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Biomarkers and Personalized Medicine
Sharing relevant articles on advancements in personalized medicine
Curated by Brian Shields
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New Drug Is First to Help Patients With Recurrent Low-Grade Ovarian Cancer - Science Daily (press release)

New Drug Is First to Help Patients With Recurrent Low-Grade Ovarian Cancer Science Daily (press release) Cancer-causing genetic mutations in BRAF and KRAS genes occur more frequently in low-grade ovarian cancer, so the researchers chose a drug that...
Brian Shields's insight:

Researchers identified that KRAS and BRAF mutations occur more frequently in low grade Ovarian cancer and chose a therapy (Selumetinib) that inhibits the molecular network, MAPK, that includes these genes. 


The outcome:


"These are remarkably encouraging results for what can ultimately be a devastating disease," said Gershenson, the paper's senior author.

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Erin Grills's curator insight, February 23, 2013 7:04 PM

This site will allow me to discuss the advancements in drugs for my pharmaceutical subtopic. This also allows me to expand my research to see how many other cancer drugs are being discovered due to the advancemens in engineering.

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JCI - An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice http://t.co/mTsWESxf...
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New Stanford model establishes guidelines for earlier cancer ...

New Stanford model establishes guidelines for earlier cancer ... | Biomarkers and Personalized Medicine | Scoop.it
Some biomarkers are in wide use today. One is the well-known PSA, for prostate cancer. Another is CA125, for ovarian cancer. But these and other currently used blood tests for cancer biomarkers weren't specifically ...
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Ovarian Serous Carcinoma: Relationship of p53 and bcl-2 Wit... : International Journal of Gynecologic Pathology

The aim of the study was to assess the microvessel density (MVD) and vascular endothelial growth fac (Current TOC: Ovarian Serous Carcinoma: Relationship of p53 and bcl-2 With Tumor Angiogenesis and VEGF Expressio...)...
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Using folate receptor alpha fluorescence imaging in ovarian cancer

Using folate receptor alpha fluorescence imaging in ovarian cancer | Biomarkers and Personalized Medicine | Scoop.it
The other day an interesting paper came to my attention entitled: “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results” Thanks to my translational research friend Angela...
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Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care - Lab on a Chip (RSC Publishing)

Ovarian cancer is asymptomatic in the early stages and most patients present with advanced levels of disease.
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Ovarian Cancer Genome Mapped, Opens Door to Personalized Medicine ...

Ovarian Cancer Genome Mapped, Opens Door to Personalized Medicine ... | Biomarkers and Personalized Medicine | Scoop.it
The result is the most expansive genomic analysis of any cancer to date and a major step toward the personalized treatment of ovarian cancer. The research is described in the June 30 issue of the journal Nature.
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Vermillion Reports Second Quarter 2012 Results - Sacramento Bee

Vermillion Reports Second Quarter 2012 Results - Sacramento Bee | Biomarkers and Personalized Medicine | Scoop.it

"In Q2, the volume of OVA1®, the company's flagship diagnostic test designed to help differentiate benign from malignant ovarian masses, was in line with management's forecast at 4150, increasing..."

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MabCure, Inc. Announces Completion Of Its Ovarian Cancer Diagnostic Study In ... - TheStreet.com (press release)

MabCure, Inc. Announces Completion Of Its Ovarian Cancer Diagnostic Study In ...TheStreet.com (press release)By Business Wire 12/15/11 - 02:09 PM EST MabCure, Inc.
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Ovarian cancer patients with BRCA2 mutated tumors live longer

Ovarian cancer patients with BRCA2 mutated tumors live longer | Biomarkers and Personalized Medicine | Scoop.it
“Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations.” MD Anderson Cancer Center press release That statement got my attention last night while browsing...
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JAK STAT Signaling: EGFR and Jak-Stat3, potential targets against cisplatin resistance in ovarian cancer

JAK STAT Signaling: EGFR and Jak-Stat3, potential targets against cisplatin resistance in ovarian cancer | Biomarkers and Personalized Medicine | Scoop.it
EGFR and Jak-Stat3, potential targets against #cisplatin resistance in ovarian cancer http://t.co/kn820078...
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FDA clears biomarker test for ovarian cancer

Approval last week by US Food and Drug Administration (FDA) clears the path for nationwide use of tools that show the greatest specificity in estimating the risk of ovarian cancer in women with a pelvic mass.
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Ovarian cancer indicator identified - mirror.co.uk

A blood molecule has been identified that could help doctors spot the very earliest signs of ovarian cancer and prevent thousands of deaths.
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