The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes.
Nutrition is important during development. This appears to be true even in utero, with potential long-lasting effects on adult phenotype and disease. Epigenetic factors are prime suspects in identifying the corresponding molecular mechanism because they can be maintained throughout cell division. Holland et al. show in mice that in utero nutritional deficits influence offspring growth through epigenetic states at multicopy ribosomal DNA elements. This effect is influenced by the genetic variation that naturally exists within the ribosomal RNA.
As a child, Dan Voytas developed a green thumb and business savvy running his own seedling business. Now, marrying his academic research with a company, he's poised to reshape 21st century agriculture. Over the past 20 years, he has pioneered new ways of precisely editing a crop's DNA to give it new traits or delete undesirable ones. It's an approach that is potentially more powerful than the traditional way of making genetically modified (GM) crops, and because it leaves no foreign DNA behind, it could free these products from the stigma and regulatory burden of being labeled as GM organisms. But to get to this point, he has had to overcome recalcitrant technologies, navigate intellectual property fights, and endure commercial failures.
Indigestible resistant starches (RS) are substrates for gut-microbial metabolism and have been shown to attenuate intestinal inflammation but the supporting evidence is inconsistent and lacks mechanistic explanation. We have recently reported dietary RS type 4 (RS4) induced improvements in immunometabolic fu
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