"Biotech and Mol Bio"
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"Biotech and Mol Bio"
Research and innovation in Molecular Biology and Biotechnology (by @ramossonia)
Curated by sonia ramos
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Rescooped by sonia ramos from Virology and Bioinformatics from Virology.ca
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Cracking the epigenetic code

Cracking the epigenetic code | "Biotech and Mol Bio" | Scoop.it

A team of researchers at The Australian National University is one step closer to better understanding how organisms function after discovering how epigenetic information is transmitted from one generation of cells to the next.


Via Integrated DNA Technologies, Chris Upton + helpers
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Rescooped by sonia ramos from Arabidopsis
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A histone acetyltransferase regulates active DNA demethylation in Arabidopsis (Science)

A histone acetyltransferase regulates active DNA demethylation in Arabidopsis (Science) | "Biotech and Mol Bio" | Scoop.it

Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function. Our study reveals how some genes are indicated by multiple epigenetic marks for active DNA demethylation and protection from silencing.


Via GMI Vienna
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