Biosynthesis & Enzymology
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Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence

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Sceptrin goes through the looking glass

Marine sponges produce a trio of compounds—sceptrin, massadine, and ageliferin—that have intrigued chemists because they seemed to result from ring-forming reactions outside the standard repertoire of enzyme catalysis. Ma et al. now report laboratory syntheses of the first two compounds that uncover a surprising twist: It turns out the real structure of sceptrin is the mirror image of the originally reported structure. The work partially bolsters the prevailing biosynthetic hypothesis, though its revelation of enantiodivergence (the emergence of distinct mirror-image motifs in one compound class) is a rare event in natural product chemistry.

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Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria | Biosynthesis & Enzymology | Scoop.it
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Balskus Group's comment, June 29, 2014 2:42 PM
This paper from Brad Moore and co-workers at Scripps Institution of Oceanography address the important question of how marine bacteria biosynthesize polybrominated diphenyl ethers. Note the particularly neat enzymatic chemistry involved in bromination and biaryl/aryl ether formation. - Emily
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Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes

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A Methyltransferase Initiates Terpene Cyclization in Teleocidin B Biosynthesis - Journal of the American Chemical Society (ACS Publications)

A Methyltransferase Initiates Terpene Cyclization in Teleocidin B Biosynthesis - Journal of the American Chemical Society (ACS Publications) | Biosynthesis & Enzymology | Scoop.it
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Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases (ACS Publications)

Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases (ACS Publications) | Biosynthesis & Enzymology | Scoop.it

From ACS Biochemistry

 

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A Chemically Competent Thiosulfuranyl Radical on the Escherichi coli Class III Ribonucleotide Reductase

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Structural rearrangements of a polyketide synthase module during its catalytic cycle

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