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New genetic sequencing lab creates 'tipping point' for personalised cancer ... - Private Healthcare UK

New genetic sequencing lab creates 'tipping point' for personalised cancer ...
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Sarah Cannon and the UCL Cancer Institute of the UK establish a genetic sequencing platform for cancer patients focused on identifying driver mutations with "actionable" available treatments.  This platform also requires less tissue for the testing and may be performed at a lower cost than traditional gene sequencing.

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Prostate Cancer Biomarker May Predict Patient Outcomes - RedOrbit

Prostate Cancer Biomarker May Predict Patient Outcomes - RedOrbit | Biomarkers and Personalized Medicine | Scoop.it
Science Codex Prostate Cancer Biomarker May Predict Patient Outcomes RedOrbit Researchers at Vanderbilt University Medical Center and the University of Alberta in Canada have identified a biomarker for a cellular switch that accurately predicts...
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PsychiatryOnline | American Journal of Psychiatry | Effect of Knowledge of APOE Genotype on Subjective and Objective Memory Performance in Healthy Older Adults

PsychiatryOnline | American Journal of Psychiatry | Effect of Knowledge of APOE Genotype on Subjective and Objective Memory Performance in Healthy Older Adults | Biomarkers and Personalized Medicine | Scoop.it
Telling ppl they have APOE genotype linked to Alzheimer’s worsens their perception of, & performance on, memory tests http://t.co/HEEoVcXQUs
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FirstTrimester Biomarker May Help Identify Early GDM Risk

FirstTrimester Biomarker May Help Identify Early GDM Risk | Biomarkers and Personalized Medicine | Scoop.it
Glycosylated fibronectin may identify women in their first trimester who are at risk for gestational diabetes.
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Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus (GDM), according to a study published online Aug. 5 in Obstetrics & Gynecology.

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FDA Approves First Rapid Diagnostic Test to Detect HIV-1 Antigen ...

FDA Approves First Rapid Diagnostic Test to Detect HIV-1 Antigen ... | Biomarkers and Personalized Medicine | Scoop.it
The Food and Drug Administration today approved the first rapid Human Immunodeficiency Virus (HIV) test for the simultaneous detection of HIV-1 p24 antigen as well as antibodies to both HIV-1 and HIV-2 in human serum, ...
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Cancer biomarker tests undervalued by doctors and patients, authors say - News-Medical.net

Cancer biomarker tests undervalued by doctors and patients, authors say
News-Medical.net
Doctors need a way to target treatments to patients most likely to benefit and avoid treating those who will not.
Brian Shields's insight:

Very interesting observations regarding the importance of biomarkers and the obstaclescreated by the current cancer research environment.  The quote below is a great summary of the current status quo preventing personalized medicine from flousishing in the U.S.:


"The regulatory process, the research funding, the reimbursement, even the standards for journal publications for tumor biomarker tests are all meager compared to the robust support for drug development, the authors say."

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Discovery of Novel Gene Mutations in Leukemia Patients Opens Up ... - Science Daily (press release)

Discovery of Novel Gene Mutations in Leukemia Patients Opens Up ... - Science Daily (press release) | Biomarkers and Personalized Medicine | Scoop.it
Discovery of Novel Gene Mutations in Leukemia Patients Opens Up ...
Science Daily (press release)
Discovery of Novel Gene Mutations in Leukemia Patients Opens Up Personalized Therapy Options. Aug.
Brian Shields's insight:

Exciting research for the treatment of Leukemia---


"The FLT3 receptor mutations we have found in these leukemia patients provide a new basis for treating the disease," says Dr. Philipp Greif. "We already have FLT3 receptor inhibitors at hand, which we can now use to treat the affected patients."

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Richard D. Hammer, M.D.'s comment, August 19, 2013 8:52 AM
Monitoring of FLT3 mutations is already performed routinely for acute myeloid leukemias in most high level institutions. It's has prognostic significance, similar to NPM. These tests have been performed for the last several years.
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Foundation Medicine Announces New Data Using Next-Generation Sequencing ... - EON: Enhanced Online News (press release)

Foundation Medicine Announces New Data Using Next-Generation Sequencing ... - EON: Enhanced Online News (press release) | Biomarkers and Personalized Medicine | Scoop.it
Foundation Medicine Announces New Data Using Next-Generation Sequencing ...
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Test for diagnosis and treatment of angina 'flawed' - The Independent

Test for diagnosis and treatment of angina 'flawed' - The Independent | Biomarkers and Personalized Medicine | Scoop.it
Test for diagnosis and treatment of angina 'flawed' The Independent As part of the project, cardiologists performed diagnostic angiograms on the patients with stable chest pain and drew up their treatment plans based on the initial assessment...
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10 ASCO '13 Abstracts You Can Read Right Now

