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MicroRNA drives both cancer onset and metastasis

MicroRNA drives both cancer onset and metastasis | Cancer :Biotechnology & Pharma | Scoop.it
A mere 25 years ago, noncoding RNAs were considered nothing more than "background noise" in the overall genomic landscape.
Nalina Nagarajan's insight:

More roles of MicroRNA

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Rescooped by Nalina Nagarajan from Cancer Research You can Trust
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ASCO: SNL the New Standard for Early Breast Cancer

ASCO: SNL the New Standard for Early Breast Cancer | Cancer :Biotechnology & Pharma | Scoop.it

"Breast cancer patients with negative sentinel lymph node (SLN) biopsies can skip axillary lymph node dissection (ALND), according to an updated clinical guideline from the American Society of Clinical Oncology.

The same advice applies to most women who have one or two SLN metastases and plan to have breast-conserving surgery and whole-breast radiation therapy. Patients who have SLN metastases and opt for mastectomy should be offered axillary lymph node dissection, according to an article published online in the Journal of Clinical Oncology.

The update represents a major departure from the original version of the guideline, which recommended axillary lymph node dissection for all women with SLN involvement.

The change came about as a result of "recent trials that suggest no difference in outcomes and fewer complications with sentinel-node biopsy alone," guideline panel chair Gary Lyman, MD, of the Fred Hutchinson Cancer Research Center in Seattle, told MedPage Today via email.


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15-minute cancer treatment: New targeted radiosurgery technology

15-minute cancer treatment: New targeted radiosurgery technology | Cancer :Biotechnology & Pharma | Scoop.it
A new cancer treatment is now available in North America that offers an alternative cancer surgery, without the incision or hospital stay, treating patients in 15 minutes or less and returning them to their everyday lives.
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DNA-built nanostructures safely target, image cancer tumors

DNA-built nanostructures safely target, image cancer tumors | Cancer :Biotechnology & Pharma | Scoop.it
A team of researchers has discovered a method of assembling "building blocks" of gold nanoparticles as the vehicle to deliver cancer medications or cancer-identifying markers directly into cancerous tumors.
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Microfluidic platform gives clear look at a crucial step in cancer metastasis

Microfluidic platform gives clear look at a crucial step in cancer metastasis | Cancer :Biotechnology & Pharma | Scoop.it
A microfluidic platform provides a high-resolution view of a crucial step in cancer metastasis.
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Network-Based Stratification of Tumor Mutations

Network-Based Stratification of Tumor Mutations | Cancer :Biotechnology & Pharma | Scoop.it

"Many forms of cancer have multiple subtypes with different causes and clinical outcomes. Somatic tumor genome sequences provide a rich new source of data for uncovering these subtypes but have proven difficult to compare, as two tumors rarely share the same mutations. Here we introduce network-based stratification (NBS), a method to integrate somatic tumor genomes with gene networks. This approach allows for stratification of cancer into informative subtypes by clustering together patients with mutations in similar network regions. We demonstrate NBS in ovarian, uterine and lung cancer cohorts from The Cancer Genome Atlas. For each tissue, NBS identifies subtypes that are predictive of clinical outcomes such as patient survival, response to therapy or tumor histology. We identify network regions characteristic of each subtype and show how mutation-derived subtypes can be used to train an mRNA expression signature, which provides similar information in the absence of DNA sequence."


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Cancer Commons's curator insight, September 16, 2013 2:15 PM

Hofree M, Shen JP, Carter H, Gross A, Ideker T. Nature Methods. Sep 15, 2013.

Cancer Commons's curator insight, September 16, 2013 2:19 PM

Hofree M, Shen JP, Carter H, Gross A, Ideker T. Nature Methods. Sep 15, 2013.

Cancer Commons's curator insight, September 16, 2013 2:19 PM

Hofree M, Shen JP, Carter H, Gross A, Ideker T. Nature Methods. Sep 15, 2013.

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Prioritizing Prevention With A Breast Cancer Vaccine: Understanding The Steps Involved | Dr. Kathleen T. Ruddy's Breast Cancer Blog

Prioritizing Prevention With A Breast Cancer Vaccine: Understanding The Steps Involved | Dr. Kathleen T. Ruddy's Breast Cancer Blog | Cancer :Biotechnology & Pharma | Scoop.it

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How DNA repair helps prevent cancer

How DNA repair helps prevent cancer | Cancer :Biotechnology & Pharma | Scoop.it
DNA damage is a natural biological occurrence that happens every time cells divide and multiply; thus, DNA repair is important for preserving the composition of the genome.
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Major Breakthrough for the Breast Cancer Community: Gene that Propagates Metastasis Discovered | Dr. Kathleen T. Ruddy's Breast Cancer Blog

Major Breakthrough for the Breast Cancer Community: Gene that Propagates Metastasis Discovered | Dr. Kathleen T. Ruddy's Breast Cancer Blog | Cancer :Biotechnology & Pharma | Scoop.it

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AnneMarie Ciccarella's curator insight, August 16, 2013 1:14 AM

MAJOR breakthrough?  First of all, this headline propagates a bunch of nonsense.  The gene that enables metastasis "could be considered a driver" meaning it also could NOT be a driver.  

