Biomarkers and Personalized Medicine
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Biomarkers and Personalized Medicine
Sharing relevant articles on advancements in personalized medicine
Curated by Brian Shields
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Matching Tumors With The Optimal Cancer Drugs - Science 2.0

Matching Tumors With The Optimal Cancer Drugs - Science 2.0 | Biomarkers and Personalized Medicine | Scoop.it
Matching Tumors With The Optimal Cancer Drugs
Science 2.0
The main driver of pancreatic cancer, a mutation in a gene called KRAS, has proven difficult to target with treatments.
Brian Shields's insight:

Very Powereful Quote and an important one for clinicians to understand, " We have a small but effective inventory of 'druggable' mutations that we know play a role in cancer"

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Oncology News - Human pancreatic cancer fusion 2 (HPC2) 1-B3: A novel monoclonal antibody to screen for pancreatic ductal dysplasia |4143995

Oncology Medical Article: Human pancreatic cancer fusion 2 (HPC2) 1-B3: A novel monoclonal antibody to screen for pancreatic ductal dysplasia (Human pancreatic cancer fusion 2 (HPC2) 1-B3: A novel monoclonal antibody to screen for pancreatic duc...)...
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Serum HSP70: A Novel Biomarker for Early Detection of Pancre... : Pancreas

Objectives: Heat shock protein 70 (HSP70) is overexpressed in human pancreatic cancer cell lines.
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Abcodia and Oxford Gene Technology form Partnership to Advance Biomarkers for the Early Diagnosis of Pancreatic Cancer

Abcodia and Oxford Gene Technology form Partnership to Advance Biomarkers for the Early Diagnosis of Pancreatic Cancer | Biomarkers and Personalized Medicine | Scoop.it
Abcodia, a specialist company engaged in the validation and discovery of biomarkers of cancer and other age-related diseases and Oxford Gene Technology (OGT) a provider of innovative clinical genetics and diagnostic solutions to advance molecular...
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New developments in the biology pancreatic cancer | Pharma Strategy Blog

EGFR is involved in the development of KRAS-pancreatic cancer and the vaccinia virus construct GLV-1h153 may be a promising oncolytic agent for the treatment and monitoring of pancreatic cancer...
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EGFR essential for the development of pancreatic cancer

The epidermal growth factor receptor (EGFR) gene is essential for KRAS-driven pancreatic cancer development, according to study results presented at the Second AACR International Conference on Frontiers in Basic Cancer Research.
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Gene test for pancreatic cancer in the works - Baltimore Sun (blog)

Gene test for pancreatic cancer in the worksBaltimore Sun (blog)They identified two mutations: one in the KRAS gene, known for its prevalence in pancreatic cancers, and the GNAS gene, not previously been associated with pancreatic cancer.
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Pten Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB-Cytokine Network

Pten Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB-Cytokine Network | Biomarkers and Personalized Medicine | Scoop.it
Article on a pathway of interest in a very difficult to treat cancer.
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Will ASCO GI herald a new era for pancreatic cancer?

Very important medical conference today in my backyard, ASCO GI. Sally Church reviews why the data presented at this meeting may finally yield an improvement in the treatment of Pancreatic Cancer.
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Biomarker panel to screen for pancreatic cancer may be possible

Biomarker panel to screen for pancreatic cancer may be possible | Biomarkers and Personalized Medicine | Scoop.it

Excerpt from article:

"The development of a highly accurate, blood-based pancreatic adenocarcinoma screen that would be accurate enough to test the general population for this deadly disease may not be far out of reach, according to data presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference."

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Plasma 25-Hydroxyvitamin D and Risk of Pancreatic Cancer

Background: Laboratory studies suggest that vitamin D may inhibit pancreatic cancer cell growth. However, epidemiologic studies of vitamin D and pancreatic cancer risk have been conflicting.
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Test in development can ease cancer concern

Test in development can ease cancer concern | Biomarkers and Personalized Medicine | Scoop.it
There is hope coming from researchers for those diagnosed with pancreatic cancer.
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AACR: EGFR Involved in KRAS-Driven Pancreatic Cancer --Doctors Lounge

AACR: EGFR Involved in KRAS-Driven Pancreatic Cancer --Doctors Lounge | Biomarkers and Personalized Medicine | Scoop.it
AACR: EGFR Involved in KRAS-Driven Pancreatic Cancer http://t.co/1qS7CbFg #Health #Medicine...
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Jon Perona's curator insight, April 28, 2014 7:08 PM

Unfortunately by the time a patient is diagnosed with pancreatic cancer the cancer has spread to far.  Most people die shortly after being diagnosed with pancreatic cancer.

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Emerging pathways and future targets for the molec... [Expert Opin Ther Targets. 2011] - PubMed result

This review explores the preclinical rationale for clinical approaches aimed at targeting the TGF-β, IGF, Hedgehog, Notch and NF-κB signaling pathways, to develop innovative therapeutic strategies for pancreatic cancer

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Symposier - EGFR induced radiotherapy resistance in tumour cells

Symposier - EGFR induced radiotherapy resistance in tumour cells | Biomarkers and Personalized Medicine | Scoop.it
Uploaded and shared in Youtube by: ecancertv — Prof Hans Peter Rodemann speaks about his work investigating how inhibition of the EGFR pathway induces resistance to radiotherapy in tumour cells.
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