10 ASCO '13 Abstracts You Can Read Right Now | Biomarkers and Personalized Medicine | Scoop.it
Get a head start on searching through ASCO abstracts with these 10 summaries.
Brian Shields's insight:

A nice resource for the hot data out of ASCO

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New Schizophrenia Diagnostic Method Found - Bioscience Technology - Bioscience Technology

New Schizophrenia Diagnostic Method Found - Bioscience Technology - Bioscience Technology | Biomarkers and Personalized Medicine | Scoop.it
Bioscience Technology New Schizophrenia Diagnostic Method Found - Bioscience Technology Bioscience Technology Researchers have discovered a method for physical diagnosis of schizophrenia by collecting tissue from the nose Schizophrenia, a...
Brian Shields's insight:

Very interesting development in psychiatry...scientists from Tel Aviv University and Johns Hopkins identify olfactory neurons that may possibly be used for early diagnosis of schizophrenia.  It is not clear yet whether this biomarker is apparent before symptoms appear.

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Florence Piron's comment, May 3, 2013 8:32 AM
Don't you find it a strange and very limited method to work on a very complex disease with strong social and psychological components??
Brian Shields's comment, May 23, 2013 10:26 PM
Yes, a very strange development for a complex disease. However, scientists are doing a nice job now of monitoring the signals that our body produces to better diagnose and treat these difficult diseases. Perhaps scientists have realized that treating schizophrenia after it has already been diagnosed is a difficult path to follow. Perhaps early detection is the path toward a better treatment paradigm?
Marcus Healey's curator insight, July 28, 4:02 PM

No good diagnostics exist for the early detection of schizophrenia, a disease that affects approximately 1% of the world's population. Researchers in Israel are exploring early detection techniques by sampling by sampling neurons in frontal part of the brain and examining the microRNA. Ouch!

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New diagnostic technology may lead to individualized treatments for prostate cancer - Cedars-Sinai

NanoVelcro Chip device captures and isolates potentially high-risk cancer cells
Brian Shields's insight:

A great advancement may be on the horizon for the treatment of patients with Prostate Cancer.  The use of circulating tumor cells or "liquid biopsies" may prevent the need for painful and invasive procedures to obtain biopsy tissue.

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Epithelial-Mesenchymal Transition and Lung Cancer: Mechanism ...

Epithelial-Mesenchymal Transition and Lung Cancer: Mechanism ... | Biomarkers and Personalized Medicine | Scoop.it
The discovery of activating mutations in EGFR radically changed the treatment options for these patients, and, indeed, treatment of advanced stage patients with EGFR-mutated tumors with erlotinib (in the US) is now front-line ...
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Raj Desai, Ph.D.,'s curator insight, April 1, 2013 6:57 PM
We still need to go extra mile to cover all bases.
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Thomas Jefferson University Researchers Discover New Pathways that Drive Metastatic Prostate Cancer

Thomas Jefferson University Researchers Discover New Pathways that Drive Metastatic Prostate Cancer | Biomarkers and Personalized Medicine | Scoop.it
Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print on December 21...Read the whole entry... »...
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Let the Hep C Drug War Begin - DailyFinance

Let the Hep C Drug War Begin - DailyFinance | Biomarkers and Personalized Medicine | Scoop.it
New York Times Let the Hep C Drug War Begin DailyFinance Sovaldi is approved to treat four different strains of hepatitis virus referred to as genotype 1-4. Olysio is only approved for genotype 1, so Gilead will have genotype 2-4 all to itself.
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CTC-Based Biomarkers Can Be Measured for Sensitivity to Novel Breast Cancer Drug

CTC-Based Biomarkers Can Be Measured for Sensitivity to Novel Breast Cancer Drug | Biomarkers and Personalized Medicine | Scoop.it
Biomarkers for sensitivity to etirinotecan pegol that are found in circulating tumor cells of breast cancer patients can be
Brian Shields's insight:

Great article on research helping to determine sensitivity to Breast Cancer Treatment through CTCs.

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Researchers identify new biomarker to predict immune response ...

Researchers identify new biomarker to predict immune response ... | Biomarkers and Personalized Medicine | Scoop.it
A team of scientists e have identified and validated a biomarker accessible in blood tests that could be used to predict which stem cell transplant patients are at highest risk for graft-versus-host disease.
Brian Shields's insight:

Article Excerpt:

"A team of scientists from the Indiana University, the University of Michigan, the Fred Hutchinson Cancer Research Center and the Dana-Farber Cancer Institute have identified and validated a biomarker accessible in blood tests that could be used to predict which stem cell transplant patients are at highest risk for a potentially fatal immune response (graft-versus-host disease)."