 

And for the 2nd helping...  even IF it is found to be a driver, "further studies chould result in the development of treatments.... reduce spread.... extend life"  ....

 

EXCELLENT news, except it's not known if this is a "targetable" driver and then, if so, compounds would have to be tested.  This Major Breakthrough is nothing more than a hypothesis.

 

Shame on a DOCTOR for writing such headlines.

Heather Swift's curator insight, August 16, 2013 7:13 PM

MAJOR breakthrough?  First of all, this headline propagates a bunch of nonsense.  The gene that enables metastasis "could be considered a driver" meaning it also could NOT be a driver.  

 

And for the 2nd helping...  even IF it is found to be a driver, "further studies chould result in the development of treatments.... reduce spread.... extend life"  ....

 

EXCELLENT news, except it's not known if this is a "targetable" driver and then, if so, compounds would have to be tested.  This Major Breakthrough is nothing more than a hypothesis.

 

Shame on a DOCTOR for writing such headlines.

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ESPYs Radio - The V Foundation for Cancer Research

ESPYs Radio - The V Foundation for Cancer Research | Cancer :Biotechnology & Pharma | Scoop.it
Make a donation to The V Foundation (RT @raymanjr: I just made a donation to The V Foundation for Cancer Research!
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Big Government Opens Big Database For Cancer Research

Big Government Opens Big Database For Cancer Research | Cancer :Biotechnology & Pharma | Scoop.it

For those of us without degrees in molecular biology, the idea of "personalized medicine" – or PM – can often seem like a vague and distant concept. In this case, the Wikipedia definition of PM is pretty good: Personalized medicine or PM is a medical...


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Closing the Gender Gap in Cancer Research

Closing the Gender Gap in Cancer Research | Cancer :Biotechnology & Pharma | Scoop.it
Women are under-represented in cancer research, a fact that has concerned researchers for years, yet has largely gone unaddressed. (More great coverage of the Research for Her registry. Ladies: Have you signed up?
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Nano drug crosses blood-brain tumor barrier, targets brain-tumor cells and blood vessels

Nano drug crosses blood-brain tumor barrier, targets brain-tumor cells and blood vessels | Cancer :Biotechnology & Pharma | Scoop.it
The blood-brain barrier protects the brain from poisons but also prevents drugs from reaching brain tumors.
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Study finds inverse link between cancer, Alzheimer's

Intriguing new research suggests having cancer may offer some protection from Alzheimer's.
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Targeted gene disruption in mammalian cell lines using programmable nucleases - AACR Education Book

(via T. Lahaye, thx)

Kim 2014

Programmable nucleases, which include zinc finger nucleases (ZFNs) (1–4), transcription activator-like (TAL) effector nucleases (TALENs) (5, 6) and RNA-guided engineered nucleases (RGENs) (7–9) derived from the Type II CRISPR/Cas system, a prokaryotic immune response, are now widely used for gene knockout and knockin studies in cultured cells and model organisms. These nucleases cleave chromosomal DNA in a targeted manner, producing site-specific DNA double-strand breaks (DSBs), whose repair via endogenous systems known as homologous recombination (HR) and non-homologous end joining (NHEJ) leads to targeted mutagenesis. Nuclease-mediated gene disruption is preferentially achieved via error-prone NHEJ rather than HR because NHEJ is a dominant DSB repair pathway over HR in mammalian cells. DSB repair by erroneous NHEJ is accompanied by small insertions and deletions (indels) at nuclease target sites, which can cause frameshift mutations in a protein-coding sequence. Unlike siRNA or shRNA that is limited by incomplete gene suppression, programmable nucleases enable complete gene disruption. Furthermore, these nucleases are much more specific than is siRNA or shRNA. Still, engineered nucleases can induce off-target mutations at sites that are highly homologous to on-target sites. Repair of off-target DNA cleavages in cells can cause gross chromosomal rearrangements such as deletions, inversions, and translocations (10, 11). In this session, I will compare these nucleases and discuss their pros and cons, focusing on their availability and off-target effects.


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Advances in nanotechnology's fight against cancer

Advances in nanotechnology's fight against cancer | Cancer :Biotechnology & Pharma | Scoop.it
Among the most promising advances in the fight against cancer has been the rise of nanomedicine, the application of tiny materials and devices to detect, diagnose and treat disease. Researchers provide one of the most comprehensive assessments to date of research on nanomedicine-based approaches to treating cancer, and offers insight into how researchers can best position nanomedicine-based cancer treatments for FDA approval.
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Microenvironmental Regulation of Tumor Progression and Metastasis

Microenvironmental Regulation of Tumor Progression and Metastasis | Cancer :Biotechnology & Pharma | Scoop.it

"Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects."


