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Research and Markets: Gestational Diabetes Global Clinical Trials Review, H1 ... Business Wire (press release) Gestational Diabetes Global Clinical Trials Review, H1, 2013" provides data on the Gestational Diabetes clinical trial scenario.
Journal of Diabetes & Metabolism is a high quality scientific journal with an international readership. It is focused on cutting edge research in the prevention, pharmacological treatment, management, and education of diabetes and related disorders.
Insulin Resistance: Definition, Symptoms, Treatment and Prevention. Insulin resistance is the term used toInsulin Resistance explain the condition when our body cells are not able to act in response to the hormone insulin’s actions.
Diabetes cost the United States an estimated $245 billion in 2012, according to a new analysis from the American Diabetes Association. (RT @WebMD: About 7% of the U.S. population is living with #diabetes, says @AmDiabetesAssn.
Diagnosing Gestational Diabetes a 2-Step Process, Says Panel Medscape Diagnosing gestational diabetes should remain a 2-step approach, a panel convened by the National Institutes of Health has decided.
A transmembrane glycoprotein which is highly expressed in adipocytes and found in tissues for glucose and lipid metabolism is known as Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1); which at the level of the alpha subunit interacts with the insulin receptor.Lessened insulin-mediated activation of tyrosine phosphorylation in beta-subunit of the insulin receptor, and downstream insulin signaling activation is result of this interaction. Single nucleotide polymorphism of the ENPP1 is linked with type 2 diabetes in humans.
Results of animal experiments elucidate that the suppression of ENPP1 expression helps in improving insulin sensitivity which further supports the hypothesis that inhibition of ENPP1 can be a potential therapeutic for treatment of type 2 diabetes but it still remained controversial in case humans due to effect of ENPP1 on complications of insulin resistance. In humans inhibitor effect of ENPP1 on insulin signaling has been found effected by the presence of 121Q gene variant, obesity, lipid disorder(Significant) or type 2 diabetes and gender. Also factors such as different ethnic origin and environment were also responsible for the failure to elucidate the linkage between ENPP1 and insulin resistance. The study also reveals that improvement on glucose homeostasis has been observed in ENPP1 K121Q variant with weight reduction, which suggests that people of the category can be benefitted more change in life style by lightening metabolic challenge which is found to be induced by positive caloric balance.
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