Read more: http://www.stemcellsfreak.com/2013/08/ST2-stem-cell-transplant.html#ixzz2bm82NOAD


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Inherited genetic variants help predict personalized treatment options in lung ... - News-Medical.net

Inherited genetic variants help predict personalized treatment options in lung ...
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Scientists Find Promising Biomarker for Predicting HPV-Related Oropharynx Cancer

Scientists Find Promising Biomarker for Predicting HPV-Related Oropharynx Cancer | Biomarkers and Personalized Medicine | Scoop.it
This graphic shows the genomic structure of HPV.
Brian Shields's insight:

Researchers have found that antibodies against the human papillomavirus (HPV) may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, which is a portion of the throat that contains the tonsils.

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Cancer care in Utah goes genetic - Salt Lake Tribune

Cancer care in Utah goes genetic - Salt Lake Tribune | Biomarkers and Personalized Medicine | Scoop.it
Cancer care in Utah goes genetic
Salt Lake Tribune
Just five years ago researchers made a big splash by targeting a colon cancer gene known as KRAS.
Brian Shields's insight:

A great article providing a glimpse into the future of Cancer Treatment.

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Autism & Asperger's: Diagnostic changes on the way... - Burlington Union

Autism & Asperger's: Diagnostic changes on the way...
Brian Shields's insight:

Very interesting article on the possible impact that the new DSM-5 Diagnostic criteria may have on the diagnosis and access to special education for children with Autism and Asperger syndrome.

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Blood Protein Test Can Identify Lung Cancer Patients Likely to Benefit from Targeted Therapy

A recent phase III clinical trial confirmed that the VeriStrat test can predict which lung cancer patients are likely to fare better when treated with EGFR inhibitors like erlotinib (Tarceva). Patients with advanced non-small cell lung cancer (NSCLC) were tested using VeriStrat before beginning Tarceva treatment. Those who had a VeriStrat result of “Good” experienced longer times without cancer growth and longer overall survival on Tarceva compared to those with a “Bad” result. VeriStrat results may help doctors distinguish patients who should be given EGFR inhibitors from those for whom the benefits would not outweigh the side effects, and who would be better served by other treatments. VeriStrat does not test for mutations in the EGFR gene. Instead, the test assesses the pattern of several proteins in the blood to pinpoint patients likely to respond to EGFR inhibitors, including patients who may not have an EGFR mutation.


Via Cancer Commons
Brian Shields's insight:

Some interesting data out of ASCO using protien signatures in the blood to help develop personalized medicine for lung cancer patients.  Article excerpt follows:

The results from the Phase 3 trial announced today, shows it can make that difference, in a prospective study, which means that patients got the Biodesix test, were treated based on its recommendation, and followed over time to see if they ended up any better off. Passing that kind of rigorous study, should greatly expands the commercial potential for VeriStrat, Brunel said.

“VeriStrat has been commercially available for several years, but adoption has been limited…. This could lead to widespread adoption,” Brunel said.

According to the American Cancer Society, about 220,000 Americans per year are diagnosed with lung cancer, and about 85-90 percent have non-small cell lung cancer.

Biodesix will now build a national sales team and develop its marketing to try to capitalize on VeriStrat’s commercial potential, which could improve as the federal government is expected to reach a decision soon about whether it will be covered by Medicare.

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Cancer Commons's curator insight, June 6, 2013 5:38 AM

Xconomy | June 3, 2013

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New genetic sequencing lab creates 'tipping point' for personalised cancer ... - Private Healthcare UK

New genetic sequencing lab creates 'tipping point' for personalised cancer ...
Brian Shields's insight:

Sarah Cannon and the UCL Cancer Institute of the UK establish a genetic sequencing platform for cancer patients focused on identifying driver mutations with "actionable" available treatments.  This platform also requires less tissue for the testing and may be performed at a lower cost than traditional gene sequencing.

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GE Healthcare Launches its First “Next-Generation” Sequencing Assay | Biomarker Commons

GE Healthcare Launches its First “Next-Generation” Sequencing Assay | Biomarker Commons | Biomarkers and Personalized Medicine | Scoop.it
GE Healthcare Launches its First “Next-Generation” Sequencing Assay http://t.co/1JUJWflRPr
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Science of genome-sequencing has rocketed forward in 10 years - Milwaukee Journal Sentinel

Science of genome-sequencing has rocketed forward in 10 years - Milwaukee Journal Sentinel | Biomarkers and Personalized Medicine | Scoop.it
Science of genome-sequencing has rocketed forward in 10 years
Milwaukee Journal Sentinel
To a degree few had expected in the 1990s, the speed of genome sequencing has increased and the cost has dropped.
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Medical School Establishes Biomarker Discovery Center - Newswise (press release)

Medical School Establishes Biomarker Discovery Center Newswise (press release) Newswise — STRATFORD, NJ – Following recent discoveries by its researchers that could significantly change the diagnosis and treatment of a number of diseases, the...
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