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Cancer Commons's curator insight, November 8, 2013 1:50 PM

Quail DF, Joyce JA. Nature Medicine. Nov 7, 2013.

Cancer Commons's curator insight, November 8, 2013 1:51 PM

Quail DF, Joyce JA. Nature Medicine. Nov 7, 2013.

Cancer Commons's curator insight, November 8, 2013 1:51 PM

Quail DF, Joyce JA. Nature Medicine. Nov 7, 2013.

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Uncovering cancer's inner workings by capturing live images of growing tumors

Uncovering cancer's inner workings by capturing live images of growing tumors | Cancer :Biotechnology & Pharma | Scoop.it
Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease.
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Possible antidote discovered for tamoxifen-related mental fog

Possible antidote discovered for tamoxifen-related mental fog | Cancer :Biotechnology & Pharma | Scoop.it
A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central

Via Heather Swift
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Heather Swift's curator insight, September 20, 2013 3:21 PM

Possible antidote discovered for tamoxifen-related mental fog
A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to "chemo brain.

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'Intolerable' breast cancer drug causes 5,000 women to quit their medication - leading to 400 deaths a year

'Intolerable' breast cancer drug causes 5,000 women to quit their medication - leading to 400 deaths a year | Cancer :Biotechnology & Pharma | Scoop.it

Women who fail to take tamoxifen for the full five years are more likely to see their cancer return and to suffer an early deathThe drug can cause side effects including hot flushes, joint pain and fatigue
Those who don't stick to their drug regime cost an extra £6,000 on averageThey also lose an average of 13 months reasonable quality of life


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Susan Zager's curator insight, September 4, 2013 6:05 PM

I think this article is flawed because many peope have done the full course of tamoxifen and still had bad results. It has nasty side effects and everone deserves quality of life.

To see the original abstract go to: http://www.nature.com/bjc/journal/v109/n5/abs/bjc2013464a.html


Pacific Cove's curator insight, September 5, 2013 7:29 AM

‘This study is a timely reminder that it’s so important that women are given support to continue taking their tamoxifen so that they have the best possible chance to outlive breast cancer.’


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Family History Links 'Unrelated' Cancers

Family History Links 'Unrelated' Cancers | Cancer :Biotechnology & Pharma | Scoop.it
A family history of one type of cancer increases the risk of not only the same variety but also of cancers at other sites, researchers reported.

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Heather Swift's curator insight, August 16, 2013 1:43 AM

Family History Links 'Unrelated' Cancers
A family history of one type of cancer increases the risk of not only the same variety but also of cancers at other sites, researchers reported.

The finding, from a large network of case-control studies, suggests there may be "cancer syndromes" among close relatives, according to Eva Negri, ScD, of the Mario Negri Institute for Pharmacological Research in Milan, and colleagues.

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'Cancer sniffing' knife designed

'Cancer sniffing' knife designed | Cancer :Biotechnology & Pharma | Scoop.it
An "intelligent" knife that can sniff out tumours to improve cancer surgery has been developed by scientists.
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Lung cancer 'secrets' to be probed

Lung cancer 'secrets' to be probed | Cancer :Biotechnology & Pharma | Scoop.it
Scientists across Britain are to map the genes of the tumours of 850 lung cancer patients in a bid to understand more about the deadly disease.
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chinese plant compound wipes out cancer in 40 days, says new research | RAW FOR BEAUTY

chinese plant compound wipes out cancer in 40 days, says new research | RAW FOR BEAUTY | Cancer :Biotechnology & Pharma | Scoop.it
A little-known plant with a truly bizarre name is now making headlines as a cancer killer, with the compound of the plant vanishing tumors in mice with pancreatic cancer.
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Ovarian Cancer Metastases Influenced by Factors in Target Tissues | Elsevier

Ovarian Cancer Metastases Influenced by Factors in Target Tissues | Elsevier | Cancer :Biotechnology & Pharma | Scoop.it
Cancer researchers find Ovarian #Cancer metastases http://t.co/83SeOimB1T influenced by factors in target tissues @Elsevier
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How Breast And Ovarian Cancers Are Instigated By BRCA1 Mutation

How Breast And Ovarian Cancers Are Instigated By BRCA1 Mutation | Cancer :Biotechnology & Pharma | Scoop.it
Scientists led by Drs. Mona Gauthier and Tak Mak at The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre have solved a key piece in the puzzle of how BRCA

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Heather Swift's curator insight, July 18, 2013 8:21 AM

How Breast And Ovarian Cancers Are Instigated By BRCA1 Mutation
Scientists led by Drs. Mona Gauthier and Tak Mak at The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre have solved a key piece in the puzzle of how BRCA1 gene mutations specifically predispose women to breast and ovarian cancers.