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Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly
Covering topics and controversies in Cognitive Neuroscience and Brain Imaging
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Rescooped by Donald J Bolger from Neuroscience_topics
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Functional anatomy of neural circuits regulating fear and extinction

Functional anatomy of neural circuits regulating fear and extinction | Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly | Scoop.it

The memory of fear extinction is context dependent: fear that is suppressed in one context readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of considerable clinical relevance for anxiety disorders. Prefrontal cortical and hippocampal inputs to the amygdala have recently been shown to regulate the retrieval of fear memories, but the cellular organization of these projections remains unclear. By using anterograde tracing in a transgenic rat in which neurons express a dendritically-targeted PSD-95:Venus fusion protein under the control of a c-fos promoter, we found that, during the retrieval of extinction memory, the dominant input to active neurons in the lateral amygdala was from the infralimbic cortex, whereas the retrieval of fear memory was associated with greater hippocampal and prelimbic inputs. This pattern of retrieval-related afferent input was absent in the central nucleus of the amygdala. Our data show functional anatomy of neural circuits regulating fear and extinction, providing a framework for therapeutic manipulations of these circuits. (...) - by Knapska E et al., PNAS October 16, 2012 vol. 109 no. 42 17093-17098


Via Julien Hering, PhD
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Jim Siders's curator insight, February 11, 2013 1:45 PM

wonder what this does with learning opportunities

Rescooped by Donald J Bolger from Learning, Brain & Cognitive Fitness
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Inside the Mind of Worry|New York Times

Inside the Mind of Worry|New York Times | Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly | Scoop.it

The basic architecture of the brain ensures that we feel first and think second."Researchers in neuroscience, psychology, economics and other disciplines have made a range of discoveries about why human beings sometimes fear more than the evidence warrants, and sometimes less than the evidence warns. That science is worth reviewing at length. But one current issue offers a crash course in the most significant of these findings: the fear of vaccines, particularly vaccines for children."


Via Maggie Rouman
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