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And why not Pichia pastoris? - GTP Technology

And why not Pichia pastoris? - GTP Technology | bioproduction | Scoop.it

Despite a few flaws, P. pastoris has key advantages that make it one of the systems of choice for the production of certain types of protein.

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Could Artificial Enzymes be the Future of Synthetic Chemistry?

Could Artificial Enzymes be the Future of Synthetic Chemistry? | bioproduction | Scoop.it
As synthetic organic chemistry struggles to reinvent itself, the field is shifting its focus to emulating and engineering enzymes. A team of researchers in Basel has developed an artificial metalloenzyme with unique functionality that can be activated in a cell.
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EMA says biologics developers need to be extra vigilant

EMA says biologics developers need to be extra vigilant | bioproduction | Scoop.it
Biologics developers need to be more vigilant about immunogenicity and manufacturing changes than small molecule drug manufacturers according to the EMA.
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Servier invests in a bioproduction programme in France

Servier invests in a bioproduction programme in France | bioproduction | Scoop.it
Servier has announced the launch of a bioproduction programme at its site in Gidy. First research batches in 2019 and first clinical batches in 2020.
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Novasep aims to fast-track mAb process development in GTP partnership

Novasep aims to fast-track mAb process development in GTP partnership | bioproduction | Scoop.it
The partnership with recombinant protein development firm GTP Technologies will create an end-to-end manufacturing service, speeding up production of monoclonal antibodies and reducing costs, says Novasep.
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Achieving Disruptive Improvement in the Bioprocessing Industry

Achieving Disruptive Improvement in the Bioprocessing Industry | bioproduction | Scoop.it
“It’s not sufficient to have incremental improvement, what we need to achieve is disruptive improvement” Q&A with Alexei Voloshin, Global Scientific Services Leader, 3M We spoke to Alexei Voloshin, Global Scientific Services Leader, 3M, in October last year (see the full interview here) about the challenges facing the bioproduction industry and how they can be…
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Antibody Alternatives | The Scientist Magazine®

Antibody Alternatives | The Scientist Magazine® | bioproduction | Scoop.it

Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

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Unlocking intrinsically disordered proteins: an interview with Peter Wright

Unlocking intrinsically disordered proteins: an interview with Peter Wright | bioproduction | Scoop.it

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years.

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Prevention and cure for endotoxins in a “standard” lab’s purified water

Prevention and cure for endotoxins in a “standard” lab’s purified water | bioproduction | Scoop.it

 What you will read about: the design, operation and maintenance for low endotoxin levels, of our well adapted and functional but not state-of-the-art  purified water distribution loop.

 

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What is the freedom to operate for T7 promoter system ?

What is the freedom to operate for T7 promoter system ? | bioproduction | Scoop.it

What you will read about : Conclusions of our freedom to operate studies on T7 promoter system.

GTP Technology's insight:

Have you ever wondered if T7 promoter system is free? We do, and share our conclusions on our blog (bit.ly/1KK3tfq).

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Bioprocess International European Summit 2015 - GTP was here!

Bioprocess International European Summit 2015 - GTP was here! | bioproduction | Scoop.it

What you will read about: our feedback on Bioprocess International European Summit  in Dusseldorf on April 14&15.

GTP Technology's insight:

GTP attended the last #Bioprocess International european summit in Dusseldorf. We share our feedback on our blog.

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Lysis of E. coli expression strain by spontaneous excision of DE3 prophage

Lysis of E. coli expression strain by spontaneous excision of DE3 prophage | bioproduction | Scoop.it

What you will read about: our investigations after E. coli culture lysis and conclusions regarding the role of prophage DE3.

GTP Technology's insight:

What drives my E.coli (DE3) strain to spontaneous lysis? In case you're wondering, read our experience on our blog. http://bit.ly/1EFqkUZ

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We have tested the MEP HyperCel™ Chromatography Sorbent from Pall as a capture step for a polyclonal antibody - GTP Technology

We have tested the MEP HyperCel™ Chromatography Sorbent from Pall as a capture step for a polyclonal antibody - GTP Technology | bioproduction | Scoop.it

Lately, we drew our focus to the characteristics of the MEP HyperCel™ sorbent developed by Pall. The most significant advantages of this mixed-mode sorbent are its unique separation mechanism and its high selectivity, which makes it suitable for direct immunoglobulin capture. Because it allows for protein binding in no salt or low salt conditions, it is also an appealing potential alternative to the HIC step. In order to verify the benefits of using this mechanism, we tested it as part of the development of a purification process for a polyclonal antibody, as the cost of using a protein A capture step was prohibitive in this project.

