Biomarkers of Heart, Lung, and Kidney Disease
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Biomarkers of Heart, Lung, and Kidney Disease
Curated news related to non-oncological blood-based molecular biomarkers of heart, lung, and kidney disease
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Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic response

The imbalance between Th17 and Treg cells has been studied in various diseases including allergic asthma but their roles have not been fully understood in the development of the late phase asthmatic response.
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New paper published in Allergy, Asthma & Clinical Immunology from our CSO Dr. Scott Tebbutt's academic lab

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Proteomic biomarkers of recovered heart function

Chronic heart failure is a costly epidemic that affects up to 2% of people in developed countries. The purpose of this study was to discover novel blood proteomic biomarker signatures of recovered heart function that could lead to more effective heart failure patient management by both primary care and specialty physicians.

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Healthcare’s digital future | McKinsey & Company

Healthcare’s digital future | McKinsey & Company | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it
Insights from our international survey can help healthcare organizations plan their next moves in the journey toward full digitization. A McKinsey & Company article.
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From the McKinsey report, "Our research revealed surprising and actionable insights about what patients really want, which can in turn inform how healthcare organizations begin their digital patient-enablement journey. Here, we present five of those insights."

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Canadian presence at BIO 2014 - BIOTECanada

BIOTECanada, along with National Biotech Accord partners, are once again leading the Canadian presence at BIO through the Canada Café on the tradeshow floor. Working with our federal and provincial partners, BIOTECanada is providing programming and opportunities for Canadian companies.

PROOF Centre's insight:

The PROOF Centre will be at BIO2014 for One-on-One Partnering. If you are attending BIO2014 and want to schedule a meeting with the PROOF Centre team, connect with us via BIO2014's partnering website: http://oneononepartnering.bio.org/BIO2014/Login

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Blood Test to Monitor for the Absence of Acute Cardiac Rejection: From Discovery to Clinical Implementation

PROOF Centre's insight:

Treatable acute rejection occurs, typically during the first 3 months post-transplant in ~20% of heart graft recipients, and remains the most important cause of early morbidity and graft injury. Ongoing monitoring is critical for effective management of patients. We undertook discovery and replication of blood-based gene expression to monitor for acute rejection.

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Global Market for In Vitro Cardiac Biomarkers to Reach $7.2 Billion in 2018; China is Fastest Growing Market With 18.6% CAGR

Wellesley, Mass. (PRWEB) April 01, 2014 BCC Research (http://www.bccresearch.com) reveals in its new report, CARDIAC BIOMARKERS: TECHNOLOGIES AND GLOBAL MARKETS, the global market for in vitro diagnostic tests for cardiac biomarkers is expected to grow to $7.2 billion by 2018, and register a five-year compound annual growth rate (CAGR) of 12.8%. China is the fastest moving market growing at a 18.6% CAGR.
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Group Aims for Biomarker Standards

Group Aims for Biomarker Standards | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it
A new alliance between industry, academia, and the government wants to boost the “dismal” success rate of biomarker development.
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COPD undertreatment widespread

A study has shown that undertreatment of chronic obstructive pulmonary disease is highly prevalent.
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'Stress Gene' Ups Heart Attack, Death Risk

By Steven C. Moyo, M.D. A gene mutation can increase your risk of heart attack and death as much as smoking does, new research suggests.
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Cardiology, Genomics and Individualized Heart Care: Framingham Heart Study and Jackson Heart Study

Cardiology, Genomics and Individualized Heart Care: Framingham Heart Study and Jackson Heart Study | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it
2.2 Assessing Cardiovascular Disease with Biomarkers. 2.2.1 Issues in Genomics of Cardiovascular Diseases 2.2.2 Endothelium, Angiogenesis, and Disordered Coagulation 2.2.3 Hypertension BioMarkers 2.2.4 Inflammatory ...
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Chronic bronchitis could indicate COPD subtype

medwireNews Chronic bronchitis is common among patients with chronic obstructive disease and may represent a subtype of the disease that places patients at risk for increased severity and exacerbations, say researchers.
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QoL, BMI predict exacerbations in Japanese COPD patients

Analysis of a cohort of Japanese chronic obstructive pulmonary disease patients with a low exacerbation frequency shows that low body mass index and poor health-related quality of life independently predict flare ups of the disease.
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What Are Biomarkers and Why Are They Useful?

What Are Biomarkers and Why Are They Useful? | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it

Biomarker is short for biological marker, and is used as an indication that a biological process in the body has happened or is ongoing. While some biomarkers are used to show that the body has been exposed to a chemical, toxin or other environmental impact — most associate biomarkers with medicine.


Definition of a Biomarker

A biomarker has to be something that can be measured: accurately and reproducibly. There are several definitions of a biomarker, the World Health Organisation definition of a biomarker includes the statement: ‘any measurement reflecting an interaction between a biological system and a potential hazard, which may be chemical, physical, or biological. The measured response may be functional and physiological, biochemical at the cellular level, or a molecular interaction. 


Biomarkers are not medical symptoms, such as a high temperature that a patient can use to determine how well they are, but an increased heart rate as a result of physical exertion is a biomarker. The increased heart rate is a physiological response to the exercise.


Medical use of Biomarkers

There are many medical uses of biomarkers and the use of biomarkers will become significantly more widespread as personalized medical care becomes standard. Biomarkers can be used to...


