RT @TapasDeCiencia: #Salud. Descubren el mecanismo molecular que da inicio al carcinoma basocelular, la forma más común de #cáncer de piel.
Khalil Kass Youssef and colleagues established the molecular signature of tumor initiating cells at different time during cancer initiation. They found that that cells at the origin of the basal cell carcinoma were progressively reprogrammed into embryonic hair follicle progenitor like fate before progressing into invasive carcinoma. “We were extremely surprised to see that tumor initiating cells were progressively and profoundly reprogram into a molecular identity that resemble to progenitor cells presented during embryonic development” comments Khalil Kass Youssef, the first author of this study.
In collaboration with bioinformaticians from the ULB and the KUL, the researchers demonstrate that Wnt/?-catenin signaling pathway is activated in BCC-initiating cells soon after oncogene expression. Using genetic or pharmacologic inhibition of the Wnt/?-catenin signaling, the researchers demonstrate that Wnt/beta-catenin signaling is essential for the reprograming of tumor initiating cells into embryonic hair follicle progenitors and for tumor initiation.
In collaboration with physicians from the Department of Dermatology, Pathology and Plastic Surgery from the Hospital Erasme, the group of Cédric Blanpain demonstrate that human BCCs also present signs of reprograming into embryonic hair follicle progenitors and activation of the Wnt/beta-catenin signaling, demonstrating the relevance of these findings for human patients.
This new work is at the frontier of multiple fields of biology and medicine and will be extremely important for researchers studying cancer, development, and stem cell biology. “I am particularly excited about this work, because this basic research turn out to be very relevant for human diseases, with the identification of potentially new avenues to treat or to prevent the occurrence of the most common cancer in humans ” comments Pr Cédric Blanpain.
This work was supported by the FNRS, the program d’excellence CIBLES of the Wallonia Region, a research grant from the Fondation Contre le Cancer, the Fondation ULB, the Fond Yvonne Boël, the Fond Gaston Ithier, a starting grant of the European Research Council (ERC) and the EMBO Young Investigator Program.
Información bibliográfica completa
Khalil Kass Youssef, Gaëlle Lapouge, Karine Bouvrée, Sandrine Rorive, Sylvain Brohée, Ornella Appelstein, Jean-Christophe Larsimont, Vijayakumar Sukumaran, Bram Van de Sande, Doriana Pucci, Sophie Dekoninck, Jean-Valery Berthe, Stein Aerts, Isabelle Salmon, Véronique del Marmol & Cédric Blanpain.
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Nature cell biology 2012, DOI: 10.1038/ncb2628
Fuente de la noticia: http://www.alphagalileo.org/ViewItem.aspx?ItemId=126243&CultureCode=en