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GEN Roundup: How to Improve Cell-Line Productivity | GEN Magazine Articles | GEN

GEN Roundup: How to Improve Cell-Line Productivity | GEN Magazine Articles | GEN | Biopharm | Scoop.it
All too often, the phrase “that dog won’t hunt” applies to cell-line optimization. A productive cell line needs more than a good pedigree, it needs proper care and feeding. Eventually, it may even need to learn new tricks, courtesy of gene editing.
H. Fai Poon's insight:
Erika with the K was former colleague of mine! Here she gave some insight
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GSK orders Sirtris execs to stop selling resveratrol | FierceBiotech

GlaxoSmithKline (NYSE: GSK) has ordered two Sirtris executives--Christoph Westphal and Michelle Dipp--to stop selling a resveratrol dietary supplement based on the drug the two companies have in
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Ascentage Pharma, Unity Biotech collab to ‘cure old age’ | FierceBiotech

Ascentage Pharma, Unity Biotech collab to ‘cure old age’ | FierceBiotech | Biopharm | Scoop.it
East meets West as cancer specialist Ascentage Pharma is teaming up with San Francisco’s Unity Biotechnology to help reverse aging in a new research pact.
H. Fai Poon's insight:
look like aging research is back to spotlight. it has been a decade.
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Aging R&D: The new, old thing in biotech | FierceBiotech

Aging R&D: The new, old thing in biotech | FierceBiotech | Biopharm | Scoop.it
If you ever wondered what kind of future to expect for R&D on drugs to slow the aging process, pay particularly close attention to this story from The Wall Street Journal.
H. Fai Poon's insight:
not sure if ad will be cured by metformin. but it seems amazing.
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Identifying the differences in mechanisms of mycophenolic acid controlling fucose content of glycoproteins expressed in different CHO cell lines. - PubMed - NCBI

Identifying the differences in mechanisms of mycophenolic acid controlling fucose content of glycoproteins expressed in different CHO cell lines. - PubMed - NCBI | Biopharm | Scoop.it
Biotechnol Bioeng. 2016 Apr 19. doi: 10.1002/bit.25995. [Epub ahead of print]
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Effect of AcHERV-GmCSF as an Influenza Virus Vaccine Adjuvant

Effect of AcHERV-GmCSF as an Influenza Virus Vaccine Adjuvant | Biopharm | Scoop.it
The first identification of swine-originated influenza A/CA/04/2009 (pH1N1) as the cause of an outbreak of human influenza accelerated efforts to develop vaccines to prevent and control influenza viruses. The current norm in many countries is to prepar
H. Fai Poon's insight:
Wonder if you can convince people to use protein as adjuvant?
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Will Eli Lilly's 11th-hour regulatory gambit salvage or sink its Alzheimer's drug?

Will Eli Lilly's 11th-hour regulatory gambit salvage or sink its Alzheimer's drug? | Biopharm | Scoop.it
Eli Lilly didn't just surprise investors with its sudden about-face last week on its long-running Phase III program for the Alzheimer's drug solanezumab.
H. Fai Poon's insight:
this is not a easy road
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Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration. - PubMed - NCBI

Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration. - PubMed - NCBI | Biopharm | Scoop.it
MAbs. 2015;7(4):792-803. doi: 10.1080/19420862.2015.1046664.
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PureTech startup sets out to develop new tech for controversial 'vaginal seeding'

PureTech startup sets out to develop new tech for controversial 'vaginal seeding' | Biopharm | Scoop.it
A couple of months ago, New York University's Maria Dominguez-Bello garnered headlines for a small pilot study she led in which a few newborn babies delivered by C-section were swabbed with their mother's vaginal fluid.
H. Fai Poon's insight:
maybe track the health of kids born naturally vs c section at different age to see if there is a different in health first.
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Jeff Kindler's biotech startup sets out to create a 'pain powerhouse,' bags Boehringer portfolio

Jeff Kindler's biotech startup sets out to create a 'pain powerhouse,' bags Boehringer portfolio | Biopharm | Scoop.it
Jeff Kindler's Centrexion Therapeutics is pulling the wraps off a deal to in-license a trio of nonopioid pain meds from Boehringer Ingelheim, which is shedding its pain assets as it concentrates on neuropsychiatric conditions.
H. Fai Poon's insight:
with 2 heavy weight ex ceo. this will build peoples confident.
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Plant to manufacture yellow fever jab slated for Dakar

Plant to manufacture yellow fever jab slated for Dakar | Biopharm | Scoop.it
Some drugmakers are expanding production in Africa to take advantage of a growing number of countries where rising incomes and national healthcare can pay for new meds.
H. Fai Poon's insight:
this ia a phase 2
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BioPharmaSpec plots Asian expansion with a focus on biosimilars

BioPharmaSpec plots Asian expansion with a focus on biosimilars | Biopharm | Scoop.it
BioPharmaSpec is expanding its business into the potentially lucrative Asian market as new business development teams begin work in India and the Asia-Pacific region this month.
H. Fai Poon's insight:
this is ananlytical work that is needed. but when it come to biosimilars. they are all pretty similar.
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Roche, Kite Pharma sign CAR-T and PD-L1 combo deal