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Top 10 Best-selling Biologicals of 2015

Top 10 Best-selling Biologicals of 2015 | bioproduction | Scoop.it
Here, we take a look at the biggest blockbuster biologicals, who produces them, what diseases they treat, and the effects of market trends like the rising tide of biosimilars, a ‘generic’ copy sold by other companies once the therapy goes off-patent.
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Novartis invests €100m to boost mAb production 70% at French biologics site

Novartis invests €100m to boost mAb production 70% at French biologics site | bioproduction | Scoop.it
Novartis has recruited Jacobs to undertake a €100m expansion at a French biomanufacturing facility which will add a second purification line and several cell culture bioreactors.
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Lonza Launches Sentinel APART™ Server-Based Platform Designed to Help Improve the Quality and Safety of Therapeutic Antibodies

Lonza Launches Sentinel APART™ Server-Based Platform Designed to Help Improve the Quality and Safety of Therapeutic Antibodies | bioproduction | Scoop.it
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Press releases - Novasep and GTP Technology join forces to ease production of mAbs and recombinant proteins

Partnership offers biotech firms full CDMO services at all development stages from gene to end product
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Achieving Cost-Effective Bioprocesses

Achieving Cost-Effective Bioprocesses | bioproduction | Scoop.it
Experts in the field share some best practices for optimizing process economics in biomanufacturing.
GTP Technology's insight:
Nice article introducing best practices to optimize the cost of your bioprocess.
As a Contract Research and Development Organization GTP can help you develop a cost-effective process!
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The “Right Protein” to Establish Recombinant Therapeutics | Insight & Intelligence™ | GEN

The “Right Protein” to Establish Recombinant Therapeutics | Insight & Intelligence™ | GEN | bioproduction | Scoop.it
Humulin was the first therapeutic recombinant protein which established the feasibility of recombinant proteins.
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An Engineered Protein Can Kill Cancer Cells in the Bloodstream

An Engineered Protein Can Kill Cancer Cells in the Bloodstream | bioproduction | Scoop.it

A protein engineered to fit onto nanoparticles successfully kills tumor cells in the bloodstreams of mice with prostate cancer.

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Retooling Protein Characterization | GEN Magazine Articles | GEN

Retooling Protein Characterization | GEN Magazine Articles | GEN | bioproduction | Scoop.it
If the biotherapeutics workshop is to progress beyond rough-hewn products, it will need a range of finely calibrated analytical platforms. In fact, each potential quality attribute suggests a different biophysical metric.
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What is the freedom to operate for the P. pastoris expression system ?

What is the freedom to operate for the P. pastoris expression system ? | bioproduction | Scoop.it

What you will read about: Conclusions of our freedom to operate studies on P. pastoris expression system.

GTP Technology's insight:

Is the P.pastoris expression system free? We have examined the question for you! Read our conclusions on our blog. bit.ly/1iilaqT

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How to make gene optimization for expression in Escherichia coli a piece of cake

How to make gene optimization for expression in Escherichia coli a piece of cake | bioproduction | Scoop.it

What you will read about: our opinion about gene optimization in E.coli.

GTP Technology's insight:

What really matters in sequence optimization for expression in Escherichia coli (according to us). Read this article from our blog and feel free to react. bit.ly/1IX5vYN

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A panel of simple measures to cure and control the occurrence of phage contamination

A panel of simple measures to cure and control the occurrence of phage contamination | bioproduction | Scoop.it

What you will read about: a panel of actions combining equipment, decontamination and monitoring that showed to be efficient in controlling phage contamination.

GTP Technology's insight:

Bacteriophage contamination? We describe a way to get rid of it on our blog : http://bit.ly/1Prj4kr.

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