

Long-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation. However, it is unclear whether sleep slow oscillation by itself induces long-term plasticity that contributes to memory retention. Using in vivo prethalamic electrical stimulation at 1 Hz, which itself does not induce immediate potentiation of evoked responses, we investigated how the cortical evoked response was modulated by different states of vigilance. We found that somatosensory evoked potentials during wake were enhanced after a slow-wave sleep episode (with or without stimulation during sleep) as compared to a previous wake episode. In vitro, we determined that this enhancement has a postsynaptic mechanism that is calcium dependent, requires hyperpolarization periods (slow waves), and requires a coactivation of both AMPA and NMDA receptors. Our results suggest that long-term potentiation occurs during slow-wave sleep, supporting its contribution to memory.

Sylvain Chauvette, Josée Seigneur, Igor Timofeev, Neuron, Volume 75, Issue 6, 1105-1113, 20 September 2012


Via Julien Hering, PhD, Eudaimonia
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