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Biomarkers and Personalized Medicine
Sharing relevant articles on advancements in personalized medicine
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PLoS ONE: Chemoresistance in Prostate Cancer Cells Is Regulated by miRNAs and Hedgehog Pathway

PLoS ONE: Chemoresistance in Prostate Cancer Cells Is Regulated by miRNAs and Hedgehog Pathway | Biomarkers and Personalized Medicine | Scoop.it

Excerpt from Abstract: "Many prostate cancers relapse due to the generation of chemoresistance rendering first-line treatment drugs like paclitaxel (PTX) ineffective. The present study aims to determine the role of miRNAs and Hedgehog (Hh) pathway in chemoresistant prostate cancer and to evaluate the combination therapy using Hh inhibitor cyclopamine (CYA)."

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Update on Medivation’s MDV3100 in advanced prostate cancer

Update on Medivation’s MDV3100 in advanced prostate cancer | Biomarkers and Personalized Medicine | Scoop.it
This weekend heralds the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) meeting in San Francisco, although ASCO held their press briefing today to provide an update on some of the key topics.
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Meta-Analysis Confirms Link Between Epigenetic Changes and Prostate Cancer

Meta-Analysis Confirms Link Between Epigenetic Changes and Prostate Cancer | Biomarkers and Personalized Medicine | Scoop.it
The discovery of effective biomarkers in cancer will have a significant impact on disease management.
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New Stanford model establishes guidelines for earlier cancer ...

New Stanford model establishes guidelines for earlier cancer ... | Biomarkers and Personalized Medicine | Scoop.it
Some biomarkers are in wide use today. One is the well-known PSA, for prostate cancer. Another is CA125, for ovarian cancer. But these and other currently used blood tests for cancer biomarkers weren't specifically ...
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Excellent news in Advanced Prostate Cancer – Medivation’s MDV3100 meets primary endpoint

It’s not often that you wake up to really exciting news in the cancer field, but that’s what happened this morning with Medivation’s announcement on the interim analysis of their androgen receptor (AR) antagonist, MDV3100: “As reported by the IDMC,...
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Fred Hutch sequencing project unveils key triggers for prostate cancer - FierceBiotech Research

Some researchers at the prestigious Fred Hutchinson Cancer Research Center allied with scientists at the University of Washington have helped illustrate just how significant sequencing can be for Read more...
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Prostate Cancer Prognostic Marker Discovery By Next Generation Sequencing

Prostate Cancer Prognostic Marker Discovery By Next Generation Sequencing | Biomarkers and Personalized Medicine | Scoop.it
Genomatix Software, the Uniformed Service University of the Health Sciences (USU), and the Henry M. Jackson Foundation (HJF) for the Advancement of Military Medicine, Inc.
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Cancer biomarker -- detectable by blood test -- could improve prostate cancer detection

A new study supports the use of a DNA-based "biomarker" blood test as a complement to the prostate-specific antigen test currently offered to screen men for prostate cancer.
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Castration resistant prostate cancer is associated with increased blood vessel stabilization and elevated levels of VEGF and Ang-2. « Medicine JournalFeeds

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Blood test targets oncology treatment | New Jersey Nursing News

Blood test targets oncology treatment | New Jersey Nursing News | Biomarkers and Personalized Medicine | Scoop.it
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FDA Approves New Blood Test to Improve Prostate Cancer Detection | Biomarker Commons

FDA Approves New Blood Test to Improve Prostate Cancer Detection | Biomarker Commons | Biomarkers and Personalized Medicine | Scoop.it

Excerpt from from article: "Beckman Coulter, Inc., the leader in prostate cancer diagnostics, announces Premarket Approval (PMA) from the U.S. Food and Drug Administration (FDA) for the Prostate Health Index (phi), a simple, non-invasive blood test that is 2.5 times more specific in detecting prostate cancer than PSA (prostate-specific antigen) in patients with PSA values in the 4-10 ng/mL range and is proven to reduce the number of prostate biopsies."

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Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments | University of Michigan Health System

Genetic sequencing could help match patients with biomarker-driven cancer trials, treatments | University of Michigan Health System | Biomarkers and Personalized Medicine | Scoop.it

"As cancer researchers continue to identify genetic mutations driving different cancer subtypes, they are also creating a catalog of possible targets for new treatments.The University of Michigan Comprehensive Cancer Center and Michigan Center for Translational Pathology (MCTP) recently completed a pilot study aimed at solving the practical challenges involved in quickly and systematically sequencing genetic material from patients with advanced or treatment-resistant cancer in order to match them with existing clinical trials based on the biomarkers identified.

 

“We’re talking about more than just examining a few genes where mutations are known to occur, or even about a hundred genes,” says co-lead investigator Dan Robinson, Ph.D., a post-doctoral fellow at MCTP. “We’re talking about the ability to sequence more than 20,000 genes and look not just for individual genetic mutations, but at combinations of mutations.”

 

The exploratory study, known as the Michigan Oncology Sequencing Project (MI-ONCOSEQ), found that identifying a patient’s “mutational landscape” provides a promising approach for identifying which trials may best help a patient, the researchers say. Their findings were published today in Science Translational Medicine..."

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A new approach to targeted therapy in some prostate cancers | Pharma Strategy Blog

A new approach to targeted therapy in some prostate cancers | Pharma Strategy Blog | Biomarkers and Personalized Medicine | Scoop.it
Study reported on largest in-depth molecular analysis of neuroendocrine prostate cancer, offered new insight into molecular events involved in disease progression...
 
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MDxHealth Reports Positive Results for its Prostate Cancer Diagnostic Test - Business Wire (press release)

MDxHealth Reports Positive Results for its Prostate Cancer Diagnostic Test - Business Wire (press release) | Biomarkers and Personalized Medicine | Scoop.it
MDxHealth Reports Positive Results for its Prostate Cancer Diagnostic TestBusiness Wire (press release)Urologists need improved methods to help identify those men who may forego these invasive procedures” MDxHealth SA (NYSE Euronext: MDXH), a leading...
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CD44 is a biomarker associated with human prostate cancer radiation sensitivity

CD44 is a biomarker associated with human prostate cancer radiation sensitivity | Biomarkers and Personalized Medicine | Scoop.it
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Cancer Biomarker -- Detectable By Blood Test -- Could Improve Prostate Cancer Detection

Cancer Biomarker -- Detectable By Blood Test -- Could Improve Prostate Cancer Detection | Biomarkers and Personalized Medicine | Scoop.it
A new study supports the use of a DNA-based biomarker blood test as a complement to the prostate-specific antigen (PSA) test currently offered to screen men for prostate cancer.
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Cancer Cell - Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer
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Custirsen – a new treatment for castrate resistant prostate cancer?

Custirsen – a new treatment for castrate resistant prostate cancer? | Biomarkers and Personalized Medicine | Scoop.it
From the PharmaStrategy Blog: "I've been following the development of Oncogenex's custirsen for a while based on various posters presented at meetings such as ASCO and AUA, but with the publication of phase II data in prostate cancer, it seems a good time to..."
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Scientists Discover New Pathway To Potential Therapies For Advanced Prostate Cancer

Scientists Discover New Pathway To Potential Therapies For Advanced Prostate Cancer | Biomarkers and Personalized Medicine | Scoop.it
UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway...
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UroToday - Circulating tumor cells as biomarkers in prostate cancer - Abstract

UroToday - Circulating tumor cells as biomarkers in prostate cancer - Abstract | Biomarkers and Personalized Medicine | Scoop.it
Circulating tumor cells as biomarkers in prostate cancer - Abstract...
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