Roche, Kite Pharma sign CAR-T and PD-L1 combo deal | Biopharm | Scoop.it
Roche and Kite Pharma are bringing together two of the hottest tickets in oncology research under a new deal announced this week.
H. Fai Poon's insight:
This is going to be big
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China's cabinet bans wholesalers from vaccine supply chain | FiercePharma

China's cabinet bans wholesalers from vaccine supply chain | FiercePharma | Biopharm | Scoop.it
China has officially banned wholesalers from acting as brokers in the sales of voluntary vaccines following a scandal that saw nearly $90 million in illegal sales over a 5-year period.
H. Fai Poon's insight:
china is working to make their health care program presentable to developed countries
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The top 10 (possible) blockbusters that (might) launch this year | FierceBiotech

The top 10 (possible) blockbusters that (might) launch this year | FierceBiotech | Biopharm | Scoop.it
Can't get enough of sell-side estimates on the big new drugs in the late-stage pipeline? Then we have a treat for you today.
H. Fai Poon's insight:
a lot of mab. a lot of potential.
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GSK doubles down on Zymeworks’ platform technologies with $908M deal | FierceBiotech

GSK doubles down on Zymeworks’ platform technologies with $908M deal | FierceBiotech | Biopharm | Scoop.it
The pharma giant has stepped back up to the bargaining table to nail down access to a second platform technology that will be employed to develop new, bispecific antibodies.
H. Fai Poon's insight:
bispecific and cart t meodifier. this technology have a lot of potential. i hope theybdont shelf it like merch shelf glyco fi
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Cheap DNA Sequencing Is Here. Writing DNA Is Next

Cheap DNA Sequencing Is Here. Writing DNA Is Next | Biopharm | Scoop.it
A new startup wants to make DNA writing cheaper and faster.
H. Fai Poon's insight:
would like to get my hand on one to play
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Ex-BGI CEO’s startup hits $1B valuation in 6 months | FierceBiotech

Ex-BGI CEO’s startup hits $1B valuation in 6 months | FierceBiotech | Biopharm | Scoop.it
Jun Wang has moved quickly since stepping down as CEO of Chinese genomics giant BGI to set up an artificial intelligence-enabled health data mining venture, iCarbonX.
H. Fai Poon's insight:
Things are in place for Jun to fly.
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Quantitative analysis of the supernatant from host and transfected CHO cells using iTRAQ 8-plex technique. - PubMed - NCBI

Quantitative analysis of the supernatant from host and transfected CHO cells using iTRAQ 8-plex technique. - PubMed - NCBI | Biopharm | Scoop.it
Biotechnol Bioeng. 2016 Apr 12. doi: 10.1002/bit.25991. [Epub ahead of print]
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MS for CHO supernatant. 
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Solo again, Allergan strikes a $3.3B deal on Heptares' Alzheimer's portfolio

Solo again, Allergan strikes a $3.3B deal on Heptares' Alzheimer's portfolio | Biopharm | Scoop.it
Just hours after Allergan backed away from a $160 billion merger with Pfizer, the company bounced back with a $3.3 billion licensing deal for global rights to a portfolio of drugs for neurological disorders from the U.K.'s Heptares.
H. Fai Poon's insight:
brian drug will be the next big boom
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Lilly's new arthritis drug beats placebo in latest successful trial

Lilly's new arthritis drug beats placebo in latest successful trial | Biopharm | Scoop.it
Eli Lilly and research partner Incyte Corporation released positive new data from the RA-BEACON Phase III trial showing its investigational rheumatoid arthritis pill baricitinib met its primary endpoint of beating a placebo as the drug looks to approval...
H. Fai Poon's insight:
this will be better than biologics
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SEC: Biotech venture chief Burrill handing over $6M to cover what he stole, plus a penalty

SEC: Biotech venture chief Burrill handing over $6M to cover what he stole, plus a penalty | Biopharm | Scoop.it
Steven Burrill has made peace with the SEC.
H. Fai Poon's insight:
what are shame!
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With two PhIII schizophrenia trials in ruins and Alzheimer's on hold, Forum chops staff and considers options

With two PhIII schizophrenia trials in ruins and Alzheimer's on hold, Forum chops staff and considers options | Biopharm | Scoop.it
Forum Pharmaceuticals' rare, high-risk strategy to launch ambitious late-stage trials for schizophrenia with a single major investor has ended in failure, triggering a company-wide reorganization.
H. Fai Poon's insight:
any kind of brian medicine will have pocelbo effect.
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WuXi's reportedly spinning off its biologics biz in an IPO

WuXi's reportedly spinning off its biologics biz in an IPO | Biopharm | Scoop.it
Chinese CRO WuXi PharmaTech just went private in a $3.3 billion deal, but the company is looking to get back on the public markets through an IPO for its biologics business, according to Bloomberg.
H. Fai Poon's insight:
@chris chen. many chinese company are doing that after they went private and then spin off part of business to go public
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Portola Pharmaceuticals, Inc. - Home

Portola Pharmaceuticals, Inc. - Home | Biopharm | Scoop.it
H. Fai Poon's insight:
Dont understand why there is a sudden change. this is supprise for everyone. i believe the data analysis must be wrong.
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