- See more at: http://www.labmate-online.com/news/news-and-views/5/breaking_news/what_are_biomarkers_and_why_are_they_useful/31934/#sthash.usI89HNe.dpuf

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Two-Stage, In Silico Deconvolution of the Lymphocyte Compartment of the Peripheral Whole Blood Transcriptome in the Context of Acute Kidney Allograft Rejection

Two-Stage, In Silico Deconvolution of the Lymphocyte Compartment of the Peripheral Whole Blood Transcriptome in the Context of Acute Kidney Allograft Rejection | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it

Acute rejection is a major complication of solid organ transplantation that prevents the long-term assimilation of the allograft. Various populations of lymphocytes are principal mediators of this process, infiltrating graft tissues and driving cell-mediated cytotoxicity. Understanding the lymphocyte-specific biology associated with rejection is therefore critical. Measuring genome-wide changes in transcript abundance in peripheral whole blood cells can deliver a comprehensive view of the status of the immune system.

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Personalized Medicine: The path forward

http://www.mckinsey.com/client_service/pharmaceuticals_and_medical_products/latest_thinking

 

Personalized medicine is now poised for rapid growth because of recent scientific advances. With the right strategies, pharmacos, biotechs, and diagnostic companies could capture many new opportunities in this surging field.


This compendium from McKinsey is available at

http://www.mckinsey.com/~/media/McKinsey/dotcom/client_service/Pharma%20and%20Medical%20Products/PMP%20NEW/PDFs/McKinsey%20on%20Personalized%20Medicine%20March%202013.ashx

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Molecular Diagnostics Are Leading the Way to Personalized, Precision Medicine

Molecular Diagnostics Are Leading the Way to Personalized, Precision Medicine, Says Society for Women’s Health Research
 Campaign to Highlight These Important Innovations in
Women’s Health Launched at SWHR 2014 Gala


Washington, D.C. – The Society for Women’s Health Research (SWHR®), the leading voice on research into the biological sex differences between women and men, is proud to announce a public awareness campaign focused on “Transforming Science: Innovations in Molecular Diagnostics.” SWHR launched the yearlong focus on this rapidly advancing field in women’s health during the 2014 Annual Gala...

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Plasma Protein Biosignatures for Detection of Cardiac Allograft Vasculopathy

Plasma Protein Biosignatures for Detection of Cardiac Allograft Vasculopathy

 

 

PROOF Centre's insight:

Members of the PROOF Centre team and collaborators will be at the International Heart and Lung Transplantation 34th Annual Meeting and Scientific Sessions. We have two presentations scheduled for Friday, April 11th, 2014. Join us.

@ISHLT #ISHLT2014

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Canadian doctors urged to limit testing to contain costs

Canadian doctors urged to limit testing to contain costs | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it
Choosing Wisely Canada campaign piggybacks on a U.S. effort that identified dozens of tests and procedures as of little or no value
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PROOF Centre Featured on Health Briefs | PROOF Centre

@PROOFCentre featured on Health Briefs TV Show hosted by #TerryBradshaw http://t.co/dRh6Z9JjsJ
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Biomarkers of kidney injury indicate increased risk of death after discharge from cardiac surgery

Biomarkers of kidney injury indicate increased risk of death after discharge from cardiac surgery | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it
Following cardiac surgery, patients with elevated levels of kidney injury biomarkers are at a significantly higher risk of dying during the next three years, a Yale study has found.
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Biomarkers in ACS and Heart Failure: Should Men and Women Be Interpreted Differently?

Biomarkers in ACS and Heart Failure: Should Men and Women Be Interpreted Differently? | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it

Sex-based differences exist in the circulating concentrations of certain novel and established biomarkers in patients with acute coronary syndromes (ACS) and heart failure (HF). However, to date, few studies have compared the diagnostic and prognostic utility of these markers in men vs women.

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MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes – APAC Analysis and Market Forecasts

Illinois – United States – December 2, 2013:Reportstack has announced a new market report on MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes

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Newly identified biomarkers help predict outcome in deadly lung disease

New Haven, Conn. – A Yale-led study has identified a gene expression profile that can predict outcomes and lead to better treatment for one of the most lethal lung diseases, idiopathic pulmonary fibrosis (IPF).
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Complementing Personalized Medicines

Complementing Personalized Medicines | Biomarkers of Heart, Lung, and Kidney Disease | Scoop.it

Mollie Roth discusses how complementary diagnostics can improve disease management and optimize therapy.

Since the human genome was first sequenced in 2000, the personalized medicine (PM) space has worked diligently to make real on the promise that co-development and launch of companion diagnostics (CDx) with targeted therapies would make drugs safer and more efficacious for patients. That promise has been born out in the intervening thirteen years with the introduction of over one dozen targeted therapies and associated CDx, including such blockbuster therapies as Herceptin, Tarceva and Gleevec.

These therapies utilize their FDA approved CDx tests to make more accurate predictions of whether an individual will respond positively to a targeted therapy based on the genetic or other molecular markers of the individual. To date, the majority of these treatments have been in oncology, where targeting specific molecular markers in the patient or the tumor represent remarkable improvements over standard chemotherapeutics.

From this initial narrow concept, the idea of PM has expanded to consider the patients’ entire journey through and engagement with the healthcare system. In order to truly bridge the gap between the concept of a targeted therapy and a CDx, the industry is now incorporating another potent tool in its arsenal — the “complementary diagnostic.”

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