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Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly
Covering topics and controversies in Cognitive Neuroscience and Brain Imaging
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Rescooped by Donald J Bolger from Neuroscience_topics
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Major Discovery For Alzheimer\'s Disease

Major Discovery For Alzheimer\'s Disease | Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly | Scoop.it

The Journal of Neuroscience has published a study led by researchers at the Max Planck Florida Institute for Neuroscience, the first and only U.S. extension of the prestigious Max Planck Society, that may hold a stunning breakthrough in the fight to treat Alzheimer's disease. The study potentially identifies a cause of Alzheimer's disease - based on a newly-discovered signaling pathway in cellular models of Alzheimer's disease - and opens the door for new treatments by successfully blocking this pathway. The Institute, which recently opened in December 2012, focuses solely on basic neuroscience research that aims to analyze, map, and decode the human brain - the most important and least understood organ in the body.(...)

The MPFI research indicates that the presence of Amyloid beta triggers increased levels of a signaling protein, called centaurin-alpha1 (CentA1), that appears to cause neuronal dysfunction - a potentially groundbreaking discovery that uncovers an important intermediary step in the progression of the disease. 
As part of the research, the scientists were able to identify CentA1 and measure its negative effects on neurons. Utilizing an RNA silencing technique, they turned down the cellular production of CentA1, and showed that affected neurons, exposed to Amyloid beta and exhibiting Alzheimer's related symptoms, returned to normal morphology and synaptic function, even with the continued presence of Amyloid beta. They further found that increased CentA1 activates a series of proteins, and these proteins form a signaling pathway from CentA1 to neuronal dysfunction. Thus, inhibiting other proteins in the pathway also "cured" affected neurons. (...) - Medical News Today, 21 March, 2013


Via Julien Hering, PhD
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Rescooped by Donald J Bolger from Neuroscience_topics
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Brain mapping reveals neurological basis of decision-making in rats

Brain mapping reveals neurological basis of decision-making in rats | Brain Imaging and Neuroscience: The Good, The Bad, & The Ugly | Scoop.it

Scientists at UC San Francisco have discovered how memory recall is linked to decision-making in rats, showing that measurable activity in one part of the brain occurs when rats in a maze are playing out memories that help them decide which way to turn. The more they play out these memories, the more likely they are to find their way correctly to the end of the maze. (...) - by UCSF, ScienceBlog


Via Julien Hering, PhD
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